LOCUS       NM_001004242            1543 bp    mRNA    linear   ROD 22-MAR-2023
DEFINITION  Rattus norvegicus Rho GTPase activating protein 8 (Arhgap8), mRNA.
ACCESSION   NM_001004242 XM_217004
VERSION     NM_001004242.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1543)
  AUTHORS   Ravichandran A and Low BC.
  TITLE     SmgGDS antagonizes BPGAP1-induced Ras/ERK activation and
            neuritogenesis in PC12 cell differentiation
  JOURNAL   Mol Biol Cell 24 (2), 145-156 (2013)
   PUBMED   23155002
  REMARK    GeneRIF: Unique role of BPGAP1 as a dual regulator for Ras and Rho
            signaling in cell morphogenesis and differentiation.
REFERENCE   2  (bases 1 to 1543)
  AUTHORS   Pan CQ, Liou YC and Low BC.
  TITLE     Active Mek2 as a regulatory scaffold that promotes Pin1 binding to
            BPGAP1 to suppress BPGAP1-induced acute Erk activation and cell
            migration
  JOURNAL   J Cell Sci 123 (Pt 6), 903-916 (2010)
   PUBMED   20179103
REFERENCE   3  (bases 1 to 1543)
  AUTHORS   Wang L, Yang L, Debidda M, Witte D and Zheng Y.
  TITLE     Cdc42 GTPase-activating protein deficiency promotes genomic
            instability and premature aging-like phenotypes
  JOURNAL   Proc Natl Acad Sci U S A 104 (4), 1248-1253 (2007)
   PUBMED   17227869
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC079089.1.
            
            On Sep 10, 2004 this sequence version replaced XM_217004.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC079089.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132266, SAMD00132276
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1543
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q34"
     gene            1..1543
                     /gene="Arhgap8"
                     /note="Rho GTPase activating protein 8"
                     /db_xref="GeneID:300115"
                     /db_xref="RGD:1303143"
     exon            1..52
                     /gene="Arhgap8"
                     /inference="alignment:Splign:2.1.0"
     exon            53..194
                     /gene="Arhgap8"
                     /inference="alignment:Splign:2.1.0"
     CDS             116..1393
                     /gene="Arhgap8"
                     /codon_start=1
                     /product="rho GTPase-activating protein 8"
                     /protein_id="NP_001004242.1"
                     /db_xref="GeneID:300115"
                     /db_xref="RGD:1303143"
                     /translation="MAGLDPTLSTSHPFYDVARHGILQVAGDDRQGRRIFTFSCCRLP
                     PLHQLNHQRLLEYLKYTLDQHVENDYTIVYFHYGLSSQNKPSLGWLQNAYKEFDRKYK
                     KNLKALYVVHPTSLIKALWNIFKPLISHKFGKKVTYCSNLRELREHLQCDQLLIPPEV
                     VRYDEKLRNLHKGQTAPPTKTPPPRPPLPTQQFGVSLQYLRDKNQGELIPPVLRWTVT
                     YLREKGLHTEGLFRRSASAQTVRQVQRLYDQGKPVNFDDYGDMHLPAVILKTFLRELP
                     QPLLTFQAYEQILGITSVESSLRVTHCRLILRSLPEHNYAVLRYLMGFLHEVSLESIS
                     NKMNSSNLACVFGLNLIWPSQGVASLSALVPLNLFTELLIEYYDKVFSAQEGPGEHIR
                     DTVETKQAGPVTKEFTQTGTPRASPYLSRLRIP"
     exon            195..282
                     /gene="Arhgap8"
                     /inference="alignment:Splign:2.1.0"
     exon            283..414
                     /gene="Arhgap8"
                     /inference="alignment:Splign:2.1.0"
     exon            415..501
                     /gene="Arhgap8"
                     /inference="alignment:Splign:2.1.0"
     exon            502..600
                     /gene="Arhgap8"
                     /inference="alignment:Splign:2.1.0"
     exon            601..711
                     /gene="Arhgap8"
                     /inference="alignment:Splign:2.1.0"
     exon            712..785
                     /gene="Arhgap8"
                     /inference="alignment:Splign:2.1.0"
     exon            786..863
                     /gene="Arhgap8"
                     /inference="alignment:Splign:2.1.0"
     exon            864..992
                     /gene="Arhgap8"
                     /inference="alignment:Splign:2.1.0"
     exon            993..1096
                     /gene="Arhgap8"
                     /inference="alignment:Splign:2.1.0"
     exon            1097..1517
                     /gene="Arhgap8"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccaggtgtg cggctagagt agctgagatc aggagaggtg ctcggtggtc cgagctgcag
       61 agacaaggaa tcagcagcca cactgagggc cacaggagga ccctcagtgg tgttcatggc
      121 tggcctggac cccacgctga gcacaagtca cccattctat gatgtggcca gacacggcat
      181 cctgcaggtg gcaggggatg accgccaggg gagacgcatc ttcactttca gctgctgccg
      241 gttgccaccc ttgcaccagc tcaaccacca gcgtctgctg gagtatctga agtacacact
      301 ggaccagcat gtggagaacg actatactat cgtctacttc cactatggcc tcagcagcca
      361 gaacaaacca tccctaggat ggctccagaa cgcctacaag gagtttgacc ggaagtacaa
      421 gaagaacctg aaggcattgt atgttgtaca tcccaccagc ctcatcaaag cactgtggaa
      481 catcttcaag cccctcatca gtcacaagtt tgggaaaaaa gtcacctact gcagcaacct
      541 gcgtgagctc cgggaacacc ttcagtgcga ccagctgctc atccccccgg aagtggtgcg
      601 gtatgacgag aagctgcgaa acctgcacaa aggccagaca gcccctccca ccaagacgcc
      661 gccacctcgg ccgcctctgc ctacccagca gttcggcgtc agtttgcaat acctcagaga
      721 caaaaatcaa ggtgaactca tcccccctgt gctgcgttgg acggtgacat atctgagaga
      781 aaaaggactg cacactgaag gcctgttccg gagatcagcc agcgcccaga ctgtccgcca
      841 ggtgcagcgg ctctatgatc aagggaagcc tgtgaacttt gatgattatg gtgacatgca
      901 cctcccagct gtgattctaa agacatttct tcgagagctg ccccagccac tgctgacctt
      961 ccaagcctac gagcagattc tcgggatcac cagtgtggag agcagcctgc gagtgaccca
     1021 ctgccgcctg atcctgagga gcctcccaga acacaactat gccgtcctcc gctacctcat
     1081 gggcttcctg catgaggtgt ctctggagag catttcaaac aagatgaaca gctctaacct
     1141 ggcatgtgtg tttgggctga acttgatctg gccatcccag ggggtggctt ccctgagcgc
     1201 cctggttcct ctgaacttgt tcacagagct gctgatagag tactatgaca aagtcttcag
     1261 tgcccaggag ggccctgggg agcacatccg ggatactgtc gaaacgaaac aggctggtcc
     1321 tgttaccaaa gaattcacac agacgggcac tccccgggcc tcaccatacc tgtctcgcct
     1381 ccgtatcccc tgagtagctg gagacacctt aagatgcccc cttccattct atgcatctgt
     1441 gtacctggtt gtcttacaaa cttactgtct ttaagaagac acgggaatta aatggaccca
     1501 gaactttcta gtagggaaaa aaaaaaaaaa aaaaaaaaaa aaa
//
