LOCUS       NM_001399400            7424 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus Rho GTPase activating protein 5 (Arhgap5), mRNA.
ACCESSION   NM_001399400 XM_008764656
VERSION     NM_001399400.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 7424)
  AUTHORS   Wang,S., Li,N. and Meng,X.
  TITLE     Silencing of the circ-Arhgap5 RNA protects neuronal PC12 cells
            against injury and depends on the miR-29a-3p/Rock1 axis
  JOURNAL   Metab Brain Dis 38 (4), 1285-1296 (2023)
   PUBMED   36790698
  REMARK    GeneRIF: Silencing of the circ-Arhgap5 RNA protects neuronal PC12
            cells against injury and depends on the miR-29a-3p/Rock1 axis.
REFERENCE   2  (bases 1 to 7424)
  AUTHORS   Fang,Y., Zhu,X., Wang,J., Li,N., Li,D., Sakib,N., Sha,Z. and
            Song,W.
  TITLE     MiR-744 functions as a proto-oncogene in nasopharyngeal carcinoma
            progression and metastasis via transcriptional control of ARHGAP5
  JOURNAL   Oncotarget 6 (15), 13164-13175 (2015)
   PUBMED   25961434
REFERENCE   3  (bases 1 to 7424)
  AUTHORS   McHenry,P.R., Sears,J.C., Herrick,M.P., Chang,P.,
            Heckman-Stoddard,B.M., Rybarczyk,M., Chodosh,L.A., Gunther,E.J.,
            Hilsenbeck,S.G., Rosen,J.M. and Vargo-Gogola,T.
  TITLE     P190B RhoGAP has pro-tumorigenic functions during MMTV-Neu mammary
            tumorigenesis and metastasis
  JOURNAL   Breast Cancer Res 12 (5), R73 (2010)
   PUBMED   20860838
REFERENCE   4  (bases 1 to 7424)
  AUTHORS   Heckman-Stoddard,B.M., Vargo-Gogola,T., McHenry,P.R., Jiang,V.,
            Herrick,M.P., Hilsenbeck,S.G., Settleman,J. and Rosen,J.M.
  TITLE     Haploinsufficiency for p190B RhoGAP inhibits MMTV-Neu tumor
            progression
  JOURNAL   Breast Cancer Res 11 (4), R61 (2009)
   PUBMED   19703301
REFERENCE   5  (bases 1 to 7424)
  AUTHORS   Heckman,B.M., Chakravarty,G., Vargo-Gogola,T., Gonzales-Rimbau,M.,
            Hadsell,D.L., Lee,A.V., Settleman,J. and Rosen,J.M.
  TITLE     Crosstalk between the p190-B RhoGAP and IGF signaling pathways is
            required for embryonic mammary bud development
  JOURNAL   Dev Biol 309 (1), 137-149 (2007)
   PUBMED   17662267
REFERENCE   6  (bases 1 to 7424)
  AUTHORS   Sordella,R., Classon,M., Hu,K.Q., Matheson,S.F., Brouns,M.R.,
            Fine,B., Zhang,L., Takami,H., Yamada,Y. and Settleman,J.
  TITLE     Modulation of CREB activity by the Rho GTPase regulates cell and
            organism size during mouse embryonic development
  JOURNAL   Dev Cell 2 (5), 553-565 (2002)
   PUBMED   12015964
REFERENCE   7  (bases 1 to 7424)
  AUTHORS   Chakravarty,G., Roy,D., Gonzales,M., Gay,J., Contreras,A. and
            Rosen,J.M.
  TITLE     P190-B, a Rho-GTPase-activating protein, is differentially
            expressed in terminal end buds and breast cancer
  JOURNAL   Cell Growth Differ 11 (7), 343-354 (2000)
   PUBMED   10939588
REFERENCE   8  (bases 1 to 7424)
  AUTHORS   Ellis,C., Moran,M., McCormick,F. and Pawson,T.
  TITLE     Phosphorylation of GAP and GAP-associated proteins by transforming
            and mitogenic tyrosine kinases
  JOURNAL   Nature 343 (6256), 377-381 (1990)
   PUBMED   1689011
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000006.1.
            
            On Jan 7, 2022 this sequence version replaced XM_008764656.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360190.1980675.1,
                                           SRR22582416.1610677.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-121               JAXUCZ010000006.1  75711718-75711838
            122-4010            JAXUCZ010000006.1  75723381-75727269
            4011-4158           JAXUCZ010000006.1  75752071-75752218
            4159-4236           JAXUCZ010000006.1  75762892-75762969
            4237-4368           JAXUCZ010000006.1  75765158-75765289
            4369-4474           JAXUCZ010000006.1  75767378-75767483
            4475-7424           JAXUCZ010000006.1  75771687-75774636
FEATURES             Location/Qualifiers
     source          1..7424
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q23"
     gene            1..7424
                     /gene="Arhgap5"
                     /gene_synonym="LRRGT00098"
                     /note="Rho GTPase activating protein 5"
                     /db_xref="GeneID:299012"
                     /db_xref="RGD:1308507"
     exon            1..121
                     /gene="Arhgap5"
                     /gene_synonym="LRRGT00098"
                     /inference="alignment:Splign:2.1.0"
     exon            122..4010
                     /gene="Arhgap5"
                     /gene_synonym="LRRGT00098"
                     /inference="alignment:Splign:2.1.0"
     CDS             291..4802
                     /gene="Arhgap5"
                     /gene_synonym="LRRGT00098"
                     /codon_start=1
                     /product="rho GTPase-activating protein 5"
                     /protein_id="NP_001386329.1"
                     /db_xref="GeneID:299012"
                     /db_xref="RGD:1308507"
                     /translation="MMAKNKEPRPPSYTVSVVGLSGTEKDKGNCGVGKSCLCNRFVRS
                     KADEYYPEHTSVLSTIDFGGRVVNNDHFLYWGDITQNGEDGVECKIHVIEQTEFIDDQ
                     TFLPHRSTNLQPYIKRAAASKLQSAEKLMYICTDQLGLEQDFEQKQMPEGKLNVDGFL
                     LCIDVSQGCNRKFDDQLKFVNNLFVQLSKSKKPVIIAATKCDECVDHYLREVQAFASN
                     KKNLLVVETSARFNVNIETCFTALVQMLDKTRGKPKIIPYLDAYKTQRQLVVTATDKF
                     EKLVQTVRDYHATWKTVSNKLKNHPDYEEYINLEGTRKARNTFSKHIEQLKQEHIRKR
                     REEYISTLPRAFNTLLPDLEEIEHLNWLEALKLMEKRADFQLCFVVLEKTPWDETDHI
                     DKINDRRIPFDLLSTLEAEKVYQNHVQHLISEKRRIEMKEKFKKTLEKIQFISPGQPW
                     EEVMCFVMEDEAFKYITEADSKEVYGRHQREIVEKAKEEFQEMLFEHSELFYDLDLNA
                     TPSSDKMSEIHTVLSEEPRYKALQKLAPDRESLLLKHIGFVYHPTKETCLSGQYCTDI
                     KVENLLANSLLHSDHNRSRLYHDSTNIDKVNLFILGKDGLAQELANEIRTQSTDDEYA
                     LDGKIYELDLRPVDAKSPYILSQLWTAAFKPHGCFCVFNSIESLSFIGEFIGKIRTEA
                     SQIRKDKYMANLPFTLILANQRDSISKNLPILRHQGQQLANKLQCPFVDVPAGTYPRK
                     FNESQIKQALRGVLESVKHNLDVVSPVPINKDVSEADLRIVMCAMCGDPFSVDIILSP
                     FLDSHSCSAAQAGQNNSLMLDKIIGEKRRRIQITILSYHSSIGVRKDELVHGYILVYS
                     AKRKASMGMLRAFLSEVQDTIPVQLVAVTDSQADFFENEAIKELMTEGEHIATEITAK
                     FTALYSLSQYHRQTEVFTLFFSDVLEKKNMIENSYLSDNTRESTHQSEDVFLPSPRDC
                     FPYNNYPDSDDDTEAPPPYSPIGDDVQLLPTPSDRSRYRLDLEGNEYPVHSTPNCHDH
                     ERNHKVPPPIKPKPVVPKTNVKKLDPNLLKTIEAGIGKNPRKQTSRVPLAHPEDMDSS
                     DNYAEPLDTIFKQKGYPDEIYVVPDDSQNRIIKIRNSFVNNTQGDEENGFSDRTSKGH
                     GERRPSKYKYKSKTLFSKAKSYYRRTHSDASDDEAFPTSKTKRKGRHRGSEEDPLLSP
                     VETWKGGIDNPAITSDQEVDDKKIKKKPHKVKEDKKQKKKTKTFNPPTRRNWESNYFG
                     MPLQDLVTAEKPIPLFVEKCVEFIEDTGLCTEGLYRVSGNKTDQDNIQKQFDQDHNIN
                     LASMEVTVNAVAGALKAFFADLPDPLIPYSLHPELLEAAKIPDKTERLHALKEIVKKF
                     HPVNYDVFRYVITHLNRVSQQNKINLMTADNLSICFWPTLMRPDFENREFLSTTKIHQ
                     SVVETFIQQCQFFFYNGEIVETANTVAAPPTSNPGQLVESMVPLQLPPPLQPQLIQPQ
                     LQTDPLGII"
     exon            4011..4158
                     /gene="Arhgap5"
                     /gene_synonym="LRRGT00098"
                     /inference="alignment:Splign:2.1.0"
     exon            4159..4236
                     /gene="Arhgap5"
                     /gene_synonym="LRRGT00098"
                     /inference="alignment:Splign:2.1.0"
     exon            4237..4368
                     /gene="Arhgap5"
                     /gene_synonym="LRRGT00098"
                     /inference="alignment:Splign:2.1.0"
     exon            4369..4474
                     /gene="Arhgap5"
                     /gene_synonym="LRRGT00098"
                     /inference="alignment:Splign:2.1.0"
     exon            4475..7424
                     /gene="Arhgap5"
                     /gene_synonym="LRRGT00098"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaggcgagcc gagagtggag gaggcggcgg cggcgggagc gctccccagg aatgtcgctg
       61 ccgccgccac caccgcggcc gctgccgttg aggaggcgac ggaggagacc ggcgttgtta
      121 ggaagatgat ccctatgatc ttgaagaaga cctttctttg gcgatgaggg aactacaaag
      181 aaccaaatat aattctgaaa ttcaggatct gtattttgag aaggttttat tttcagaatg
      241 aaaagtatat atggttacct ttatgaatgt aaagacatga gaaaagagtt atgatggcaa
      301 agaacaaaga gcctcgaccc ccatcctata ctgtcagtgt ggttggactc tctgggactg
      361 aaaaagacaa aggaaactgt ggagttggaa aatcttgttt gtgcaataga tttgtacgtt
      421 caaaagcaga tgaatattat ccagagcata cttctgtgct tagcaccatt gactttggag
      481 gacgagtagt aaacaatgat cactttttat actggggtga cataacacaa aatggtgaag
      541 atggagtaga atgcaaaatt catgtcattg aacaaacaga gttcattgat gatcagactt
      601 tcttgcctca tcgaagtaca aatttgcaac catacataaa acgtgcagct gcctctaaat
      661 tgcagtcagc agaaaaactg atgtacattt gcaccgatca gctaggcttg gagcaagact
      721 ttgaacagaa gcagatgcct gaagggaaac tcaatgtaga tggattttta ttgtgtattg
      781 atgtgagtca aggatgtaat aggaagtttg atgatcaact taaatttgtg aataaccttt
      841 ttgtccagct atcaaaatcc aaaaagcctg tgataatagc agcaactaaa tgtgatgaat
      901 gtgtggatca ttaccttaga gaagttcaag cctttgcttc aaacaaaaag aaccttctag
      961 tagtggaaac atcagcacga tttaatgtca acattgagac atgtttcact gctttggtac
     1021 aaatgttgga taaaactcgt ggcaaaccta aaattattcc ctatctggat gcttataaaa
     1081 cacagagaca acttgttgtc acagcaacag acaagtttga aaaacttgta cagactgtga
     1141 gagattatca tgcaacttgg aaaactgtta gtaataaatt aaaaaaccac cctgattatg
     1201 aagaatatat caacttagag ggaacaagaa aggccagaaa tacattttca aagcatatag
     1261 agcaactcaa acaggaacat ataagaaaaa ggagagaaga atatataagt accttaccaa
     1321 gggcttttaa tactctcttg ccagatctag aagagattga acatttgaat tggttggaag
     1381 ctttgaagtt aatggaaaag agagcagatt tccagttatg ttttgtggtg ctagaaaaaa
     1441 caccttggga tgaaactgac catatagaca aaattaatga tagacggatc ccattcgacc
     1501 ttctgagcac tttagaagca gaaaaggtct atcaaaacca tgtacaacat ctgatatcag
     1561 agaaaagaag aatagaaatg aaggagaaat tcaagaagac tttagaaaaa attcagttca
     1621 tttcacctgg gcagccgtgg gaggaagtta tgtgttttgt catggaggat gaagcattca
     1681 aatacatcac tgaggctgat agcaaagaag tatatggtag acatcagcga gagatagtag
     1741 aaaaagccaa agaagagttt caggaaatgc tttttgagca ttctgaactt ttttatgatt
     1801 tagatcttaa tgcaacacca agttctgata aaatgagtga aattcataca gttctaagtg
     1861 aagaacctag atataaagct ttacagaaac ttgcacctga tagagaatct cttctcctta
     1921 agcacatagg attcgtttat catcccacta aagaaacatg cctcagtggc caatactgta
     1981 cagacattaa agtggaaaac ttacttgcca atagtctatt acattcggat cataaccgct
     2041 cacgcttgta tcatgatagt accaatatag acaaagttaa tcttttcatt ttagggaaag
     2101 atggccttgc ccaggaacta gcaaatgaga taaggactca atccactgat gatgagtatg
     2161 ccttagatgg aaaaatttat gaacttgatc ttcggcctgt tgatgccaaa tcgccttaca
     2221 ttttgagtca gctatggact gcagccttta aaccacatgg gtgcttctgt gtatttaatt
     2281 ccatcgagtc actgagtttt attggggagt ttattggaaa aataagaact gaagcatctc
     2341 agatcagaaa agataaatat atggctaatc ttccatttac attaattctt gctaatcaga
     2401 gagattccat tagtaaaaat ctaccaattc tcaggcatca aggtcaacag ttggccaata
     2461 aattgcagtg tcctttcgtc gacgtacctg ctggtacgta tcctcgtaaa ttcaatgaat
     2521 cacaaataaa gcaagctcta cgaggagtat tagaatcagt taaacacaat ttagatgtgg
     2581 tgagcccagt tcctatcaat aaggatgtgt cagaagctga cttgagaatt gtcatgtgtg
     2641 ccatgtgtgg cgatcctttt agtgtggata ttattctttc acctttcctt gactctcatt
     2701 cttgcagtgc tgctcaagct ggacagaata attcattaat gcttgacaaa attattggtg
     2761 aaaaaaggag gcgaatacag atcacaatat tgtcatacca ctcctcaatt ggagtaagaa
     2821 aagatgaact agttcatggg tatatattag tttattctgc aaaaaggaaa gcatcaatgg
     2881 gaatgcttcg tgcatttcta tcagaagttc aagataccat tcctgtacaa ctggtggcag
     2941 ttactgacag tcaagctgat ttttttgaaa atgaagctat caaggagtta atgactgaag
     3001 gagaacacat tgcaactgag ataactgcta aatttacagc attatattct ttatctcagt
     3061 atcataggca aactgaggtt tttactttgt ttttcagtga cgttctagag aaaaaaaata
     3121 tgatagaaaa ttcctatttg tctgataata caagggaatc cactcatcaa agtgaagatg
     3181 tttttcttcc gtctccaaga gactgctttc cctacaacaa ctacccagat tcagatgatg
     3241 acacagaagc accacctcca tatagtccaa ttggggatga tgtacagttg cttccaacac
     3301 ctagtgaccg ttccagatac aggttagatt tggaaggaaa tgagtatcct gttcatagca
     3361 ctccaaattg tcacgatcat gagcgtaacc ataaagtgcc tccacctatt aaacctaaac
     3421 cagtcgttcc taaaacaaat gtgaaaaaac tggatccaaa cctattaaaa acgattgaag
     3481 ctggtattgg taaaaatcca agaaaacaga cttctcgggt gcctttggca catcctgaag
     3541 atatggattc ctcagataac tatgcggaac cccttgacac aatttttaag cagaagggct
     3601 atcctgatga gatttatgtt gtcccagatg atagtcagaa tcgaattatt aaaattcgaa
     3661 actcatttgt aaataacact caaggagatg aagaaaatgg gttttctgat agaacctcaa
     3721 aaggtcatgg ggaacgtagg ccttcaaaat acaagtataa gtctaaaact ctgtttagta
     3781 aagccaagtc atactataga agaacacact cagatgcaag cgatgatgag gctttcccta
     3841 cttctaaaac aaaaagaaaa ggaaggcatc gtggaagtga agaagatcca ttactttctc
     3901 ctgttgaaac ttggaaaggt ggtattgata atcctgcaat cacatctgac caggaggtag
     3961 atgataagaa gataaagaag aaaccccaca aagtaaaaga agataaaaag cagaaaaaga
     4021 aaactaagac cttcaaccca ccaacacgta gaaattggga aagtaattac tttgggatgc
     4081 ccctccagga tctggttaca gctgagaagc ctataccact atttgttgag aaatgtgtgg
     4141 aatttattga agacacagga ttatgtaccg aaggactata ccgtgttagt ggaaataaaa
     4201 cggatcaaga caacattcaa aagcagtttg atcaagatca taatatcaat ctagcatcaa
     4261 tggaagtgac agtaaatgct gtagctggag ctctcaaagc tttctttgct gatctgccag
     4321 atcctttgat tccatactca ctccacccag agctattgga agcagcaaaa atcccagata
     4381 aaacagaacg ccttcatgcc ttgaaagaaa ttgttaagaa atttcatcct gtaaactatg
     4441 atgtattcag atatgtgata acacatctaa acagggttag tcagcaaaat aaaatcaacc
     4501 taatgacagc agacaactta tccatctgtt tttggccaac tttgatgaga cctgactttg
     4561 aaaatcggga gtttctgtct accactaaaa tccatcaatc tgtcgttgaa acatttattc
     4621 aacagtgcca gtttttcttt tacaatggag aaattgtaga aactgcaaat actgtggctg
     4681 ctccaccaac ttcaaatcca ggacaattgg tggagtcaat ggtaccactt caattgccac
     4741 cacccttgca acctcagcta attcaaccac agttgcagac agatcctctt ggtattattt
     4801 aaatagaatg tgattgcaga tggcctgaaa ttggacaaaa acaaatctag acatgcatgt
     4861 ttcaggggtt agtagtgtat ttcatgtttc atacagataa tccacatgaa aatgatgaga
     4921 cattttctct ttgaactata tggtattccc tattcagtta cattacgaat ctaaaaaaca
     4981 tgtgataagc atgaccggag aggtttaatt tttataaaca aaaaatagtt ataaaaatgc
     5041 aaagctgctg ctgcatgcaa ccttattgca atcagtatat cattcctgtg gcaatttctg
     5101 tcacattata ttgtgaatac aatttttcta tagaaattaa atgatttaaa aactcatata
     5161 tgaaatgttt aatgctttca gcctgcttta tggctggttt tgttatttga ttgctaattt
     5221 ggggacctaa ttccagcagt ctgtatagat aactaaagcc cagttaagta ttttttaatt
     5281 tcaggttact atgccatgct tgggatgttt gaaagaaaga aaaaaagtac atgtaatatg
     5341 tttcacattt ctgcaccttc atcttctaag taaatctgtg ggtgacttga tgaggagtga
     5401 gtggacctgt ttcttttact cacacaccaa ggacacacct gtggttaaag tgagttgata
     5461 atgtgatgta aagaatagtt gtcacaaact catttcttta tgatctataa tgaaagatac
     5521 attttgtata catggttaat tctgtaaaca gatgcatgtt taaaagatct atgatggtct
     5581 tataatctta atctaatata ttttagatat tttaattttt ccctcttggg gaatacattt
     5641 agtatagtgt agaaaactac ttcatgacat tttcatataa ggttatataa cttttcatac
     5701 ataaacatga agtttgttgt agaaagttct ttaaaccaaa catttaatct aggatttcaa
     5761 tttaatctgt tccttgaatc tatttttatg tggcccttga gaatatatcc caaaaaattc
     5821 cattgctaat acagcaataa aaatactttg ggtactgaca gactccttgg agtgtgtata
     5881 tatatataaa atcacaaact tgtattcaga ctctttctgt ggtgtgttgt tctagaatcc
     5941 agaatggctt ttgcaccatt ttttaaacca gtcctcccac ccccacccca ccccacccca
     6001 ccccacgtcc cttttgctat tggtaccaga gttgctataa atgactgctg ctttaggggt
     6061 taaatatttt gttagtgaag atacaaccag aacactaaat tatgataaac ctttctgact
     6121 gggtgatagg taaatttagt tgggttatat tcaaaattat tttaattacc aaacccatac
     6181 catttgtttt actggagaag tggtttgctt tttactgctg ggtcatattt tgtgtagtaa
     6241 agaaattctt tggtcaatgt tgtaatcttt atatttcaat tttaaggttt ccttatttgt
     6301 attatagtaa attgatgatt ttgagattca aggctcctaa gagtttgatt tgttccattt
     6361 tgtcttaaaa tattctttct caattgttag atcttagata ttgtacttcc aatttcaact
     6421 aagatgtcaa catgaaccag gctactgttg aagtacatgt atattataaa ttaccttatt
     6481 tgtgttatta tcttttctaa gaaaacaaag tccctattat tcctattgca aagcacacag
     6541 gaatttaaga aagtacagta atttttaaaa agaaaatatc cggtaaatgt agtattccta
     6601 acttgttcta tattacttat acctattgtc tatatagctt taatttatag ctgtcagttt
     6661 aacattggca tgtctggcaa agaaaattaa actttaagag ttttataaac tgtttctagg
     6721 ttgctaaaga atttattttt ctactataaa tggtatagac aaagcatcga ctatgtacag
     6781 gataaaagcc tgactatttc tattggaagt aggcttacga gagaattttc agaactgttc
     6841 atatctttgg ttccttctgt cctaacttta ctattgtaat atgtgagtcc cagtttattt
     6901 aagctattat cttttataat gtgttaattt aacattcatt tacatttaaa actatttttg
     6961 ttattaaaat tagcatttat aagtttccac attaaccacc ttacacctct tccaaactga
     7021 tctcttactt ttctatgcat tctatcattg atttgacaca ctacatagtg agtcacttaa
     7081 atattctaca tctggttcat tttactacta ggttacagat attgaaaatt aaagtatggt
     7141 ttaaagctca gtctgttaca ctgacttgtg tttgtttttg gacaagggta taggtatatt
     7201 tttaaatatt agaacagtaa ttctaaaaag tgattaacat aattaaatca tttgttgctt
     7261 gtaagttact ggaacattgc actgtttagg gacacacaca tacacacatg tgtatatgag
     7321 actaaatgga tttaaagaat agtagataat cttataataa tggtagataa tcttacaata
     7381 atgggtcaac attgacattc acaatattaa aaaaattcca tcta
//
