LOCUS       NM_001419596            4103 bp    mRNA    linear   ROD 09-APR-2024
DEFINITION  Rattus norvegicus Rho GTPase activating protein 44 (Arhgap44),
            mRNA.
ACCESSION   NM_001419596 XM_006246834
VERSION     NM_001419596.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4103)
  AUTHORS   Luo,M., Miao,Y.R., Ke,Y.J., Guo,A.Y. and Zhang,Q.
  TITLE     A comprehensive landscape of transcription profiles and data
            resources for human leukemia
  JOURNAL   Blood Adv 7 (14), 3435-3449 (2023)
   PUBMED   36595475
REFERENCE   2  (bases 1 to 4103)
  AUTHORS   Zhang,J., Yang,C., Gong,L., Zhu,S., Tian,J., Zhang,F., Zhu,Q.,
            Wang,J., Lan,M., Li,Y. and Zhang,W.
  TITLE     RICH2, a potential tumor suppressor in hepatocellular carcinoma
  JOURNAL   Front Biosci (Landmark Ed) 24 (8), 1363-1376 (2019)
   PUBMED   31136984
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4103)
  AUTHORS   Xu,J., Jiao,J., Xu,W., Ji,L., Jiang,D., Xie,S., Kubra,S., Li,X.,
            Fu,J., Xiao,J. and Zhang,B.
  TITLE     Mutant p53 promotes cell spreading and migration via ARHGAP44
  JOURNAL   Sci China Life Sci 60 (9), 1019-1029 (2017)
   PUBMED   28527113
REFERENCE   4  (bases 1 to 4103)
  AUTHORS   Liu,S., Wang,Y., Xue,W., Liu,H., Xu,Y., Shi,Q., Wu,W., Zhu,D.,
            Amos,C.I., Fang,S., Lee,J.E., Hyslop,T., Li,Y., Han,J. and Wei,Q.
  TITLE     Genetic variants in the genes encoding rho GTPases and related
            regulators predict cutaneous melanoma-specific survival
  JOURNAL   Int J Cancer 141 (4), 721-730 (2017)
   PUBMED   28510328
REFERENCE   5  (bases 1 to 4103)
  AUTHORS   Paximadis,M., Ngqobe,R.N., Chaisson,R.E., Martinson,N.A. and
            Tiemessen,C.T.
  TITLE     RICH2 is implicated in viraemic control of HIV-1 in black South
            African individuals
  JOURNAL   Infect Genet Evol 49, 78-87 (2017)
   PUBMED   28069446
REFERENCE   6  (bases 1 to 4103)
  AUTHORS   Galic,M., Tsai,F.C., Collins,S.R., Matis,M., Bandara,S. and
            Meyer,T.
  TITLE     Dynamic recruitment of the curvature-sensitive protein ArhGAP44 to
            nanoscale membrane deformations limits exploratory filopodia
            initiation in neurons
  JOURNAL   Elife 3, e03116 (2014)
   PUBMED   25498153
  REMARK    GeneRIF: expression increases during neuronal development,
            concurrent with a decrease in the rate of filopodia formation.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 4103)
  AUTHORS   Raynaud,F., Moutin,E., Schmidt,S., Dahl,J., Bertaso,F.,
            Boeckers,T.M., Homburger,V. and Fagni,L.
  TITLE     Rho-GTPase-activating protein interacting with Cdc-42-interacting
            protein 4 homolog 2 (Rich2): a new Ras-related C3 botulinum toxin
            substrate 1 (Rac1) GTPase-activating protein that controls
            dendritic spine morphogenesis
  JOURNAL   J Biol Chem 289 (5), 2600-2609 (2014)
   PUBMED   24352656
REFERENCE   8  (bases 1 to 4103)
  AUTHORS   Raynaud,F., Janossy,A., Dahl,J., Bertaso,F., Perroy,J.,
            Varrault,A., Vidal,M., Worley,P.F., Boeckers,T.M., Bockaert,J.,
            Marin,P., Fagni,L. and Homburger,V.
  TITLE     Shank3-Rich2 interaction regulates AMPA receptor recycling and
            synaptic long-term potentiation
  JOURNAL   J Neurosci 33 (23), 9699-9715 (2013)
   PUBMED   23739967
REFERENCE   9  (bases 1 to 4103)
  AUTHORS   Galic,M., Jeong,S., Tsai,F.C., Joubert,L.M., Wu,Y.I., Hahn,K.M.,
            Cui,Y. and Meyer,T.
  TITLE     External push and internal pull forces recruit curvature-sensing
            N-BAR domain proteins to the plasma membrane
  JOURNAL   Nat Cell Biol 14 (8), 874-881 (2012)
   PUBMED   22750946
REFERENCE   10 (bases 1 to 4103)
  AUTHORS   Le Clerc,S., Coulonges,C., Delaneau,O., Van Manen,D., Herbeck,J.T.,
            Limou,S., An,P., Martinson,J.J., Spadoni,J.L., Therwath,A.,
            Veldink,J.H., van den Berg,L.H., Taing,L., Labib,T., Mellak,S.,
            Montes,M., Delfraissy,J.F., Schachter,F., Winkler,C., Froguel,P.,
            Mullins,J.I., Schuitemaker,H. and Zagury,J.F.
  TITLE     Screening low-frequency SNPS from genome-wide association study
            reveals a new risk allele for progression to AIDS
  JOURNAL   J Acquir Immune Defic Syndr 56 (3), 279-284 (2011)
   PUBMED   21107268
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Apr 12, 2023 this sequence version replaced XM_006246834.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.61183.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760389,
                                           SAMEA5760393 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-364               JAXUCZ010000010.1  50321646-50322009   c
            365-404             JAXUCZ010000010.1  50229505-50229544   c
            405-509             JAXUCZ010000010.1  50228775-50228879   c
            510-586             JAXUCZ010000010.1  50222613-50222689   c
            587-698             JAXUCZ010000010.1  50213804-50213915   c
            699-775             JAXUCZ010000010.1  50211425-50211501   c
            776-893             JAXUCZ010000010.1  50204412-50204529   c
            894-962             JAXUCZ010000010.1  50194925-50194993   c
            963-1044            JAXUCZ010000010.1  50192481-50192562   c
            1045-1172           JAXUCZ010000010.1  50191952-50192079   c
            1173-1284           JAXUCZ010000010.1  50186045-50186156   c
            1285-1366           JAXUCZ010000010.1  50185605-50185686   c
            1367-1447           JAXUCZ010000010.1  50180283-50180363   c
            1448-1561           JAXUCZ010000010.1  50177809-50177922   c
            1562-1653           JAXUCZ010000010.1  50176564-50176655   c
            1654-1834           JAXUCZ010000010.1  50175394-50175574   c
            1835-1852           JAXUCZ010000010.1  50165876-50165893   c
            1853-2080           JAXUCZ010000010.1  50164855-50165082   c
            2081-2238           JAXUCZ010000010.1  50162998-50163155   c
            2239-2616           JAXUCZ010000010.1  50161048-50161425   c
            2617-4103           JAXUCZ010000010.1  50154724-50156210   c
FEATURES             Location/Qualifiers
     source          1..4103
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q24"
     gene            1..4103
                     /gene="Arhgap44"
                     /gene_synonym="RGD1305664; RICH-2"
                     /note="Rho GTPase activating protein 44"
                     /db_xref="GeneID:303222"
                     /db_xref="RGD:1305664"
     exon            1..364
                     /gene="Arhgap44"
                     /gene_synonym="RGD1305664; RICH-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             312..2756
                     /gene="Arhgap44"
                     /gene_synonym="RGD1305664; RICH-2"
                     /note="rho-type GTPase-activating protein RICH2; rhoGAP
                     interacting with CIP4 homologs protein 2"
                     /codon_start=1
                     /product="rho GTPase-activating protein 44"
                     /protein_id="NP_001406525.1"
                     /db_xref="GeneID:303222"
                     /db_xref="RGD:1305664"
                     /translation="MKKQFNRMRQLANQTVGRAEKTEVLSEDLLQVEKRLELVKQVSH
                     STHKKLTACLQGQQGAEADKRSKKLPLTTLAQCLMEGSAILGDDTLLGKMLKLCGETE
                     DELAQELIHFELRVERDVIEPLFLLAEVEIPNIQKQRKHLAKLVLDMDSSRTRWQQTS
                     KSSGLSSSLQPAGAKADALREEMEEAANRVEICRDQLSADMYSFVAKEIDYANYFQTL
                     IEVQAEYHRKSLTLLQAVLPQIKAQQEAWVEKPSFGKPLEEHLMISGREIAFPIEACV
                     TMLLECGMQEEGLFRVAPSASKLKKLKAALDCCVVDVQEYSADPHAIAGALKSYLREL
                     PEPLMTFELYDEWIQASNIQEQDKRLQALWNACEKLPKANHNNIRYLIKFLSKLSEYQ
                     DVNKMTPSNMAIVLGPNLLWPQSEGNITEMMTTVSLQIVGIIEPIIQHADWFFPGEIE
                     FNITGSYGSPVHVNHNANYSSMPSPDMDPADRRQPEQARRPLSVATDNMMLEFYKKDG
                     LRKIQSMGVRVMDTSWVARRGSSAGRKAACAPPSMQPPAPPSELAAPLPSPLPEQVPD
                     SPATPAPALSPSGASLQPTPERPSVSKSKELSPGSGQKGSPGSIQGTTCPGTQLGPQP
                     AASPSQLPADQSPHTLRKVSKKLAPIPPKVPFVQPGTVSDQPTGQPSPVSLSPTPPST
                     PSPYGLSYPPGYSMASGQLSPASAPPLASPSVFTSTLAKSRPTPKPRQRPTLPPPQPP
                     SVSLSASSPQSTEHPMLDGMSPGESMSTDLVHFDVPSIHIELGSTLRLSPLEHARRHS
                     VTDKRDSEEESESTAL"
     exon            365..404
                     /gene="Arhgap44"
                     /gene_synonym="RGD1305664; RICH-2"
                     /inference="alignment:Splign:2.1.0"
     exon            405..509
                     /gene="Arhgap44"
                     /gene_synonym="RGD1305664; RICH-2"
                     /inference="alignment:Splign:2.1.0"
     exon            510..586
                     /gene="Arhgap44"
                     /gene_synonym="RGD1305664; RICH-2"
                     /inference="alignment:Splign:2.1.0"
     exon            587..698
                     /gene="Arhgap44"
                     /gene_synonym="RGD1305664; RICH-2"
                     /inference="alignment:Splign:2.1.0"
     exon            699..775
                     /gene="Arhgap44"
                     /gene_synonym="RGD1305664; RICH-2"
                     /inference="alignment:Splign:2.1.0"
     exon            776..893
                     /gene="Arhgap44"
                     /gene_synonym="RGD1305664; RICH-2"
                     /inference="alignment:Splign:2.1.0"
     exon            894..962
                     /gene="Arhgap44"
                     /gene_synonym="RGD1305664; RICH-2"
                     /inference="alignment:Splign:2.1.0"
     exon            963..1044
                     /gene="Arhgap44"
                     /gene_synonym="RGD1305664; RICH-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1045..1172
                     /gene="Arhgap44"
                     /gene_synonym="RGD1305664; RICH-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1173..1284
                     /gene="Arhgap44"
                     /gene_synonym="RGD1305664; RICH-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1285..1366
                     /gene="Arhgap44"
                     /gene_synonym="RGD1305664; RICH-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1367..1447
                     /gene="Arhgap44"
                     /gene_synonym="RGD1305664; RICH-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1448..1561
                     /gene="Arhgap44"
                     /gene_synonym="RGD1305664; RICH-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1562..1653
                     /gene="Arhgap44"
                     /gene_synonym="RGD1305664; RICH-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1654..1834
                     /gene="Arhgap44"
                     /gene_synonym="RGD1305664; RICH-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1835..1852
                     /gene="Arhgap44"
                     /gene_synonym="RGD1305664; RICH-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1853..2080
                     /gene="Arhgap44"
                     /gene_synonym="RGD1305664; RICH-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2081..2238
                     /gene="Arhgap44"
                     /gene_synonym="RGD1305664; RICH-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2239..2616
                     /gene="Arhgap44"
                     /gene_synonym="RGD1305664; RICH-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2617..4103
                     /gene="Arhgap44"
                     /gene_synonym="RGD1305664; RICH-2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acccggccag ctggctagcc agcctgcgga gactccccgg ttcgctcgcc aggctgaggc
       61 tgggggctgc agccggggct gacggccggg tgcctaggga ggctccgggt gtggcacaga
      121 gaaggatgcg gcgggcggac taggtggagg tgctctctgg aggctgggcg cgggccaggc
      181 ggctccccag gctccgcagt gccgccgccg tcgcccggga ggctgggcgc gggagccatg
      241 taaccctgcg gcgggctccg ggcagctccg tctttcccca gctcccgggc tagcgcggca
      301 gcggggccac gatgaagaag cagtttaacc gtatgcgcca gttggccaac cagacggtgg
      361 gcagggcaga aaagactgaa gttctgagcg aagaccttct ccaggtggag aagcgcctag
      421 agctggtgaa acaggtgtcc cacagcacac acaagaagct caccgcttgt ctgcagggtc
      481 agcaaggagc agaggctgac aagcgctcaa aaaagctgcc tttgacgaca ctggcccagt
      541 gcctgatgga ggggtctgcg atcctgggag atgacacact tctcgggaag atgctgaagc
      601 tctgtggaga gacggaggac gagctagctc aggagctgat ccactttgag ctgcgagtgg
      661 agagggatgt gatcgagccc ctgttcctgc tggcggaggt ggagattcca aatattcaaa
      721 agcaaaggaa acatttagca aagctggtgc ttgacatgga ttcttcccgg accaggtggc
      781 agcagacttc caagtcttca gggctttcca gcagccttca gcctgcgggt gccaaagccg
      841 atgccctcag ggaggagatg gaggaagctg ccaatagagt ggagatttgc cgggaccagc
      901 tttccgctga catgtacagt tttgtggcca aagaaattga ctatgcaaac tactttcaaa
      961 cgctaataga agtgcaagct gagtaccaca ggaagtcgct gacactgctg caggctgtgt
     1021 tgcctcagat caaagcacag caggaggcct gggtggagaa gccttccttt gggaagcccc
     1081 tggaggagca cctgatgatc agcggccgtg agatcgcctt ccctatcgag gcgtgtgtga
     1141 cgatgctgct ggagtgtggg atgcaggagg agggcctctt ccgggtagcc ccctcagcct
     1201 ccaagctgaa gaagctgaaa gctgccctgg actgctgtgt ggtggatgtc caggagtatt
     1261 cagcagaccc ccatgccata gcaggggctt tgaagtctta tctccgagag ttgccagagc
     1321 ctcttatgac ctttgaactc tatgatgaat ggatccaggc ttctaatatc caggagcaag
     1381 acaagagact tcaggctctc tggaatgctt gtgagaagtt gcccaaggcc aaccacaaca
     1441 acatccgata cttgatcaaa tttttatcaa aactgtctga atatcaggat gtaaacaaga
     1501 tgactcccag taacatggca atcgtcctgg gacccaacct cctttggcca cagtcagagg
     1561 ggaacatcac cgagatgatg accacagttt ccctgcagat cgttggcatc attgagccta
     1621 ttattcagca tgcagactgg ttcttccctg gggagataga gttcaacatc acaggcagtt
     1681 atgggagtcc ggtccacgtg aaccacaatg ccaactatag ctcaatgccc tccccagaca
     1741 tggaccctgc tgaccggcgc cagccagagc aggcccgccg gcccctcagt gttgccacag
     1801 acaacatgat gctggagttt tacaagaagg atggccttag gaaaatccaa agcatgggtg
     1861 tgagggtcat ggacacatct tgggtggcac gaagaggctc ctctgctggt cggaaagcag
     1921 cctgcgcccc gccttccatg cagcctcctg ccccaccctc cgagctggct gcgcccctgc
     1981 cttcacccct gccggagcag gtcccagaca gccccgccac tccagctcct gcgctctctc
     2041 cgtcaggtgc cagcctgcag cccacccccg agcgccccag tgtgtctaaa agcaaggaac
     2101 tgtcaccagg gtctgggcag aaaggaagtc caggttccat ccaggggaca acctgcccag
     2161 ggacgcaact ggggccacag ccggctgcca gccccagcca gcttcctgca gaccagagtc
     2221 cgcataccct ccggaaagtt tcaaagaagt tggcaccaat tcctcccaag gtcccctttg
     2281 tgcagccagg gactgtttct gatcagccca ctggccagcc atccccagtc agcctgtctc
     2341 ctactccacc aagcacccca tcaccctatg gactgagcta ccctccgggg tactccatgg
     2401 cctctggcca gctttctcct gcctcagctc ctcccctggc ctccccctct gtctttacaa
     2461 gcactttagc caaatctcgg cccaccccta agccccgaca gaggcccacc ctaccgcctc
     2521 ctcagcctcc cagtgtcagc ctgtcggctt caagtccaca gtccacagag caccccatgt
     2581 tagacggcat gtcgccgggg gaaagcatgt ctacagatct tgtccacttt gatgtcccct
     2641 ccatccacat agagctgggg tcaacgctcc gcctgagccc cctggaacat gcacggcggc
     2701 actcagtgac tgacaagagg gactcagaag aggagtctga gagtacagcc ctttgatgtg
     2761 acgcacccca acatgtgtgc atacatccat ggccccccct aacacgtgtg catacatcca
     2821 tggcccccca acacatgtgc atacatccat gggcccagac accacccagg gcagcgcctc
     2881 ctagcctgcc aaggattttc catcagccct ttgctatcat gcccaacacc agggtggagt
     2941 tgggtagagg aagagctctc ctgtccatgt ggccagtgtt ggtggtgcag attctgtttg
     3001 ttcattttgg gtgatgaatt ccagcctttt ttttgacctt tgccttttga ctttgtgcct
     3061 atcttgatcc ctctttggcc tctatggcaa gcagcatcca cctctccatt caagggcttg
     3121 tcagaatggc ctttgcagga tgagggtaca agagagtccc cttactgcct cgactgggac
     3181 atcaggtcct gcagcatcac cataacagcc agaggggaag caagacagga agagaccctt
     3241 ttactagggc aagagatgtc ctgatcattg tctgtcctct gcctgctgcc agggtcccag
     3301 ccaaccagaa agaccattca ggctaccctt aatcacagct cccaagtaaa cgcttaatac
     3361 acctacttct gacagcttta cttcctctgt gcgatgaagg cttcctttag tccatgctga
     3421 caatctaaat tgaggatttg aacatagatg gccctacata ggtctccgtg ttccccaaac
     3481 acattaggta tcctagagca ctttcccatc aggcacccac ctcggtaggt gtgtggggcc
     3541 tggcactcct cttctggagg ttccagctca ctagcaataa ttctgtttcc caaggcaggt
     3601 agagggggtg gtccgaggcc cacagcgtgg cctgcgttgc taaccagcag accctgctca
     3661 tccttctcac catgtcccat gcagccctgg agcaagggcg caggaagcct gttcacactt
     3721 tgggattaag ggaatagaac aaatctgggc catgcatgca gtcaaagttt aaagtttgtt
     3781 cttctgaaaa tagatatacc tatacatgat atatttgtat atatgaaatc tatatttgtt
     3841 taatttgagc cattcaatct aaacctatgt acaggtgtac aatgaaaaat tctaaatgct
     3901 tagttatttt tcccagcagc gtgaactcac ccttctccga gagtgggatc tgcagacttg
     3961 aagttacagc tttgctcact tcctggcaag ggcagtccac tccccaagtc tgtaacagag
     4021 cctgggggtt gaaggttgtc tttacatata tgtacaaact gttgtcaaga gcaatgttat
     4081 taaaatagat ttattaaccc tga
//
