LOCUS       NP_001406525             814 aa            linear   ROD 09-APR-2024
DEFINITION  rho GTPase-activating protein 44 [Rattus norvegicus].
ACCESSION   NP_001406525 XP_006246896
VERSION     NP_001406525.1
DBSOURCE    REFSEQ: accession NM_001419596.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 814)
  AUTHORS   Luo,M., Miao,Y.R., Ke,Y.J., Guo,A.Y. and Zhang,Q.
  TITLE     A comprehensive landscape of transcription profiles and data
            resources for human leukemia
  JOURNAL   Blood Adv 7 (14), 3435-3449 (2023)
   PUBMED   36595475
REFERENCE   2  (residues 1 to 814)
  AUTHORS   Zhang,J., Yang,C., Gong,L., Zhu,S., Tian,J., Zhang,F., Zhu,Q.,
            Wang,J., Lan,M., Li,Y. and Zhang,W.
  TITLE     RICH2, a potential tumor suppressor in hepatocellular carcinoma
  JOURNAL   Front Biosci (Landmark Ed) 24 (8), 1363-1376 (2019)
   PUBMED   31136984
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 814)
  AUTHORS   Xu,J., Jiao,J., Xu,W., Ji,L., Jiang,D., Xie,S., Kubra,S., Li,X.,
            Fu,J., Xiao,J. and Zhang,B.
  TITLE     Mutant p53 promotes cell spreading and migration via ARHGAP44
  JOURNAL   Sci China Life Sci 60 (9), 1019-1029 (2017)
   PUBMED   28527113
REFERENCE   4  (residues 1 to 814)
  AUTHORS   Liu,S., Wang,Y., Xue,W., Liu,H., Xu,Y., Shi,Q., Wu,W., Zhu,D.,
            Amos,C.I., Fang,S., Lee,J.E., Hyslop,T., Li,Y., Han,J. and Wei,Q.
  TITLE     Genetic variants in the genes encoding rho GTPases and related
            regulators predict cutaneous melanoma-specific survival
  JOURNAL   Int J Cancer 141 (4), 721-730 (2017)
   PUBMED   28510328
REFERENCE   5  (residues 1 to 814)
  AUTHORS   Paximadis,M., Ngqobe,R.N., Chaisson,R.E., Martinson,N.A. and
            Tiemessen,C.T.
  TITLE     RICH2 is implicated in viraemic control of HIV-1 in black South
            African individuals
  JOURNAL   Infect Genet Evol 49, 78-87 (2017)
   PUBMED   28069446
REFERENCE   6  (residues 1 to 814)
  AUTHORS   Galic,M., Tsai,F.C., Collins,S.R., Matis,M., Bandara,S. and
            Meyer,T.
  TITLE     Dynamic recruitment of the curvature-sensitive protein ArhGAP44 to
            nanoscale membrane deformations limits exploratory filopodia
            initiation in neurons
  JOURNAL   Elife 3, e03116 (2014)
   PUBMED   25498153
  REMARK    GeneRIF: expression increases during neuronal development,
            concurrent with a decrease in the rate of filopodia formation.
            Publication Status: Online-Only
REFERENCE   7  (residues 1 to 814)
  AUTHORS   Raynaud,F., Moutin,E., Schmidt,S., Dahl,J., Bertaso,F.,
            Boeckers,T.M., Homburger,V. and Fagni,L.
  TITLE     Rho-GTPase-activating protein interacting with Cdc-42-interacting
            protein 4 homolog 2 (Rich2): a new Ras-related C3 botulinum toxin
            substrate 1 (Rac1) GTPase-activating protein that controls
            dendritic spine morphogenesis
  JOURNAL   J Biol Chem 289 (5), 2600-2609 (2014)
   PUBMED   24352656
REFERENCE   8  (residues 1 to 814)
  AUTHORS   Raynaud,F., Janossy,A., Dahl,J., Bertaso,F., Perroy,J.,
            Varrault,A., Vidal,M., Worley,P.F., Boeckers,T.M., Bockaert,J.,
            Marin,P., Fagni,L. and Homburger,V.
  TITLE     Shank3-Rich2 interaction regulates AMPA receptor recycling and
            synaptic long-term potentiation
  JOURNAL   J Neurosci 33 (23), 9699-9715 (2013)
   PUBMED   23739967
REFERENCE   9  (residues 1 to 814)
  AUTHORS   Galic,M., Jeong,S., Tsai,F.C., Joubert,L.M., Wu,Y.I., Hahn,K.M.,
            Cui,Y. and Meyer,T.
  TITLE     External push and internal pull forces recruit curvature-sensing
            N-BAR domain proteins to the plasma membrane
  JOURNAL   Nat Cell Biol 14 (8), 874-881 (2012)
   PUBMED   22750946
REFERENCE   10 (residues 1 to 814)
  AUTHORS   Le Clerc,S., Coulonges,C., Delaneau,O., Van Manen,D., Herbeck,J.T.,
            Limou,S., An,P., Martinson,J.J., Spadoni,J.L., Therwath,A.,
            Veldink,J.H., van den Berg,L.H., Taing,L., Labib,T., Mellak,S.,
            Montes,M., Delfraissy,J.F., Schachter,F., Winkler,C., Froguel,P.,
            Mullins,J.I., Schuitemaker,H. and Zagury,J.F.
  TITLE     Screening low-frequency SNPS from genome-wide association study
            reveals a new risk allele for progression to AIDS
  JOURNAL   J Acquir Immune Defic Syndr 56 (3), 279-284 (2011)
   PUBMED   21107268
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Apr 12, 2023 this sequence version replaced XP_006246896.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.61183.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760389,
                                           SAMEA5760393 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..814
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q24"
     Protein         1..814
                     /product="rho GTPase-activating protein 44"
                     /note="rho-type GTPase-activating protein RICH2; rhoGAP
                     interacting with CIP4 homologs protein 2"
                     /calculated_mol_wt=88984
     Region          13..260
                     /region_name="BAR"
                     /note="The Bin/Amphiphysin/Rvs (BAR) domain, a
                     dimerization module that binds membranes and detects
                     membrane curvature; cl12013"
                     /db_xref="CDD:472257"
     Site            order(21,24..25,32,34..35,38..39,41..42,70..71,73..74,
                     77..78,80..81,84,98,101..102,202,205..206,208,212,
                     215..216,218..219,222..223,226..227,229..230,233..234,
                     236..237)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:153271"
     Region          249..449
                     /region_name="RhoGAP"
                     /note="GTPase-activator protein (GAP) for Rho-like
                     GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases.
                     Small GTPases (G proteins) cluster into distinct families,
                     and all act as molecular switches, active in their
                     GTP-bound form but inactive when bound to...; cl02570"
                     /db_xref="CDD:470621"
     Site            order(291,328,332,401,404..405,431)
                     /site_type="other"
                     /note="GTPase interaction site"
                     /db_xref="CDD:238090"
     Site            291
                     /site_type="active"
                     /note="catalytic residue [active]"
                     /db_xref="CDD:238090"
     Region          467..493
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (F1LQX4.2)"
     Site            493
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q5SSM3; propagated from
                     UniProtKB/Swiss-Prot (F1LQX4.2)"
     Region          531..768
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (F1LQX4.2)"
     Region          <553..809
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     Region          <555..>673
                     /region_name="PRK10263"
                     /note="DNA translocase FtsK; Provisional"
                     /db_xref="CDD:236669"
     Region          727..814
                     /region_name="Interaction with BST2.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (F1LQX4.2)"
     Region          784..814
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (F1LQX4.2)"
     Site            805
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (F1LQX4.2)"
     Region          811..814
                     /region_name="PDZ-binding. /evidence=ECO:0000305"
                     /note="propagated from UniProtKB/Swiss-Prot (F1LQX4.2)"
     CDS             1..814
                     /gene="Arhgap44"
                     /gene_synonym="RGD1305664; RICH-2"
                     /coded_by="NM_001419596.1:312..2756"
                     /db_xref="GeneID:303222"
                     /db_xref="RGD:1305664"
ORIGIN      
        1 mkkqfnrmrq lanqtvgrae ktevlsedll qvekrlelvk qvshsthkkl taclqgqqga
       61 eadkrskklp lttlaqclme gsailgddtl lgkmlklcge tedelaqeli hfelrverdv
      121 ieplfllaev eipniqkqrk hlaklvldmd ssrtrwqqts kssglssslq pagakadalr
      181 eemeeaanrv eicrdqlsad mysfvakeid yanyfqtlie vqaeyhrksl tllqavlpqi
      241 kaqqeawvek psfgkpleeh lmisgreiaf pieacvtmll ecgmqeeglf rvapsasklk
      301 klkaaldccv vdvqeysadp haiagalksy lrelpeplmt felydewiqa sniqeqdkrl
      361 qalwnacekl pkanhnniry likflsklse yqdvnkmtps nmaivlgpnl lwpqsegnit
      421 emmttvslqi vgiiepiiqh adwffpgeie fnitgsygsp vhvnhnanys smpspdmdpa
      481 drrqpeqarr plsvatdnmm lefykkdglr kiqsmgvrvm dtswvarrgs sagrkaacap
      541 psmqppapps elaaplpspl peqvpdspat papalspsga slqptperps vskskelspg
      601 sgqkgspgsi qgttcpgtql gpqpaaspsq lpadqsphtl rkvskklapi ppkvpfvqpg
      661 tvsdqptgqp spvslsptpp stpspyglsy ppgysmasgq lspasappla spsvftstla
      721 ksrptpkprq rptlpppqpp svslsasspq stehpmldgm spgesmstdl vhfdvpsihi
      781 elgstlrlsp leharrhsvt dkrdseeese stal
//
