LOCUS       NM_144740               3195 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus Rho GTPase activating protein 4 (Arhgap4), mRNA.
ACCESSION   NM_144740 XM_579669
VERSION     NM_144740.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3195)
  AUTHORS   Guez-Haddad J, Sporny M, Sasson Y, Gevorkyan-Airapetov L,
            Lahav-Mankovski N, Margulies D, Radzimanowski J and Opatowsky Y.
  TITLE     The Neuronal Migration Factor srGAP2 Achieves Specificity in Ligand
            Binding through a Two-Component Molecular Mechanism
  JOURNAL   Structure 23 (11), 1989-2000 (2015)
   PUBMED   26365803
REFERENCE   2  (bases 1 to 3195)
  AUTHORS   Vogt DL, Gray CD, Young WS 3rd, Orellana SA and Malouf AT.
  TITLE     ARHGAP4 is a novel RhoGAP that mediates inhibition of cell motility
            and axon outgrowth
  JOURNAL   Mol Cell Neurosci 36 (3), 332-342 (2007)
   PUBMED   17804252
  REMARK    GeneRIF: These observations suggest that ARHGAP4 can act as a
            potent inhibitor of cell and axon motility when it is localized to
            the leading edge of motile cells and axons.
REFERENCE   3  (bases 1 to 3195)
  AUTHORS   Foletta VC, Brown FD and Young WS 3rd.
  TITLE     Cloning of rat ARHGAP4/C1, a RhoGAP family member expressed in the
            nervous system that colocalizes with the Golgi complex and
            microtubules
  JOURNAL   Brain Res Mol Brain Res 107 (1), 65-79 (2002)
   PUBMED   12414125
  REMARK    GeneRIF: ARHGAP4 occured in the hippocampus, ventral region of the
            brainstem and striatum, and in cerebellar granule cells.
            Subcellularly, ARHGAP4 localized to the Golgi complex and could
            redistribute to the microtubules, for example during mitosis.
REFERENCE   4  (bases 1 to 3195)
  AUTHORS   Pruitt KD and Maglott DR.
  TITLE     RefSeq and LocusLink: NCBI gene-centered resources
  JOURNAL   Nucleic Acids Res 29 (1), 137-140 (2001)
   PUBMED   11125071
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF401635.1 and CO572120.1.
            
            On Nov 1, 2005 this sequence version replaced NM_144740.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF401635.1, AY742900.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-70                AF401635.1         10-79
            71-2287             AF401635.1         81-2297
            2288-2289           CO572120.1         284-285
            2290-3195           AF401635.1         2300-3205
FEATURES             Location/Qualifiers
     source          1..3195
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq37"
     gene            1..3195
                     /gene="Arhgap4"
                     /note="Rho GTPase activating protein 4"
                     /db_xref="GeneID:246249"
                     /db_xref="RGD:628901"
     exon            1..165
                     /gene="Arhgap4"
                     /inference="alignment:Splign:2.1.0"
     CDS             99..2996
                     /gene="Arhgap4"
                     /codon_start=1
                     /product="rho GTPase-activating protein 4"
                     /protein_id="NP_653341.2"
                     /db_xref="GeneID:246249"
                     /db_xref="RGD:628901"
                     /translation="MAAHGKLRRERGLQPEYEAQVKVMRGQLSEQLHCLELQGELRRD
                     LLLELAEFMRRRAEVELEYSRGLDKLAERFTSRSGRLGGSSREQQSFRKEPTLLSPLH
                     CWAMLLEHTRQQSRESATLSEVLAGPLAQRLSHIAEDVGRIVKKSKDLVQQLQDELLE
                     VVSELQTQGYLAWASLQTKKTYHVYHLESMNAETKLREAERQEEKRSGKSALPTTTAA
                     SATTTITIETELHRKGSLKKGGRLVEKRQAKFLEHKLKCTKARNEYLLSLASVNAAVS
                     NYYLHDILDLMDCCDTGFHLALEQALRSYTAAESRTQTSHMQGLGSLEEALEALDPPG
                     DKAKVLEVHAMAFCPPLRFDYQPHEGDEVAEIQVEMELRDEILPRAQNIQSRLDQKTI
                     ETEEVNKTLKATLQALLEVVASEDGDILDSLQASPSTESLKSTSSDPGTRQAGRRRNQ
                     QQETETFYITKLQEYLSGRSILAKLQAKHEKLQEAIQRGNKEEQETSSWTQCTERKFH
                     KSHHPYPGSQCTQRLFGGDLEKFIQSTGQPVPLVVKSCIRFINLNGLQHEGIFRVSGA
                     QARILEIRDAFERGEDPLVEGCTAHDLDSVAGVLKLYFRSLEPPLFPLDMFNELLASA
                     ELEVVGERVELVSHLLSRLPRPVLVVLRYLFTFLNHLAQYSDENMMDSYNLAVCFGPT
                     LLPVPAGQDPVALQGRVNQLVQTLILQPAWVFPPTAMLPGPIYEKCMAPPSASCLGDG
                     QLESLAGEPELELKTGTKAQEDDSEGVVEAVACFAYTGRTAQELTFQQGDTLRLYARA
                     SSDWWRGEHAGVRGLIPHKYITLSEGDEKQMTGSGLQAMGESLSHPESVLTLEFTNRL
                     ELGTPPEALGPSGHRRHCLVPTSPEQHVEMDKAVAQNMDSVFKELLGKAAVRQGHGLA
                     STASPSLGTRNLKPLACSSFSKNKVFSRGPGAPVSPSVSHPQGPDSTRKPV"
     exon            166..373
                     /gene="Arhgap4"
                     /inference="alignment:Splign:2.1.0"
     exon            374..536
                     /gene="Arhgap4"
                     /inference="alignment:Splign:2.1.0"
     exon            537..599
                     /gene="Arhgap4"
                     /inference="alignment:Splign:2.1.0"
     exon            600..833
                     /gene="Arhgap4"
                     /inference="alignment:Splign:2.1.0"
     exon            834..962
                     /gene="Arhgap4"
                     /inference="alignment:Splign:2.1.0"
     exon            963..1184
                     /gene="Arhgap4"
                     /inference="alignment:Splign:2.1.0"
     exon            1185..1286
                     /gene="Arhgap4"
                     /inference="alignment:Splign:2.1.0"
     exon            1287..1478
                     /gene="Arhgap4"
                     /inference="alignment:Splign:2.1.0"
     exon            1479..1563
                     /gene="Arhgap4"
                     /inference="alignment:Splign:2.1.0"
     exon            1564..1594
                     /gene="Arhgap4"
                     /inference="alignment:Splign:2.1.0"
     exon            1595..1697
                     /gene="Arhgap4"
                     /inference="alignment:Splign:2.1.0"
     exon            1698..1758
                     /gene="Arhgap4"
                     /inference="alignment:Splign:2.1.0"
     exon            1759..1836
                     /gene="Arhgap4"
                     /inference="alignment:Splign:2.1.0"
     exon            1837..1971
                     /gene="Arhgap4"
                     /inference="alignment:Splign:2.1.0"
     exon            1972..2077
                     /gene="Arhgap4"
                     /inference="alignment:Splign:2.1.0"
     exon            2078..2311
                     /gene="Arhgap4"
                     /inference="alignment:Splign:2.1.0"
     exon            2312..2385
                     /gene="Arhgap4"
                     /inference="alignment:Splign:2.1.0"
     exon            2386..2569
                     /gene="Arhgap4"
                     /inference="alignment:Splign:2.1.0"
     exon            2570..2662
                     /gene="Arhgap4"
                     /inference="alignment:Splign:2.1.0"
     exon            2663..2762
                     /gene="Arhgap4"
                     /inference="alignment:Splign:2.1.0"
     exon            2763..3195
                     /gene="Arhgap4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggtgctggc tttagcaccc ctggtccctg ctctcggcgg tctcgcctcg ctgcttccgc
       61 gtggaagcgt tgggacttgg tgcaatcgcc cctcagccat ggcggcgcac gggaagttgc
      121 ggcgggagcg gggactgcaa cccgagtatg aggcacaggt caaagtgatg cgcgggcagt
      181 tgagtgagca gcttcattgc ctggagcttc agggagagct gcggcgcgat ttgctgctgg
      241 agctagctga gttcatgcgg cgtcgagcag aggtggagct ggagtattct cggggcctgg
      301 acaagttggc tgaacgcttt actagccgca gtggacgcct tggaggcagc agccgggagc
      361 agcaaagttt ccggaaggag ccaactctcc tgtcaccctt gcactgctgg gctatgctgc
      421 tggaacatac tcggcagcag agtcgggaaa gtgctaccct cagtgaggtg ctggctggac
      481 ctctggcaca gcgcctgagt cacattgccg aggatgtagg acgcattgtc aaaaagagta
      541 aggacctggt gcagcaactg caggatgagc tcctggaggt ggtctcagaa ctccagacac
      601 agggctacct tgcctgggcc tccctgcaga ccaagaagac gtaccatgta taccacttgg
      661 agagcatgaa tgctgagact aaacttcggg aagctgagag gcaagaggag aagcggtcag
      721 gcaagagtgc cttgcccacc actactgctg cctctgccac caccaccatc accattgaga
      781 cagagctcca ccgaaagggc tctctcaaga aaggagggcg gctagtggag aagcgtcagg
      841 ccaagttctt ggaacataaa cttaaatgca ccaaggcccg aaatgagtac ctgctcagcc
      901 tggccagtgt caatgctgct gtcagcaact actacttaca cgatatcttg gacctcatgg
      961 attgctgtga cacaggtttc cacttggccc tggagcaggc cctccgaagc tacacagccg
     1021 ctgaaagccg cacccaaacc tctcacatgc agggtttagg cagtctggaa gaggctctag
     1081 aggccttgga tcctccaggg gacaaagcca aagtgcttga ggttcatgcc atggccttct
     1141 gtccccctct acgttttgac taccagcccc atgaaggtga tgaggtggct gagatccagg
     1201 ttgagatgga acttcgggat gagattttgc ccagagccca aaacatccaa agtcgcctgg
     1261 accaaaagac cattgagaca gaagaggtga ataagacact gaaggcaaca cttcaggctc
     1321 tgctagaggt ggtggcatca gaggatggag atatactgga ctctttgcag gccagcccct
     1381 ccactgagtc cctcaagtct acaagctcag acccaggcac ccgacaggca ggccgcagac
     1441 ggaaccagca gcaggagaca gaaaccttct atattacgaa gctgcaggaa tatctgagtg
     1501 gccggagcat ccttgccaag ctgcaggcca agcatgaaaa gctccaggaa gccatacaac
     1561 gaggtaacaa ggaagagcaa gagacatctt cttggaccca atgcacagag agaaaattcc
     1621 ataagagcca ccacccctat cctggatccc agtgtaccca gagacttttt ggaggtgatc
     1681 tagagaagtt tatccagagc acaggccaac ctgtgcccct tgtggtgaag agctgtatcc
     1741 gcttcattaa cctcaatggc ctgcaacatg aaggcatctt ccgggtatca ggtgcccagg
     1801 cccggatatt ggagatccga gatgcctttg aaagagggga ggaccctctg gtggaaggct
     1861 gtactgccca tgacctagac tcagtggctg gggtactaaa gctgtacttc cggagcctgg
     1921 agcccccact gttccccttg gacatgttta atgagctgct ggcttcagca gaactggaag
     1981 ttgtgggtga gcgggtagag cttgtgagcc atctactatc cagactaccc agacctgtgc
     2041 tagtggtctt gcgatatctc ttcaccttcc tcaaccacct ggcccagtac agcgatgaga
     2101 acatgatgga ctcctacaac ttggctgtat gttttgggcc cacgctgttg cctgtgcctg
     2161 ctgggcagga ccctgtagcc ttgcagggcc gagtgaacca gctggtccag acccttatcc
     2221 tgcaaccagc atgggttttc ccacccacag ccatgctacc aggtcccatc tatgagaagt
     2281 gcatggcacc accttctgcc agctgcctgg gggatggcca gttggagagc cttgctgggg
     2341 agccagagct ggaattgaaa actgggacca aagctcagga agatgactcc gagggagttg
     2401 tggaggctgt ggcctgcttt gcttacactg gccgcacggc ccaggagctg acattccagc
     2461 aaggggatac gctgagattg tatgctcggg catcaagtga ctggtggcga ggggagcatg
     2521 ctggtgtgcg ggggctcatt ccccataagt acatcacact gtctgagggg gatgagaagc
     2581 agatgactgg ttcaggatta caggccatgg gggaatctct gagccatcca gaaagcgtcc
     2641 tgaccttgga gtttaccaac cgactggaac taggcacccc acctgaggct ttgggcccct
     2701 ctggtcacag acgacactgt ttggtcccta cctcccctga gcaacatgtg gaaatggata
     2761 aggctgtggc gcagaacatg gattctgtgt ttaaggagct cttgggaaag gctgctgtcc
     2821 gccagggcca tgggctagca tctacagcct cccccagtct aggaactcga aacctgaagc
     2881 ccctggcctg cagcagcttc agcaaaaaca aagtcttctc ccggggacct ggggctccag
     2941 tttccccctc agtttcccat ccccagggtc cagattcaac tcgcaagcca gtctgaggca
     3001 gctcacctcc aacagacacc agcaagccca ccattacacc aagcctcacc ccagccctgc
     3061 tctaggtctc ttgggaggta gcaaaggaag gaggctggag agaagccctt cttgtgcctt
     3121 tgcttggaag ctttgggctg tagctgtgga aggtggaagc aacagtaatt cataaagacc
     3181 catgtactgt tgtaa
//
