LOCUS       NM_001271132            8364 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Rattus norvegicus Rho GTPase activating protein 35 (Arhgap35),
            mRNA.
ACCESSION   NM_001271132 XM_001053554
VERSION     NM_001271132.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 8364)
  AUTHORS   Stiegler,A.L. and Boggon,T.J.
  TITLE     The N-Terminal GTPase Domain of p190RhoGAP Proteins Is a
            PseudoGTPase
  JOURNAL   Structure 26 (11), 1451-1461 (2018)
   PUBMED   30174148
  REMARK    GeneRIF: Results find that N-GTPase adopts an extended GTPase-like
            fold with six unique inserts. It bounds constitutively to GTP/Mg2+
            and lacks intrinsic catalytic activity. Mutational analysis shows
            that GTP and Mg2+ binding stabilizes the domain. This data supports
            both that p190RhoGAP N-GTPase is a nucleotide binding,
            non-hydrolyzing, pseudoGTPase domain that cannot bind canonical
            ligands, acting as a protein-protein module.
REFERENCE   2  (bases 1 to 8364)
  AUTHORS   Biname,F., Bidaud-Meynard,A., Magnan,L., Piquet,L., Montibus,B.,
            Chabadel,A., Saltel,F., Lagree,V. and Moreau,V.
  TITLE     Cancer-associated mutations in the protrusion-targeting region of
            p190RhoGAP impact tumor cell migration
  JOURNAL   J Cell Biol 214 (7), 859-873 (2016)
   PUBMED   27646271
  REMARK    GeneRIF: the molecular processes responsible for p190A targeting to
            actin protrusions, were studied.
REFERENCE   3  (bases 1 to 8364)
  AUTHORS   Klimova,Z., Braborec,V., Maninova,M., Caslavsky,J., Weber,M.J. and
            Vomastek,T.
  TITLE     Symmetry breaking in spreading RAT2 fibroblasts requires the
            MAPK/ERK pathway scaffold RACK1 that integrates FAK, p190A-RhoGAP
            and ERK2 signaling
  JOURNAL   Biochim Biophys Acta 1863 (9), 2189-2200 (2016)
   PUBMED   27212270
  REMARK    GeneRIF: RACK1 promotes adhesion-mediated activation of ERK2 that
            in turn inhibits p190A-RhoGAP signaling by reducing the peripheral
            localization of p190A-RhoGAP.
REFERENCE   4  (bases 1 to 8364)
  AUTHORS   Stewart,K., Gaitan,Y., Shafer,M.E., Aoudjit,L., Hu,D., Sharma,R.,
            Tremblay,M., Ishii,H., Marcotte,M., Stanga,D., Tang,Y.C.,
            Boualia,S.K., Nguyen,A.H., Takano,T., Lamarche-Vane,N., Vidal,S.
            and Bouchard,M.
  TITLE     A Point Mutation in p190A RhoGAP Affects Ciliogenesis and Leads to
            Glomerulocystic Kidney Defects
  JOURNAL   PLoS Genet 12 (2), e1005785 (2016)
   PUBMED   26859289
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 8364)
  AUTHORS   Kerrisk,M.E., Greer,C.A. and Koleske,A.J.
  TITLE     Integrin alpha3 is required for late postnatal stability of
            dendrite arbors, dendritic spines and synapses, and mouse behavior
  JOURNAL   J Neurosci 33 (16), 6742-6752 (2013)
   PUBMED   23595732
REFERENCE   6  (bases 1 to 8364)
  AUTHORS   Brouns,M.R., Matheson,S.F., Hu,K.Q., Delalle,I., Caviness,V.S.,
            Silver,J., Bronson,R.T. and Settleman,J.
  TITLE     The adhesion signaling molecule p190 RhoGAP is required for
            morphogenetic processes in neural development
  JOURNAL   Development 127 (22), 4891-4903 (2000)
   PUBMED   11044403
REFERENCE   7  (bases 1 to 8364)
  AUTHORS   Tatsis,N., Lannigan,D.A. and Macara,I.G.
  TITLE     The function of the p190 Rho GTPase-activating protein is
            controlled by its N-terminal GTP binding domain
  JOURNAL   J Biol Chem 273 (51), 34631-34638 (1998)
   PUBMED   9852136
REFERENCE   8  (bases 1 to 8364)
  AUTHORS   Settleman,J., Narasimhan,V., Foster,L.C. and Weinberg,R.A.
  TITLE     Molecular cloning of cDNAs encoding the GAP-associated protein
            p190: implications for a signaling pathway from ras to the nucleus
  JOURNAL   Cell 69 (3), 539-549 (1992)
   PUBMED   1581965
REFERENCE   9  (bases 1 to 8364)
  AUTHORS   LeClerc,S., Palaniswami,R., Xie,B.X. and Govindan,M.V.
  TITLE     Molecular cloning and characterization of a factor that binds the
            human glucocorticoid receptor gene and represses its expression
  JOURNAL   J Biol Chem 266 (26), 17333-17340 (1991)
   PUBMED   1894621
REFERENCE   10 (bases 1 to 8364)
  AUTHORS   Moran,M.F., Polakis,P., McCormick,F., Pawson,T. and Ellis,C.
  TITLE     Protein-tyrosine kinases regulate the phosphorylation, protein
            interactions, subcellular distribution, and activity of p21ras
            GTPase-activating protein
  JOURNAL   Mol Cell Biol 11 (4), 1804-1812 (1991)
   PUBMED   2005883
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Sep 1, 2012 this sequence version replaced XM_001053554.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643293.1590.1,
                                           SRR26643429.1021.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-502               JAXUCZ010000001.1  86446913-86447414   c
            503-4371            JAXUCZ010000001.1  86392477-86396345   c
            4372-4516           JAXUCZ010000001.1  86379982-86380126   c
            4517-4594           JAXUCZ010000001.1  86345801-86345878   c
            4595-4726           JAXUCZ010000001.1  86344509-86344640   c
            4727-4832           JAXUCZ010000001.1  86334795-86334900   c
            4833-8364           JAXUCZ010000001.1  86330566-86334097   c
FEATURES             Location/Qualifiers
     source          1..8364
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..8364
                     /gene="Arhgap35"
                     /gene_synonym="Grlf1; p190RhoGAP"
                     /note="Rho GTPase activating protein 35"
                     /db_xref="GeneID:306400"
                     /db_xref="RGD:1308738"
     exon            1..502
                     /gene="Arhgap35"
                     /gene_synonym="Grlf1; p190RhoGAP"
                     /inference="alignment:Splign:2.1.0"
     exon            503..4371
                     /gene="Arhgap35"
                     /gene_synonym="Grlf1; p190RhoGAP"
                     /inference="alignment:Splign:2.1.0"
     CDS             691..5190
                     /gene="Arhgap35"
                     /gene_synonym="Grlf1; p190RhoGAP"
                     /note="glucocorticoid receptor DNA-binding factor 1;
                     GAP-associated protein p190"
                     /codon_start=1
                     /product="rho GTPase-activating protein 35"
                     /protein_id="NP_001258061.1"
                     /db_xref="GeneID:306400"
                     /db_xref="RGD:1308738"
                     /translation="MMMARKQDVRIPTYNISVVGLSGTEKEKGQCGIGKSCLCNRFVR
                     PSADEFHLDHTSVLSTSDFGGRVVNNDHFLYWGEVSRSLEDCVECKMHIVEQTEFIDD
                     QTFQPHRSTALQPYIKRAAATKLASAEKLMYFCTDQLGLEQDFEQKQMPDGKLLVDGF
                     LLGIDVSRGMNRNFDDQLKFVSNLYNQLAKTKKPIVIVLTKCDEGVERYIRDAHTFAL
                     SKKNLQVVETSARSNVNVDLAFSTLVQLIDKSRGKTKIIPYFEALKQQSQQIATAKDK
                     YEWLVSRIVKSHNENWLSVSRKMQASPEYQDYVYLEGTQKAKKLFLQHIHRLKHEHIE
                     RRRKLYLAALPLAFEALIPNLDEVDHLSCIKAKKLLETKPEFLKWFVVLEETPWDETS
                     HIDNMENERIPFDLMDTVPAEQLYETHLEKLRNERKRAEMRRAFKENLETSPFITPGK
                     PWEEARSFIMNEDFYQWLEESVYMDIYGKHQKQIIDRAKEEFQELLLEYSELFYELEL
                     DAKPSKEKMGVIQDVLGEEQRFKALQKLQAERDALILKHIHFVYHPTKETCPSCPACV
                     DAKIEHLISSRFIRPSDRNQKNSLSDPNIDRINLVILGKDGLARELANEIRALCTNDD
                     KYVIDGKMYELSLRPIEGNVRLPVNSFQTPTFQPHGCLCLYNSKESLSYVVESIEKSR
                     ESTLGRRDNHLVHLPLTLILVNKRGDTSGETLHSLIQQGQQIASKLQCVFLDPASAGI
                     GYGRNINEKQISQVLKGLLDSKRNLNLVSSTASIKDLADVDLRIVMCLMCGDPFSADD
                     ILSPVLQSQTCKSSHCGSSNSVLLELPIGVHKKRIELSVLSYHSSFSIRKSRLVHGYI
                     VFYSAKRKASLAMLRAFLCEVQDIIPIQLVALTDGAIDVLDNDLSREQLTEGEEIAQE
                     IDGRFTSIPCSQPQHKLELFHPFFKDVVEKKNIIEATHMYDNVAEACSTTEEVFNSPR
                     AGSPLCNSNLQDSEEDVEPPSYHLFREDATLPSLSKDHSKFSMELEGNDGLSFIMSNF
                     ESKLNNKVPPPVKPKPPVHFEITKDLSYLDQGHREGQRKSMSSSPWMPQDGFDPSDYA
                     EPMDAVVKPRNEEENIYSVPHDSTQGKIITIRNINKAQSNGSGNGSDSEMDTSSLERG
                     RKVSAVSKPVLYRTRCTRLGRFASYRTSFSVGSDDELGPIRKKEEDQASQGYKGDNAV
                     IPYETDEDPRRRNILRSLRRNTKKPKPKPRPSITKATWESNYFGVPLTTVVTPEKPIP
                     IFIERCIEYIEATGLSTEGIYRVSGNKSEMESLQRQFDQDHNLDLAEKDFTVNTVAGA
                     MKSFFSELPDPLVPYSMQIDLVEAHKINDREQKLHALKEVLKKFPKENHEVFKYVISH
                     LNRVSHNNKVNLMTSENLSICFWPTLMRPDFSSMDALTATRSYQTIIELFIQQCPFFF
                     YNRPISEPPGAAPGSPSAMAPTVPFLTSTPATSQPSPPQSPPPTPQSPMQPLLSSQLQ
                     AEHTL"
     exon            4372..4516
                     /gene="Arhgap35"
                     /gene_synonym="Grlf1; p190RhoGAP"
                     /inference="alignment:Splign:2.1.0"
     exon            4517..4594
                     /gene="Arhgap35"
                     /gene_synonym="Grlf1; p190RhoGAP"
                     /inference="alignment:Splign:2.1.0"
     exon            4595..4726
                     /gene="Arhgap35"
                     /gene_synonym="Grlf1; p190RhoGAP"
                     /inference="alignment:Splign:2.1.0"
     exon            4727..4832
                     /gene="Arhgap35"
                     /gene_synonym="Grlf1; p190RhoGAP"
                     /inference="alignment:Splign:2.1.0"
     exon            4833..8364
                     /gene="Arhgap35"
                     /gene_synonym="Grlf1; p190RhoGAP"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggtgtccgtg cgtgcctgtc ctcctgggct actgtcctcg aggtgcgctt ggccctgtgg
       61 gccgttatcc accttccatc ccccgcccca gcgcctttcg cccctcagaa acgcacgcgc
      121 acttgcgaga gggtctccag cacgcgcacg gccgcggcgg ccgcaggaag gaggcgacaa
      181 cgccgccgcc gccgccattg cgcgggaggg agggagcgag cgagcgagcg aggctggtcc
      241 gccctccccc tggttcccgc ccctcccccc ttcccctccc cgcccccccg ccccgaggga
      301 gagccgcggc gcggcgggag gaggtggagg aggcggagga gggagcccgc gagggagggt
      361 ccgcccggcc ccccgccgga gccgccaccg ccgcctcagc cgcctcagga acgagtcgct
      421 aggggaacat ggcgccgggc ccgccgtcgc agcggccggg atcgcggagg ccggggccgc
      481 gctgagggcg cccccaaggc tggcagacat gttggctatt tgtcgatgag aagtaggaag
      541 aactgacata ctggtttaga acactatggg acctaacatt tgcgctgctt gggcagccag
      601 tgtccactgg cactgctaag aagccctcac tctactgcag aacactaatc tgatcttgga
      661 agtggctgtt tgtggcagga tgtttcgaag atgatgatgg caagaaagca agatgtccga
      721 atccccacct acaacatcag tgtggtggga ttgtccggca ctgagaagga gaaaggccag
      781 tgcggcattg ggaagtcttg tctatgtaac cgctttgtgc gcccaagtgc tgatgagttt
      841 cacctggacc acacttctgt cctcagcacc agtgactttg gtgggcgggt ggtcaataat
      901 gaccattttc tgtactgggg agaagttagc cgctccctgg aggactgtgt ggaatgtaag
      961 atgcacattg tggagcagac tgagtttatt gacgatcaga cttttcaacc tcatcgaagc
     1021 acggcactgc agccctacat caagagagcc gcagccacca agcttgcttc agctgaaaaa
     1081 ctcatgtatt tttgcactga ccagctaggg ctggagcaag actttgagca gaaacagatg
     1141 ccagatggga agctgctggt tgacggtttc cttctgggca tcgatgttag caggggcatg
     1201 aacaggaact tcgatgacca gctcaagttt gtctccaatc tctacaatca gcttgcaaaa
     1261 acaaaaaagc ccatagtaat agtcctgacc aagtgtgatg agggtgttga gcggtacatt
     1321 agagatgcac atacttttgc cttaagcaaa aagaacctcc aggttgtaga gacctctgca
     1381 aggtccaatg tgaatgtgga cttggctttc agcaccttag tgcaactcat tgataagagt
     1441 cgagggaaga cgaaaatcat cccttacttt gaagctctca agcagcagag tcagcagata
     1501 gctacagcaa aggacaagta tgagtggttg gtgagccgca ttgtgaaaag tcacaatgag
     1561 aactggctga gtgtcagccg aaagatgcag gcctcccctg agtaccagga ctatgtctat
     1621 ctggaaggga cacagaaagc caagaagctc ttcctgcagc acattcaccg cctcaagcat
     1681 gagcatattg agcgccggag aaagctgtac ctggcagccc tgccattggc ttttgaagcc
     1741 ctcataccta atctagatga agtagaccac ctgagctgca ttaaagcaaa aaagctgtta
     1801 gagactaagc cagagttctt aaagtggttt gttgtacttg aagagacacc atgggatgaa
     1861 accagccaca ttgacaacat ggaaaatgag cggattccct ttgacttgat ggatactgtc
     1921 cctgctgagc agttgtatga gacccacttg gagaagctga ggaatgagag gaagagagct
     1981 gagatgcgaa gggctttcaa agaaaacctg gagacctctc ctttcataac tcctgggaaa
     2041 ccttgggaag aagctcgtag ttttattatg aatgaagact tctaccagtg gctggaagaa
     2101 tctgtgtaca tggacatcta tggcaagcac caaaagcaga ttatagaccg ggcaaaggaa
     2161 gagttccaag agttgctttt ggagtattca gaattgtttt atgagctgga gctggatgct
     2221 aaacccagta aggaaaagat gggtgttatc caggatgttc tgggtgaaga gcaacgattt
     2281 aaagcattgc agaaactcca agcagagcgt gatgccctca ttctgaagca cattcatttt
     2341 gtgtaccacc caacaaagga gacatgccca agctgtccag cttgcgtaga tgctaagatt
     2401 gaacatttga tcagttctcg ctttatccga ccatctgata ggaatcagaa gaactctttg
     2461 tctgacccca atattgatag gatcaatttg gttattttag gcaaagatgg ccttgcccga
     2521 gagttagcca atgaaattcg agctctttgt acaaatgatg acaagtatgt aatagatggt
     2581 aaaatgtatg agctttctct gaggccaata gaggggaatg ttcggcttcc tgtgaactct
     2641 ttccagacac caaccttcca accccatggc tgtctctgcc tttacaattc aaaggagtcg
     2701 ctgtcctatg tggtggagag tatagagaag agcagagaat ctacactggg caggcgggat
     2761 aatcacttag tccacctccc cttgacttta attttagtta acaagagagg ggacacaagt
     2821 ggagagactc tgcacagctt aatacagcaa ggccagcaga ttgctagcaa acttcagtgt
     2881 gtctttcttg atcctgcgtc tgctggcatt ggttatggac gcaacattaa cgagaagcag
     2941 atcagtcaag ttctgaaggg actcctggac tctaagcgca acttaaacct ggttagttct
     3001 actgctagta tcaaagattt ggctgatgtg gaccttcgaa ttgtcatgtg tctcatgtgt
     3061 ggtgatcctt ttagtgcaga tgacattctc tctcctgtcc tgcagtccca aacttgtaaa
     3121 tcttcccact gtgggagcag caactctgtt ttacttgaac ttccaattgg agtacacaag
     3181 aagcgcattg agctgtctgt tctttcatac cattcctcat ttagcatccg aaagagccgg
     3241 ttggttcatg ggtacattgt tttttattca gccaaacgta aggcctcctt ggcaatgtta
     3301 cgtgcctttc tttgtgaagt gcaggatatt atccccatcc agcttgtcgc actcactgat
     3361 ggcgctatag atgtcctgga caatgactta agtcgagagc agctaacaga gggagaggaa
     3421 attgcacaag aaattgatgg gagattcaca agcatccctt gtagccagcc ccagcataaa
     3481 ctcgagctct tccatccctt ttttaaagat gtggtggaga aaaagaacat aatcgaggcc
     3541 acacacatgt acgataatgt ggctgaggcc tgcagcacca ctgaggaggt attcaactcc
     3601 cccagggctg ggtcacccct ctgcaattca aacttacagg actcagaaga agatgtggag
     3661 cctccatcgt accacctttt tcgggaagat gcgacattgc cctccctgtc caaagatcat
     3721 tccaagttct caatggagct ggagggaaac gacgggctgt ctttcataat gagcaacttt
     3781 gagagtaaac tgaacaacaa agtacctcca ccagtcaaac caaagcctcc tgtgcatttt
     3841 gagatcacaa aagatctttc ttacttagac caaggtcatc gggagggaca gaggaagtct
     3901 atgtcttcta gcccctggat gcctcaggat ggatttgatc cttctgacta cgcagagccc
     3961 atggatgctg tggtcaagcc aaggaatgag gaagaaaaca tatactcagt gccccacgac
     4021 agcacccagg gcaagatcat taccattcgg aacatcaaca aagcccagtc caatggcagt
     4081 ggcaatggtt ctgacagtga gatggacaca agctctctag agcgaggccg caaagtatct
     4141 gcagtgagta agcctgtgct gtacaggacg agatgcaccc gcctggggcg gtttgctagt
     4201 taccgcacca gcttcagtgt tgggagtgat gatgagctgg gacccatccg aaagaaagag
     4261 gaggaccagg catcccaagg ttataaaggg gacaatgctg tcattcctta tgaaacagat
     4321 gaggacccca ggaggaggaa tatccttcga agtctaagga ggaacaccaa gaaaccaaag
     4381 cccaaacccc gaccatccat cacaaaggca acctgggaga gtaactattt tggggtgcct
     4441 ttaacaacag tggtgactcc agagaagccg atacccattt tcattgaaag atgcattgag
     4501 tacattgaag ccacaggact aagcacagaa ggcatctacc gggtcagcgg aaacaagtca
     4561 gaaatggaaa gtttgcaaag acagtttgat caagatcaca atctggacct ggcagagaaa
     4621 gacttcactg tgaacactgt ggcaggggcc atgaagagtt ttttctcgga gctaccagac
     4681 cccctggtac catacagcat gcagattgac ttggtggaag ctcacaagat caacgacagg
     4741 gagcagaagc tgcatgctct gaaggaagtg ctgaagaagt tccctaagga gaaccatgaa
     4801 gtcttcaaat atgtcatctc ccacctgaac agagtcagcc acaacaacaa ggtgaatctt
     4861 atgaccagtg agaacctgtc catctgcttc tggcccacgt tgatgcggcc tgacttcagc
     4921 agcatggacg cactcacagc cactcgatcc taccagacca tcatcgagct cttcatccag
     4981 cagtgcccct tcttcttcta caaccggccg atcagtgagc caccgggggc tgcgcctggc
     5041 tccccttcag ccatggcacc cactgtcccc ttcctcacct ctacacctgc taccagtcag
     5101 ccatcacctc cccagtcacc tcctccaacc cctcagtccc caatgcagcc attgctctcc
     5161 tctcagctcc aagccgaaca cacgctgtga gccaccacag cccaggaagc aggaaaatca
     5221 gttgtcttct tgacagggtg gcatttggcc ttgaacaaaa tcaggtctcc tggggtggag
     5281 ctcacagcca agcgcctttt taagacttca gtggcagcac cagccagtgt ccaccactgc
     5341 tgggcagttg agccctgctg ttcgtttacc tgccctggct atggctgtgg caagctctta
     5401 ggccccgcct tggtctgggc caatctgaga actgaactga ccagatggcg gccccatcac
     5461 ccttactgct ccttggaccc cttggcccaa cccgtttgcc tgcaccagcg tcaggcccca
     5521 ccgtcaggac atcaccccag cctctgccag gggcagaggt aaccccagca gggctggccc
     5581 ctctacagag gacgtttccc agtttgtcct ctctcatcat ccacacacat acctgcaacg
     5641 gggtcttggg gacatgtggg ctatggctct gctaccccat gggacacact ggggcactgg
     5701 catggcccaa cagcacagca agaggagagc tttgtgccta gacccagtgt gtggctttcc
     5761 tccaacccct tcccaggctt ctgatccatt ccctgccgca aaggaacact ggaagaaaga
     5821 tggactcctc cacagagaca gaaagaccga aatcacggaa agaaaacaga cctcaagttt
     5881 ccactcccac ctgccaggtg gccactgggt aacaatcccc tttgtctatg tgtgacagca
     5941 aagtaaggac acctgggcag ttactacaaa cacagacccc aacccctacc cccagagaag
     6001 acagagccct tggaaagatt attagcacgg cccctgcccc tgctgccaac caacacacta
     6061 catacataca tacatacact actatagaaa cactgcaggc gtgtgcacac agcacccagg
     6121 ttggcgtgtt tggtttgaag tggggtcatt tcatcccatg ctgtgaatga accagaaaaa
     6181 ggtgtctggg atatgagcag gcatagcacc ttccagaaat gatgaactgg ctatggaatg
     6241 agggatcctg ttcttaggca caggtaccca tgcctggctt gttgtcacac tgaccagccc
     6301 tgacacttcc cccagcagcc tccccatact cctcctgata tggcagccct tgtgggctct
     6361 tgcctttgcc cccactttaa tctaagcact gggccatgaa atctgacact aaggtaccct
     6421 gagcatagga ggggcatggg tcgcaccatt gcactttaga aatagcatgt gggagtgttc
     6481 ccaagggcct caggtggcct gccaccctgc ctttacctct gtaggacaag agaaggatgc
     6541 ctggcctctg gcctagggtc ctgccctaga gaagctggct gtctccctat ctctagtact
     6601 tggcaacata aggtgcttgc aaacactaag gctgccccct gcaaagtaat ctccaagaca
     6661 aaaccaaacg caaggtacaa atgtgttata cgtaagtgtc tcccttcctg ggggtctgtg
     6721 tcgggtgctg tggcctggaa tcaataggag cataatgtgt gtagtgccca ctaaggttgc
     6781 agtccgtcct ctgccctgac ttcatgcccc aagcctcagc tattgaaatg gcttccattc
     6841 agtagcttct gtgttgggtc tttgcagaga tggaattgga gccatcctgc tgtgaacaga
     6901 gttatgaacc catctatgag gctgctgcct attatgtcga cagggcagtg ggtggcagac
     6961 agaggtaggc acatggctag tagagccctg cttggagctc acttctgctt caggcactct
     7021 aagtgacctt cccactcatg acaagccaac tggggaacta cagacgacag agcactcagg
     7081 gcttcagtag atggcaggtc agctgctgcc ctacccagaa agtagccctg gaggtgacca
     7141 caacctggca ccacccaaca ttaccacggg gcccagggct gggtttcgag tttcacactg
     7201 ggtagtatgc attccttctg cactgtccca tccttctcac ctcaaccttt taagggatat
     7261 ggaaaggtct ggtgctctgt cttcccccac gctctccatt ttctccagcc aatgcaggca
     7321 gcagcagtaa cagacttctt agaaccttca cactgtatct accactacat agggtgacaa
     7381 aagagcaact tgtaggccag aggggtgggg tgagccctcc tgtggtctgt acctccaccc
     7441 ctggtctagc gggaggaatc cttgaagacc tgcatcacct aagtgaggac cctacagggt
     7501 accttatgct ctgctcccag accctgactt aacattgggc caacaacgat cctcatcccc
     7561 caaagtcatc tacagatggc aggtggaaga gggaggttct ccattccaca cccactacca
     7621 gtgtgcatgg ggagggaatg gggatgaact aggtcaatcc agggacacta gagaggctaa
     7681 ggctctagcc ctattaccca gccatgaagc cacccaagta gtggagccag gacataagtt
     7741 attgttcaca ttaaagaatc atgttccctg tgtacatttt aagcaaagaa aagtcttggg
     7801 attgtatggg aataaaactt gtttgaaaat ttggaatagt gctgttgtcg gcttattttt
     7861 ctggtacttg tattttcaca tgttaaatga tctttatatg tgttggatta acaagtattt
     7921 tgagttttct gagaacaaac agaaacatta atggtattga agtgtgttag tagtctggcc
     7981 gtgtgcccaa acttctgttt tgcagcaaaa gtggaaacct gtctgtacag cgagtgtaat
     8041 gatttcctgt atcgtggctc aaaccagggc ctctctagtt gctgttagca atgtctgctt
     8101 cgtttccagg cttttttaaa aaacacatca tgggtttctg aggctccagc ctgtttagtg
     8161 catgcagcca tcacggcagc caagcatctc tgagtgaggt gtttttgttt ggttttggtt
     8221 tttaagatca tgtatttgct acaaagtatt gtacttgtct caatgggaat ggtataaaaa
     8281 aaaagaaaag aaaaggcctt atgtgatatg taccatagtt aataaatcaa tcttgtaaaa
     8341 aacataaata aaaacaggcc tgag
//
