LOCUS       NM_001105879            4566 bp    mRNA    linear   ROD 01-AUG-2023
DEFINITION  Rattus norvegicus Rho GTPase activating protein 31 (Arhgap31),
            mRNA.
ACCESSION   NM_001105879 XM_001061135 XM_221438
VERSION     NM_001105879.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4566)
  AUTHORS   Horne BD, Hauser ER, Wang L, Muhlestein JB, Anderson JL, Carlquist
            JF, Shah SH and Kraus WE.
  TITLE     Validation study of genetic associations with coronary artery
            disease on chromosome 3q13-21 and potential effect modification by
            smoking
  JOURNAL   Ann Hum Genet 73 (Pt 6), 551-558 (2009)
   PUBMED   19706030
REFERENCE   2  (bases 1 to 4566)
  AUTHORS   Jenna S, Hussain NK, Danek EI, Triki I, Wasiak S, McPherson PS and
            Lamarche-Vane N.
  TITLE     The activity of the GTPase-activating protein CdGAP is regulated by
            the endocytic protein intersectin
  JOURNAL   J Biol Chem 277 (8), 6366-6373 (2002)
   PUBMED   11744688
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473967.1.
            
            On or before Oct 3, 2007 this sequence version replaced
            XM_221438.4, XM_001061135.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5756307,
                              SAMEA5760383 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..4566
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q21"
     gene            1..4566
                     /gene="Arhgap31"
                     /gene_synonym="Cdgap"
                     /note="Rho GTPase activating protein 31"
                     /db_xref="GeneID:288093"
                     /db_xref="RGD:1306093"
     exon            1..319
                     /gene="Arhgap31"
                     /gene_synonym="Cdgap"
                     /inference="alignment:Splign:2.1.0"
     CDS             220..4506
                     /gene="Arhgap31"
                     /gene_synonym="Cdgap"
                     /note="Cdc42 GTPase-activating protein"
                     /codon_start=1
                     /product="rho GTPase-activating protein 31"
                     /protein_id="NP_001099349.1"
                     /db_xref="GeneID:288093"
                     /db_xref="RGD:1306093"
                     /translation="MKNKGAKQKLKRKGAASAFGCDLTEYLESSGQDVPYVLKSCAEF
                     IETHGIVDGIYRLSGVTSNIQRLRQEFGSDQCPDLTREVYLQDIHCVGSLCKLYFREL
                     PNPLLTYELYEKFTEAVSHCPEEGQLARIQNVIQELPPPHYRTLEYLIRHLAHIASFS
                     SKTNMHARNLALVWAPNLLRSKKIEATICNGDAAFLAVRVQQVVIEFILNHADQIFNG
                     GAPGALQQDESRTITKSLTLPALSLPMKLVSLEEAQARSLATNHPARKERRENSLPEI
                     VPSMGTPFHTVLELPDNKRKLSSKSKKWKSIFNLGRSGSDSKSKLSRNGSVFVRGQRL
                     SVEKATIRPAKSMDSLCSVPVEGKENKGNFNRTVTTGGFFIPATKMHASSTGSSCDLS
                     KEGEWSQEGMPAGAEGGCEVGGQIRPLPEQLKVFRPIGDPESEQSAPKLLGMFYTSSD
                     SPGKSVFTSSLFQMEPSPRHQRKALNISEPFAVSVPLRVSAVISTNSTPCRTPPKELQ
                     SLSSLEEFSFQGSESGGWPEEEKPLGAEPFPGSVPKKAATEDTKPEHEAPGRAECNQS
                     LPLDPGTPLEKKTLDISLGSQLSKEPEKWPNAEKAMEESQGASQTKLSTPQESPRART
                     KPVLLHEMDEDDLAQALIWPEIQQELKIIESEEEFSSLPPPAQKTSPMTESSPAPFPS
                     PEAPESLPSSSAPLEVWTRDSANQSIQETAILTNREKLEPVCSLLESESEQAVSPDPS
                     TLAPLEILLFEKVSSPARIEIGGPGNLSPPLPPAPPPPTPLEEEPQVLLSHEGPDRED
                     ASRDSRTDLYTEQPNSEDSPGIPRLCQREEAIASPNEKQDAKQAVPESKDPGLPSPTK
                     EVEVIPQEEGDASHSAQEPSDCDEDDTVIDTAQHGLEMVEPWEEPQWVTSPLHSPTLK
                     EIQESQTQGSQGHRLERRLRHRPSLRQSHSLDSKTTGQSHWALEAPFSSSCASLETER
                     NYEPLQTPSARIKIAGLEEKALKAFREFSGLKGLEVLPSQKGSSGIQPKPVETNFISL
                     TEGKEQGPQLEFSNPQIKHNDVPGPDSSEGSSPGAQDSTSPGEHPLKLQLKSTECGPS
                     KGKHRPSSLNLDSAIPIADLFRVENGASFSSPGIELSELGDTKVIWMSSSQGKAAPWS
                     SQDTQDLGIVAHALTGRRNSAPVSVSAVRTSFMVKMCQAKAVPVIPPKIQYTQIPQPL
                     PSQNTGEGGAQPPERNQEEPGSTPETPQKPTKDDSPSSLGSPEEEQPKQEQGASASRR
                     KASTTSCVAEGSFCSAEPGPSTLVSSQDAMGQCRKRTSETEPSEDNLLSSKLERASGG
                     PKPTHRPRPGRPQSLILFPIMDHLPSSPTVIDSKVLLSPIRSPSQTVSPGLLCGELAE
                     NTWVTPEGVTLRNKMTIPKNGQRLETSTSCFYQPQRRSVILDGRSGRQIE"
     exon            320..422
                     /gene="Arhgap31"
                     /gene_synonym="Cdgap"
                     /inference="alignment:Splign:2.1.0"
     exon            423..567
                     /gene="Arhgap31"
                     /gene_synonym="Cdgap"
                     /inference="alignment:Splign:2.1.0"
     exon            568..650
                     /gene="Arhgap31"
                     /gene_synonym="Cdgap"
                     /inference="alignment:Splign:2.1.0"
     exon            651..758
                     /gene="Arhgap31"
                     /gene_synonym="Cdgap"
                     /inference="alignment:Splign:2.1.0"
     exon            759..901
                     /gene="Arhgap31"
                     /gene_synonym="Cdgap"
                     /inference="alignment:Splign:2.1.0"
     exon            902..1100
                     /gene="Arhgap31"
                     /gene_synonym="Cdgap"
                     /inference="alignment:Splign:2.1.0"
     exon            1101..1225
                     /gene="Arhgap31"
                     /gene_synonym="Cdgap"
                     /inference="alignment:Splign:2.1.0"
     exon            1226..1288
                     /gene="Arhgap31"
                     /gene_synonym="Cdgap"
                     /inference="alignment:Splign:2.1.0"
     exon            1289..1837
                     /gene="Arhgap31"
                     /gene_synonym="Cdgap"
                     /inference="alignment:Splign:2.1.0"
     exon            1838..2115
                     /gene="Arhgap31"
                     /gene_synonym="Cdgap"
                     /inference="alignment:Splign:2.1.0"
     exon            2116..4566
                     /gene="Arhgap31"
                     /gene_synonym="Cdgap"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcccgggct cctcgcaagg ctcagccgag aagcgcgggg agactccgcg ggagcccgag
       61 tagggaggtg acacccgccc ggggcggtgc acggcccgat ctgcgcgccc atgccgaccc
      121 ccggcgccgc tctgccccgg tgacccgacc ccgaaaccct caacagcggt gcggagtaag
      181 agagcgcaga cggaggggca gcctctgtgg ggctaactca tgaagaacaa gggtgccaag
      241 cagaagctga aacgaaaggg agccgccagt gcgtttggat gtgacctgac ggagtatctg
      301 gagagctcgg gacaggatgt tccatatgtg ctgaagagct gtgctgaatt tatagagact
      361 cacggcattg tggatgggat ctatcgcctc tcgggtgtca cttcaaacat ccagcggcta
      421 cggcaagagt tcggctcaga tcaatgccca gatctgacaa gggaggtgta ccttcaagac
      481 atccactgtg tgggctccct gtgcaagctg tacttcaggg agctgcccaa ccccctcctg
      541 acctacgagc tctatgagaa attcacggaa gcggtgtctc actgtccgga agaaggccag
      601 ctggcccgaa tccagaatgt tatccaggag ctccccccac cccattatag gaccttggaa
      661 tacctgattc gacacctggc ccacatcgcc tcattcagta gcaagaccaa catgcacgcc
      721 aggaacctgg ccctggtgtg ggccccaaac ctcctcagga gtaaaaaaat cgaagctact
      781 atttgcaacg gagatgcagc gttcctggca gtccgggtcc agcaggtggt gattgagttc
      841 atactgaatc acgctgatca aatcttcaac ggtggtgctc cgggggctct gcagcaggat
      901 gaaagccgca ctatcacaaa gagcctgacc ttgccagccc tgtccctgcc catgaagttg
      961 gtgagcctgg aggaggctca ggcccgaagc ttggcgacaa accaccctgc tcgaaaagaa
     1021 agacgggaga acagcctgcc cgagatcgtc ccttccatgg gcacgccctt ccacacagtc
     1081 cttgagttac cggacaacaa gagaaagctt tccagcaaat caaagaagtg gaaatcaata
     1141 tttaacctgg gtcgttctgg atcggactcg aaatccaagc tgagcagaaa tgggagtgtg
     1201 ttcgtgagag gccagaggct gtcggtggaa aaggctacta ttcgaccagc taaaagcatg
     1261 gactcactgt gttcagtacc cgtggaaggg aaagaaaaca aaggaaattt caatcgaaca
     1321 gtcaccactg gtggattttt catcccagcc acaaaaatgc acgcgagcag caccggcagc
     1381 tcctgtgacc tcagcaagga gggcgaatgg agtcaggagg ggatgccagc cggggctgag
     1441 gggggctgtg aggtgggcgg tcagatccgg cccctgcctg agcagctgaa ggtgttccgc
     1501 cccatcggag accctgagag cgagcagtca gccccaaagc ttctggggat gttctacacc
     1561 tccagcgaca gtcctggcaa atccgtcttc acaagcagcc tcttccagat ggaaccctcg
     1621 ccgcgccacc agcggaaggc gctcaacatc tccgagccct tcgcggtgtc tgtgccactc
     1681 cgtgtgtccg ctgtcatcag taccaacagc accccgtgca ggacaccccc caaagagcta
     1741 cagtccctct ccagcctaga agagttttct ttccaaggtt cagagagtgg aggatggcca
     1801 gaagaagaga agcctctggg agctgagcct tttccaggtt ctgttcctaa aaaggcagct
     1861 accgaggaca ccaagccaga acatgaagcc ccggggagag cagaatgtaa ccaaagcctt
     1921 cccctagacc caggtacccc actggagaag aaaaccttgg atatatccct gggctctcaa
     1981 ctgtcaaagg aaccagagaa gtggccaaat gcagagaagg cgatggaaga gagccagggt
     2041 gccagccaga cgaagctcag cactccacaa gagagcccca gggcgcggac caagccagtg
     2101 ctccttcatg agatggatga ggatgacttg gctcaggcct tgatctggcc tgaaattcaa
     2161 caagaactga aaatcatcga atcagaggag gagttctcgt cattgccacc ccctgctcag
     2221 aagacaagcc caatgactga gtcaagtccg gccccatttc cctccccaga ggcccctgag
     2281 agcttgccca gtagctccgc ccctctggag gtgtggacta gggactcagc caatcagagc
     2341 atacaggaga ctgccatcct caccaacaga gagaagctgg agccagtctg cagcctcctt
     2401 gagtcagagt ctgagcaggc ggtcagccca gacccgtcca ctctagcacc actggaaata
     2461 cttctgtttg agaaggtgtc ttctccagct aggatagaga taggaggccc aggaaatctc
     2521 tccccgccac ttcctcctgc tcctcctccc ccaactcctc tggaggagga gcctcaagtc
     2581 ttgctgtcac acgaaggtcc tgacagagaa gacgcatcca gggattccag gacagatctc
     2641 tacacagagc agccaaactc cgaagacagc cctggaatcc ctaggctctg tcagagagag
     2701 gaggctattg caagcccaaa tgagaagcaa gatgcaaagc aggctgttcc cgagagcaaa
     2761 gaccctggtc ttccaagccc aacaaaggag gttgaagtca tcccacaaga agagggagat
     2821 gcttcccatt cagcccaaga gccttcagac tgtgacgaag atgacactgt gatagacact
     2881 gcccagcatg gcctggagat ggtagaacca tgggaggagc cccagtgggt gaccagtccc
     2941 cttcattctc ccaccctgaa agaaattcag gagtcccaga cgcaaggttc ccagggccac
     3001 cggttagaga ggagacttcg ccacaggccc agccttcgcc agagccattc tctagacagc
     3061 aaaaccactg gacagagcca ctgggctctt gaggctccct tctccagcag ttgtgccagt
     3121 cttgaaacag agaggaatta tgagcctctg cagacaccat cagccagaat taaaattgct
     3181 ggattggaag agaaagccct aaaagccttc agagagttct ctggcctgaa agggttagag
     3241 gttcttccca gccagaaggg atcatccggt atacagccca aaccagtaga aaccaacttc
     3301 atcagtttga cagagggaaa ggagcaggga ccacaactgg aatttagcaa ccctcagatt
     3361 aaacacaacg atgttcccgg gccagatagc agcgagggga gttcacctgg ggctcaagac
     3421 agcacctcac ctggggaaca ccccctaaag ttacagctta agagcactga gtgtgggccc
     3481 tcgaaaggga aacaccggcc gtcttccctc aacctggact ctgccattcc catcgccgac
     3541 cttttccgcg ttgagaatgg ggcttccttt agttcacctg gaatagagct ctctgaacta
     3601 ggggacacca aggtcatctg gatgagctcc tcacaaggta aagcagcccc ctggagttct
     3661 caggacacac aggacctggg catcgttgcc catgccctga caggccgccg gaattcggct
     3721 cctgtgagcg tgtcagctgt gagaacctct ttcatggtca aaatgtgcca ggccaaggca
     3781 gtccctgtca tcccacccaa gattcaatac acacagatcc cacagcccct gccctctcag
     3841 aacacagggg aaggaggggc tcagcctccg gaaaggaacc aggaagaacc tggttcaacc
     3901 cctgagaccc ctcagaaacc caccaaagat gactctccct cctccctggg aagcccagag
     3961 gaagagcaac caaagcaaga gcaaggagcc tctgcatccc ggaggaaggc cagcaccacg
     4021 tcctgcgtgg ctgaggggtc cttctgctct gcagaaccag ggccatccac tctggtctcc
     4081 tcacaggatg caatggggca gtgcagaaag cgcacatcag agacagagcc atcagaagac
     4141 aaccttcttt cttcaaaact ggagcgagca tctgggggtc caaaacctac ccacaggcca
     4201 aggccaggaa gacctcagag cctaatctta ttccccatca tggaccacct accttcctca
     4261 cccacagtga tagattccaa ggtcctgctg tcccctatca gaagcccttc tcagacagtg
     4321 tcccctggcc ttctctgtgg agagttggct gaaaacacgt gggtcacgcc agaaggggtt
     4381 acgcttagga ataaaatgac catccctaag aacggccaaa ggctagagac ttcaacaagc
     4441 tgtttttacc agccccagcg gagatccgtg attctggatg gaaggagtgg gcggcagata
     4501 gaatgagacc agctgagcct gctgctgttg tccgtaaacg ttaccaggtt catctggtcc
     4561 ttacag
//
