LOCUS       NP_001009405            1182 aa            linear   ROD 24-JUN-2024
DEFINITION  rho GTPase-activating protein 29 [Rattus norvegicus].
ACCESSION   NP_001009405 XP_227651
VERSION     NP_001009405.1
DBSOURCE    REFSEQ: accession NM_001009405.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 1182)
  AUTHORS   de Kreuk,B.J., Gingras,A.R., Knight,J.D., Liu,J.J., Gingras,A.C.
            and Ginsberg,M.H.
  TITLE     Heart of glass anchors Rasip1 at endothelial cell-cell junctions to
            support vascular integrity
  JOURNAL   Elife 5, e11394 (2016)
   PUBMED   26780829
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 1182)
  AUTHORS   Guo,Z., Neilson,L.J., Zhong,H., Murray,P.S., Zanivan,S. and
            Zaidel-Bar,R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 1182)
  AUTHORS   Ahmed,S.M., Theriault,B.L., Uppalapati,M., Chiu,C.W., Gallie,B.L.,
            Sidhu,S.S. and Angers,S.
  TITLE     KIF14 negatively regulates Rap1a-Radil signaling during breast
            cancer progression
  JOURNAL   J Cell Biol 199 (6), 951-967 (2012)
   PUBMED   23209302
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC087167.1.
            
            On Jan 7, 2005 this sequence version replaced XP_227651.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC087167.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132293, SAMD00132294
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1182
                     /organism="Rattus norvegicus"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q42"
     Protein         1..1182
                     /product="rho GTPase-activating protein 29"
                     /note="rho-type GTPase-activating protein 29;
                     PTPL1-associated RhoGAP 1"
                     /calculated_mol_wt=132190
     Region          131..347
                     /region_name="BAR"
                     /note="The Bin/Amphiphysin/Rvs (BAR) domain, a
                     dimerization module that binds membranes and detects
                     membrane curvature; cl12013"
                     /db_xref="CDD:472257"
     Region          524..574
                     /region_name="C1_GMIP-like"
                     /note="protein kinase C conserved region 1 (C1 domain)
                     found in the GEM-interacting protein (GMIP)-like family;
                     cd20816"
                     /db_xref="CDD:410366"
     Region          582..794
                     /region_name="RhoGAP"
                     /note="GTPase-activator protein (GAP) for Rho-like
                     GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases.
                     Small GTPases (G proteins) cluster into distinct families,
                     and all act as molecular switches, active in their
                     GTP-bound form but inactive when bound to...; cl02570"
                     /db_xref="CDD:470621"
     Site            order(620,657,661,754,757..758,785)
                     /site_type="other"
                     /note="GTPase interaction site"
                     /db_xref="CDD:238090"
     Site            620
                     /site_type="active"
                     /note="catalytic residue [active]"
                     /db_xref="CDD:238090"
     CDS             1..1182
                     /gene="Arhgap29"
                     /gene_synonym="B130017i01rik; RGD1306185"
                     /coded_by="NM_001009405.1:473..4021"
                     /db_xref="GeneID:310833"
                     /db_xref="RGD:1306185"
ORIGIN      
        1 mskhqnlnsv dlqnaaetla skvkavnfte vndenkndlf revfssietl aftfgniltn
       61 flmgdvgnds ilrlpisres ksfenismds vdlphekgnf spieldnlll knsdsielal
      121 syaktwskyt knivswvekk lnlelestrn ivklaeatrs sigiqefmpl qslftnalln
      181 dihsshllqq tiaalqankf vqpllgrkne mekqrkeike lwkqqqnkll etetalkkak
      241 llcmqrqdey ekakssmfra eeeqlsssvg lgknlnklle krrrleeeal qkveeanehy
      301 kvcvtnveer rndlentkre iltqlrtlvf qcdltlkavt vnlfhmqqlq aaslanslqs
      361 lcdsaklydp gqeysefvka tssseleekv dgnvnkqias spqtsgyepa dsledvarlp
      421 dschkleedr csnsadmtgp sfirswkfgm fsdsestggs sesrsldses ispgdfhrkl
      481 prtpssgtms saddlderep pspseagpns lgtfkktlms kaalthkfrk lrsptkcrdc
      541 egivmfpgve ceecllvchr kclenlvivc ghqklqgkmh ifgaefiqva kkepdgipfv
      601 lkicaseies ralclqgiyr vcgnkiktek lcqalengmh lvdisefssh dicdvlklyl
      661 rqlpepfilf rlykefidla keiqhvneeq eakkdspedk khphvsiein rillrskdll
      721 rqlpasnfns lhylivhlkr vvdhaeenkm nsknlgvifg ptlirprptt apvtisslae
      781 yssqarvvef lityaqkifd gslqpqagvi antgaiapqv dhgchpkpll spderdsdhs
      841 lkqlffsske dirtmdcesk tfelttsfee serkqnalgk cdapildnkv hllfdqeles
      901 ashktedtck spkllllrsd rvansvqrpt prtrlrpvsl pvdrllllag spterssrnt
      961 gntdsdkfgk naafeglhrk dnsnttcskv ngfdqqnvqk swdkqnerns ftakttviip
     1021 sayaekglav stgnnrghss gaaqpskaha dparsardts ehsssdscpv aavraprtlq
     1081 pqhwttfykp pnptfnvrgt eektafpsaa vppvlvhapq shvaksdpdl eatlacpvqt
     1141 sgqpkessee pglpegtptc qrprlkrmqq fedledeipq fv
//
