LOCUS       NM_001395140            7856 bp    mRNA    linear   ROD 26-MAR-2024
DEFINITION  Rattus norvegicus Rho GTPase activating protein 26 (Arhgap26),
            mRNA.
ACCESSION   NM_001395140 XM_006254662
VERSION     NM_001395140.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 7856)
  AUTHORS   Eberth,A., Lundmark,R., Gremer,L., Dvorsky,R., Koessmeier,K.T.,
            McMahon,H.T. and Ahmadian,M.R.
  TITLE     A BAR domain-mediated autoinhibitory mechanism for RhoGAPs of the
            GRAF family
  JOURNAL   Biochem J 417 (1), 371-377 (2009)
   PUBMED   18954304
REFERENCE   2  (bases 1 to 7856)
  AUTHORS   Borkhardt,A., Bojesen,S., Haas,O.A., Fuchs,U., Bartelheimer,D.,
            Loncarevic,I.F., Bohle,R.M., Harbott,J., Repp,R., Jaeger,U.,
            Viehmann,S., Henn,T., Korth,P., Scharr,D. and Lampert,F.
  TITLE     The human GRAF gene is fused to MLL in a unique t(5;11)(q31;q23)
            and both alleles are disrupted in three cases of myelodysplastic
            syndrome/acute myeloid leukemia with a deletion 5q
  JOURNAL   Proc Natl Acad Sci U S A 97 (16), 9168-9173 (2000)
   PUBMED   10908648
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            On Jun 4, 2021 this sequence version replaced XM_006254662.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643288.59387.1,
                                           SRR26643297.49987.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-474               JAXUCZ010000018.1  31089787-31090260
            475-570             JAXUCZ010000018.1  31203287-31203382
            571-632             JAXUCZ010000018.1  31205149-31205210
            633-704             JAXUCZ010000018.1  31208627-31208698
            705-806             JAXUCZ010000018.1  31217249-31217350
            807-917             JAXUCZ010000018.1  31218745-31218855
            918-1022            JAXUCZ010000018.1  31224652-31224756
            1023-1152           JAXUCZ010000018.1  31226094-31226223
            1153-1253           JAXUCZ010000018.1  31227873-31227973
            1254-1348           JAXUCZ010000018.1  31232965-31233059
            1349-1427           JAXUCZ010000018.1  31249620-31249698
            1428-1464           JAXUCZ010000018.1  31305515-31305551
            1465-1530           JAXUCZ010000018.1  31327856-31327921
            1531-1605           JAXUCZ010000018.1  31331216-31331290
            1606-1693           JAXUCZ010000018.1  31344571-31344658
            1694-1752           JAXUCZ010000018.1  31346568-31346626
            1753-1858           JAXUCZ010000018.1  31348102-31348207
            1859-2018           JAXUCZ010000018.1  31389110-31389269
            2019-2157           JAXUCZ010000018.1  31400252-31400390
            2158-2308           JAXUCZ010000018.1  31410921-31411071
            2309-2419           JAXUCZ010000018.1  31470531-31470641
            2420-2511           JAXUCZ010000018.1  31475985-31476076
            2512-7856           JAXUCZ010000018.1  31483703-31489047
FEATURES             Location/Qualifiers
     source          1..7856
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18p11"
     gene            1..7856
                     /gene="Arhgap26"
                     /note="Rho GTPase activating protein 26"
                     /db_xref="GeneID:307459"
                     /db_xref="RGD:1310923"
     exon            1..474
                     /gene="Arhgap26"
                     /inference="alignment:Splign:2.1.0"
     CDS             321..2600
                     /gene="Arhgap26"
                     /codon_start=1
                     /product="rho GTPase-activating protein 26"
                     /protein_id="NP_001382069.1"
                     /db_xref="GeneID:307459"
                     /db_xref="RGD:1310923"
                     /translation="MGLPALEFSDCCLDSPHFRETLKSHEAELDKTNKFIKELIKDGK
                     SLISALKNLSSAKRKFADSLNEFKFQCIGDAETDDEMCIARSLQEFATVLRNLEDERS
                     RMIENASEVLITPLEKFRKEQIGAAREAKKKYDKETEKYCGTLEKHLNLSSKKKESQL
                     QEADSQVDLVRQHFYEVSLEYVFKVQEVQERKMFEFVEPLLAFLQGLFTFYHHGYELA
                     KDFGDFKTQLTISIQNTRNRFEGTRSEVESLMKKMKENPLEHKTISPYTMEGYLYVQE
                     KRHFGTSWVKHYCTYQRDSKQITMVPFDQKSGGKGGEDESVTLKSCTRRKTDSIEKRF
                     CFDVEAVDRPGVITMQALSEEDRRLWMEAMDGREPVYNSNKDSQSEGTAQLDSIGFSI
                     IRKCIHAVETRGINEQGLYRIVGVNSRVQKLLSVLMDPKAASETETDICAEWEIKTVT
                     SALKTYLRMLPGPLMMYQFQRSFIKAAKLENQETRVSEIHSLVHRLPEKNRQMLQLLM
                     NHLANVANNHKQNLMTVANLGVVFGPTLLRPQEETVAAIMDIKFQNIVIEILIENHEK
                     IFNTVPDVPLTNAQLHLSRKKSSDSKPPSCSERPLTLFHAVPSTEKQEQRNSIINSSL
                     ESVSSSANSILNSSSSLQPNMNFSDPSLDVVKPTRPNSLPPNPSPTSPLSPSWPMFSA
                     PSSPMPTSSTSSDSSPISTPFRKAKALYACKAEHDSELSFTAGTVFDNVHPSQEPGWL
                     EGTLNGKTGLIPENYVEFL"
     exon            475..570
                     /gene="Arhgap26"
                     /inference="alignment:Splign:2.1.0"
     exon            571..632
                     /gene="Arhgap26"
                     /inference="alignment:Splign:2.1.0"
     exon            633..704
                     /gene="Arhgap26"
                     /inference="alignment:Splign:2.1.0"
     exon            705..806
                     /gene="Arhgap26"
                     /inference="alignment:Splign:2.1.0"
     exon            807..917
                     /gene="Arhgap26"
                     /inference="alignment:Splign:2.1.0"
     exon            918..1022
                     /gene="Arhgap26"
                     /inference="alignment:Splign:2.1.0"
     exon            1023..1152
                     /gene="Arhgap26"
                     /inference="alignment:Splign:2.1.0"
     exon            1153..1253
                     /gene="Arhgap26"
                     /inference="alignment:Splign:2.1.0"
     exon            1254..1348
                     /gene="Arhgap26"
                     /inference="alignment:Splign:2.1.0"
     exon            1349..1427
                     /gene="Arhgap26"
                     /inference="alignment:Splign:2.1.0"
     exon            1428..1464
                     /gene="Arhgap26"
                     /inference="alignment:Splign:2.1.0"
     exon            1465..1530
                     /gene="Arhgap26"
                     /inference="alignment:Splign:2.1.0"
     exon            1531..1605
                     /gene="Arhgap26"
                     /inference="alignment:Splign:2.1.0"
     exon            1606..1693
                     /gene="Arhgap26"
                     /inference="alignment:Splign:2.1.0"
     exon            1694..1752
                     /gene="Arhgap26"
                     /inference="alignment:Splign:2.1.0"
     exon            1753..1858
                     /gene="Arhgap26"
                     /inference="alignment:Splign:2.1.0"
     exon            1859..2018
                     /gene="Arhgap26"
                     /inference="alignment:Splign:2.1.0"
     exon            2019..2157
                     /gene="Arhgap26"
                     /inference="alignment:Splign:2.1.0"
     exon            2158..2308
                     /gene="Arhgap26"
                     /inference="alignment:Splign:2.1.0"
     exon            2309..2419
                     /gene="Arhgap26"
                     /inference="alignment:Splign:2.1.0"
     exon            2420..2511
                     /gene="Arhgap26"
                     /inference="alignment:Splign:2.1.0"
     exon            2512..7856
                     /gene="Arhgap26"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgagagggc gctcgaggct gctcgaggct gctgaggagc aagcccgcag aggaggcggg
       61 gaggcggtgg ccgcgctcgt tcgcttccag gcgccgccaa gggtccgacg ctgcgccttc
      121 ggccggtgtg cagttcggtg tctctcagca gtagtagccg ccgtccgtcc ggatccgggt
      181 tgctgtcctg agtctcctgc tcccgctgac cccgcgcgcg ggataaccgg cgccacccac
      241 acctgtggat cggccgtcgt cgcgtgtgtc cgccgaccag cgtgcaaggc gcatcccttc
      301 agcccggctc cacagggaga atggggctcc cggcgctcga gttcagcgac tgctgcctcg
      361 acagccctca cttccgagag actctcaagt cccacgaagc ggagctggac aagaccaaca
      421 aattcatcaa ggaactcatc aaggacggga agtcgctcat cagcgcgctc aagaatttat
      481 cttcagcaaa gcggaagttt gcagattcct taaatgaatt taaatttcag tgtataggag
      541 atgcagaaac agatgacgag atgtgtatag cgagatcttt gcaagaattt gccactgttc
      601 tcaggaatct tgaagatgaa cggagtcgaa tgattgagaa tgccagtgag gtgctcatca
      661 cacccttgga gaagtttcgc aaggagcaga tcggggcagc cagggaagcc aaaaagaagt
      721 atgacaaaga gacagagaag tattgtggca ccttagaaaa gcatctgaat ttgtcttcca
      781 aaaagaagga atcccagcta caggaggcag acagccaagt ggacctagtt cgacaacatt
      841 tctacgaagt gtccctggag tatgtcttta aggtgcagga agtgcaagag agaaagatgt
      901 ttgagttcgt agagcctcta ctggccttcc tgcaaggact cttcactttc taccaccatg
      961 gttatgagct ggccaaggat tttggtgact ttaagacaca gttgaccatc agcatacaaa
     1021 atacaagaaa ccgctttgaa ggaaccaggt ctgaagtgga atctctgatg aagaagatga
     1081 aggaaaaccc ccttgaacac aagaccatca gcccgtacac catggaaggg tacctgtatg
     1141 tgcaggagaa acgtcacttt ggaacttcct gggtgaagca ctactgtaca taccaacggg
     1201 attccaagca aatcaccatg gttccgtttg accaaaagtc aggaggaaag gggggagaag
     1261 acgagtctgt caccctcaaa tcctgcacac ggcgaaagac agactccatc gagaagagat
     1321 tctgctttga tgtggaagcg gtagacaggc caggggttat caccatgcag gcgttgtcgg
     1381 aagaggaccg taggctctgg atggaagcca tggacggccg ggaacctgtc tacaactcga
     1441 acaaagacag ccagagtgaa gggactgcac agttggacag catcggcttc agcataataa
     1501 ggaaatgcat ccatgcggtg gaaaccagag ggatcaatga acagggactc taccgaatcg
     1561 tgggggtcaa ctccagagtg cagaagttgc tgagtgtcct gatggacccc aaagcagcgt
     1621 ctgagacaga aactgacatc tgtgccgaat gggagataaa gaccgtcact agtgctctga
     1681 agacctacct gagaatgctt ccaggaccgc tcatgatgta ccagtttcaa agaagtttca
     1741 tcaaggctgc aaagctggaa aaccaagaga ctcgcgtctc tgagatccat agccttgttc
     1801 atcggctccc agagaagaat cggcagatgt tgcagctgct catgaaccac ctggcaaacg
     1861 ttgctaacaa ccacaagcag aatctgatga ctgtggcaaa ccttggtgta gtgtttggac
     1921 ccaccttgct gcgacctcag gaagaaaccg tggcagccat catggacatc aagtttcaga
     1981 acattgtcat cgagatctta atagagaacc atgagaagat attcaacacg gtgcctgatg
     2041 tgcccctcac caacgcccag ctacacctgt cccggaagaa aagcagcgac tccaagcccc
     2101 catcctgcag tgagaggccc ctgacactct tccatgctgt gccgtccaca gaaaaacagg
     2161 agcaaaggaa tagtatcatc aactccagtt tggaatcagt ctcctcaagt gcgaacagca
     2221 tccttaattc tagcagcagc ctgcagccca acatgaactt cagcgaccca agcctggatg
     2281 tggtcaaacc tactcggccc aattcactcc ccccgaatcc aagcccaact tcacccctct
     2341 cgccatcatg gcccatgttc tcggcgccat ccagccctat gcccacctca tccacgtcca
     2401 gcgactcatc ccccatcagc acaccgttcc ggaaggcaaa ggctttgtac gcctgcaaag
     2461 ctgagcacga ctcggaactc tccttcacgg caggcaccgt cttcgataat gttcacccgt
     2521 ctcaggagcc tggctggttg gaggggactc tgaatggaaa gactggcctc atcccagaga
     2581 actacgtgga gttcctctaa cctccagccc cagtggagct gctgagcttt acgtggtctc
     2641 catgacaaca ctgcttctgg tgttgtgggc cacttttcat tgccactgag gaagcaggga
     2701 gcctgactgt tgtttcctgc caaaaaacga atgcatctgg gaacgtgtgc cacccttctc
     2761 cgcaatcatc tcagcttaca gcacagcgat gctgcgagaa ctgtacgtca atcaacagag
     2821 gaggccattt gattttgata acccagagga aggctcgaga agctgtcttc tcctgagtgc
     2881 cctaaataga gagccctgat ttcatctcaa cagtcatcca aacccccagc cttctgggaa
     2941 gaggaagcag gggagaatag tgctaaaaga gtacagcact gctgagttgc atgaggcagg
     3001 gcgaagagac aaggtgcagg ctgcctctac tgctgctgct cttctgctgt agcagacaat
     3061 ttctctcctt ccttctccca gagacagggt gctgcaggca gctgggcctg tctgcaagtg
     3121 cacaggatga aggggtcacc acactgttta tatgtgatcc aggcactcag cacctcttga
     3181 gcagctgttg gcctgtaatc agcagatttc agtccagtcc ttcgtgcaaa gaaaacacac
     3241 acccctcacg ttctctgctg ctgaaggctt ccatcactgc catcacctag taaccatagc
     3301 aacccaacct actctaaaac taagccaaaa ataatactcc tctttgtata acaccccctc
     3361 tcccagctct ggtggttttt ggtttctgtt ttgctttttg tttttggttt tgttttttgt
     3421 tttgttttgt tttgttttgt tttgttttgt tttgttttgt ttgaatggtc ttccaacaat
     3481 ctgaagcaga ggattaggcc attagggtgg actatctggg gcagacagct ccctagagtc
     3541 ttttgttact gaggtcctgt agattttaga ggtgattctt gggccaaacc tgtagcctga
     3601 ttttaaaagg acatgtatat cactgccacc cagaaaaaaa tagggaatca ttaactagga
     3661 cagaacgtta agagtccgta ggacaccaga agtggaggct tggaggctag gctgagtacc
     3721 ttctaagaga gggaattctg gttaaaaggg cgggtcttaa ctgtcttgca cctggatgag
     3781 catcacatga cctcaaaaga acacaatcat ggcatcttcg tactctaatg cccttgctag
     3841 agggactctg acaagctgtc acactctcca ggagcccctc tgatggcgat gttgcaccca
     3901 ggcagtgtct ctggctcctg gaattccctt agggttcttt aatgaagaaa agaaaaactt
     3961 gaattgtgtt gaattactgt accttctgct ttttttttta aaaaagataa acttgtaaat
     4021 agaatgattt gaaatattat atggtaaagt tttatatttg atattcttta agctagttgc
     4081 tccatgcatt tagtatttcg atggctgaac aagtgtttaa aaggctgcaa gagaggccgg
     4141 gttaaagagt caaggtcatg tgcccactct ggcccagtga aagaatgttt cctcacggtt
     4201 cccattgggg agcctgagaa gttggttgta ttcagttgtc tttgcctaca tgtgatttgg
     4261 ggctgcggag ttcaaaaaag catattcagg caacggattt tcaaagaact cccacccaat
     4321 agtaacgtga cactcaggat ttaaaaaggt ggggaaaggg ttgatatgtt tgtttctgtt
     4381 tgtgtgtttg ttcttctcag gtgtatttct tggtacccca ggattctcct aaggtgatac
     4441 attttcatat atatctatat atgaccaaat tagtttgtaa atgtgtctat cagctctaag
     4501 aacaaaacaa gaaagtcagc tgctatggtt ctcggtcagt ggtgaacttc actctcttcc
     4561 tgtagacatg ttcctgcact tacttccctt ccccctccag attcccagca gccacaaact
     4621 caaaaagaat ccccaagagg gatgcagact gcactgttaa agtttctaga gtggctataa
     4681 tgttaagagt tcattgttag gattcagtat tgagttttcc aacttgggat tgtactgttg
     4741 ccaaccaaga acccagccag gagcaaggga gactggaact tgcaaacaga attgcaaact
     4801 gcccattgct gggtgtgagg cccctgctgt ggtcttagca cttgagagac aaggacagga
     4861 caggacccag ccaggtatga gggcgggagg agggttggag actaaaggaa gggaggaagt
     4921 agactcgggt tccaggccca gtccctgtga gcttgagaaa aggttgggca atggggcccg
     4981 cagggcctgc acactcaagt agtggggctc ctgccaaatt gatagagccc agcatgatac
     5041 ttttaaaaca tctgatggtt taaattgtca cctgccccat aataaatgta gtattcttga
     5101 agtcagggcc cagcctgact gctcagacac acattccttc tctcctgagt tggccctggt
     5161 ttgaagctac tctcttaggc tgacctcctt ccagtgtccc tgaggccatg tgtggcctct
     5221 gacagatggt tgctctgttt ccttttgttc agctaggcct ccttcctcct cctcaggtaa
     5281 aagaactgga gagattaata tgagccaagt gggaaggaac tcgaagatta aagtgaaatg
     5341 tgccctctct ggacccctca gctccctgtg aatgagggaa gctggggtag atggtgagga
     5401 atgagttgat gtcagaatgg aagtccattg accaggtccc aaagatttcc caggagcttt
     5461 gagtttctct tgtgaggccc tgggatgggt tcgctgtggt ttgaattttg gagcattgag
     5521 atggttgggc tcactctctg aaacgcagtt ccgtaactga accatgctgt gccatgaaac
     5581 gagaagtttg ctgctctcac atctctgccc ccaagctagt aaggtggact tgctcaacac
     5641 tttttcaaaa taaatgtgtg cggctggcct ccacttagtg ggtgacccag tcagagtctc
     5701 tgggattaga gccggtttgt agtatttcca aagccattct gcaaagtctt gtgggtgctt
     5761 tttttttttt ttttttttca ttacgacact gagaggaaat gagaaccagg cactggtggg
     5821 tcagagccat gttcactgct tgggagttac agtcccttac ccacaactcc accagacatg
     5881 agtgtaccgt gcctagatcc ttgagggaaa tccttctcaa ctgcttctcc ctcctgaaga
     5941 cagtagcagt cacaccaaaa gctgtttctc agtcatagaa cttccggaag catgcattgt
     6001 tgaggcatgg tagtggacta aagatggtgc gatcatctgt tcttggccgg ctgtcactgc
     6061 ttcctgagac aaggctgttt acctagcttc atagccatgg agctctgggg gtgcaccagt
     6121 gacctccctg gcatcccaca tttgccctag catccactgt tctgataaac aagggagcca
     6181 agtgtctgtt tagctacctg acttttgtag gaatgttctg ggtgtctggg aagggagtgg
     6241 tctgccacct ctggcaaact tgacagtgat cacttaggtt aacagccccg ccccaacagc
     6301 ccttctttaa tcagtcaggt gcccctcaca ccccatagta gtgttggaaa aatgcctttt
     6361 gtgctgaaat atttctgcag ccatgctgat ctagtggctg tctgtgaaca tagcatcaaa
     6421 atgacaacag cagagagctg tgaaccttgc acattcctcc aacatacctg agacaagact
     6481 ccaccaagcc ataattggct ttcttccttt tgtcgctcac agcacttgtc taacttaaag
     6541 agcttcccac agaagatgga gattccagat gtcacttgga gcctccccct actcctggaa
     6601 ggaaagcata gatataataa aaacaccagg atcaggaagg aaaaggtaac cacactcagg
     6661 aaccgcggat ctttaaggaa ggctaagata ctgctcttac ctgggaggaa aaaccatccc
     6721 agaaagaaaa atacacaaca aataatcttc cacaagtctg taggacatta taaaatgaaa
     6781 ctgctctgca tggtaaaatg tactagagag tgagagctga gcataggctt aacccacaga
     6841 gggagagcca aggaccatcc tgtcaaaatt ctcattagtg tagtcagtgg ggatcagaga
     6901 actggacagt gcccgagaga cctggagtag cttcagccag gctgacgtac tctctctgcc
     6961 atcacagcca ccatgctcac aggcttctga ataaaaccaa caaaaggcat tattggggtt
     7021 caagatgccg gaatcagctt ggtgtctggt gattctacaa tgtgtgtgtg catgtgtcgt
     7081 gtgtatgtgt ttgtgtgtag cacatacatg tgtaaaggtg cagcctcggg tgtagacaca
     7141 caagctggca tttgtaaagg ttttacagcc tttggaggga gcgtgtcaga agaactagag
     7201 actagttccc agcaaatgat caaagctaca aacgagacgt catccgaagc ctctgttcat
     7261 gtttataaca tgttataaca tgtttataac atagttatcc acagctgcgt tccttggtga
     7321 cttattacaa gtcatgttaa aaacgcaaac ccataaattc ccagtagcta atgctaggtt
     7381 agtgttcaaa tgcactctaa aagacattta gtccatattt tgggaaagaa actatttgca
     7441 tgtttaattc atcttttagg ctaccattga gtatactgta aagtgctgtg tgatatcaag
     7501 tcagtaaagt acttataaat ggcactttaa tattttcttt tgagaaatca taaaaacgca
     7561 ctgttgtaaa tttcagtatt gactattgac tggtacatag aatcaaattc tgtaattaaa
     7621 aaagtaacct gcagctagga taggacattt tcttgttatt agaggaaaaa gaaaccactt
     7681 ttgctatgtt caggctttaa aaaccgtgtt tctgtgccat tgtgtgtatc gataaagaaa
     7741 atacaatttc tgtcaggcac ctctgaaacc tggcttttta tgtttggttc gtgtctgtgg
     7801 caatctctat aaagtgagtg gaagtatgat tttgaattaa atacttttcc atttga
//
