LOCUS       NM_001109247            3412 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus Rho GTPase activating protein 25 (Arhgap25),
            mRNA.
ACCESSION   NM_001109247 XM_001070699 XM_575596
VERSION     NM_001109247.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3412)
  AUTHORS   Schlam D, Bagshaw RD, Freeman SA, Collins RF, Pawson T, Fairn GD
            and Grinstein S.
  TITLE     Phosphoinositide 3-kinase enables phagocytosis of large particles
            by terminating actin assembly through Rac/Cdc42 GTPase-activating
            proteins
  JOURNAL   Nat Commun 6, 8623 (2015)
   PUBMED   26465210
  REMARK    Publication Status: Online-Only
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473957.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_575596.2, XM_001070699.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA5756307, SAMEA5760383
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3412
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q34"
     gene            1..3412
                     /gene="Arhgap25"
                     /gene_synonym="RGD1562105"
                     /note="Rho GTPase activating protein 25"
                     /db_xref="GeneID:500246"
                     /db_xref="RGD:1562105"
     exon            1..434
                     /gene="Arhgap25"
                     /gene_synonym="RGD1562105"
                     /inference="alignment:Splign:2.1.0"
     CDS             374..2320
                     /gene="Arhgap25"
                     /gene_synonym="RGD1562105"
                     /codon_start=1
                     /product="rho GTPase-activating protein 25"
                     /protein_id="NP_001102717.1"
                     /db_xref="GeneID:500246"
                     /db_xref="RGD:1562105"
                     /translation="MSLKLPRNWDFNLKVETVKIARSRSVMTGEQMAAFHPPTTPNPL
                     ERPIKMGWLKKQRSIVKNWQQRYFVLKARQLYYYKDEEDSKPQGCMYLPGSTVKEIAT
                     NPEEAGKFVFEVIPASSDQNRTGQDSYVLMASSQVEMEEWVKFLRRVAGTPSGAVFGQ
                     RLDETVAYEQKFGPHLVPILVEKCSEFILEHGVSEEGIFRLPGQDNLVKQLRDAFDAG
                     ERPSFDRDTDVHTVASLLKLYLRDLPEPVVPWSQYEGFLLCGQLTNADEAKAQQELEK
                     QLSILPRDNYNLLSYICRFLHEIQLNCAVNKMSVDNLATVIGVNLIRSKVEDPAVIMR
                     GTPQIQRVMTMMIRDHEVLFPKSKDAPLSPPAQKNDAKKAPVPRSSVGWDATEDPPLS
                     RTDSFNNTASSPDATSPTGPQPGDQHQEDSGKAPKENPGDWKMQSRKRTQTLPNRKCF
                     LTSAFQGTTSSKLEIFKNEFWSPSSEAKAGEGHRRTMSQDLRHLSNDQRTSTYDNVPN
                     PPVSQGNPAGELSPPASDSKRDAPVSTDSEMESGSKNSGEEDPDSLQRTVQHLQKEIE
                     AQKQMYEEQIKNLEKENYDVWAKVVRLNEELERERKKFAALEISLRNVERSREDVEKR
                     NRVLEEEVKEFVKSMEKSKTKTDA"
     exon            435..634
                     /gene="Arhgap25"
                     /gene_synonym="RGD1562105"
                     /inference="alignment:Splign:2.1.0"
     exon            635..722
                     /gene="Arhgap25"
                     /gene_synonym="RGD1562105"
                     /inference="alignment:Splign:2.1.0"
     exon            723..839
                     /gene="Arhgap25"
                     /gene_synonym="RGD1562105"
                     /inference="alignment:Splign:2.1.0"
     exon            840..1047
                     /gene="Arhgap25"
                     /gene_synonym="RGD1562105"
                     /inference="alignment:Splign:2.1.0"
     exon            1048..1180
                     /gene="Arhgap25"
                     /gene_synonym="RGD1562105"
                     /inference="alignment:Splign:2.1.0"
     exon            1181..1254
                     /gene="Arhgap25"
                     /gene_synonym="RGD1562105"
                     /inference="alignment:Splign:2.1.0"
     exon            1255..1376
                     /gene="Arhgap25"
                     /gene_synonym="RGD1562105"
                     /inference="alignment:Splign:2.1.0"
     exon            1377..1573
                     /gene="Arhgap25"
                     /gene_synonym="RGD1562105"
                     /inference="alignment:Splign:2.1.0"
     exon            1574..2106
                     /gene="Arhgap25"
                     /gene_synonym="RGD1562105"
                     /inference="alignment:Splign:2.1.0"
     exon            2107..3412
                     /gene="Arhgap25"
                     /gene_synonym="RGD1562105"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcagttgttt atcacaactt cacttcagca aggcctgaga ttcttccgag caggggctcg
       61 gcttcccaag aggcagtgtc aactgggata cttctggtaa atctgaacgc aaagcagggt
      121 gtcagcccct gggggactgt gggtgggact tggggagttt gggtgccatc cccgagtgac
      181 agatggatgg acggttcatc tgagagaaag gaggagacac gtgggcagat cggtctggag
      241 cgtgagagtg actgcaaagc catctccagg cagagaagtc agaggaactg aagggaagag
      301 cagaaaagca agacgggcac agcctgtgac acactggcca cttgaccagc tactcaccca
      361 cgtcggaagc aaaatgtccc tcaagttgcc aaggaactgg gatttcaact tgaaagtgga
      421 gactgtgaaa atagctcggt cgaggagcgt gatgactggg gagcagatgg cggccttcca
      481 cccaccaacc actcccaacc ccctggaaag gccaattaag atgggctggc tgaagaagca
      541 gaggtccatt gtgaaaaact ggcagcagcg gtattttgtg ctgaaagctc ggcagctcta
      601 ctactacaag gacgaagagg actcaaagcc acagggatgc atgtatctgc caggcagcac
      661 agtcaaagaa atcgccacaa acccggaaga agctgggaaa tttgtctttg aagttattcc
      721 agcctcaagt gaccagaacc gcactggaca agactcctat gtcctcatgg ccagctccca
      781 ggtagagatg gaggagtggg ttaagttcct caggagagtt gctggcacac cctctggagc
      841 ggtgtttggc cagcgtctgg atgagactgt ggcctatgag cagaagtttg gccctcacct
      901 ggtgcccatc ctggtggaga agtgctcgga gttcatcctg gagcatggtg tgagtgaaga
      961 gggcatcttc cgcttgccgg ggcaggacaa cctggtgaag cagctgagag atgctttcga
     1021 tgcgggggag cggccctcct ttgacaggga cacagatgtg cacacggtgg cctctctatt
     1081 aaagctctac ctccgagacc tgccagagcc tgtggttcct tggagccagt atgaggggtt
     1141 cctgctctgt ggacagctca ccaacgcaga tgaggccaag gctcagcagg agctggagaa
     1201 gcagctttcc attctccccc gtgacaacta caacctcctg agctacatct gcagatttct
     1261 gcatgaaatc cagctgaact gtgccgtcaa caagatgagc gtggacaact tggccactgt
     1321 gatcggtgtg aacctcatca ggtcgaaggt tgaagacccc gctgtgatca tgagaggaac
     1381 tcctcagatc caaagagtga tgaccatgat gatcagagac cacgaagtcc tcttccccaa
     1441 gtctaaggat gcaccactgt caccccctgc ccagaaaaac gatgccaaga aggctccagt
     1501 gccccgaagc tctgtgggat gggacgccac cgaagaccca ccactttcta ggacggacag
     1561 cttcaacaac acagcaagta gccctgatgc caccagcccc actggaccac agccaggtga
     1621 ccagcatcag gaagatagtg gaaaagcccc caaggaaaac ccaggagact ggaagatgca
     1681 atcccgtaaa aggactcaaa cgctccccaa ccggaagtgt ttcctgacat ccgcattcca
     1741 aggcaccact agcagcaaac tggaaatctt taaaaatgag ttctggtctc catcttcaga
     1801 ggctaaggca ggagaagggc acaggagaac tatgtctcaa gacttgcgcc acctttccaa
     1861 tgaccagagg acttctacct atgataatgt ccccaaccca ccagtgtccc aagggaaccc
     1921 agcaggtgaa ctctctcccc ctgccagtga ctctaagaga gatgctcctg tcagcacaga
     1981 ctctgaaatg gagtctggaa gcaagaactc tggcgaggaa gaccctgatt ctttgcagag
     2041 gacggtccag cacctgcaaa aggaaataga agctcagaag cagatgtatg aggaacagat
     2101 taaaaacctg gagaaggaaa attacgatgt ctgggctaag gtggtgaggc tcaatgaaga
     2161 actggagagg gagaggaaga aattcgcagc cctggaaatc agccttcgaa atgtggagcg
     2221 ctcccgagag gacgttgaga agaggaacag agtcttggaa gaagaagtca aggagtttgt
     2281 gaaatcaatg gagaagtcca agacgaagac cgatgcttaa gggtttgagt catgtgatag
     2341 ggacagtcaa ctccacccca tttcttcatg ttcctaatga gcaggaagca ggatcacctc
     2401 ctaggatgga catggtatct ggggggtgtg ccacaatcct gagcaagtaa atggaagatg
     2461 agagagccgg aactcgccag gacacctgtg accatgtgct gtgctcaaag ggttgtgtta
     2521 ttccactgtg ggaagagtga actgtagtct tccagtgcac gaccagctcc aaaggagaca
     2581 tttaaggtgt gtgacatctc aggaccccag gccagagcta ggcaaaggcc tcagtttttc
     2641 attttctatg tggctgactt gtgtggtcag atggctctgg tcagctctgg aacatggaca
     2701 gaaaatgata cttagctctc cagtgctaac caagtgaggg ctgcttggag aggctggact
     2761 gttgggacca gaatcaaata atatttatga aagcaaaatt ggtgggaaaa gtatatattc
     2821 aaataaagaa aacagaaaac aagaattgag cgaggatgtt gacagtctat gaaacacttt
     2881 gattagaatt agtaaaaggg ggttggagag ttggctcggt gactaagagc actgactgcc
     2941 ctttcagagg acccagcatc cacactgtgg cttagaacca cagtagctac agttccagga
     3001 gatctgacac cctctgggag catcatatat acatatggtg tgcaaagaga tatgcaagcc
     3061 aacacctata cacatcaaat aaataaacac atacataaaa acagtaagag gcatctctcg
     3121 cctgaagcag gtggatcttt tctcatggtc catggctgtg tgactagggc tgggttccat
     3181 cctgagttac cctccagtgg atcaaacttg tctggaaggc ctaagagcaa aggtttccaa
     3241 ctaggggtga ctttaggagt gtggatttgt acagtgcaga gtcaggataa ctggttctta
     3301 tcatcattgc ttttgctgtt acttcaccaa aatgaaaatg aatttattta ttctttagag
     3361 agggatcagg cactattatc tgttttctca attataccta atgtcacctg cc
//
