LOCUS       NM_001393820            3282 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus Rho GTPase activating protein 24 (Arhgap24),
            transcript variant 1, mRNA.
ACCESSION   NM_001393820 XM_039091824
VERSION     NM_001393820.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3282)
  AUTHORS   Saito,K., Yokawa,S., Kurihara,H., Yaoita,E., Mizuta,S., Tada,K.,
            Oda,M., Hatakeyama,H. and Ohta,Y.
  TITLE     FilGAP controls cell-extracellular matrix adhesion and process
            formation of kidney podocytes
  JOURNAL   FASEB J 38 (5), e23504 (2024)
   PUBMED   38421271
  REMARK    GeneRIF: FilGAP controls cell-extracellular matrix adhesion and
            process formation of kidney podocytes.
REFERENCE   2  (bases 1 to 3282)
  AUTHORS   Akilesh,S., Suleiman,H., Yu,H., Stander,M.C., Lavin,P.,
            Gbadegesin,R., Antignac,C., Pollak,M., Kopp,J.B., Winn,M.P. and
            Shaw,A.S.
  TITLE     Arhgap24 inactivates Rac1 in mouse podocytes, and a mutant form is
            associated with familial focal segmental glomerulosclerosis
  JOURNAL   J Clin Invest 121 (10), 4127-4137 (2011)
   PUBMED   21911940
REFERENCE   3  (bases 1 to 3282)
  AUTHORS   Horiba,N., Masuda,S., Takeuchi,A., Saito,H., Okuda,M. and Inui,K.
  TITLE     Gene expression variance based on random sequencing in rat remnant
            kidney
  JOURNAL   Kidney Int 66 (1), 29-45 (2004)
   PUBMED   15200410
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            On Mar 18, 2021 this sequence version replaced XM_039091824.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643299.53868.1,
                                           SRR26643295.48201.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-411               JAXUCZ010000014.1  7488027-7488437     c
            412-608             JAXUCZ010000014.1  7418386-7418582     c
            609-696             JAXUCZ010000014.1  7321107-7321194     c
            697-819             JAXUCZ010000014.1  7158416-7158538     c
            820-1027            JAXUCZ010000014.1  7142089-7142296     c
            1028-1160           JAXUCZ010000014.1  7128980-7129112     c
            1161-1234           JAXUCZ010000014.1  7126266-7126339     c
            1235-1356           JAXUCZ010000014.1  7123370-7123491     c
            1357-2434           JAXUCZ010000014.1  7109721-7110798     c
            2435-3282           JAXUCZ010000014.1  7105200-7106047     c
FEATURES             Location/Qualifiers
     source          1..3282
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14p22"
     gene            1..3282
                     /gene="Arhgap24"
                     /gene_synonym="DR-NR#2"
                     /note="Rho GTPase activating protein 24"
                     /db_xref="GeneID:305156"
                     /db_xref="RGD:1306669"
     exon            1..411
                     /gene="Arhgap24"
                     /gene_synonym="DR-NR#2"
                     /inference="alignment:Splign:2.1.0"
     exon            412..608
                     /gene="Arhgap24"
                     /gene_synonym="DR-NR#2"
                     /inference="alignment:Splign:2.1.0"
     CDS             432..2678
                     /gene="Arhgap24"
                     /gene_synonym="DR-NR#2"
                     /note="isoform 1 is encoded by transcript variant 1; rho
                     GTPase-activating protein 24; Down-regulated in
                     nephrectomized rat kidney #2; rho-type GTPase-activating
                     protein 24"
                     /codon_start=1
                     /product="rho GTPase-activating protein 24 isoform 1"
                     /protein_id="NP_001380749.1"
                     /db_xref="GeneID:305156"
                     /db_xref="RGD:1306669"
                     /translation="MEENCDSTENPHSQGRQNATKCGWLRKQGGFVKTWHTRWFVLKG
                     DQLHYFKDEDETKPLGTIFLPGNKVIEHPCNEESPGKFLFEVVPGGERDRMTANHESY
                     LLMASTQNDMEDWVKSIRRVIWGPFGGGIFGQKLEDTVRYEKRYGNRLAPMLVEQCVD
                     FIRQRGLKEEGLFRLPGQANLVKELQDAFDCGEKPSFDSNTDVHTVASLLKLYLRELP
                     EPVVPYAKYEDFLSCATLLSKEEEAGVKELTKQVKSLPVVNYNLLKYICRFLDEVQSY
                     SGVNKMSAQNLATVFGPNILRPKVEDPLTIMEGTVVVQQLMSVMISKHDRLFPKDTEP
                     QSKPQEGPNSNNNDGHKKVTMGQLQNKENNNTKESPVRRCSWDKPESPQRSSMDNGSP
                     TALSGSKTNSPRNSIHKLDVSRSPPLTVKKNPAFNKGSGIVTNGSFSSSNAEGVEKTQ
                     TTPNGSLQARRTSSLKSSGTKMGTHSVQNGTVRMGILNTDTLGNSLNGRSMSWLPNGY
                     VTLRDNKQKEPAGESGQHNRLSTYDNVHQQFSLMNLDDKHSVDSATWSTSSCEISLPE
                     NSNSCRSSTTTCPEQDFYGGNFEDPVLDGPPQDDLSHPGDYENKSDRRSVGGRSSRAT
                     SSSDNSETFVGNTSSNHSALHSLVSSLKQEMTKQKIEYESRIKSLEQRNLTLETEMLN
                     LHDELDQERKKFTMIEIKMRNAERAKEDAEKRNDMLQKEMEQFFSTFGDLTVEPRRSE
                     RGNTIWIQ"
     exon            609..696
                     /gene="Arhgap24"
                     /gene_synonym="DR-NR#2"
                     /inference="alignment:Splign:2.1.0"
     exon            697..819
                     /gene="Arhgap24"
                     /gene_synonym="DR-NR#2"
                     /inference="alignment:Splign:2.1.0"
     exon            820..1027
                     /gene="Arhgap24"
                     /gene_synonym="DR-NR#2"
                     /inference="alignment:Splign:2.1.0"
     exon            1028..1160
                     /gene="Arhgap24"
                     /gene_synonym="DR-NR#2"
                     /inference="alignment:Splign:2.1.0"
     exon            1161..1234
                     /gene="Arhgap24"
                     /gene_synonym="DR-NR#2"
                     /inference="alignment:Splign:2.1.0"
     exon            1235..1356
                     /gene="Arhgap24"
                     /gene_synonym="DR-NR#2"
                     /inference="alignment:Splign:2.1.0"
     exon            1357..2434
                     /gene="Arhgap24"
                     /gene_synonym="DR-NR#2"
                     /inference="alignment:Splign:2.1.0"
     exon            2435..3282
                     /gene="Arhgap24"
                     /gene_synonym="DR-NR#2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acacaatcac tctttctaac ttcttgactc tttgcgcaac tgctaggatt tctcaagtgc
       61 atgtggcaac tcagcccggg tgagggaaag ccggtgggac tcgggaggga atcacggggc
      121 cgcggggcca ccaaggctgc ggagggggac tacagcgaga ggctgcggag gggactagag
      181 cgagacagcg gcggctgggg agtcccccca actttccacg cagctgtggc tctgcggcgg
      241 tcccgggctt cctctgagag cagcacgcag gcccggcgaa tgggcttccg cgctcaccct
      301 ggaaagtaaa gggcaccctg ccggcccgaa ctcatcttta ggccagtcct aggagcctgg
      361 acatcggcgc agccgccagc catctcttgt aggtcccgca tccctggcag gggaaatcca
      421 tcagcttgag aatggaggaa aattgtgact ccacagagaa tccccacagc caagggcggc
      481 agaatgccac caagtgtggg tggctgagga agcaaggagg ctttgtcaag acttggcata
      541 cacgctggtt tgtgctcaag ggggaccagc ttcattactt caaagacgaa gacgaaacca
      601 agcccttggg gactattttc ctgcctggaa ataaagtcat tgagcatccg tgcaatgaag
      661 aaagtccagg aaagttcctt ttcgaagtgg ttccaggagg ggaacgagat cggatgacag
      721 ccaatcatga gagctatctc ctcatggcga gcacccagaa tgacatggaa gactgggtga
      781 agtccatccg ccgagtcata tggggacctt ttggaggagg tatttttgga cagaaactgg
      841 aggacacggt ccgatatgag aagagatacg ggaaccggct ggcgcccatg ctggtggagc
      901 agtgcgtgga cttcatccga cagcgggggc tgaaggaaga gggcctcttc cgactgcccg
      961 gccaggcaaa ccttgtcaag gagctccagg atgcattcga ctgtggagag aagccctcct
     1021 tcgacagcaa cacagacgtc cacactgtgg catccctcct gaaactgtat ctccgagaac
     1081 ttccagagcc ggtcgttcct tacgcaaagt acgaagactt tttgtcctgt gccacgctgc
     1141 tcagcaagga ggaagaagct ggcgtgaagg agctaacgaa acaagtgaag agtttgccag
     1201 tggttaacta caacctcctg aagtacattt gcaggttcct ggatgaagtg cagtcctatt
     1261 cgggagttaa caagatgagc gcacagaact tggcaactgt cttcggtcct aacatcctgc
     1321 gcccaaaggt ggaagatcct ttaaccatca tggagggcac tgtggtggtc cagcagttaa
     1381 tgtcagtgat gatcagcaaa catgatcgcc tcttccccaa agacacagag ccacaaagca
     1441 agccccaaga aggaccgaac agcaataaca acgatggtca taagaaagtc accatgggtc
     1501 agttacagaa caaagaaaac aacaatacca aggagagtcc ggtcagacgg tgctcttggg
     1561 acaagcctga atccccccag agaagcagca tggacaacgg atcccccaca gctctatcag
     1621 ggagcaaaac caacagccca cggaacagta tccacaagct ggatgtctcc aggagcccgc
     1681 ctctcacggt caaaaagaac ccagccttca ataagggcag cgggatcgtc accaatgggt
     1741 ccttcagcag cagcaatgca gaaggtgtgg agaaaaccca aaccactcct aatgggagtt
     1801 tacaagccag aaggacctct tccctgaaga gttctggtac caaaatgggt actcatagcg
     1861 tacagaatgg caccgtgcgc atgggtattt tgaacactga cacactaggg aattccttga
     1921 atggccggag catgagttgg ctgcccaatg gctacgtgac cctgagagat aacaagcaga
     1981 aggagcccgc gggagagtca ggccagcaca acagactctc cacctacgac aacgtccacc
     2041 agcagttctc cttgatgaac ctcgacgaca agcacagcgt ggacagtgcc acgtggtcca
     2101 cctcctcctg tgaaatctcc ctccccgaga actccaactc ctgccgctcc tctaccacta
     2161 cgtgcccgga gcaagacttc tacggcggga actttgagga ccctgtttta gacggcccgc
     2221 ctcaggatga cctttctcat cctggggact atgagaacaa aagcgaccgc aggagcgtgg
     2281 ggggccgaag cagccgtgcc acgagcagca gcgacaacag cgagacgttc gtcggtaaca
     2341 ccagcagcaa ccacagtgca cttcacagtt tagtctccag cctgaagcag gagatgacca
     2401 aacagaagat cgagtatgag tccaggataa aaagcttaga acagcggaac ttgactttgg
     2461 aaacggaaat gctgaacctc catgacgaac tggatcaaga gaggaaaaag ttcaccatga
     2521 tagaaatcaa gatgagaaac gccgagcgcg cgaaagagga tgctgagaag aggaacgaca
     2581 tgctccagaa ggaaatggag cagttcttct ccacattcgg agacctgacg gtggaaccca
     2641 ggagaagcga gaggggaaac acaatctgga tccagtgagc ctttctctct gtcctggacc
     2701 actccaggga ggactctggg aactcgggga caaacagtgt tggggaacaa tgtgggatca
     2761 ggtggctggt ctgtgtagag cttcatctgg tgaaggactg tcatttacgg aaatcactat
     2821 ccatatctgc agtgtgtacc aaagttatac catgctccat aatgctactg tcaagtgtta
     2881 caactggatc tacgtgtaga gggtagtttc taaaatgtcg gtaagaggta gaagcatata
     2941 tctcaatgat tattttattg caagtcctgt atttaaatgt cgaatcaata cattgttgca
     3001 atttagcttg cattcaagct tcaccccgtg cacttaacat aagctatttt tggcatcgtg
     3061 ttatcatctg cttattttat agatcaatat ttttatttcc ccttttgctg aggaaatgaa
     3121 gataagaaga aatataaata tataaatata tataagatga gttattaaag tcaaaagaat
     3181 acttcgtggc tgtgctgttt gtgccaatag accttgccat gaccaaaaaa agagaaatgt
     3241 aaaacagaaa aggttttata aactatagca gaatacctgt ca
//
