LOCUS       NM_001012032            2838 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus Rho GTPase activating protein 24 (Arhgap24),
            transcript variant 2, mRNA.
ACCESSION   NM_001012032 XM_223168
VERSION     NM_001012032.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2838)
  AUTHORS   Saito,K., Yokawa,S., Kurihara,H., Yaoita,E., Mizuta,S., Tada,K.,
            Oda,M., Hatakeyama,H. and Ohta,Y.
  TITLE     FilGAP controls cell-extracellular matrix adhesion and process
            formation of kidney podocytes
  JOURNAL   FASEB J 38 (5), e23504 (2024)
   PUBMED   38421271
  REMARK    GeneRIF: FilGAP controls cell-extracellular matrix adhesion and
            process formation of kidney podocytes.
REFERENCE   2  (bases 1 to 2838)
  AUTHORS   Akilesh,S., Suleiman,H., Yu,H., Stander,M.C., Lavin,P.,
            Gbadegesin,R., Antignac,C., Pollak,M., Kopp,J.B., Winn,M.P. and
            Shaw,A.S.
  TITLE     Arhgap24 inactivates Rac1 in mouse podocytes, and a mutant form is
            associated with familial focal segmental glomerulosclerosis
  JOURNAL   J Clin Invest 121 (10), 4127-4137 (2011)
   PUBMED   21911940
REFERENCE   3  (bases 1 to 2838)
  AUTHORS   Horiba,N., Masuda,S., Takeuchi,A., Saito,H., Okuda,M. and Inui,K.
  TITLE     Gene expression variance based on random sequencing in rat remnant
            kidney
  JOURNAL   Kidney Int 66 (1), 29-45 (2004)
   PUBMED   15200410
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            On Mar 18, 2021 this sequence version replaced NM_001012032.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC085797.1, AB108670.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760393,
                                           SAMEA5760400 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-375               JAXUCZ010000014.1  7153696-7154070     c
            376-583             JAXUCZ010000014.1  7142089-7142296     c
            584-716             JAXUCZ010000014.1  7128980-7129112     c
            717-790             JAXUCZ010000014.1  7126266-7126339     c
            791-912             JAXUCZ010000014.1  7123370-7123491     c
            913-1990            JAXUCZ010000014.1  7109721-7110798     c
            1991-2838           JAXUCZ010000014.1  7105200-7106047     c
FEATURES             Location/Qualifiers
     source          1..2838
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14p22"
     gene            1..2838
                     /gene="Arhgap24"
                     /gene_synonym="DR-NR#2"
                     /note="Rho GTPase activating protein 24"
                     /db_xref="GeneID:305156"
                     /db_xref="RGD:1306669"
     exon            1..375
                     /gene="Arhgap24"
                     /gene_synonym="DR-NR#2"
                     /inference="alignment:Splign:2.1.0"
     CDS             261..2234
                     /gene="Arhgap24"
                     /gene_synonym="DR-NR#2"
                     /note="isoform 2 is encoded by transcript variant 2; rho
                     GTPase-activating protein 24; Down-regulated in
                     nephrectomized rat kidney #2; rho-type GTPase-activating
                     protein 24"
                     /codon_start=1
                     /product="rho GTPase-activating protein 24 isoform 2"
                     /protein_id="NP_001012032.2"
                     /db_xref="GeneID:305156"
                     /db_xref="RGD:1306669"
                     /translation="MMPEDRNSGGRPSGALASTPFIPKTTYRRIKRCFSFRKGIFGQK
                     LEDTVRYEKRYGNRLAPMLVEQCVDFIRQRGLKEEGLFRLPGQANLVKELQDAFDCGE
                     KPSFDSNTDVHTVASLLKLYLRELPEPVVPYAKYEDFLSCATLLSKEEEAGVKELTKQ
                     VKSLPVVNYNLLKYICRFLDEVQSYSGVNKMSAQNLATVFGPNILRPKVEDPLTIMEG
                     TVVVQQLMSVMISKHDRLFPKDTEPQSKPQEGPNSNNNDGHKKVTMGQLQNKENNNTK
                     ESPVRRCSWDKPESPQRSSMDNGSPTALSGSKTNSPRNSIHKLDVSRSPPLTVKKNPA
                     FNKGSGIVTNGSFSSSNAEGVEKTQTTPNGSLQARRTSSLKSSGTKMGTHSVQNGTVR
                     MGILNTDTLGNSLNGRSMSWLPNGYVTLRDNKQKEPAGESGQHNRLSTYDNVHQQFSL
                     MNLDDKHSVDSATWSTSSCEISLPENSNSCRSSTTTCPEQDFYGGNFEDPVLDGPPQD
                     DLSHPGDYENKSDRRSVGGRSSRATSSSDNSETFVGNTSSNHSALHSLVSSLKQEMTK
                     QKIEYESRIKSLEQRNLTLETEMLNLHDELDQERKKFTMIEIKMRNAERAKEDAEKRN
                     DMLQKEMEQFFSTFGDLTVEPRRSERGNTIWIQ"
     exon            376..583
                     /gene="Arhgap24"
                     /gene_synonym="DR-NR#2"
                     /inference="alignment:Splign:2.1.0"
     exon            584..716
                     /gene="Arhgap24"
                     /gene_synonym="DR-NR#2"
                     /inference="alignment:Splign:2.1.0"
     exon            717..790
                     /gene="Arhgap24"
                     /gene_synonym="DR-NR#2"
                     /inference="alignment:Splign:2.1.0"
     exon            791..912
                     /gene="Arhgap24"
                     /gene_synonym="DR-NR#2"
                     /inference="alignment:Splign:2.1.0"
     exon            913..1990
                     /gene="Arhgap24"
                     /gene_synonym="DR-NR#2"
                     /inference="alignment:Splign:2.1.0"
     exon            1991..2838
                     /gene="Arhgap24"
                     /gene_synonym="DR-NR#2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 caacaacaaa aaaaatcctc aaaactcact gaattaggca aagggagaag gagagtaatt
       61 tgttttgttt cttaccaaag aggactaaat gagatgttac cttaactcgg gacttggatg
      121 atcaaaaccc cggagttcta ggaatcagca cttgagactt gacacataaa caaacatgag
      181 gaagagcgtc tgtgggcttc cacacagagg caggttttaa agaagcctga gctgatctta
      241 taaaaactcg gggggcctgc atgatgcctg aagaccgaaa ttcgggggga cgcccttcag
      301 gtgccttagc atcaactcct ttcatcccca aaactacata cagaagaatc aaacggtgct
      361 ttagtttccg gaaaggtatt tttggacaga aactggagga cacggtccga tatgagaaga
      421 gatacgggaa ccggctggcg cccatgctgg tggagcagtg cgtggacttc atccgacagc
      481 gggggctgaa ggaagagggc ctcttccgac tgcccggcca ggcaaacctt gtcaaggagc
      541 tccaggatgc attcgactgt ggagagaagc cctccttcga cagcaacaca gacgtccaca
      601 ctgtggcatc cctcctgaaa ctgtatctcc gagaacttcc agagccggtc gttccttacg
      661 caaagtacga agactttttg tcctgtgcca cgctgctcag caaggaggaa gaagctggcg
      721 tgaaggagct aacgaaacaa gtgaagagtt tgccagtggt taactacaac ctcctgaagt
      781 acatttgcag gttcctggat gaagtgcagt cctattcggg agttaacaag atgagcgcac
      841 agaacttggc aactgtcttc ggtcctaaca tcctgcgccc aaaggtggaa gatcctttaa
      901 ccatcatgga gggcactgtg gtggtccagc agttaatgtc agtgatgatc agcaaacatg
      961 atcgcctctt ccccaaagac acagagccac aaagcaagcc ccaagaagga ccgaacagca
     1021 ataacaacga tggtcataag aaagtcacca tgggtcagtt acagaacaaa gaaaacaaca
     1081 ataccaagga gagtccggtc agacggtgct cttgggacaa gcctgaatcc ccccagagaa
     1141 gcagcatgga caacggatcc cccacagctc tatcagggag caaaaccaac agcccacgga
     1201 acagtatcca caagctggat gtctccagga gcccgcctct cacggtcaaa aagaacccag
     1261 ccttcaataa gggcagcggg atcgtcacca atgggtcctt cagcagcagc aatgcagaag
     1321 gtgtggagaa aacccaaacc actcctaatg ggagtttaca agccagaagg acctcttccc
     1381 tgaagagttc tggtaccaaa atgggtactc atagcgtaca gaatggcacc gtgcgcatgg
     1441 gtattttgaa cactgacaca ctagggaatt ccttgaatgg ccggagcatg agttggctgc
     1501 ccaatggcta cgtgaccctg agagataaca agcagaagga gcccgcggga gagtcaggcc
     1561 agcacaacag actctccacc tacgacaacg tccaccagca gttctccttg atgaacctcg
     1621 acgacaagca cagcgtggac agtgccacgt ggtccacctc ctcctgtgaa atctccctcc
     1681 ccgagaactc caactcctgc cgctcctcta ccactacgtg cccggagcaa gacttctacg
     1741 gcgggaactt tgaggaccct gttttagacg gcccgcctca ggatgacctt tctcatcctg
     1801 gggactatga gaacaaaagc gaccgcagga gcgtgggggg ccgaagcagc cgtgccacga
     1861 gcagcagcga caacagcgag acgttcgtcg gtaacaccag cagcaaccac agtgcacttc
     1921 acagtttagt ctccagcctg aagcaggaga tgaccaaaca gaagatcgag tatgagtcca
     1981 ggataaaaag cttagaacag cggaacttga ctttggaaac ggaaatgctg aacctccatg
     2041 acgaactgga tcaagagagg aaaaagttca ccatgataga aatcaagatg agaaacgccg
     2101 agcgcgcgaa agaggatgct gagaagagga acgacatgct ccagaaggaa atggagcagt
     2161 tcttctccac attcggagac ctgacggtgg aacccaggag aagcgagagg ggaaacacaa
     2221 tctggatcca gtgagccttt ctctctgtcc tggaccactc cagggaggac tctgggaact
     2281 cggggacaaa cagtgttggg gaacaatgtg ggatcaggtg gctggtctgt gtagagcttc
     2341 atctggtgaa ggactgtcat ttacggaaat cactatccat atctgcagtg tgtaccaaag
     2401 ttataccatg ctccataatg ctactgtcaa gtgttacaac tggatctacg tgtagagggt
     2461 agtttctaaa atgtcggtaa gaggtagaag catatatctc aatgattatt ttattgcaag
     2521 tcctgtattt aaatgtcgaa tcaatacatt gttgcaattt agcttgcatt caagcttcac
     2581 cccgtgcact taacataagc tatttttggc atcgtgttat catctgctta ttttatagat
     2641 caatattttt atttcccctt ttgctgagga aatgaagata agaagaaata taaatatata
     2701 aatatatata agatgagtta ttaaagtcaa aagaatactt cgtggctgtg ctgtttgtgc
     2761 caatagacct tgccatgacc aaaaaaagag aaatgtaaaa cagaaaaggt tttataaact
     2821 atagcagaat acctgtca
//
