LOCUS       NM_001170575            2292 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus Rho GTPase activating protein 18 (Arhgap18),
            mRNA.
ACCESSION   NM_001170575 XM_001062453 XM_215247
VERSION     NM_001170575.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2292)
  AUTHORS   Lovelace MD, Powter EE, Coleman PR, Zhao Y, Parker A, Chang GH, Lay
            AJ, Hunter J, McGrath AP, Jormakka M, Bertolino P, McCaughan G,
            Kavallaris M, Vadas MA and Gamble JR.
  TITLE     The RhoGAP protein ARHGAP18/SENEX localizes to microtubules and
            regulates their stability in endothelial cells
  JOURNAL   Mol Biol Cell 28 (8), 1066-1078 (2017)
   PUBMED   28251925
REFERENCE   2  (bases 1 to 2292)
  AUTHORS   Guo Z, Neilson LJ, Zhong H, Murray PS, Zanivan S and Zaidel-Bar R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2292)
  AUTHORS   Maeda M, Hasegawa H, Hyodo T, Ito S, Asano E, Yuang H, Funasaka K,
            Shimokata K, Hasegawa Y, Hamaguchi M and Senga T.
  TITLE     ARHGAP18, a GTPase-activating protein for RhoA, controls cell
            shape, spreading, and motility
  JOURNAL   Mol Biol Cell 22 (20), 3840-3852 (2011)
   PUBMED   21865595
REFERENCE   4  (bases 1 to 2292)
  AUTHORS   Potkin SG, Turner JA, Fallon JA, Lakatos A, Keator DB, Guffanti G
            and Macciardi F.
  TITLE     Gene discovery through imaging genetics: identification of two
            novel genes associated with schizophrenia
  JOURNAL   Mol Psychiatry 14 (4), 416-428 (2009)
   PUBMED   19065146
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CK367489.1, CV116120.1, FM089382.1, FM117434.1 and CB579768.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA5756307, SAMEA5760383
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-657               CK367489.1         10-666
            658-1211            CV116120.1         141-694
            1212-1754           FM089382.1         157-699
            1755-1910           FM117434.1         502-657
            1911-2292           CB579768.1         41-422              c
FEATURES             Location/Qualifiers
     source          1..2292
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1p12"
     gene            1..2292
                     /gene="Arhgap18"
                     /note="Rho GTPase activating protein 18"
                     /db_xref="GeneID:293947"
                     /db_xref="RGD:1305053"
     exon            1..186
                     /gene="Arhgap18"
                     /inference="alignment:Splign:2.1.0"
     CDS             74..2071
                     /gene="Arhgap18"
                     /codon_start=1
                     /product="rho GTPase-activating protein 18"
                     /protein_id="NP_001164046.1"
                     /db_xref="GeneID:293947"
                     /db_xref="RGD:1305053"
                     /translation="MNWLSSSSGVVLTAYHPSGKDQVAGDSHAKGGDEATSSRRYGQY
                     TMNPESSTKLSERPPFDRSSSQDSLDEVSMEAYWTELENIKRSTENCQEGQEAIVVKE
                     PDEGELEEEWLKEAGLSNLFGESADDSQESIVFLSTLTRTQAAAVQKRVETVSQTLRK
                     KSKQYHIPDVRDIFAQQREAQEKSPDDSDLRSVRTNENEDQGKDDQPSSGAVDNKEPI
                     PRVPEDIPASETDINLEVSFAEQAVNQKELSKERMQKTRGNDASLPSFRLPKDKTGTT
                     RIGDLAPQDMKKVCYLSLIELTALYDVLGVELKQQKAVKIKTRDSGLFGIPLTILLEQ
                     DQRKVPGTRIPLIFQKLISCIEEGSLETEGLLRIPGAAMRVKNLCQELEAKFYEGTFN
                     WESVKQHDAASLLKLFLRELPQPLLSTEYLKAFQAVQNLPTKKEQLQALNLLVILLPD
                     ANRDTLKALLEFLQRVIDNKEKNKMTAVNVAMVMAPNLFMCHALGLKSSEHREFEMAA
                     GTANTMHLLIRYQKLLWTIPKFIVNQVRKHNTAHQKKERRAMKKLLKKMAYDREKHEK
                     QDRAANGADVPQGVIRVQAPHLSKVSMAIQLTEELKASDVLARFLSQESGVAQTLKKG
                     EVFLYEIGGNIGERCLDDDTYMKDLYHLNPNAEWVIKSKPV"
     exon            187..386
                     /gene="Arhgap18"
                     /inference="alignment:Splign:2.1.0"
     exon            387..622
                     /gene="Arhgap18"
                     /inference="alignment:Splign:2.1.0"
     exon            623..686
                     /gene="Arhgap18"
                     /inference="alignment:Splign:2.1.0"
     exon            687..865
                     /gene="Arhgap18"
                     /inference="alignment:Splign:2.1.0"
     exon            866..1031
                     /gene="Arhgap18"
                     /inference="alignment:Splign:2.1.0"
     exon            1032..1123
                     /gene="Arhgap18"
                     /inference="alignment:Splign:2.1.0"
     exon            1124..1201
                     /gene="Arhgap18"
                     /inference="alignment:Splign:2.1.0"
     exon            1202..1361
                     /gene="Arhgap18"
                     /inference="alignment:Splign:2.1.0"
     exon            1362..1444
                     /gene="Arhgap18"
                     /inference="alignment:Splign:2.1.0"
     exon            1445..1651
                     /gene="Arhgap18"
                     /inference="alignment:Splign:2.1.0"
     exon            1652..1792
                     /gene="Arhgap18"
                     /inference="alignment:Splign:2.1.0"
     exon            1793..1917
                     /gene="Arhgap18"
                     /inference="alignment:Splign:2.1.0"
     exon            1918..1979
                     /gene="Arhgap18"
                     /inference="alignment:Splign:2.1.0"
     exon            1980..2288
                     /gene="Arhgap18"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agttggccag gcgagacagg aacttcattc ccctctgtgt caggattcca gaaattatgc
       61 cccttctctc accatgaact ggctctcgag ttcctcggga gttgtgctaa ctgcttacca
      121 ccccagcggc aaggaccagg tcgctgggga cagccatgca aagggaggcg acgaagccac
      181 ctccagtcgc agatatggcc agtacaccat gaacccagaa agctccacca aactttcaga
      241 gagacctcca ttcgatcgat caagttctca ggattctttg gatgaagtgt caatggaagc
      301 ctattggaca gaactagaaa acatcaagag gtctactgaa aactgccaag aaggtcaaga
      361 agccatagtt gtcaaagaac ctgatgaggg agaactggaa gaagaatggc tcaaggaggc
      421 aggtctgtcc aatcttttcg gggagtccgc cgatgactct caggagagca tcgtgttttt
      481 gtctacgctg acccggactc aggcagcagc tgtccagaaa cgggtagaaa cggtctccca
      541 aaccctgagg aagaaaagca aacagtacca cattcctgac gtcagagaca tatttgctca
      601 acagagagag gcacaagaaa aatctccaga tgactcagac ttgcggtcag tcagaacaaa
      661 tgaaaacgaa gaccaaggaa aagatgacca gccatctagt ggggctgtgg ataacaagga
      721 gccgatccca cgggtgcctg aggatatacc tgcctctgaa acagacatca atctggaggt
      781 gtcctttgcg gaacaagctg tcaatcagaa agagctcagt aaggagagga tgcagaagac
      841 gagaggaaac gatgcctctt tacccagttt cagactgcct aaagataaaa caggtacaac
      901 aaggattgga gacttggcac ctcaagacat gaagaaagtt tgctatctat ccctgatcga
      961 actcactgcc ctatatgatg tattgggtgt ggagctcaaa caacagaaag ctgtgaaaat
     1021 caaaaccaga gactctggtc tttttggtat tcctttaact atattgttag aacaagatca
     1081 aagaaaagtg cctggaacgc gaataccctt gatctttcaa aaactgattt cttgcattga
     1141 agaaggcagt ctggaaactg agggcctcct gcggatacca ggagcagcca tgagagtcaa
     1201 gaatctttgc caagaattag aagcaaagtt ttatgaagga actttcaact gggaaagtgt
     1261 caagcagcac gatgcggcca gcctgctgaa gctctttctg agagaactgc cccagcctct
     1321 gctgagcacg gagtacctca aagccttcca ggctgttcag aatcttccaa ccaaaaagga
     1381 acaattgcag gctttgaacc tccttgtcat tcttctacct gacgcaaaca gagacacact
     1441 gaaggccttg ctagaatttc tccaaagagt catcgataac aaagagaaaa acaagatgac
     1501 agccgtgaat gtagcaatgg tcatggcccc gaatctcttc atgtgccatg cactgggctt
     1561 gaagtccagt gaacaccgag aatttgaaat ggcagcaggg acagcaaata ccatgcactt
     1621 attgattcgg taccagaaac ttctgtggac aatccctaaa tttattgtga accaagtgag
     1681 gaagcacaat actgcgcatc agaagaagga aaggagagcc atgaagaaat tgctgaagaa
     1741 aatggcgtat gaccgggaaa aacacgaaaa gcaagacaga gctgcaaatg gtgctgacgt
     1801 tcctcaggga gtgattcgag tgcaagctcc ccatctttca aaagtttcca tggcaataca
     1861 gctaactgaa gaactaaaag ccagcgacgt acttgccagg tttctgagcc aagaaagtgg
     1921 ggttgcccag acactcaaga aaggagaagt tttcctgtat gagattggag gaaatattgg
     1981 ggaacgttgc cttgatgacg atacatacat gaaggacttg taccatctga acccaaatgc
     2041 tgaatgggtc ataaaatcaa agccagtgta gatgactacc ccgaggccat gtcatcattc
     2101 ttgctggatc aagagtgtaa ataaaagcaa caggtttctt aactattcag ccgtacccaa
     2161 ttattacaaa gtgacaccct caagccttaa aattatagat tttttttgtg gcttccacag
     2221 ttgttaatta ttattattat tttagaaaat gagtattttt ggagcataat taaatgactt
     2281 tttctaaaaa aa
//
