LOCUS       NM_001270693            3426 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus Rho GTPase activating protein 17 (Arhgap17),
            transcript variant 3, mRNA.
ACCESSION   NM_001270693
VERSION     NM_001270693.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3426)
  AUTHORS   Ren,Y.S., Li,H.H., Yao,J.C., Tan,Y.J., Pan,L.H., Peng,T.,
            Zhao,L.L., Zhang,G.M., Yue,J., Hu,X.M., Liu,Z. and Li,J.
  TITLE     Application quantitative proteomics approach to identify
            differentially expressed proteins associated with cardiac
            protection mediated by cycloastragenol in acute myocardial
            infarction rats
  JOURNAL   J Proteomics 222, 103691 (2020)
   PUBMED   32068187
REFERENCE   2  (bases 1 to 3426)
  AUTHORS   Galic,M., Jeong,S., Tsai,F.C., Joubert,L.M., Wu,Y.I., Hahn,K.M.,
            Cui,Y. and Meyer,T.
  TITLE     External push and internal pull forces recruit curvature-sensing
            N-BAR domain proteins to the plasma membrane
  JOURNAL   Nat Cell Biol 14 (8), 874-881 (2012)
   PUBMED   22750946
REFERENCE   3  (bases 1 to 3426)
  AUTHORS   Furuta,B., Harada,A., Kobayashi,Y., Takeuchi,K., Kobayashi,T. and
            Umeda,M.
  TITLE     Identification and functional characterization of nadrin variants,
            a novel family of GTPase activating protein for rho GTPases
  JOURNAL   J Neurochem 82 (5), 1018-1028 (2002)
   PUBMED   12358749
REFERENCE   4  (bases 1 to 3426)
  AUTHORS   Harada,A., Furuta,B., Takeuchi,K., Itakura,M., Takahashi,M. and
            Umeda,M.
  TITLE     Nadrin, a novel neuron-specific GTPase-activating protein involved
            in regulated exocytosis
  JOURNAL   J Biol Chem 275 (47), 36885-36891 (2000)
   PUBMED   10967100
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC085736.1, JAXUCZ010000001.1 and AB042827.1.
            
            Transcript Variant: This variant (3) contains an alternate 3' exon
            with an in-frame stop codon compared to variant 1. The resulting
            isoform (3) has a shorter and distinct C-terminus compared to
            isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB060556.1, SRR21887621.965723.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMN12840106 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2531              BC085736.1         2-2532
            2532-2579           JAXUCZ010000001.1  187244767-187244814 c
            2580-3363           BC085736.1         2533-3316
            3364-3426           AB042827.1         3080-3142
FEATURES             Location/Qualifiers
     source          1..3426
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q36"
     gene            1..3426
                     /gene="Arhgap17"
                     /gene_synonym="Rich1"
                     /note="Rho GTPase activating protein 17"
                     /db_xref="GeneID:63994"
                     /db_xref="RGD:628767"
     exon            1..138
                     /gene="Arhgap17"
                     /gene_synonym="Rich1"
                     /inference="alignment:Splign:2.1.0"
     CDS             86..2578
                     /gene="Arhgap17"
                     /gene_synonym="Rich1"
                     /note="isoform 3 is encoded by transcript variant 3; rho
                     GTPase-activating protein 17; neuron-specific
                     GTPase-activating protein; rho-type GTPase-activating
                     protein 17; neuron-associated developmentally-regulated
                     protein"
                     /codon_start=1
                     /product="rho GTPase-activating protein 17 isoform 3"
                     /protein_id="NP_001257622.1"
                     /db_xref="GeneID:63994"
                     /db_xref="RGD:628767"
                     /translation="MKKQFNRMKQLANQTVGRAEKTEVLSEDLLQIERRLDTVRSMCH
                     HSHKRLIACFQGQHGTDAERRHKKLPLTALAQNMQEASAQLEESLLGKMLETCGDAEN
                     QLAFELSQHEVFVEKEIMDPLYGIAEVEIPNIQKQRKQLARLVLDWDSVRARWNQAHK
                     SSGTNFQGLPSKIDTLKEEMDEAGNKVEQCKDQLAADMYNFMAKEGEYGKFFVTLLEA
                     QADYHRKALAVLEKALPEMRAHQDKWAEKPAFGTPLEEHLKRSGREIALPIEACVMLL
                     LETGMKEEGLFRIGAGASKLKKLKAALDCSTSHLDEFYSDPHAVAGALKSYLRELPEP
                     LMTFSLYEEWTQVASVQDQDKKLQYLWTTCQKLPPQNFVNFRYLIKFLAKLAQTSDVN
                     KMTPSNIAIVLGPNLLWAKQEGTLAEIAAATSVHVVAVIEPIIQHADWFFPGEVEFNV
                     SEAFVPLATPNSNHSSHTGNDSDSGTLERKRPASMAVMEGDLVKKESFGVKLMDFQAH
                     RRGGTLNRKHISPAFQPPLPPTDGNALAPAGPELPSQSSRADSNSVGGPVPSSSGILE
                     QGLSPGDSSPPKPKDSVSAAAPVAGRNSNQITTVPNQAQTGGNSHQLSVGTAHSAAGP
                     SPHTLRRAVKKPAPAPPKPGNPPPGHPGGQSSPGTGTSPKPSTRSPSPPQQQQQQQQQ
                     QQQQQQQQQQQQQQQQQQQQTPGMRRCSSSLPPIQAPNHPPPQPPTQPRLGEQGPEPG
                     PTPPQTPTPPSTPPPAKQNSSQSETTQLHGTLPRPRPVPKPRNRPSVPPPPNPPGTHM
                     GDGGLTPSVPTASRIVTDALPGALTGGEGFQN"
     exon            139..178
                     /gene="Arhgap17"
                     /gene_synonym="Rich1"
                     /inference="alignment:Splign:2.1.0"
     exon            179..283
                     /gene="Arhgap17"
                     /gene_synonym="Rich1"
                     /inference="alignment:Splign:2.1.0"
     exon            284..357
                     /gene="Arhgap17"
                     /gene_synonym="Rich1"
                     /inference="alignment:Splign:2.1.0"
     exon            358..469
                     /gene="Arhgap17"
                     /gene_synonym="Rich1"
                     /inference="alignment:Splign:2.1.0"
     exon            470..546
                     /gene="Arhgap17"
                     /gene_synonym="Rich1"
                     /inference="alignment:Splign:2.1.0"
     exon            547..658
                     /gene="Arhgap17"
                     /gene_synonym="Rich1"
                     /inference="alignment:Splign:2.1.0"
     exon            659..727
                     /gene="Arhgap17"
                     /gene_synonym="Rich1"
                     /inference="alignment:Splign:2.1.0"
     exon            728..809
                     /gene="Arhgap17"
                     /gene_synonym="Rich1"
                     /inference="alignment:Splign:2.1.0"
     exon            810..937
                     /gene="Arhgap17"
                     /gene_synonym="Rich1"
                     /inference="alignment:Splign:2.1.0"
     exon            938..1049
                     /gene="Arhgap17"
                     /gene_synonym="Rich1"
                     /inference="alignment:Splign:2.1.0"
     exon            1050..1131
                     /gene="Arhgap17"
                     /gene_synonym="Rich1"
                     /inference="alignment:Splign:2.1.0"
     exon            1132..1212
                     /gene="Arhgap17"
                     /gene_synonym="Rich1"
                     /inference="alignment:Splign:2.1.0"
     exon            1213..1326
                     /gene="Arhgap17"
                     /gene_synonym="Rich1"
                     /inference="alignment:Splign:2.1.0"
     exon            1327..1418
                     /gene="Arhgap17"
                     /gene_synonym="Rich1"
                     /inference="alignment:Splign:2.1.0"
     exon            1419..1575
                     /gene="Arhgap17"
                     /gene_synonym="Rich1"
                     /inference="alignment:Splign:2.1.0"
     exon            1576..1809
                     /gene="Arhgap17"
                     /gene_synonym="Rich1"
                     /inference="alignment:Splign:2.1.0"
     exon            1810..1979
                     /gene="Arhgap17"
                     /gene_synonym="Rich1"
                     /inference="alignment:Splign:2.1.0"
     exon            1980..2531
                     /gene="Arhgap17"
                     /gene_synonym="Rich1"
                     /inference="alignment:Splign:2.1.0"
     exon            2532..2579
                     /gene="Arhgap17"
                     /gene_synonym="Rich1"
                     /inference="alignment:Splign:2.1.0"
     exon            2580..3416
                     /gene="Arhgap17"
                     /gene_synonym="Rich1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcgatgtagg taggacccgc cagacggtcc ccagctctcc tcgtcccgag ccccgcggcc
       61 tgccgctgcc gccaccgccg ccgccatgaa gaagcaattc aaccgcatga agcagctggc
      121 caaccagact gtcggcagag ctgagaagac agaagtcctc agtgaagatc tgctacagat
      181 tgaacgtcga ctggacactg tgcggtcaat gtgccaccat tcacataagc gtttgatagc
      241 ctgcttccaa ggtcagcatg gcaccgatgc tgagaggaga cataaaaagc ttcctctgac
      301 agctctcgcc cagaacatgc aggaagcttc agcccagctg gaagagtctc tcttggggaa
      361 gatgctggaa acctgtgggg atgctgagaa tcagctggct tttgaactct ctcagcatga
      421 ggtctttgtg gagaaggaga tcatggaccc tctctacggc atagcggagg tggagattcc
      481 caacatccaa aagcaaagga aacagcttgc tagattggtg ctggactggg attcagtcag
      541 agcaagatgg aaccaagcac acaagtcttc aggaaccaac tttcagggac ttccatctaa
      601 aatagatacc ctaaaggaag agatggatga agctggaaat aaagtcgagc agtgcaagga
      661 tcaacttgca gcagacatgt acaacttcat ggccaaagaa ggggaatacg gcaagttctt
      721 tgtgacgtta ttagaagccc aagcagatta ccatagaaaa gcattagcag tcttagaaaa
      781 ggcccttccc gaaatgcgcg cccatcaaga taaatgggca gagaagccag ccttcggtac
      841 acctctggag gaacacctga agaggagtgg acgtgagatc gctctcccta ttgaggcctg
      901 cgtcatgttg ttactggaga ctggcatgaa ggaggagggc ctttttcgga tcggagctgg
      961 agcctccaag ttgaagaagc tgaaagctgc tctcgactgc tccacgtctc acctggatga
     1021 gttctattca gacccccatg ctgtcgcagg tgctttaaag tcctatttgc gggaactgcc
     1081 tgagccctta atgactttca gtctgtatga agagtggaca caagttgcaa gtgtgcagga
     1141 tcaagacaaa aaacttcaat atttatggac aacatgtcag aagttgccgc cacaaaattt
     1201 tgttaacttt aggtatttaa tcaagttcct tgcaaagctc gcccagacca gtgatgttaa
     1261 taaaatgact cctagcaaca tagccatcgt gttgggccct aacctcctgt gggccaaaca
     1321 agaaggaacc ctggctgaaa tagcggctgc cacatctgtc cacgtggtcg cagtgattga
     1381 acctatcatc cagcatgccg attggttctt ccccggagag gtagaattca atgtatcaga
     1441 agcattcgtg cctcttgcta ccccaaattc taatcactca tcccatactg gaaatgactc
     1501 tgactcgggg actctggaga ggaagcgacc cgccagcatg gcagtgatgg aaggggactt
     1561 ggtgaagaag gagagctttg gtgtgaagct tatggacttc caggcccacc ggcggggtgg
     1621 cactctaaat agaaagcaca tatctcctgc tttccagccg ccactcccgc ccacggatgg
     1681 caacgccttg gctccagcag gcccagagct cccttctcag agctctaggg ctgacagcaa
     1741 ctcagtgggt gggcctgtcc cctcttcttc gggcatattg gagcaggggc tgagcccagg
     1801 tgacagcagt cctccaaaac ccaaagactc tgtgtctgca gctgcccctg tggcaggaag
     1861 aaacagcaac cagataacca cggtcccaaa ccaggcccag acaggtggca actcccatca
     1921 gctctcagta ggcacagctc acagtgcagc tggccccagc ccgcacactc tgcgtcgagc
     1981 tgtgaagaaa cctgctccgg caccccccaa accaggaaac ccacctcctg gccaccctgg
     2041 aggacagagc tctccaggca caggcacatc cccaaagcca agcacccgaa gcccatcacc
     2101 gcctcagcag cagcagcagc agcaacaaca acaacagcag cagcaacaac aacagcagca
     2161 acaacaacaa caacaacagc agcagcagca gaccccgggc atgcgccgct gttccagcag
     2221 cctgcctcct atccaggcac ccaaccaccc accaccgcag ccccccacac agcctcggct
     2281 gggtgaacag ggaccagagc caggccccac gccacctcag acccccacac cacccagcac
     2341 cccacccccg gccaagcaga attcatccca aagcgagacc acacagctgc atggaaccct
     2401 cccaaggcca cggccagtgc ctaaaccccg caaccggcct agtgtgccac cacccccgaa
     2461 tccacctggc acccacatgg gggatggtgg cctcacacct tcagtgccca cagcctccag
     2521 aatcgtcact gatgcccttc ccggtgccct cacaggtggg gaaggtttcc agaactaaga
     2581 caccaattct agggtttctg aatcacttcg aaacatcttt cctgaaatac attcagactt
     2641 ggcaagcaaa gaagtgcctg gccatatcct gctggacata gacaatgaca cagagagcac
     2701 cgccttgtga agaaagtcac ttgccagcct ttggccctcc atcccagtga gcggatctgg
     2761 gtcaggcaag cctctgtctc tgcagaccaa acagtgagaa gctttcgggg gggaaggaag
     2821 gtctgaccac gaaggactag actcccacgg cccaaggaga atgtgagggc cagtcctcaa
     2881 agctgaatga cctgtgtcgt aaagaagttg gcttgcttta tctaggacga atatcatgcc
     2941 aaaaaatgat cagaacagaa atatctacag cagagagtgt ttactgccga gaaatgtatg
     3001 gaagcctttg ccagtgctgt cagctcagtc agcactggga gtgactagga agagacttac
     3061 ctatctattt aataaaacat taattatgca agatgcctac ttcctgctac ttggactttg
     3121 gttctcacat accagaggga gcttccgttc cttcagactt gctgcagaat cattttgtat
     3181 tagatacagt ctgtctcctc caacccccag aacctcgagc attgttggcg actgctggct
     3241 ctgttgcctc atcagaatgg atgtgagttg tgccttgtgg atcaccagaa tatggagaga
     3301 aatataccat tcttttttaa aaaaacaaaa ctataattgc tacttgataa agagcgaatg
     3361 ttattctagt ttcatgttta atttgaatta aatatattct gtggtttata tgaaaaaaaa
     3421 aaaaaa
//
