LOCUS       NM_001107747            2894 bp    mRNA    linear   ROD 22-MAR-2023
DEFINITION  Rattus norvegicus Rho GTPase activating protein 1 (Arhgap1), mRNA.
ACCESSION   NM_001107747 XM_001078147 XM_230284
VERSION     NM_001107747.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2894)
  AUTHORS   Zhang X, Guan J, Guo M, Dai H, Cai S, Zhou C, Wang Y and Qin Q.
  TITLE     Rho GTPase-activating protein 1 promotes apoptosis of myocardial
            cells in an ischemic cardiomyopathy model
  JOURNAL   Kardiol Pol 77 (12), 1163-1169 (2019)
   PUBMED   31664016
  REMARK    GeneRIF: The expression of ARHGAP1 as a result of hypoxic
            conditions in the cellular and rat models was observed. ARHGAP1 was
            also shown to initiate the apoptosis pathway by regulating the cell
            death modulators B-cell lymphoma 2 (Bcl-2) and Bcl-2-associated X
            protein.
REFERENCE   2  (bases 1 to 2894)
  AUTHORS   Guo Z, Neilson LJ, Zhong H, Murray PS, Zanivan S and Zaidel-Bar R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2894)
  AUTHORS   Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta
            R, Wang NS and Knepper MA.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   4  (bases 1 to 2894)
  AUTHORS   Shen Y, Li N, Wu S, Zhou Y, Shan Y, Zhang Q, Ding C, Yuan Q, Zhao
            F, Zeng R and Zhu X.
  TITLE     Nudel binds Cdc42GAP to modulate Cdc42 activity at the leading edge
            of migrating cells
  JOURNAL   Dev Cell 14 (3), 342-353 (2008)
   PUBMED   18331715
REFERENCE   5  (bases 1 to 2894)
  AUTHORS   Wang L, Yang L, Debidda M, Witte D and Zheng Y.
  TITLE     Cdc42 GTPase-activating protein deficiency promotes genomic
            instability and premature aging-like phenotypes
  JOURNAL   Proc Natl Acad Sci U S A 104 (4), 1248-1253 (2007)
   PUBMED   17227869
REFERENCE   6  (bases 1 to 2894)
  AUTHORS   Pixley FJ, Xiong Y, Yu RY, Sahai EA, Stanley ER and Ye BH.
  TITLE     BCL6 suppresses RhoA activity to alter macrophage morphology and
            motility
  JOURNAL   J Cell Sci 118 (Pt 9), 1873-1883 (2005)
   PUBMED   15860730
REFERENCE   7  (bases 1 to 2894)
  AUTHORS   Berfield AK, Andress DL and Abrass CK.
  TITLE     IGFBP-5(201-218) stimulates Cdc42GAP aggregation and filopodia
            formationin migrating mesangial cells
  JOURNAL   Kidney Int 57 (5), 1991-2003 (2000)
   PUBMED   10792618
REFERENCE   8  (bases 1 to 2894)
  AUTHORS   Prakash SK, Paylor R, Jenna S, Lamarche-Vane N, Armstrong DL, Xu B,
            Mancini MA and Zoghbi HY.
  TITLE     Functional analysis of ARHGAP6, a novel GTPase-activating protein
            for RhoA
  JOURNAL   Hum Mol Genet 9 (4), 477-488 (2000)
   PUBMED   10699171
REFERENCE   9  (bases 1 to 2894)
  AUTHORS   Lancaster CA, Taylor-Harris PM, Self AJ, Brill S, van Erp HE and
            Hall A.
  TITLE     Characterization of rhoGAP. A GTPase-activating protein for
            rho-related small GTPases
  JOURNAL   J Biol Chem 269 (2), 1137-1142 (1994)
   PUBMED   8288572
REFERENCE   10 (bases 1 to 2894)
  AUTHORS   Barfod ET, Zheng Y, Kuang WJ, Hart MJ, Evans T, Cerione RA and
            Ashkenazi A.
  TITLE     Cloning and expression of a human CDC42 GTPase-activating protein
            reveals a functional SH3-binding domain
  JOURNAL   J Biol Chem 268 (35), 26059-26062 (1993)
   PUBMED   8253717
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CK480577.1, EV768858.1, DN932805.1, CO573331.1, DV725096.1 and
            AA900696.1.
            
            On Nov 1, 2008 this sequence version replaced NM_001107747.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ224002.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-708               CK480577.1         1-708
            709-1200            EV768858.1         180-671
            1201-1559           DN932805.1         361-719
            1560-2102           CO573331.1         147-689
            2103-2572           DV725096.1         268-737
            2573-2894           AA900696.1         1-322               c
FEATURES             Location/Qualifiers
     source          1..2894
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q24"
     gene            1..2894
                     /gene="Arhgap1"
                     /note="Rho GTPase activating protein 1"
                     /db_xref="GeneID:311193"
                     /db_xref="RGD:1306068"
     exon            1..110
                     /gene="Arhgap1"
                     /inference="alignment:Splign:2.1.0"
     exon            111..268
                     /gene="Arhgap1"
                     /inference="alignment:Splign:2.1.0"
     CDS             136..1455
                     /gene="Arhgap1"
                     /codon_start=1
                     /product="rho GTPase-activating protein 1"
                     /protein_id="NP_001101217.2"
                     /db_xref="GeneID:311193"
                     /db_xref="RGD:1306068"
                     /translation="MDPLSELQDDLTLDDTSQALNQLKLASIDEKNWPSDEMPDFPKS
                     DDSKSSSPEPVTHLKWDDPYYDIARHQIVEVAGDDKYGRKIIVFSACRMPPSHQLDHS
                     KLLGYLKHTLDQYVESDYTLLYLHHGLTSDNKPSLSWLRDAYREFDRKYKKNIKALYI
                     VHPTMFIKTLLILFKPLISFKFGRKIFYVNYLSELSEHVKLEQLGIPRQVLKYDDFLK
                     STQKSPATAPKPMPPRPPLPNQQFGVSLQHLREKNPNQEPIPIVLRETVAYLQAHALT
                     AEGIFRRSANTQVVREVQQKYNMGLPVDFDQYNELHLPAVILKTFLRELPEPLLTFDL
                     YPHIVGFLDLDDDQRVEVTQQVLQTLPEENYRVLHFLTAFLVQVSAHSYQNRMNNTNL
                     AVVFGPNLLWAKDAAITLKAINPINTFTKFLLDHQGELFPSTDAQGV"
     exon            269..364
                     /gene="Arhgap1"
                     /inference="alignment:Splign:2.1.0"
     exon            365..452
                     /gene="Arhgap1"
                     /inference="alignment:Splign:2.1.0"
     exon            453..584
                     /gene="Arhgap1"
                     /inference="alignment:Splign:2.1.0"
     exon            585..671
                     /gene="Arhgap1"
                     /inference="alignment:Splign:2.1.0"
     exon            672..770
                     /gene="Arhgap1"
                     /inference="alignment:Splign:2.1.0"
     exon            771..878
                     /gene="Arhgap1"
                     /inference="alignment:Splign:2.1.0"
     exon            879..955
                     /gene="Arhgap1"
                     /inference="alignment:Splign:2.1.0"
     exon            956..1033
                     /gene="Arhgap1"
                     /inference="alignment:Splign:2.1.0"
     exon            1034..1162
                     /gene="Arhgap1"
                     /inference="alignment:Splign:2.1.0"
     exon            1163..1266
                     /gene="Arhgap1"
                     /inference="alignment:Splign:2.1.0"
     exon            1267..2877
                     /gene="Arhgap1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aagtggttgg gagctaaggg cccccgaggg ggcggttccc attcccacct cggagccgga
       61 tgtttgccga gctttgacag gcgtggcaaa gggagcatta cccgaacgcg gcttctcttc
      121 tggttctcct tagccatgga tcctctctca gaactgcaag atgacctgac cctggatgat
      181 accagccaag ccctgaacca gttgaagctg gcctctattg atgagaagaa ctggccttct
      241 gatgaaatgc cagactttcc caagtcagat gactccaaaa gcagctctcc agaacctgtc
      301 acacacctga agtgggatga cccttactac gacattgcca ggcaccagat tgtggaagtg
      361 gcaggtgatg ataagtacgg gcggaagata attgtattta gtgcttgccg gatgcccccc
      421 agccaccagc tggaccacag caagctcttg gggtacttga aacacacact ggaccagtat
      481 gtggaaagtg actacacact cctgtacctg caccatggcc tgaccagtga caacaagccc
      541 tccctcagct ggctacggga tgcctaccga gagtttgacc gcaagtacaa gaagaacatc
      601 aaggctctgt acattgtgca cccaaccatg ttcatcaaaa ctctgcttat cctctttaag
      661 cccctcatca gtttcaagtt tggacggaag atcttctatg tgaattacct gagtgagtta
      721 agcgagcacg tgaagctgga gcagttgggg atccctcgcc aagtgctcaa gtatgatgac
      781 ttcctcaagt ccacccagaa gagccctgca acagctccca agcccatgcc accacggccc
      841 cccctgccta atcagcaatt tggggtctcg ttacagcacc tccgggagaa aaacccgaac
      901 caggagccca tccccattgt gctcagggag acagtcgcct acttgcaggc gcacgctctc
      961 accgccgagg gcatcttccg gaggtctgcc aacacccagg tagtaagaga agtgcagcag
     1021 aaatacaata tggggctgcc agtggacttt gaccagtaca atgagctgca cctgccagcc
     1081 gtcatactca agacattcct tcgggagctt cctgaaccct tgctaacctt tgacctctac
     1141 ccccacattg tgggcttcct cgatcttgat gacgaccaga gagtggaggt aacacagcag
     1201 gttctccaaa ctctgccaga ggagaactac cgggtacttc acttcctgac tgccttcctt
     1261 gtacaggtat ctgcccactc ttaccagaac aggatgaata acactaacct ggctgtggtc
     1321 ttcggcccta acctgctgtg ggctaaggat gctgccatca ccctcaaggc cattaatccc
     1381 atcaacacct tcactaaatt cctcctggat catcaagggg aattgttccc cagcacagat
     1441 gcccaggggg tctgagctca gcccccacct ccagcccctt ctctggcagc tccagttgga
     1501 cttgtcctcc tggtatcaac cttattggag cttctgccta ggaagggacc ctgaagcccc
     1561 tcccaggaga tgtaggttgg agcccactaa ctgggcagcc cctcctctcc ctctgtccat
     1621 cccaccttac cggccctgga ggcctgttac cctaagacat tttctttgcc ttacacttct
     1681 cactgcctct ttggttgctg ggcttgactc ttccaggatt cagcccaagt aatccttttc
     1741 tttttttcct gcctgtttcc ctggcaactg tagaagacta catcactgcc agctgtgctg
     1801 gtagctgggg ctggtcctct cttgcctgtt aggaagtgag tgttgacctg ggtgcaagtt
     1861 ccccgtgcct gccctcccta ctagtaggga tgaccagagt tggcctgtca cttctgcctc
     1921 cagggtctgt tcctccccaa gtggtactgc ccccagagtg tcctgtcccc tcatttctgc
     1981 cacacttggc accttggata tctatcaaga ctcagaatct gagtccctat tgaaatggtc
     2041 ttgtccactc ccagggagag ccatagtgtc tggtgggatc agttccagca gtcctggccc
     2101 tccatgcctt cccttcattc tcacgtgcac agaccttcag ccaaaggctg cacagtagat
     2161 ctttctggtg tggagtcact ctaatccctg ttctggccag ggattctaat gcctcaggat
     2221 ccatggtagc tctcacctct tgcctgggga ctcttggaga gtcaggagct cagaagcccc
     2281 taagattgtc agatgtttta ctaatagatc acccctgcta gataggttct agcaattccc
     2341 ttaggggagt gtggtggcca taggccctct tgactttcag aaagcctgaa ccccagtgat
     2401 tggtaacttt cactctattc ctagtgaagc cttgtgaccc tcttcctgaa gtctgtcccc
     2461 taatgacagg gagctagctg cagtggccct gccctacagg tgtggccagg cacaccagct
     2521 ggagaggcgg tactgggtac tgtaggatct gcactgatga ccttgcagag gaggctcttt
     2581 gctgcaccac tgttgtgtca ggtgcttcaa gtgctgctgt cagtccccag ccttatacct
     2641 gcccagcctg ggcctttgct tctgtccact ctggtgtcga gtgtcgctac actccactta
     2701 ctgagggcca tccggacctc ttttgtcttt ctcttgcccc tgccctgtca gtctgtggct
     2761 gggggtgctt ttactgtgaa tccagtgttc acatttacca caatttcctt ggcaccaatc
     2821 atgtatttta ccgtttgcac tttttgtatt tcaataaaaa tgtaaatgaa aaatgccaaa
     2881 aaaaaaaaaa aaaa
//
