LOCUS       NM_019168               1432 bp    mRNA    linear   ROD 24-OCT-2024
DEFINITION  Rattus norvegicus arginase 2 (Arg2), mRNA; nuclear gene for
            mitochondrial product.
ACCESSION   NM_019168
VERSION     NM_019168.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1432)
  AUTHORS   Huang,Y., Yue,S., Yan,Z., Liu,Y., Qiao,J., Zhang,M., Dong,Y. and
            Zheng,J.
  TITLE     Lactate-upregulated ARG2 expression induces cellular senescence in
            fibroblast-like synoviocytes of osteoarthritis via activating the
            mTOR/S6K1 signaling pathway
  JOURNAL   Int Immunopharmacol 142 (Pt A), 113071 (2024)
   PUBMED   39236462
  REMARK    GeneRIF: Lactate-upregulated ARG2 expression induces cellular
            senescence in fibroblast-like synoviocytes of osteoarthritis via
            activating the mTOR/S6K1 signaling pathway.
REFERENCE   2  (bases 1 to 1432)
  AUTHORS   El-Bassossy,H.M., Neamatallah,T., Balamash,K.S., Abushareb,A.T. and
            Watson,M.L.
  TITLE     Arginase overexpression and NADPH oxidase stimulation underlie
            impaired vasodilation induced by advanced glycation end products
  JOURNAL   Biochem Biophys Res Commun 499 (4), 992-997 (2018)
   PUBMED   29627571
  REMARK    GeneRIF: The present results indicate that Advanced glycation
            endproducts impairs endothelial-dependent vasodilation, and this
            effect is mediated via arginase overexpression and NADPH oxidase
            stimulation.
REFERENCE   3  (bases 1 to 1432)
  AUTHORS   McGovern,N., Shin,A., Low,G., Low,D., Duan,K., Yao,L.J.,
            Msallam,R., Low,I., Shadan,N.B., Sumatoh,H.R., Soon,E., Lum,J.,
            Mok,E., Hubert,S., See,P., Kunxiang,E.H., Lee,Y.H., Janela,B.,
            Choolani,M., Mattar,C.N.Z., Fan,Y., Lim,T.K.H., Chan,D.K.H.,
            Tan,K.K., Tam,J.K.C., Schuster,C., Elbe-Burger,A., Wang,X.N.,
            Bigley,V., Collin,M., Haniffa,M., Schlitzer,A., Poidinger,M.,
            Albani,S., Larbi,A., Newell,E.W., Chan,J.K.Y. and Ginhoux,F.
  TITLE     Human fetal dendritic cells promote prenatal T-cell immune
            suppression through arginase-2
  JOURNAL   Nature 546 (7660), 662-666 (2017)
   PUBMED   28614294
REFERENCE   4  (bases 1 to 1432)
  AUTHORS   Geiger,R., Rieckmann,J.C., Wolf,T., Basso,C., Feng,Y., Fuhrer,T.,
            Kogadeeva,M., Picotti,P., Meissner,F., Mann,M., Zamboni,N.,
            Sallusto,F. and Lanzavecchia,A.
  TITLE     L-Arginine Modulates T Cell Metabolism and Enhances Survival and
            Anti-tumor Activity
  JOURNAL   Cell 167 (3), 829-842 (2016)
   PUBMED   27745970
REFERENCE   5  (bases 1 to 1432)
  AUTHORS   Xu,W., Ghosh,S., Comhair,S.A., Asosingh,K., Janocha,A.J.,
            Mavrakis,D.A., Bennett,C.D., Gruca,L.L., Graham,B.B.,
            Queisser,K.A., Kao,C.C., Wedes,S.H., Petrich,J.M., Tuder,R.M.,
            Kalhan,S.C. and Erzurum,S.C.
  TITLE     Increased mitochondrial arginine metabolism supports bioenergetics
            in asthma
  JOURNAL   J Clin Invest 126 (7), 2465-2481 (2016)
   PUBMED   27214549
REFERENCE   6  (bases 1 to 1432)
  AUTHORS   Que,L.G., Kantrow,S.P., Jenkinson,C.P., Piantadosi,C.A. and
            Huang,Y.C.
  TITLE     Induction of arginase isoforms in the lung during hyperoxia
  JOURNAL   Am J Physiol 275 (1), L96-L102 (1998)
   PUBMED   9688940
REFERENCE   7  (bases 1 to 1432)
  AUTHORS   Carraway,M.S., Piantadosi,C.A., Jenkinson,C.P. and Huang,Y.C.
  TITLE     Differential expression of arginase and iNOS in the lung in sepsis
  JOURNAL   Exp Lung Res 24 (3), 253-268 (1998)
   PUBMED   9635249
REFERENCE   8  (bases 1 to 1432)
  AUTHORS   Iyer,R.K., Bando,J.M., Jenkinson,C.P., Vockley,J.G., Kim,P.S.,
            Kern,R.M., Cederbaum,S.D. and Grody,W.W.
  TITLE     Cloning and characterization of the mouse and rat type II arginase
            genes
  JOURNAL   Mol Genet Metab 63 (3), 168-175 (1998)
   PUBMED   9608538
REFERENCE   9  (bases 1 to 1432)
  AUTHORS   Iyer,R., Jenkinson,C.P., Vockley,J.G., Kern,R.M., Grody,W.W. and
            Cederbaum,S.
  TITLE     The human arginases and arginase deficiency
  JOURNAL   J Inherit Metab Dis 21 Suppl 1, 86-100 (1998)
   PUBMED   9686347
  REMARK    Review article
REFERENCE   10 (bases 1 to 1432)
  AUTHORS   Gotoh,T., Sonoki,T., Nagasaki,A., Terada,K., Takiguchi,M. and
            Mori,M.
  TITLE     Molecular cloning of cDNA for nonhepatic mitochondrial arginase
            (arginase II) and comparison of its induction with nitric oxide
            synthase in a murine macrophage-like cell line
  JOURNAL   FEBS Lett 395 (2-3), 119-122 (1996)
   PUBMED   8898077
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000006.1.
            
            On Nov 26, 2020 this sequence version replaced NM_019168.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U90887.1, AF508019.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760475
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-214               JAXUCZ010000006.1  103669001-103669214
            215-287             JAXUCZ010000006.1  103670081-103670153
            288-465             JAXUCZ010000006.1  103686111-103686288
            466-625             JAXUCZ010000006.1  103688292-103688451
            626-720             JAXUCZ010000006.1  103689176-103689270
            721-825             JAXUCZ010000006.1  103689399-103689503
            826-962             JAXUCZ010000006.1  103690162-103690298
            963-1432            JAXUCZ010000006.1  103693906-103694375
FEATURES             Location/Qualifiers
     source          1..1432
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q24"
     gene            1..1432
                     /gene="Arg2"
                     /note="arginase 2"
                     /db_xref="GeneID:29215"
                     /db_xref="RGD:2151"
     exon            1..214
                     /gene="Arg2"
                     /inference="alignment:Splign:2.1.0"
     CDS             104..1168
                     /gene="Arg2"
                     /EC_number="3.5.3.1"
                     /note="arginase-2, mitochondrial; arginase II; kidney-type
                     arginase; non-hepatic arginase; arginase type II; type II
                     arginase; AII type II arginase"
                     /codon_start=1
                     /product="arginase-2, mitochondrial precursor"
                     /protein_id="NP_062041.2"
                     /db_xref="GeneID:29215"
                     /db_xref="RGD:2151"
                     /translation="MFLRSSVSRLLHGQIPCALTRSVHSVAVVGAPFSRGQKKKGVEY
                     GPAAIREAGLLKRLSMLGCHLKDFGDLSFTNVPKDDPYNNLVVYPRSVGIANQELAEV
                     VSRAVSGGYSCVTMGGDHSLAIGTIIGHARHHPDLCVIWVDAHADINTPLTTVSGNIH
                     GQPLSFLIRELQDKVPQLPGFSWIKPCLSPPNIVYIGLRDVEPAEHFILKSFDIQYFS
                     MRDIDRLGIQKVMEQTFDRLIGKRKRPIHLSFDIDAFDPKLAPATGTPVVGGLTYREG
                     LYITEEIHSTGLLSALDLVEVNPHLATSEEEAKATASLAVDVIASSFGQTREGGHIAY
                     DHLPTPSSPHESEKEECVRI"
     exon            215..287
                     /gene="Arg2"
                     /inference="alignment:Splign:2.1.0"
     exon            288..465
                     /gene="Arg2"
                     /inference="alignment:Splign:2.1.0"
     exon            466..625
                     /gene="Arg2"
                     /inference="alignment:Splign:2.1.0"
     exon            626..720
                     /gene="Arg2"
                     /inference="alignment:Splign:2.1.0"
     exon            721..825
                     /gene="Arg2"
                     /inference="alignment:Splign:2.1.0"
     exon            826..962
                     /gene="Arg2"
                     /inference="alignment:Splign:2.1.0"
     exon            963..1432
                     /gene="Arg2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcgcttgcct agtgaagctg cgaagctgtg ggaggctgca ctcactcgag gtcctgagtt
       61 gcgcggagct gcttctgcta gggcgatcgc ctccctgcca atcatgttcc tgaggagcag
      121 cgtctcccgt ctcctccacg ggcaaattcc ttgtgccctg acgagatccg tccactctgt
      181 agctgtagtc ggagcccctt tctctcgggg acagaaaaag aaaggagtgg aatatggccc
      241 agccgccatc cgagaagctg gcttgctgaa gaggctttct atgttgggat gccatctaaa
      301 agactttgga gacttgagtt ttactaacgt tcccaaagat gatccctaca ataatctggt
      361 cgtgtatcct cgctcagtgg gcattgccaa ccaggaactg gctgaggtgg ttagtagagc
      421 tgtgtcaggt ggctacagct gcgtcaccat gggaggagac cacagcctgg caataggcac
      481 cattatcggc cacgcccgac accacccaga tctctgtgtc atctgggttg atgctcatgc
      541 tgacattaat acacccctca ccactgtatc tggaaatatc catgggcagc ctctttcctt
      601 tctcatcaga gaactacaag acaaggtacc acaactgcca ggattttcct ggatcaaacc
      661 ttgcctctct cccccaaata ttgtatacat tggcttacga gatgtggagc ctgccgaaca
      721 ctttatttta aagagttttg acatccagta tttctccatg agagatattg atcgacttgg
      781 tatccagaag gtcatggaac agacatttga tcggctgatt ggcaagagga agaggccgat
      841 ccacctgagc tttgacatag atgcatttga ccctaagctg gctccagcca caggaacccc
      901 tgtggtaggg gggctgacct acagagaagg actgtacatt actgaagaaa tacatagcac
      961 agggttgctg tcggctctgg atcttgttga agtcaatcct catttggcca cttctgagga
     1021 agaggccaag gctacagcca gcctagcagt ggatgtgatt gcttcaagtt ttggtcagac
     1081 aagagaaggc ggacacattg cctatgacca ccttcctact cctagttcac cacatgaatc
     1141 agaaaaggaa gaatgtgtga gaatttagga aacactgtac tctggcacct ttcacgacag
     1201 cattccagag ttgggaggca tttaaaggga caaagagtaa atggctgtct ggatcaatat
     1261 tgccttaatg agaacatctg tgcactctca caagtgtaga gtccccttct ctattttggt
     1321 cacaatacta tcactgtaaa tgtatctgtt gggtttttgt ttctgaagtt tacaagctat
     1381 tgttattata cacgtgtgtt tgaaggagtc ataaacagca tttattacct ta
//
