LOCUS       NM_017134               1507 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Rattus norvegicus arginase 1 (Arg1), mRNA.
ACCESSION   NM_017134
VERSION     NM_017134.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1507)
  AUTHORS   Zhang,M., Wu,Z., Salas,S.S., Aguilar,M.M., Trillos-Almanza,M.C.,
            Buist-Homan,M. and Moshage,H.
  TITLE     Arginase 1 expression is increased during hepatic stellate cell
            activation and facilitates collagen synthesis
  JOURNAL   J Cell Biochem 124 (6), 808-817 (2023)
   PUBMED   37042199
  REMARK    GeneRIF: Arginase 1 expression is increased during hepatic stellate
            cell activation and facilitates collagen synthesis.
REFERENCE   2  (bases 1 to 1507)
  AUTHORS   Kim,J., Yang,Y.L., Jeong,Y. and Jang,Y.S.
  TITLE     Middle East Respiratory Syndrome-Coronavirus Infection into
            Established hDPP4-Transgenic Mice Accelerates Lung Damage Via
            Activation of the Pro-Inflammatory Response and Pulmonary Fibrosis
  JOURNAL   J Microbiol Biotechnol 30 (3), 427-438 (2020)
   PUBMED   31838832
REFERENCE   3  (bases 1 to 1507)
  AUTHORS   Cao,Y., Ding,W., Zhang,J., Gao,Q., Yang,H., Cao,W., Wang,Z.,
            Fang,L. and Du,R.
  TITLE     Significant Down-Regulation of Urea Cycle Generates Clinically
            Relevant Proteomic Signature in Hepatocellular Carcinoma Patients
            with Macrovascular Invasion
  JOURNAL   J Proteome Res 18 (5), 2032-2044 (2019)
   PUBMED   30901224
REFERENCE   4  (bases 1 to 1507)
  AUTHORS   Grandvuillemin,I., Buffat,C., Boubred,F., Lamy,E., Fromonot,J.,
            Charpiot,P., Simoncini,S., Sabatier,F., Dignat-George,F.,
            Peyter,A.C., Simeoni,U. and Yzydorczyk,C.
  TITLE     Arginase upregulation and eNOS uncoupling contribute to impaired
            endothelium-dependent vasodilation in a rat model of intrauterine
            growth restriction
  JOURNAL   Am J Physiol Regul Integr Comp Physiol 315 (3), R509-R520 (2018)
   PUBMED   29741931
REFERENCE   5  (bases 1 to 1507)
  AUTHORS   Sepa-Kishi,D.M., Katsnelson,G., Bikopoulos,G., Iqbal,A. and
            Ceddia,R.B.
  TITLE     Cold acclimation reduces hepatic protein Kinase B and AMP-activated
            protein kinase phosphorylation and increases gluconeogenesis in
            Rats
  JOURNAL   Physiol Rep 6 (5) (2018)
   PUBMED   29504286
REFERENCE   6  (bases 1 to 1507)
  AUTHORS   Kanyo,Z.F., Chen,C.Y., Daghigh,F., Ash,D.E. and Christianson,D.W.
  TITLE     Crystallization and oligomeric structure of rat liver arginase
  JOURNAL   J Mol Biol 224 (4), 1175-1177 (1992)
   PUBMED   1569574
REFERENCE   7  (bases 1 to 1507)
  AUTHORS   Takiguchi,M. and Mori,M.
  TITLE     In vitro analysis of the rat liver-type arginase promoter
  JOURNAL   J Biol Chem 266 (14), 9186-9193 (1991)
   PUBMED   2026618
REFERENCE   8  (bases 1 to 1507)
  AUTHORS   Yagi,Y., Saheki,T., Imamura,Y., Kobayashi,K., Sase,M., Nakano,K.,
            Matuo,S., Inoue,I., Hagihara,S. and Noda,T.
  TITLE     The heterogeneous distribution of argininosuccinate synthetase in
            the liver of type II citrullinemic patients. Its specificity and
            possible clinical implications
  JOURNAL   Am J Clin Pathol 89 (6), 735-741 (1988)
   PUBMED   3369364
REFERENCE   9  (bases 1 to 1507)
  AUTHORS   Ohtake,A., Takiguchi,M., Shigeto,Y., Amaya,Y., Kawamoto,S. and
            Mori,M.
  TITLE     Structural organization of the gene for rat liver-type arginase
  JOURNAL   J Biol Chem 263 (5), 2245-2249 (1988)
   PUBMED   2892837
REFERENCE   10 (bases 1 to 1507)
  AUTHORS   Kawamoto,S., Amaya,Y., Murakami,K., Tokunaga,F., Iwanaga,S.,
            Kobayashi,K., Saheki,T., Kimura,S. and Mori,M.
  TITLE     Complete nucleotide sequence of cDNA and deduced amino acid
            sequence of rat liver arginase
  JOURNAL   J Biol Chem 262 (13), 6280-6283 (1987)
   PUBMED   3571256
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1, FM100195.1 and FM120421.1.
            
            On Aug 30, 2012 this sequence version replaced NM_017134.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC091158.1, FQ219159.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: experimental evidence
                                                (PMID:3571256)
            RefSeq Select criteria           :: based on conservation,
                                                expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-41                JAXUCZ010000001.1  22295269-22295309
            42-663              FM100195.1         11-632
            664-671             JAXUCZ010000001.1  22306011-22306018
            672-963             FM120421.1         314-605
            964-1507            JAXUCZ010000001.1  22307177-22307720
FEATURES             Location/Qualifiers
     source          1..1507
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1p12"
     gene            1..1507
                     /gene="Arg1"
                     /note="arginase 1"
                     /db_xref="GeneID:29221"
                     /db_xref="RGD:2150"
     exon            1..202
                     /gene="Arg1"
                     /inference="alignment:Splign:2.1.0"
     CDS             146..1117
                     /gene="Arg1"
                     /EC_number="3.5.3.1"
                     /note="type I arginase; liver-type arginase; AI type I
                     arginase; arginase, liver"
                     /codon_start=1
                     /product="arginase-1"
                     /protein_id="NP_058830.2"
                     /db_xref="GeneID:29221"
                     /db_xref="RGD:2150"
                     /translation="MSSKPKPIEIIGAPFSKGQPRGGVEKGPAALRKAGLVEKLKETE
                     YNVRDHGDLAFVDVPNDSPFQIVKNPRSVGKANEQLAAVVAETQKNGTISVVLGGDHS
                     MAIGSISGHARVHPDLCVIWVDAHTDINTPLTTSSGNLHGQPVAFLLKELKGKFPDVP
                     GFSWVTPCISAKDIVYIGLRDVDPGEHYIIKTLGIKYFSMTEVDKLGIGKVMEETFSY
                     LLGRKKRPIHLSFDVDGLDPVFTPATGTPVVGGLSYREGLYITEEIYKTGLLSGLDIM
                     EVNPTLGKTPEEVTRTVNTAVALTLSCFGTKREGNHKPETDYLKPPK"
     exon            203..275
                     /gene="Arg1"
                     /inference="alignment:Splign:2.1.0"
     exon            276..450
                     /gene="Arg1"
                     /inference="alignment:Splign:2.1.0"
     exon            451..610
                     /gene="Arg1"
                     /inference="alignment:Splign:2.1.0"
     exon            611..705
                     /gene="Arg1"
                     /inference="alignment:Splign:2.1.0"
     exon            706..810
                     /gene="Arg1"
                     /inference="alignment:Splign:2.1.0"
     exon            811..947
                     /gene="Arg1"
                     /inference="alignment:Splign:2.1.0"
     exon            948..1507
                     /gene="Arg1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gttggataaa cagatccaac ccgattataa gggagaaaaa agatgtgccc tctgtctttt
       61 agggctacag ctggtagtga gcagctgagc agctggacag ccgaggcaga tgcagcagca
      121 gcagcagcag gaaccctgga tgagcatgag ctccaagcca aagcccatag agattatcgg
      181 agcgcctttc tctaagggac agcctcgagg aggggtagag aaaggtcccg cagcattaag
      241 gaaagctggc ctggtggaga agcttaaaga aacagagtac aatgtgagag accacgggga
      301 tctggccttt gtggatgtcc ccaatgacag cccctttcaa attgtgaaga acccacggtc
      361 tgtgggaaaa gccaatgaac agctggctgc tgtggtagca gagacccaga agaatggaac
      421 aatcagtgtg gtgctgggtg gagaccacag tatggcaatt ggaagcatct ctggccacgc
      481 cagggtccac cctgacctat gcgtcatttg ggtggatgct cacactgaca tcaacactcc
      541 gctgacaacc agctctggga atctgcacgg gcaaccggtg gcctttctcc tgaaggaact
      601 gaaaggaaag ttcccagatg taccaggatt ctcctgggtg accccctgca tatctgccaa
      661 ggacatcgtg tacatcggct tgcgagatgt ggaccctggg gaacactata taataaaaac
      721 tctgggcatt aagtatttct caatgactga agtggacaag ctgggaattg gcaaagtgat
      781 ggaagagacc ttcagctacc tgctgggaag gaagaaaagg cccattcacc tgagttttga
      841 tgttgatgga ctggacccag tattcacccc ggctacgggc acacccgttg tgggaggcct
      901 atcttacaga gaaggtctct acatcacaga agaaatttac aagacagggc tactttcagg
      961 actagatatc atggaagtga acccaactct tgggaagaca ccagaggagg tgactcgtac
     1021 tgtgaacacg gcagtggcgt tgaccttgtc ttgttttgga acgaaacggg aaggtaatca
     1081 taagccagag actgactacc ttaaaccacc gaaataaatg tgaatacatc gcataaaagt
     1141 catctggggc atcacagcaa accgaacaga accaggccaa cgctgctcct cccaagggct
     1201 tgttctttta gaaaaagaat gttttttcca atatgtatgt attctagcag ttcctttctg
     1261 gaatgaaatt cagggtgtgg gaattaaaac agctatgaaa ttaggagaca cgtacttccc
     1321 attttagcag aagttatcct taagaagtag tataaattaa tatctaatta aaaaatgcac
     1381 caggagttaa aatacacagt gatgtcaagt gtcaactcac ggttggaagc aaaggcatct
     1441 ggagacgagg cctgcatcca cgtcgttcaa aacatgtgat ttttgtaata aactctttat
     1501 aataaaa
//
