LOCUS       NM_001004222            1799 bp    mRNA    linear   ROD 12-NOV-2024
DEFINITION  Rattus norvegicus ARF interacting protein 2 (Arfip2), mRNA.
ACCESSION   NM_001004222 XM_215031
VERSION     NM_001004222.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1799)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1799)
  AUTHORS   Herlo,R., Lund,V.K., Lycas,M.D., Jansen,A.M., Khelashvili,G.,
            Andersen,R.C., Bhatia,V., Pedersen,T.S., Albornoz,P.B.C.,
            Johner,N., Ammendrup-Johnsen,I., Christensen,N.R., Erlendsson,S.,
            Stoklund,M., Larsen,J.B., Weinstein,H., Kjaerulff,O., Stamou,D.,
            Gether,U. and Madsen,K.L.
  TITLE     An Amphipathic Helix Directs Cellular Membrane Curvature Sensing
            and Function of the BAR Domain Protein PICK1
  JOURNAL   Cell Rep 23 (7), 2056-2069 (2018)
   PUBMED   29768204
REFERENCE   3  (bases 1 to 1799)
  AUTHORS   Guo,Z., Neilson,L.J., Zhong,H., Murray,P.S., Zanivan,S. and
            Zaidel-Bar,R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1799)
  AUTHORS   Cruz-Garcia,D., Ortega-Bellido,M., Scarpa,M., Villeneuve,J.,
            Jovic,M., Porzner,M., Balla,T., Seufferlein,T. and Malhotra,V.
  TITLE     Recruitment of arfaptins to the trans-Golgi network by PI(4)P and
            their involvement in cargo export
  JOURNAL   EMBO J 32 (12), 1717-1729 (2013)
   PUBMED   23695357
REFERENCE   5  (bases 1 to 1799)
  AUTHORS   Rangone,H., Pardo,R., Colin,E., Girault,J.A., Saudou,F. and
            Humbert,S.
  TITLE     Phosphorylation of arfaptin 2 at Ser260 by Akt Inhibits
            PolyQ-huntingtin-induced toxicity by rescuing proteasome impairment
  JOURNAL   J Biol Chem 280 (23), 22021-22028 (2005)
   PUBMED   15809304
  REMARK    GeneRIF: arfaptin 2 phosphorylation at Ser260 by Akt inhibits
            PolyQ-huntingtin-induced toxicity by rescuing proteasome impairment
REFERENCE   6  (bases 1 to 1799)
  AUTHORS   Peters,P.J., Ning,K., Palacios,F., Boshans,R.L., Kazantsev,A.,
            Thompson,L.M., Woodman,B., Bates,G.P. and D'Souza-Schorey,C.
  TITLE     Arfaptin 2 regulates the aggregation of mutant huntingtin protein
  JOURNAL   Nat Cell Biol 4 (3), 240-245 (2002)
   PUBMED   11854752
REFERENCE   7  (bases 1 to 1799)
  AUTHORS   D'Souza-Schorey,C., Boshans,R.L., McDonough,M., Stahl,P.D. and Van
            Aelst,L.
  TITLE     A role for POR1, a Rac1-interacting protein, in ARF6-mediated
            cytoskeletal rearrangements
  JOURNAL   EMBO J 16 (17), 5445-5454 (1997)
   PUBMED   9312003
REFERENCE   8  (bases 1 to 1799)
  AUTHORS   Van Aelst,L., Joneson,T. and Bar-Sagi,D.
  TITLE     Identification of a novel Rac1-interacting protein involved in
            membrane ruffling
  JOURNAL   EMBO J 15 (15), 3778-3786 (1996)
   PUBMED   8670882
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC079174.1.
            
            On Sep 10, 2004 this sequence version replaced XM_215031.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC079174.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1799
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q32"
     gene            1..1799
                     /gene="Arfip2"
                     /gene_synonym="POR"
                     /note="ARF interacting protein 2"
                     /db_xref="GeneID:293344"
                     /db_xref="RGD:1303204"
     exon            1..96
                     /gene="Arfip2"
                     /gene_synonym="POR"
                     /inference="alignment:Splign:2.1.0"
     exon            97..237
                     /gene="Arfip2"
                     /gene_synonym="POR"
                     /inference="alignment:Splign:2.1.0"
     CDS             139..1164
                     /gene="Arfip2"
                     /gene_synonym="POR"
                     /note="ADP-ribosylation factor interacting protein 2
                     (arfaptin 2); partner of Rac1; ADP-ribosylation
                     factor-interacting protein 2"
                     /codon_start=1
                     /product="arfaptin-2"
                     /protein_id="NP_001004222.1"
                     /db_xref="GeneID:293344"
                     /db_xref="RGD:1303204"
                     /translation="MTDGILGKAATMEIPIHGNGEAGQLPEDDGLEQDLQQVMVSGPN
                     LNETSIVSGGYGGSGDGLIPTGSGRHPSHSTSPSGPGDEVARGIAGEKFDIVKKWGIN
                     TYKCTKQLLSERFGRGSRTVDLELELQIELLRETKRKYESVLQLGRALTAHLYSLLQT
                     QHALGDAFADLSQKSPELQEEFGYNAETQKLLCKNGETLLGAVNFFVSSINTLVTKTM
                     EDTLMTVKQYEAARLEYDAYRTDLEELSLGPRDAGTRGRLESAQATFQTHRDKYEKLR
                     GDVAIKLKFLEENKIKVMHKQLLLFHNAVSAYFAGNQKQLEQTLQQFNIKLRPPGAEK
                     PSWLEEQ"
     exon            238..334
                     /gene="Arfip2"
                     /gene_synonym="POR"
                     /inference="alignment:Splign:2.1.0"
     exon            335..453
                     /gene="Arfip2"
                     /gene_synonym="POR"
                     /inference="alignment:Splign:2.1.0"
     exon            454..675
                     /gene="Arfip2"
                     /gene_synonym="POR"
                     /inference="alignment:Splign:2.1.0"
     exon            676..833
                     /gene="Arfip2"
                     /gene_synonym="POR"
                     /inference="alignment:Splign:2.1.0"
     exon            834..1008
                     /gene="Arfip2"
                     /gene_synonym="POR"
                     /inference="alignment:Splign:2.1.0"
     exon            1009..1775
                     /gene="Arfip2"
                     /gene_synonym="POR"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctctgacctg ctgctaggat cgcgacggga actggaaccc gaggtccccg cgcggtccgg
       61 gcctcgcgcc ctgaggggaa gagcggcccg gcccagcgtg ctggggtgga gaccttgact
      121 cctgtccctt ccctagccat gacggacggg attctaggga aggcagccac aatggagatt
      181 cccatccacg gaaatggcga ggctgggcag cttcctgaag acgatgggct ggagcaggac
      241 ctccagcagg tgatggtgtc aggacccaac ctcaatgaaa ctagcattgt gtctggtggc
      301 tatgggggct ctggtgacgg actcatcccc acagggtctg gccgccatcc gtctcacagc
      361 acctcacctt ctggccctgg tgatgaggtg gcccgaggca tcgctggaga aaagtttgac
      421 attgtcaaga aatggggcat caacacatat aagtgcacaa agcagctgtt atcagagaga
      481 tttggccgag gctcccggac tgtggatctg gagctagagc tgcagattga gttgctgcgt
      541 gagacgaagc gcaagtatga aagtgtcctg cagctgggcc gggcactgac agcccacctc
      601 tacagcctgt tgcagaccca gcatgcacta ggtgatgcct ttgctgacct cagccagaag
      661 tccccagagc ttcaggagga atttggctat aatgcagaga cacaaaagct gctgtgcaag
      721 aatggggaga cgctgctggg ggctgtcaac ttctttgtct ctagcatcaa cacgctggtc
      781 accaagacca tggaagacac actcatgact gtcaaacagt atgaggctgc caggctggaa
      841 tatgatgcct accggacaga cttagaagag ctgagcctag ggccccggga tgcagggact
      901 cgtggtcgac ttgagagtgc ccaagccact ttccagaccc atcgggacaa atatgagaag
      961 ctgcggggag atgtggccat caagctgaag ttcctggaag aaaacaagat caaggtgatg
     1021 cacaagcagt tgctgctctt ccacaatgcc gtgtctgcct acttcgctgg gaaccagaaa
     1081 caactggagc agactctaca gcagttcaac atcaagctgc ggcctccagg agccgagaag
     1141 ccttcctggt tagaggagca gtgagcggct cccagcccaa cttggctatc aagaaggaca
     1201 ctgggcgggg cagccccagg gtgaaggaga ttggacatgg gatgtccttt gccacttact
     1261 tgctggcttg ggctcccctt tcctggctgg ggtctgacac cagttttgcc catcctgctg
     1321 tggtctgaag agggcctgta ggcccagaag ctgctgccct gtcctttatc ttcccagcca
     1381 ctgggcttca ttcccaggtc ttttcctttc actccacagc caaaggctat gacaaaacac
     1441 tccctggcca atggcaccac tcctcaggcc tatccccagc tcttgggatg tgcccctgac
     1501 caaagacagg acctcaaaag gctctgtcag ccaatggcag ctcttcttgg gctcccctgg
     1561 gccaatagtg ttgcctccag taccctttgt ccctcctcaa tgtgtgtcca ttgcagagaa
     1621 gggaactggg accaaagggg tgggaataat ggggagcccc acttgtggcc ctgcatctga
     1681 atgggccttc ccctcatcca cccacccagt tgaactgtgc ttagagcctc agaagactgg
     1741 gttctagcac taggaataaa cctttcataa aagcaaaaaa aaaaaaaaaa aaaaaaaaa
//
