LOCUS       XM_039098801            8268 bp    mRNA    linear   ROD 11-JUN-2023
DEFINITION  PREDICTED: Rattus norvegicus ARFGEF family member 3 (Arfgef3),
            transcript variant X1, mRNA.
ACCESSION   XM_039098801
VERSION     XM_039098801.1
DBLINK      BioProject: PRJNA677964
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_051336.1) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            [WARNING] On Feb 3, 2024 this sequence was replaced by
            NM_001427849.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_015227675.2-RS_2023_06
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.1
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 06/06/2023
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..8268
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN/NHsdMcwi"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /sex="male"
                     /tissue_type="kidney"
                     /geo_loc_name="USA: Wisconsin, Milwaukee, Medical College
                     of Wisconsin"
                     /collection_date="2019-03-08"
                     /collected_by="Rebecca Schilling"
     gene            1..8268
                     /gene="Arfgef3"
                     /note="ARFGEF family member 3; Derived by automated
                     computational analysis using gene prediction method:
                     Gnomon. Supporting evidence includes similarity to: 4
                     ESTs, 3 Proteins, and 100% coverage of the annotated
                     genomic feature by RNAseq alignments, including 44 samples
                     with support for all annotated introns"
                     /db_xref="GeneID:292947"
                     /db_xref="RGD:1309903"
     CDS             410..6922
                     /gene="Arfgef3"
                     /codon_start=1
                     /product="brefeldin A-inhibited guanine
                     nucleotide-exchange protein 3 isoform X1"
                     /protein_id="XP_038954729.1"
                     /db_xref="GeneID:292947"
                     /db_xref="RGD:1309903"
                     /translation="MEEILRKLQRDASGSKYKAIKESCTWALETLGGLDTVAKIPPHL
                     LREKCLLPLQLALESKNVKLAQHALAGMQKLLSEERFVSMETDSDDKQLLNQILNAVK
                     VTPSLNEDLQVEVMKVLLCITYTPTFDMNGSAVLKIAEVCIETYTCSCHQRSINTAVR
                     ATLSQMLGDLTLQLRQRQENTIIENPDAPQGFRSQGLTVEALCDDVVSVLAVLCEKLQ
                     ASINDSQQLQLLYLECILSILSSSSSSMYLHRGFTDLIWKSLCPALVVILGNPIHDKT
                     ITSAHSTSTGTSMESDSASLGVSDHGRGSGCSCTAPTLSGPVARTIYYLATELVRLVG
                     SVDSLKPVLQSLYHRVLLYPPPQHRVEAIKIMREILGSPQRLYDLAGPSSLESEPRKR
                     SISKRKSHLDLLKLIMDGMTEACIKGGIEACYAAVSCVCTLLGALDELSQGKGLNDNQ
                     VQQLLLRLEELRDGAESSRDSMEINEADFRWQRKVLSSEHTPWETGNERSPDISISVT
                     TDTGQTTLEGELGQTTPEDHKNGLKSPAIQEGRETMSKVSEPETIDQPDVVQRSHTVP
                     YPDITNFLSVDCRTRSYGSRYSESNFSVDDQDLSRTEFDSCDQYSMAAEKDSGRSDVS
                     DIGSDNCSLADEEQTPRDYMGHRSLRTAALSLKLLKNQEADQHSARLFIQSLEGLLPR
                     LLALSSVEEVDSALQNFASTFCSGMMHSPGFDGGSSLSIQMLMNADSLYTAAHCALLL
                     NLKLSHGDYYRKRPNVAPGMMKEFMKQVQTSGVLMVFSQAWIEELFHQVLDRNMLGEA
                     GYWGSPEDNNLPLITMLTDIDGLESSAIGGQLMASASMESPFTQSRKLDDSTVAGIAF
                     ARYILVGCWKNLIDTLSTPLTGRMAGSSKGLAFILGAEGIKEQNQKERDAICMSLDGL
                     RKAARLSCALGVAANCASALAQMAAASCVQEEKEERESQEPSDALAQVKLKVEQKLEQ
                     MGKAQGVWLHTAHVLCMDAILSVGLEMGSHNPDCWPHVFRVCEYVGTLEHTHFSDGLS
                     QPPLTIHQPQKTSGSSGLLGELEFKSSSQEQSLEQGPSLNAAPVVQPHTIQELVRECS
                     RGRTSDFRGGSLSGNSAAKVVLSLSTQADRLFDDATDKLNLTALGGFLYQLKKASQSQ
                     LFHSVTDTVDYSLTMPGEVKSTQDQKSALHLYRLGDAMLRIVRSKARPLLHVMRCWSL
                     VAPHLVEAACHKERHVSQKAVSFIHDILTEVLTDWSEPPHFHFNEALFRPFERIMQLE
                     LCDEDVQDQVVTSIGELVEVCSAQIQSGWRPLFSALETVHSGNKSEVKEYLVGDYSMG
                     KGQAPVFDVFEAFLNTDNIQVFANAATSYIMCLMKFVKGLGEVDCKEIGDCVPGAGAT
                     STDLCLPALDYLRRCSQLLAKIYKMPLKPIFLSGRLASLPRRLQEQSASSEDGIESVL
                     SDFDDDTGLIDVWIILLEQLTAAVSICPRQHQPPTLDLLFELLRDVTKTPGPGFGIYA
                     VVHLLLPVMSLWLRRSHKDHSYWDVASANFKHAIGLSCELVVEHIQSFLHSDIRYESM
                     INTMLKDLFELLVVCVAKPTETISRVGCSCIRYVLVTAGPVFTEEMWRLACCALQDAF
                     SATLKPVKDLLGCFHSGTEGFSGEGCQVRVAAPSSSPSAEAEYWRIRAMAQQVFMLDT
                     QSSPKTPNNFDHAQSCQLIIELPPDERPNGHAKKSVSFREIVVSLLSHQVLLQNLYDI
                     LLEEFVKGPSPGEEKTVQAPDTKLAGFLRYISMQNLAVIFDLLLDSYRTAREFDTSPG
                     LKCLLKKVSGIGGAANLYRQSAMSFNIYFHALVCAVLTNQETITAEQVKKVLFEEEER
                     SSDSSQQCSSEDEDIFEETAQVSPPRGKEKRQWRARLPSLSVQPVSNADWVWLVKRLH
                     KLCMELCNHYIQMHLDLESSLEEPLAFKSDPFFILPSFQSESSTPSTGGFSGKNTPSE
                     DDRREHLSEPLSLRVGSGDILMLPPSPKTEKKDPGRKKEWWESAGNKIYTMAADKTIS
                     KLMTEYKKRRQPHNLPPFPKEVKVDKKGEPLGPRGPDSPLLQRPQHLIDQGQMRHSFS
                     AGPELLRQEKRPRSGSTGSSLSISVRDAEAQIQAWTNMVLTVLNQIQILPDPTFTALQ
                     PAVFPCISQLTCHVTDIRVRQAVREWLGRVGRVYDIIV"
ORIGIN      
        1 actctctacc ccctagagta gagaggctgg gaggcgctgg cccagcaggt gattggcaca
       61 agcgaccagg cccctccctg ctctatgccc gcggatctcg gtgaattccc tagggcagag
      121 cctggccggc agccagccgc agatccccac ctttggatga agcctggtac cccaggtcct
      181 cctaggcact aggtaggcgg ctgcggcctc ccgggttccc cggctggtga gcgcacctga
      241 cccggcgggc gtggcaacag gcggggcggc gaggctgacg tggcccgtgg cgtggagcgg
      301 gcgtgattca tcagcggcgg ccgagagtga tggggacgag tgccgaggcc tcctaggcgc
      361 gtcccctgcg cgatctcggg gtcggtggcc tggctctggg aaagccaata tggaagagat
      421 cctgaggaag ctgcagagag atgcgtccgg gagcaaatac aaagccatca aagagagctg
      481 tacctgggcc ctggaaaccc tcgggggcct ggacactgtg gcaaagatcc ctccccactt
      541 gttgagggag aaatgcttgc tgcctctcca gttggctttg gaatcaaaga atgtgaagct
      601 ggcccaacat gctctggcag gaatgcagaa gctcctgtcg gaagagagat ttgtatccat
      661 ggagacagac tccgatgaca agcagctgct caatcagatc ctgaatgccg tgaaagtgac
      721 gccttcgctc aatgaggacc tgcaggtgga agtgatgaag gttttactgt gcatcaccta
      781 caccccgaca tttgacatga atgggagtgc cgtactgaag atcgcagagg tgtgcatcga
      841 gacgtacaca tgcagctgtc accagcgcag tatcaacact gccgtgcgtg ccactctcag
      901 ccagatgttg ggtgacctga cgctacagtt acggcagaga caggagaaca cgataattga
      961 aaacccagat gccccacagg gattccgcag tcaaggctta acagtagagg cgctttgtga
     1021 tgacgttgtc tctgtccttg ctgttctgtg tgagaagcta caagcctcca taaatgacag
     1081 ccagcagctg cagcttctgt acctggaatg cattctctcc atactcagca gctcctcttc
     1141 atccatgtac ctgcacaggg gcttcaccga cctcatctgg aaaagcctct gccctgctct
     1201 cgttgtgatc ctggggaacc caattcacga caaaacaatc acctctgccc acagcaccag
     1261 caccggcacc agcatggagt cggattctgc ctccctcggt gtgtctgacc atggccgggg
     1321 ctcaggctgc tcttgcactg cccctaccct cagtgggcct gtggcccgca ccatctatta
     1381 ccttgcgact gagctcgtcc gcttagtggg gtcagtggac tctctgaagc ctgtgctcca
     1441 gtccctctat caccgtgtgc tcctgtatcc cccgccccag caccgagtgg aagccatcaa
     1501 gatcatgaga gagatacttg ggagcccaca gcgtctgtat gatttggcgg gaccaagctc
     1561 tcttgagtca gaaccaagga aaagatctat ttccaaaagg aagtcccact tggatcttct
     1621 caaactcatc atggacggca tgacggaagc atgcatcaaa ggtggcattg aagcctgcta
     1681 tgccgctgtg tcctgtgtct gcactctgct cggggctctg gatgaactca gccaggggaa
     1741 gggcttgaat gacaaccaag tgcagcagct gcttctgcgt cttgaagagc tgagggatgg
     1801 ggcagagtca agccgggact ccatggagat taacgaggct gacttccgct ggcagcggaa
     1861 ggtgctgtct tcggagcaca caccatggga gacagggaat gagaggagcc ctgacatcag
     1921 catcagtgtc accacagaca caggccagac taccttggaa ggagaattgg gtcagacaac
     1981 accagaggac cacaagaatg ggctcaagtc accagccatt caggaaggca gggagaccat
     2041 gagcaaagtg tcagaacctg agaccataga ccagcctgat gtggttcaga gaagccacac
     2101 ggtcccttac cctgacatca ctaacttcct gtcagtggac tgcaggacaa ggtcctacgg
     2161 atctaggtat agtgagagca acttcagtgt agatgaccaa gacctgtcga ggactgaatt
     2221 tgattcttgt gatcagtatt ccatggcagc tgaaaaggac tcaggcaggt ctgatgtgtc
     2281 ggacattggg tcagacaact gttcactcgc tgatgaagaa cagacccctc gggactacat
     2341 gggccatcgg tccctgcgaa ccgctgctct gtctctcaag ctgctgaaga accaggaggc
     2401 agaccagcac agtgcacgac tattcataca gtcccttgag ggcctccttc cccggctcct
     2461 ggccctgtcc agtgtggaag aggtggactc tgcccttcag aactttgcct ctactttctg
     2521 ctcaggcatg atgcactctc ctggctttga tggaggcagt agcctaagca tccagatgct
     2581 gatgaatgca gacagcttgt acacagcggc acactgtgcc ctactgctca acctgaaact
     2641 gtcccatggc gactactacc ggaagcgacc aaacgtggca ccaggcatga tgaaagagtt
     2701 catgaaacag gtgcagacca gcggtgtgct gatggtcttc tcccaggcct ggatcgagga
     2761 actcttccat caggtgctgg acagaaacat gctgggagaa gctggctact ggggcagccc
     2821 tgaggacaac aaccttcccc tcatcaccat gctcacagat attgatggct tagagagcag
     2881 tgcaattggt ggccagttga tggcgtcagc ttcaatggag tcgcctttca cccagagcag
     2941 gaaacttgat gactccacgg tagcaggtat tgcatttgcc cgttacattt tggttggctg
     3001 ctggaagaac ctgattgata ctctgtcaac ccccttgact ggtcggatgg caggaagctc
     3061 taaagggttg gcctttatcc ttggagctga gggcatcaaa gagcagaacc agaaagagcg
     3121 ggacgccatc tgcatgagcc ttgatgggct gcgcaaagct gcccggctga gctgtgcact
     3181 aggggttgct gctaactgcg cctcagctct tgcacaaatg gcagctgctt cctgtgtcca
     3241 ggaagagaaa gaagaaagag aatcccagga gcccagcgat gccctggcac aagtgaaact
     3301 aaaagtggag cagaaactgg agcagatggg gaaggcgcag ggggtgtggc tgcacacagc
     3361 ccacgtcttg tgcatggatg ccatcctcag cgtaggcctg gagatgggaa gccacaaccc
     3421 ggactgctgg ccacacgtgt tcagggtatg tgagtatgtg ggcacactgg agcataccca
     3481 cttcagcgac ggtctctccc aaccccctct gaccatccat cagccacaga agacatctgg
     3541 gagctcaggc ctccttgggg aacttgagtt taagagctca tcccaggagc agagtctgga
     3601 acagggacct tccctgaacg cggcccctgt ggtccagccc cacaccatcc aggagcttgt
     3661 tcgggaatgt agccgtggcc ggacctcaga cttccgcgga ggtagtctga gtgggaacag
     3721 tgctgccaag gtggtgctca gtctttctac ccaggccgac aggctctttg atgatgctac
     3781 ggataagttg aacttaacag ccttgggagg gttcctctac caactcaaaa aagcatccca
     3841 gtcccagctt ttccattctg tgacagacac agttgattac tctctgacaa tgccaggcga
     3901 agtcaagtct acccaggatc agaaaagtgc tctgcacctg taccgcctgg gggacgccat
     3961 gctgaggatc gtgaggagca aagcgcggcc cctgctccac gtgatgcgct gctggagcct
     4021 cgtggcccca cacctggtgg aggctgcctg ccataaagaa cgccatgtgt ctcagaaggc
     4081 tgtttccttc atccatgata tcctgaccga ggttctcact gactggagtg agcctcccca
     4141 ctttcacttt aacgaagcac tcttccggcc ctttgagcgt atcatgcagc ttgagctctg
     4201 tgatgaagat gttcaagacc aggtggtcac ctccattggg gagctggttg aggtgtgctc
     4261 tgcacagatc cagtcgggat ggagacccct gttcagtgct ctggagacag tgcacagtgg
     4321 gaacaagtca gaggtgaagg agtacctggt tggggactac tctatgggaa aaggccaggc
     4381 tcctgtattc gatgtgtttg aagcttttct caataccgac aacatccagg tctttgccaa
     4441 tgcagctact agttacatca tgtgccttat gaagtttgtc aaggggctgg gggaggtaga
     4501 ctgtaaagag attggagact gtgttcctgg agctggagcc acatctacag acctgtgcct
     4561 gcctgccttg gattacctca gacgttgttc tcagttattg gccaagatct acaaaatgcc
     4621 cttaaagcca atattcctta gtgggagact tgccagtttg ccacgaagac ttcaggagca
     4681 gtcggcaagc agtgaagacg gaattgaatc agtcttgtca gattttgatg acgacactgg
     4741 tctgatagac gtctggatca tcctgttgga gcagctaaca gcagctgtgt ccatctgtcc
     4801 ccgacaacac caacctccca ccttagatct gctctttgaa ctgttgagag acgtcaccaa
     4861 gacacctggc ccagggtttg gaatctatgc agtcgttcac cttctccttc ccgtgatgtc
     4921 tctttggctc cgccgtagcc acaaggacca ttcctactgg gatgtggcat ccgctaactt
     4981 caagcacgcc attggtctgt cttgtgagct ggtggtggag cacatccaga gtttcctaca
     5041 ctcagacatt aggtacgaga gtatgatcaa caccatgctg aaggacctct ttgagctgct
     5101 ggtagtatgt gtggccaagc ccacagaaac catctccaga gtgggctgtt cctgcatcag
     5161 gtacgtcctg gtgacggcag gtcccgtgtt cacagaagag atgtggagac tggcatgctg
     5221 tgctcttcag gatgctttct ctgccacact gaagccggtg aaggacctgc taggctgctt
     5281 ccacagtggc acggagggct tcagtgggga aggctgtcag gtgcgagtag cagcaccgtc
     5341 ttcctcccca agtgccgagg cagagtactg gcgcatccgg gccatggccc agcaggtgtt
     5401 tatgttggac acccagtcct caccaaagac tccaaacaac ttcgaccatg cccagtcctg
     5461 tcagctcatc attgaactgc ctcctgatga gagaccaaac ggacatgcca agaaaagcgt
     5521 ctctttcagg gagattgtgg ttagcttgct ctctcaccaa gttctgctcc agaacctgta
     5581 tgacattctg ctggaagaat ttgtcaaagg cccctctccg ggagaggaga agacagttca
     5641 agcgccagac accaagctgg ccggtttcct cagatacatt tccatgcaga acctggctgt
     5701 gatatttgac ctgctgctgg actcctatag gacagcccgg gaattcgaca caagcccggg
     5761 gctgaaatgc ctgctgaaga aagtgtctgg cattggggga gcagccaacc tctaccgcca
     5821 gtccgccatg agctttaaca tttactttca cgccctggtc tgtgcggttc tcaccaacca
     5881 agagactatc acagccgaac aagtaaagaa agtgctattc gaggaggagg agagaagctc
     5941 agattcctcc cagcagtgct cctcggagga tgaagacatc ttcgaggaga cagcacaggt
     6001 gagcccgcca cgaggcaagg aaaaaaggca gtggagggcc cgcctgcctt ctctcagtgt
     6061 gcagcccgtc agcaatgcag actgggtgtg gctggtcaag aggctgcaca agctgtgcat
     6121 ggagctctgt aaccactaca tccagatgca cctggaccta gagagcagct tggaggagcc
     6181 gcttgccttc aagagcgacc ccttcttcat tctcccctcc ttccagtccg aatcgtccac
     6241 cccatcaaca ggtggcttct ctgggaaaaa cacaccctcc gaagatgacc gcagggagca
     6301 cctaagtgag cctctgagtc tgagggtggg cagtggggac atacttatgc tgcctcccag
     6361 ccccaagaca gagaagaagg atcctggccg caagaaagag tggtgggaga gtgcagggaa
     6421 caagatttac acaatggccg ctgacaagac catctcaaag ctgatgactg agtacaagaa
     6481 gaggaggcag ccacacaacc tgcccccctt ccctaaggaa gtcaaagtgg ataagaaagg
     6541 ggagcccctg ggacctcggg gtcctgattc cccgctgctt cagaggccac agcatctcat
     6601 tgaccaaggg cagatgcgcc attcctttag cgcaggccca gagctgctgc ggcaggagaa
     6661 gagaccccgc tcaggctcca ctggaagctc cctgagcatc tctgtgcgag acgcagaggc
     6721 acagatccag gcgtggacca acatggtgct aactgttctc aaccagattc agatccttcc
     6781 agacccgacc ttcactgctc tccagccagc tgtgttccca tgcatcagcc agctgacctg
     6841 tcacgtgact gacatcagag ttcgtcaagc tgtgagggaa tggctgggaa gagtgggtcg
     6901 tgtctatgac atcatcgtct agaggactca gatcctaagg aaatgcctat agtcagagtc
     6961 tgcctgtcga tccagcagat tgcattttcc caaccaccat cccactcaaa ccaagtctct
     7021 gaaaaactag ttctctgaaa cctggtaaca aagcttttcc caagctctcc ttaattagtc
     7081 aaccttgggt tagtctggat gccaacatag tgacataatg atctctggcc ttgaacattg
     7141 ttacaaaaga gtctgcgtta cttgatacat ttctaaatct aatttccaag tgcatttgct
     7201 tgcagtatta taccccaatg ggtaattttc aacattctcc tttggaagcc ctaggctgat
     7261 ccatttgagc catcattttc aaaattaatt cctaagaaaa catttgctgg taagtcaagc
     7321 tgatgtaaaa aaaaaatcat ataactggca ccagacataa ttaatcagaa aaacttatat
     7381 tctgattata tagtgtggtt gggaagaaaa ctgcaaaagt cttttttttt tcagtgttct
     7441 aatcaagaaa gaaattactt ctaaaatata ttcaggaaca tttcaacatt attcttgagg
     7501 tttttagatc tttgtgttaa tagtcacaaa ttccccaggt aaggtactgt tgtgccttta
     7561 tgtctctgtt tctaaaggga gggaattttt tccaagcatg atttcaagcc tgtggcttta
     7621 acaggaagtg gtacacattg tcaccagact tgacactgac taccctatgt gtttctttgc
     7681 ttctgttctc aaggcagacg aagaaagaca attggtgcct tagtctttgt tgcacagatt
     7741 atttctatgc cccacaatta tctgaacaat aaggtacgac actcggtttt aagaaagatt
     7801 cagattcatt ttctatcagt atcctttgga ggaaaggaac tcaagagtcc tccgtctggt
     7861 gagcatactt ctcaggggag gggcaagaac tgtgggatgg ggagccagct ggaaggggtg
     7921 ggctggggct gtaatagaat cattgtaaaa tcttcaacta ggatacagct gtgaaaagat
     7981 ggtgtcagtt atacacactc tggactgaat aggaagggac acggtaaatt tagaaaatta
     8041 ttttttttcc tatgtaaaat acctctctct agcaaattta ctctctcaac tcatgttatt
     8101 cagaccgata ttttacctgg aaatttcttt ttctaagcat tattagaaaa cgaacttgaa
     8161 atatagaacc atatctattg ggggttagtt gagcctgagg cttatacata cttagaaacc
     8221 actgggctcc cctgggccct tactacaata tattttatat attttaca
//
