LOCUS       NM_145090               1857 bp    mRNA    linear   ROD 12-NOV-2024
DEFINITION  Rattus norvegicus ARF GTPase activating protein 1 (Arfgap1), mRNA.
ACCESSION   NM_145090
VERSION     NM_145090.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1857)
  AUTHORS   Schultz,M.L., Tecedor,L., Stein,C.S., Stamnes,M.A. and
            Davidson,B.L.
  TITLE     CLN3 deficient cells display defects in the ARF1-Cdc42 pathway and
            actin-dependent events
  JOURNAL   PLoS One 9 (5), e96647 (2014)
   PUBMED   24792215
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1857)
  AUTHORS   Xiong,Y., Yuan,C., Chen,R., Dawson,T.M. and Dawson,V.L.
  TITLE     ArfGAP1 is a GTPase activating protein for LRRK2: reciprocal
            regulation of ArfGAP1 by LRRK2
  JOURNAL   J Neurosci 32 (11), 3877-3886 (2012)
   PUBMED   22423108
REFERENCE   3  (bases 1 to 1857)
  AUTHORS   Stafa,K., Trancikova,A., Webber,P.J., Glauser,L., West,A.B. and
            Moore,D.J.
  TITLE     GTPase activity and neuronal toxicity of Parkinson's
            disease-associated LRRK2 is regulated by ArfGAP1
  JOURNAL   PLoS Genet 8 (2), e1002526 (2012)
   PUBMED   22363216
REFERENCE   4  (bases 1 to 1857)
  AUTHORS   Rawet,M., Levi-Tal,S., Szafer-Glusman,E., Parnis,A. and Cassel,D.
  TITLE     ArfGAP1 interacts with coat proteins through tryptophan-based
            motifs
  JOURNAL   Biochem Biophys Res Commun 394 (3), 553-557 (2010)
   PUBMED   20211604
  REMARK    GeneRIF: these findings point to mechanistic differences between
            ArfGAP1 and the other ArfGAPs known to function in the COPI system.
REFERENCE   5  (bases 1 to 1857)
  AUTHORS   Weimer,C., Beck,R., Eckert,P., Reckmann,I., Moelleken,J.,
            Brugger,B. and Wieland,F.
  TITLE     Differential roles of ArfGAP1, ArfGAP2, and ArfGAP3 in COPI
            trafficking
  JOURNAL   J Cell Biol 183 (4), 725-735 (2008)
   PUBMED   19015319
  REMARK    GeneRIF: Differential roles of ArfGAP1, ArfGAP2, and ArfGAP3 in
            COPI trafficking
REFERENCE   6  (bases 1 to 1857)
  AUTHORS   Goldberg,J.
  TITLE     Structural and functional analysis of the ARF1-ARFGAP complex
            reveals a role for coatomer in GTP hydrolysis
  JOURNAL   Cell 96 (6), 893-902 (1999)
   PUBMED   10102276
REFERENCE   7  (bases 1 to 1857)
  AUTHORS   Huber,I., Cukierman,E., Rotman,M., Aoe,T., Hsu,V.W. and Cassel,D.
  TITLE     Requirement for both the amino-terminal catalytic domain and a
            noncatalytic domain for in vivo activity of ADP-ribosylation factor
            GTPase-activating protein
  JOURNAL   J Biol Chem 273 (38), 24786-24791 (1998)
   PUBMED   9733781
REFERENCE   8  (bases 1 to 1857)
  AUTHORS   Aoe,T., Cukierman,E., Lee,A., Cassel,D., Peters,P.J. and Hsu,V.W.
  TITLE     The KDEL receptor, ERD2, regulates intracellular traffic by
            recruiting a GTPase-activating protein for ARF1
  JOURNAL   EMBO J 16 (24), 7305-7316 (1997)
   PUBMED   9405360
REFERENCE   9  (bases 1 to 1857)
  AUTHORS   Cukierman,E., Huber,I., Rotman,M. and Cassel,D.
  TITLE     The ARF1 GTPase-activating protein: zinc finger motif and Golgi
            complex localization
  JOURNAL   Science 270 (5244), 1999-2002 (1995)
   PUBMED   8533093
REFERENCE   10 (bases 1 to 1857)
  AUTHORS   Makler,V., Cukierman,E., Rotman,M., Admon,A. and Cassel,D.
  TITLE     ADP-ribosylation factor-directed GTPase-activating protein.
            Purification and partial characterization
  JOURNAL   J Biol Chem 270 (10), 5232-5237 (1995)
   PUBMED   7890632
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Nov 27, 2020 this sequence version replaced NM_145090.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U35776.1, SRR22582419.1849538.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-63                JAXUCZ010000003.1  188462210-188462272
            64-274              JAXUCZ010000003.1  188462550-188462760
            275-338             JAXUCZ010000003.1  188465648-188465711
            339-448             JAXUCZ010000003.1  188466146-188466255
            449-620             JAXUCZ010000003.1  188466536-188466707
            621-721             JAXUCZ010000003.1  188467128-188467228
            722-808             JAXUCZ010000003.1  188467949-188468035
            809-905             JAXUCZ010000003.1  188468504-188468600
            906-962             JAXUCZ010000003.1  188470750-188470806
            963-995             JAXUCZ010000003.1  188471767-188471799
            996-1052            JAXUCZ010000003.1  188473691-188473747
            1053-1112           JAXUCZ010000003.1  188474208-188474267
            1113-1189           JAXUCZ010000003.1  188474936-188475012
            1190-1857           JAXUCZ010000003.1  188475575-188476242
FEATURES             Location/Qualifiers
     source          1..1857
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q43"
     gene            1..1857
                     /gene="Arfgap1"
                     /gene_synonym="Arf GAP1; Arf1gap"
                     /note="ARF GTPase activating protein 1"
                     /db_xref="GeneID:246310"
                     /db_xref="RGD:708452"
     exon            1..63
                     /gene="Arfgap1"
                     /gene_synonym="Arf GAP1; Arf1gap"
                     /inference="alignment:Splign:2.1.0"
     exon            64..274
                     /gene="Arfgap1"
                     /gene_synonym="Arf GAP1; Arf1gap"
                     /inference="alignment:Splign:2.1.0"
     exon            275..338
                     /gene="Arfgap1"
                     /gene_synonym="Arf GAP1; Arf1gap"
                     /inference="alignment:Splign:2.1.0"
     CDS             279..1526
                     /gene="Arfgap1"
                     /gene_synonym="Arf GAP1; Arf1gap"
                     /note="ARF1 GAP; ADP-ribosylation factor GTPase activating
                     protein 1; ARF GAP 1; ARF1-directed GTPase-activating
                     protein; ADP-ribosylation factor 1 GTPase-activating
                     protein"
                     /codon_start=1
                     /product="ADP-ribosylation factor GTPase-activating
                     protein 1"
                     /protein_id="NP_659558.1"
                     /db_xref="GeneID:246310"
                     /db_xref="RGD:708452"
                     /translation="MASPRTRKVLKEVRAQDENNVCFECGAFNPQWVSVTYGIWICLE
                     CSGRHRGLGVHLSFVRSVTMDKWKDIELEKMKAGGNAKFREFLEAQDDYEPSWSLQDK
                     YSSRAAALFRDKVATLAEGKEWSLESSPAQNWTPPQPKTLQFTAHRPAGQPQNVTTSG
                     DKAFEDWLNDDLGSYQGAQENRYVGFGNTVPPQKREDDFLNSAMSSLYSGWSSFTTGA
                     SKFASAAKEGATKFGSQASQKASELGHSLNENVLKPAQEKVKEGRIFDDVSSGVSQLA
                     SKVQGVGSKGWRDVTTFFSGKAEDTSDRPLEGHSYQNSSGDNSQNSTIDQSFWETFGS
                     AEPPKAKSPSSDSWTCADASTGRRSSDSWDIWGSGSASNNKNSNSDGWESWEGASGEG
                     RAKATKKAAPSTAADEGWDNQNW"
     exon            339..448
                     /gene="Arfgap1"
                     /gene_synonym="Arf GAP1; Arf1gap"
                     /inference="alignment:Splign:2.1.0"
     exon            449..620
                     /gene="Arfgap1"
                     /gene_synonym="Arf GAP1; Arf1gap"
                     /inference="alignment:Splign:2.1.0"
     exon            621..721
                     /gene="Arfgap1"
                     /gene_synonym="Arf GAP1; Arf1gap"
                     /inference="alignment:Splign:2.1.0"
     exon            722..808
                     /gene="Arfgap1"
                     /gene_synonym="Arf GAP1; Arf1gap"
                     /inference="alignment:Splign:2.1.0"
     exon            809..905
                     /gene="Arfgap1"
                     /gene_synonym="Arf GAP1; Arf1gap"
                     /inference="alignment:Splign:2.1.0"
     exon            906..962
                     /gene="Arfgap1"
                     /gene_synonym="Arf GAP1; Arf1gap"
                     /inference="alignment:Splign:2.1.0"
     exon            963..995
                     /gene="Arfgap1"
                     /gene_synonym="Arf GAP1; Arf1gap"
                     /inference="alignment:Splign:2.1.0"
     exon            996..1052
                     /gene="Arfgap1"
                     /gene_synonym="Arf GAP1; Arf1gap"
                     /inference="alignment:Splign:2.1.0"
     exon            1053..1112
                     /gene="Arfgap1"
                     /gene_synonym="Arf GAP1; Arf1gap"
                     /inference="alignment:Splign:2.1.0"
     exon            1113..1189
                     /gene="Arfgap1"
                     /gene_synonym="Arf GAP1; Arf1gap"
                     /inference="alignment:Splign:2.1.0"
     exon            1190..1857
                     /gene="Arfgap1"
                     /gene_synonym="Arf GAP1; Arf1gap"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggggatctga gtgcctagtc cagcttggca cctgggccgg acccgacccc ctcggggcag
       61 caggatccca gtgtgcggcg gtccagaccc ccccgccccg cccccggcct gtgagccttg
      121 ccgcccttca gcatagcggt tgcgcggatc tacgtggcct ttcagcgctc aggtcccgag
      181 cactctcaga cgcagactgg ttttgcagag cccatttggc cgggaaaggg cccctgccct
      241 tcacttcgaa agaagattct gtccagaggt gccgcaccat ggccagccca agaaccagaa
      301 aagttcttaa ggaagtccgg gcacaggacg agaataatgt ttgctttgag tgtggtgcgt
      361 tcaatcctca gtgggtcagc gtgacctatg gcatctggat ctgcctggaa tgctctggga
      421 gacaccgtgg gcttggggtg catctcagct tcgtgcgctc tgtgacaatg gacaagtgga
      481 aggacattga actggagaag atgaaagctg gtgggaatgc taagttccga gagttcctgg
      541 aggcacagga cgactatgag cctagctggt cactgcagga caagtatagc agcagagctg
      601 cagcgctctt cagggataag gtggctactt tggcagaagg taaagaatgg tctctggagt
      661 catcgcctgc ccagaactgg accccacctc agcccaagac gctgcagttc actgcccacc
      721 gacccgctgg ccagccacag aatgtaacta cctctgggga caaggccttt gaggattggc
      781 tgaatgatga cctgggttcc tatcagggtg ctcaggagaa tcgctatgtg gggtttggga
      841 acacagtgcc acctcagaag agagaagatg acttcctcaa cagcgccatg tcatctctgt
      901 actcgggctg gagcagtttt accactgggg cgagcaagtt tgcgtctgca gcaaaggagg
      961 gtgctacaaa atttggatct caagcaagtc aaaaggcttc ggagttgggc cacagcctga
     1021 atgagaatgt tctcaagcct gcacaggaga aggtgaaaga gggaaggatt tttgatgatg
     1081 tgtccagtgg ggtctctcag ttggcatcca aggtccaggg agttggcagt aagggatggc
     1141 gtgatgtcac gacctttttt tctgggaaag ctgaagacac ttcagacaga cccttagagg
     1201 gccacagcta ccagaacagc agtggagaca actctcagaa cagcaccata gaccagagct
     1261 tctgggagac cttcgggagt gctgagcccc ccaaggccaa gtccccaagc agtgacagct
     1321 ggacctgcgc agatgcctca acgggaagga ggagctcgga cagctgggac atttggggct
     1381 caggttctgc atccaacaac aagaacagca atagcgatgg ctgggagagc tgggagggag
     1441 ccagtgggga gggaagggca aaggctacca agaaggcagc tccatctaca gccgccgacg
     1501 agggctggga caaccagaac tggtaggagc cttgctgcac cctaacccag ccctgctggg
     1561 agaccgctgt gtttgcactt tacccttgtt cctccttcat ttgacctcag tgtgaagaca
     1621 gtggctcagg caggacttga gttggtgctg cctgcctggt gtggggtggc tttctcttag
     1681 acctcagggg acatgtcatc cacctgcctc ttgggtcctc tgagcagcct tcctggattc
     1741 tgggttcttg ggacccaggc actgtctctg cagccctagc atagcctggg actgcagccc
     1801 tgtgcaatgt cagctaagcc agacatctgc tttcgttgaa atgtcttttt aaacttg
//
