LOCUS       NM_024152               1172 bp    mRNA    linear   ROD 12-NOV-2024
DEFINITION  Rattus norvegicus ARF GTPase 6 (Arf6), mRNA.
ACCESSION   NM_024152
VERSION     NM_024152.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1172)
  AUTHORS   Kim,H., Jung,H., Jung,H., Kwon,S.K., Ko,J. and Um,J.W.
  TITLE     The small GTPase ARF6 regulates GABAergic synapse development
  JOURNAL   Mol Brain 13 (1), 2 (2020)
   PUBMED   31907062
  REMARK    GeneRIF: The small GTPase ARF6 regulates GABAergic synapse
            development.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1172)
  AUTHORS   Hu,J., Yang,Q., Chen,Z., Liang,W., Feng,J. and Ding,G.
  TITLE     Small GTPase Arf6 regulates diabetes-induced cholesterol
            accumulation in podocytes
  JOURNAL   J Cell Physiol 234 (12), 23559-23570 (2019)
   PUBMED   31206670
  REMARK    GeneRIF: High glucose-induced cholesterol accumulation and cellular
            injury in podocytes may be related to the recycling disorder of
            ABCA1 caused by the downexpression of Arf6 in diabetic kidney
            disease.
REFERENCE   3  (bases 1 to 1172)
  AUTHORS   Mohanan,V., Nakata,T., Desch,A.N., Levesque,C., Boroughs,A.,
            Guzman,G., Cao,Z., Creasey,E., Yao,J., Boucher,G., Charron,G.,
            Bhan,A.K., Schenone,M., Carr,S.A., Reinecker,H.C., Daly,M.J.,
            Rioux,J.D., Lassen,K.G. and Xavier,R.J.
  TITLE     C1orf106 is a colitis risk gene that regulates stability of
            epithelial adherens junctions
  JOURNAL   Science 359 (6380), 1161-1166 (2018)
   PUBMED   29420262
REFERENCE   4  (bases 1 to 1172)
  AUTHORS   Miura,Y., Hongu,T., Yamauchi,Y., Funakoshi,Y., Katagiri,N.,
            Ohbayashi,N. and Kanaho,Y.
  TITLE     ACAP3 regulates neurite outgrowth through its GAP activity specific
            to Arf6 in mouse hippocampal neurons
  JOURNAL   Biochem J 473 (17), 2591-2602 (2016)
   PUBMED   27330119
REFERENCE   5  (bases 1 to 1172)
  AUTHORS   Yan,X., Nykanen,N.P., Brunello,C.A., Haapasalo,A., Hiltunen,M.,
            Uronen,R.L. and Huttunen,H.J.
  TITLE     FRMD4A-cytohesin signaling modulates the cellular release of tau
  JOURNAL   J Cell Sci 129 (10), 2003-2015 (2016)
   PUBMED   27044754
REFERENCE   6  (bases 1 to 1172)
  AUTHORS   Radhakrishna,H., Al-Awar,O., Khachikian,Z. and Donaldson,J.G.
  TITLE     ARF6 requirement for Rac ruffling suggests a role for membrane
            trafficking in cortical actin rearrangements
  JOURNAL   J Cell Sci 112 (Pt 6), 855-866 (1999)
   PUBMED   10036235
REFERENCE   7  (bases 1 to 1172)
  AUTHORS   Andreev,J., Simon,J.P., Sabatini,D.D., Kam,J., Plowman,G.,
            Randazzo,P.A. and Schlessinger,J.
  TITLE     Identification of a new Pyk2 target protein with Arf-GAP activity
  JOURNAL   Mol Cell Biol 19 (3), 2338-2350 (1999)
   PUBMED   10022920
REFERENCE   8  (bases 1 to 1172)
  AUTHORS   D'Souza-Schorey,C., Boshans,R.L., McDonough,M., Stahl,P.D. and Van
            Aelst,L.
  TITLE     A role for POR1, a Rac1-interacting protein, in ARF6-mediated
            cytoskeletal rearrangements
  JOURNAL   EMBO J 16 (17), 5445-5454 (1997)
   PUBMED   9312003
REFERENCE   9  (bases 1 to 1172)
  AUTHORS   Hosaka,M., Toda,K., Takatsu,H., Torii,S., Murakami,K. and
            Nakayama,K.
  TITLE     Structure and intracellular localization of mouse ADP-ribosylation
            factors type 1 to type 6 (ARF1-ARF6)
  JOURNAL   J Biochem 120 (4), 813-819 (1996)
   PUBMED   8947846
REFERENCE   10 (bases 1 to 1172)
  AUTHORS   Price,S.R., Nightingale,M.S., Tsuchiya,M., Moss,J. and Vaughan,M.
  TITLE     Interspecies relationships among ADP-ribosylation factors (ARFs):
            evidence of evolutionary pressure to maintain individual identities
  JOURNAL   Mol Cell Biochem 159 (1), 15-23 (1996)
   PUBMED   8813705
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC091146.1.
            
            On Mar 27, 2005 this sequence version replaced NM_024152.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC091146.1, L12385.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1172
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q24"
     gene            1..1172
                     /gene="Arf6"
                     /note="ARF GTPase 6"
                     /db_xref="GeneID:79121"
                     /db_xref="RGD:621279"
     exon            1..1149
                     /gene="Arf6"
                     /inference="alignment:Splign:2.1.0"
     CDS             153..680
                     /gene="Arf6"
                     /EC_number="3.6.5.2"
                     /codon_start=1
                     /product="ADP-ribosylation factor 6"
                     /protein_id="NP_077066.1"
                     /db_xref="GeneID:79121"
                     /db_xref="RGD:621279"
                     /translation="MGKVLSKIFGNKEMRILMLGLDAAGKTTILYKLKLGQSVTTIPT
                     VGFNVETVTYKNVKFNVWDVGGQDKIRPLWRHYYTGTQGLIFVVDCADRDRIDEARQE
                     LHRIINDREMRDAIILIFANKQDLPDAMKPHEIQEKLGLTRIRDRNWYVQPSCATSGD
                     GLYEGLTWLTSNYKS"
ORIGIN      
        1 cccctgcccc tagcaggcag cttcgcgcaa gccgggccgc agggcgtcct cgcggcgggg
       61 cggctacttt tcgggctcgc agcggcggcg gcgttgtagg ctgaggggac ccgggacacc
      121 tgaatgcccc cggccccggc tcttccgacg cgatggggaa ggtgctatcc aagatcttcg
      181 ggaacaagga aatgcggatc ctcatgctgg gcctggacgc agccggcaag acaacgatcc
      241 tgtacaagtt gaagctgggc cagtctgtga ccaccattcc cacggtgggt ttcaacgtgg
      301 agacggtgac ttacaaaaac gtcaagttca acgtgtggga tgtgggcggc caggacaaga
      361 tccggccgct ctggcggcat tactacaccg ggacccaggg tctgatcttc gtggtagact
      421 gcgccgaccg cgaccgcatc gatgaggccc gccaggagct gcaccgcatt atcaatgacc
      481 gggagatgag ggacgccata atcctcatct tcgccaacaa gcaggacctg cctgatgcca
      541 tgaaacccca tgagatccag gagaaactgg gcctgacccg gattcgggac aggaactggt
      601 atgtgcagcc ctcctgtgcc acctccgggg acggactcta tgaggggctc acatggttaa
      661 cctctaacta caaatcctaa tgagcgccct ccacccagcc cccggaagga gagaaatcaa
      721 aaacccattc ataggattat cgccaccatc atcacctctt tcaattgcca ctctcttttt
      781 tgaaactgaa ctcgagttac tgttctaccg tttagtgggg ttgggggttt tctttgttcc
      841 ccttaccccc cctcttctat ttcctttcgg ctttgcgtta ggatgctctg atctgacatt
      901 tgacacgaat acagtgctat atgctcttgt gacttccagc aaacggggtg gggtaatagc
      961 aactcttggt aaagtccttt ataataatgg ttttgatttt ttttttttat ttcgagagaa
     1021 tctcccccca tgtatgcctt tttccttttt gcccagtttc ttatcacttg ctgtagatgg
     1081 cttattttgc attcatgcag actatgttcc aagtctgttt catctagtaa actgaaaatt
     1141 attgcttaaa aaaaaaaaaa aaaaaaaaaa aa
//
