LOCUS       NM_001106744            4982 bp    mRNA    linear   ROD 26-OCT-2024
DEFINITION  Rattus norvegicus apoptosis resistant E3 ubiquitin protein ligase 1
            (Arel1), transcript variant 1, mRNA.
ACCESSION   NM_001106744 XM_001056938 XM_234415
VERSION     NM_001106744.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4982)
  AUTHORS   Lear,T.B., McKelvey,A.C., Evankovich,J.W., Rajbhandari,S.,
            Coon,T.A., Dunn,S.R., Londino,J.D., McVerry,B.J., Zhang,Y.,
            Valenzi,E., Burton,C.L., Gordon,R., Gingras,S., Lockwood,K.C.,
            Jurczak,M.J., Lafyatis,R., Shlomchik,M.J., Liu,Y. and Chen,B.B.
  TITLE     KIAA0317 regulates pulmonary inflammation through SOCS2 degradation
  JOURNAL   JCI Insight 4 (19), 129110 (2019)
   PUBMED   31578312
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4982)
  AUTHORS   Kim,J.B., Kim,S.Y., Kim,B.M., Lee,H., Kim,I., Yun,J., Jo,Y., Oh,T.,
            Jo,Y., Chae,H.D. and Shin,D.Y.
  TITLE     Identification of a novel anti-apoptotic E3 ubiquitin ligase that
            ubiquitinates antagonists of inhibitor of apoptosis proteins SMAC,
            HtrA2, and ARTS
  JOURNAL   J Biol Chem 288 (17), 12014-12021 (2013)
   PUBMED   23479728
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CH473982.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_234415.4, XM_001056938.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132261, SAMD00132262
                              [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..4982
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q31"
     gene            1..4982
                     /gene="Arel1"
                     /gene_synonym="RGD1307597"
                     /note="apoptosis resistant E3 ubiquitin protein ligase 1"
                     /db_xref="GeneID:299197"
                     /db_xref="RGD:1307597"
     exon            1..117
                     /gene="Arel1"
                     /gene_synonym="RGD1307597"
                     /inference="alignment:Splign:2.1.0"
     exon            118..178
                     /gene="Arel1"
                     /gene_synonym="RGD1307597"
                     /inference="alignment:Splign:2.1.0"
     CDS             163..2634
                     /gene="Arel1"
                     /gene_synonym="RGD1307597"
                     /EC_number="2.3.2.26"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="apoptosis-resistant E3 ubiquitin protein ligase
                     1 isoform 1"
                     /protein_id="NP_001100214.1"
                     /db_xref="GeneID:299197"
                     /db_xref="RGD:1307597"
                     /translation="MFYVIGGIIVSVVAFFFTIKFLFELAARVVSFLQNEDRERRGDR
                     TIYDYVRGNYLDPRSCKVSWDWKDPYEVGHSMAFRVHLFYKNGQPFPAHRPVGLRVHI
                     SHVELAVEIPVTQEVLQEPNSNVVKVAFTVRKAGRYEITVKLGGLNVAYSPYYKIFQP
                     GMVVPSKTKIVCHFSTLVLTCGQPHTLQIVPRDEYDNPTNNSMSLREEHNYSLSIHEL
                     GPQEEENSEVSFEKSVTSNRQTCQVFLRLTLHSRGCFHACISYQNQPINNGEFDIIVL
                     SENEKNIVERNVSTSGVSIYFEAYLYNANSYSSAPWHLPPMHMSSSQRRPSTALEEEE
                     EDSPSECHTPEKVKKPKKVYCYVSPKQFSVKEFYLKIIPWRLYTFRVCPGTKFSYLGP
                     DPVHKLLTLVVDDGIQPPVELSCKERNILAATFIRSLHKNIGGSETFQDKVNFFQREL
                     RQVHMKRPHSKVTLKVSRHALLESSLKATRNFSISDWSKNFEVVFQDEEALDWGGPRR
                     EWFELICKALFDTTSQLFTRFSDNNQALVHPNPNRPAHLRLKMYEFAGRLVGKCLYES
                     SLGGAYKQLVRARFTRSFLAQIIGLRMHYKYFETDDPEFYKSKVCFILNNDMSEMELV
                     FAEEKYNKSGQLDKIVELMTGGAQTPVTNANKTFYLNLLAQYRLASQVKEEVEHFLKG
                     LNELVPENLLAIFDENELELLMCGTGDISVSDFKAHAVVVGGSWHFREKVMRWFWTVV
                     SSLTQEELARLLQFTTGSSQLPPGGFAALCPSFQIIAAPTHSTLPTAHTCFNQLCLPT
                     YDSYEEVHRMLQLAISEGCEGFGML"
     exon            179..405
                     /gene="Arel1"
                     /gene_synonym="RGD1307597"
                     /inference="alignment:Splign:2.1.0"
     exon            406..643
                     /gene="Arel1"
                     /gene_synonym="RGD1307597"
                     /inference="alignment:Splign:2.1.0"
     exon            644..813
                     /gene="Arel1"
                     /gene_synonym="RGD1307597"
                     /inference="alignment:Splign:2.1.0"
     exon            814..994
                     /gene="Arel1"
                     /gene_synonym="RGD1307597"
                     /inference="alignment:Splign:2.1.0"
     exon            995..1242
                     /gene="Arel1"
                     /gene_synonym="RGD1307597"
                     /inference="alignment:Splign:2.1.0"
     exon            1243..1320
                     /gene="Arel1"
                     /gene_synonym="RGD1307597"
                     /inference="alignment:Splign:2.1.0"
     exon            1321..1462
                     /gene="Arel1"
                     /gene_synonym="RGD1307597"
                     /inference="alignment:Splign:2.1.0"
     exon            1463..1584
                     /gene="Arel1"
                     /gene_synonym="RGD1307597"
                     /inference="alignment:Splign:2.1.0"
     exon            1585..1660
                     /gene="Arel1"
                     /gene_synonym="RGD1307597"
                     /inference="alignment:Splign:2.1.0"
     exon            1661..1770
                     /gene="Arel1"
                     /gene_synonym="RGD1307597"
                     /inference="alignment:Splign:2.1.0"
     exon            1771..1950
                     /gene="Arel1"
                     /gene_synonym="RGD1307597"
                     /inference="alignment:Splign:2.1.0"
     exon            1951..2076
                     /gene="Arel1"
                     /gene_synonym="RGD1307597"
                     /inference="alignment:Splign:2.1.0"
     exon            2077..2206
                     /gene="Arel1"
                     /gene_synonym="RGD1307597"
                     /inference="alignment:Splign:2.1.0"
     exon            2207..2265
                     /gene="Arel1"
                     /gene_synonym="RGD1307597"
                     /inference="alignment:Splign:2.1.0"
     exon            2266..2355
                     /gene="Arel1"
                     /gene_synonym="RGD1307597"
                     /inference="alignment:Splign:2.1.0"
     exon            2356..2531
                     /gene="Arel1"
                     /gene_synonym="RGD1307597"
                     /inference="alignment:Splign:2.1.0"
     exon            2532..4982
                     /gene="Arel1"
                     /gene_synonym="RGD1307597"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtctgctcc tggcttcctt tgatagagat gtagaactct cagctctccc agcaccatgc
       61 ctgtctggat gctgccatgc tcccaccttg atgataatgg actgagcctc aaaacctttg
      121 cagctgtgat cctcggcttt ctgtaggcat tgaagagacc tgatgtttta cgttattggt
      181 ggaatcatag tgtctgtggt tgcattcttt ttcacaatta agttcctctt tgagcttgcc
      241 gcacgtgtag tcagctttct tcagaatgaa gaccgtgaac gccgagggga ccggactatt
      301 tatgactacg tgcggggaaa ttacctggat ccccggtcct gcaaagtgtc ctgggattgg
      361 aaggacccct atgaggtggg ccacagcatg gccttccgag tgcatttgtt ctataagaat
      421 ggacagcctt tccctgcaca ccgacctgtg ggactgcgag ttcacatctc tcacgttgaa
      481 ctagcagtgg aaattccagt gacccaggag gtcctccagg agccaaactc taacgtggtg
      541 aaggtggcct tcactgtgcg caaggctggg cgctatgaga ttactgtgaa gctcggtgga
      601 ttaaatgtgg cctatagtcc ctactacaaa atttttcagc ctggaatggt agttccttcc
      661 aaaaccaaaa ttgtgtgcca tttttctact ctggtgttga cgtgtgggca gccacacact
      721 ctgcagatag tgccccgaga tgagtatgac aatccgacca acaattccat gtccctgaga
      781 gaagagcaca actacagcct gtccattcat gagcttggtc ctcaagaaga agagaatagc
      841 gaagtctcat ttgagaagtc agtgacctcc aacagacaga cttgccaggt gttcttgcgg
      901 ctcaccctgc attcccgagg ttgcttccat gcctgcattt cataccagaa ccaacccatc
      961 aataatggtg aatttgacat cattgtcctt agtgagaatg agaagaatat cgttgaacga
     1021 aatgtgtcca cctcaggagt gagcatttac tttgaggctt acctttacaa tgctaacagc
     1081 tatagcagtg caccatggca tctgcctccc atgcacatga gctcttctca gcgccggccc
     1141 tccactgctc ttgaagagga ggaggaagac tcgccctcag agtgccacac ccctgagaag
     1201 gtgaagaaac cgaagaaggt gtactgctat gtgtcaccaa agcaattctc agtgaaggaa
     1261 ttttacctga aaatcatccc ctggcgcctc tacaccttcc gagtgtgccc cggaaccaaa
     1321 ttctcatacc ttggccctga ccctgttcac aagctgctca cattggtggt ggatgacggc
     1381 attcagcctc ctgtggagct cagctgcaag gagaggaaca ttctagcagc cactttcatc
     1441 cgttccttgc acaagaacat tggaggctcc gaaacctttc aagacaaggt gaactttttt
     1501 cagagagagc ttcggcaggt acatatgaag agacctcatt ccaaagtcac cctgaaggtc
     1561 agcagacacg ccttgttgga atcgtctttg aaggccactc ggaacttttc catctcagat
     1621 tggagcaaga actttgaagt ggttttccag gatgaagaag ctttggattg gggagggcct
     1681 cgccgggaat ggtttgagct aatctgcaaa gcactgtttg ataccaccag tcagctcttc
     1741 acccggttca gtgacaacaa ccaagcacta gtgcatccta accctaatcg cccggctcac
     1801 ctgcgcttga agatgtatga gtttgcaggg cggctggtgg gcaagtgttt gtatgaatcc
     1861 tctctaggag gagcctacaa gcagttggtc cgtgcccgtt tcactcggtc tttcctggcc
     1921 caaatcatag gactacgtat gcattacaag tactttgaaa cagatgaccc agaattctat
     1981 aaatccaaag tatgttttat cctcaacaat gacatgagtg agatggagct ggtctttgca
     2041 gaagagaaat acaacaaatc aggtcaacta gataagattg tagaactcat gacaggtgga
     2101 gctcaaaccc cagtcaccaa tgcaaataaa accttctatt taaacttgtt ggctcagtac
     2161 cggctggcca gtcaggtgaa agaggaggtg gagcactttc tgaaaggctt gaatgagttg
     2221 gttcctgaga accttttggc tatttttgat gagaatgagc ttgagctgct gatgtgtggg
     2281 actggagaca tcagtgtgtc tgacttcaaa gcccatgctg tagtggtggg tggatcctgg
     2341 catttcagag aaaaggtcat gaggtggttt tggactgtgg tttccagtct gacccaggag
     2401 gaactggctc ggctgcttca gttcacaaca ggctcttctc agctcccacc tggaggattt
     2461 gctgccctct gtccctcatt tcagattatt gctgctccaa cccacagcac gcttcctact
     2521 gcacacacgt gttttaacca actgtgcctc cctacatatg actcatatga agaggtacac
     2581 aggatgctac agctggccat cagtgagggt tgcgagggct ttggcatgct ctgaccgttc
     2641 ctctgtcacc tgcttgactc ccaagctctc tagagcattt ggacacatgt taacaagcat
     2701 aaccactgac cttaaccaca accattagcc agaagatact gcatgctccc ttgtgtcagg
     2761 agtattctgt catctacaag cactgttctt acctcacctt ctgtccacat ttaccacagg
     2821 ccacttgagc atgtggcacc tatccgagct ctactcagtc atgagaggag gaccatgctg
     2881 ctgtcatttt gttggtcctt ggaagacctc tggctggatc tgcctcagtg gctggaagag
     2941 atgcatgaca cagaggactc gattctgatg gaaagccagt attgagaccc ggcagccacg
     3001 cttcatccca gcaccctctg ctccttggaa atgccctcct tgatctcact acttgaccag
     3061 actgggcaac ccatcacctc ttctcaccag tggtcaggag aagcacagct agaaagtggc
     3121 tcgcacaagc catctgattt gtcctcccac ctgatggcag gcacaggcca tggcacagca
     3181 ttagttctca tggggactgg tagtacaaaa ggatctcttt atggtgacag aactggaaaa
     3241 gacactccct gcggacattt tttaagatga tcattaatct ataaggaatt tggtaagctt
     3301 tctcttgaat ttgagccagt gagaaaagca gtcagaagaa tgtgaaggat ggttgtgctg
     3361 tagcctccag tgctgggtac gcttctctct cggggaaggg ctgtgtccag gcatgtggat
     3421 ggcttgaaga ctactgatgc ttttctctga gtttgttctt tgcactgaag gaggacttgg
     3481 cctgacctcc aacttacgta gtttgttaag agctgtcttt agccttctgc tggaggagct
     3541 tttggagcaa cagactggga cagtgaaaat agactgacag ctctctggtg gtgatctctg
     3601 gcagcactga ggcaaagaaa ctgtgatcac aggtcctggg tcaaaccagt ggggatagat
     3661 gaggtggaga tccagcagca gtaaatacct agcaattcca agtgcttggc ttcatcagtt
     3721 accaagaagt ggggaaccat ggagggagaa tgctgtactg agttcgcagt tacatggtga
     3781 tgacagagaa ctcagtttca aggaagagta tttgaatgaa aacaacacga aggcccagca
     3841 ttgcatggat ttcccgattt ctgtctttaa taaggctttt ctataagcca ctattttcca
     3901 tggggcactt agaatattac aagccatttt attgccaaaa ccagcacgta cacagaatcc
     3961 cgagataagg cagttcctgt gacagtgcct tggcctcctg gaagcagtct gagccctcct
     4021 gttcccaggg atcatgagaa acaagccctc ctgagctgca agaagcctga ctgacctcct
     4081 ttacagtcat ctgttttctc ttggcgtggg tgctcacctc acttatcctt ggggtttggg
     4141 acctggcatc aggacctctt cacccagggt cctccatgcc acatggtcac tgctttcctc
     4201 agggaccagg acaaggtgct gctgcctgcc cacactttcc caaggaacac gtacagaatc
     4261 atttagccac taccctgctg cttctcaggc ctccgctggg gcttccagct gggtacatgg
     4321 ctgcttggct gtttggggcg gtccttcctc cttgggtcca caatcctggc tccagcaccc
     4381 cctgcagact acacagtggg ggtcggtgga tgtgagtggc tagacctctc attttcagct
     4441 ctagtcatag cccttcttca gcgtctccta ggcactactg cagccccact ggggcagcta
     4501 gtatcccagg gtggacttta ggcaccagag tctttaacaa gaaaatcctc tagtattgtg
     4561 tggttttcta tttttccagt ttactctcct aactattcag aagcattttg ctctctcttg
     4621 cattttcttt taccttgttt ttctaatact gctttggtac tagcccatgt ggggaagaga
     4681 tacagtatgt tggacagata aaaaggtgtg ttatttcttg gtcaattttc tattcgtatt
     4741 ccttattttg gccagttctt ttgtttatgc tttgtgacat aggtacttgg gaggctagct
     4801 gccctcctgg cttttggctt ttcggtgtcc ttgaaggaga ccagtcatga ccaccaagga
     4861 gagtgtcagc ttgattcaga acttggcaga ggccgagctc tgctgcactg tcaggccagg
     4921 tctggatgtc agcagttgga gatgtaaata ttttgtacag taaataaaat gcctacaata
     4981 at
//
