LOCUS       NM_017123               1149 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus amphiregulin (Areg), mRNA.
ACCESSION   NM_017123
VERSION     NM_017123.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1149)
  AUTHORS   Ji,M., Liu,Y., Zuo,Z., Xu,C., Lin,L. and Li,Y.
  TITLE     Downregulation of amphiregulin improves cardiac hypertrophy via
            attenuating oxidative stress and apoptosis
  JOURNAL   Biol Direct 17 (1), 21 (2022)
   PUBMED   35996142
  REMARK    GeneRIF: Downregulation of amphiregulin improves cardiac
            hypertrophy via attenuating oxidative stress and apoptosis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1149)
  AUTHORS   Yu,Y., Zhang,X., Han,Z., Zhao,W. and Zhang,L.
  TITLE     Expression and regulation of miR-449a and AREG in cerebral ischemic
            injury
  JOURNAL   Metab Brain Dis 34 (3), 821-832 (2019)
   PUBMED   30773606
  REMARK    GeneRIF: study demonstrated that miR-449a was downregulated while
            AREG was upregulated in cerebral ischemic injury
REFERENCE   3  (bases 1 to 1149)
  AUTHORS   Kelly,F.L., Sun,J., Fischer,B.M., Voynow,J.A., Kummarapurugu,A.B.,
            Zhang,H.L., Nugent,J.L., Beasley,R.F., Martinu,T., Gwinn,W.M.,
            Morgan,D.L. and Palmer,S.M.
  TITLE     Diacetyl induces amphiregulin shedding in pulmonary epithelial
            cells and in experimental bronchiolitis obliterans
  JOURNAL   Am J Respir Cell Mol Biol 51 (4), 568-574 (2014)
   PUBMED   24816162
  REMARK    GeneRIF: Report increased AREG transcript and protein levels in the
            lungs of rodents with DA-induced bronchiolitis obliterans.
REFERENCE   4  (bases 1 to 1149)
  AUTHORS   Gupta,A., Dong,A. and Lowe,A.W.
  TITLE     AGR2 gene function requires a unique endoplasmic reticulum
            localization motif
  JOURNAL   J Biol Chem 287 (7), 4773-4782 (2012)
   PUBMED   22184114
REFERENCE   5  (bases 1 to 1149)
  AUTHORS   Kariagina,A., Xie,J., Leipprandt,J.R. and Haslam,S.Z.
  TITLE     Amphiregulin mediates estrogen, progesterone, and EGFR signaling in
            the normal rat mammary gland and in hormone-dependent rat mammary
            cancers
  JOURNAL   Horm Cancer 1 (5), 229-244 (2010)
   PUBMED   21258428
  REMARK    GeneRIF: estrogen and progeterone increased cell proliferation in
            normal gland and mammary cancers through the increased production
            of amphiregulin
REFERENCE   6  (bases 1 to 1149)
  AUTHORS   Mishima,K., Asai,A., Sugiyama,A., Miyagi,Y., Kitanaka,C.,
            Kagaya,S., Kirino,T. and Kuchino,Y.
  TITLE     Increased expression of schwannoma-derived growth factor (SDGF)
            mRNA in rat tumor cells: involvement of SDGF in the growth
            promotion of rat gliomas
  JOURNAL   Int J Cancer 66 (3), 352-357 (1996)
   PUBMED   8621257
REFERENCE   7  (bases 1 to 1149)
  AUTHORS   Panico,L., D'Antonio,A., Salvatore,G., Mezza,E., Tortora,G., De
            Laurentiis,M., De Placido,S., Giordano,T., Merino,M., Salomon,D.S.,
            Mullick,W.J., Pettinato,G., Schnitt,S.J., Bianco,A.R. and
            Ciardiello,F.
  TITLE     Differential immunohistochemical detection of transforming growth
            factor alpha, amphiregulin and CRIPTO in human normal and malignant
            breast tissues
  JOURNAL   Int J Cancer 65 (1), 51-56 (1996)
   PUBMED   8543395
REFERENCE   8  (bases 1 to 1149)
  AUTHORS   Kenney,N.J., Huang,R.P., Johnson,G.R., Wu,J.X., Okamura,D.,
            Matheny,W., Kordon,E., Gullick,W.J., Plowman,G., Smith,G.H. et al.
  TITLE     Detection and location of amphiregulin and Cripto-1 expression in
            the developing postnatal mouse mammary gland
  JOURNAL   Mol Reprod Dev 41 (3), 277-286 (1995)
   PUBMED   8588926
REFERENCE   9  (bases 1 to 1149)
  AUTHORS   Kimura,H. and Schubert,D.
  TITLE     Schwannoma-derived growth factor promotes the neuronal
            differentiation and survival of PC12 cells
  JOURNAL   J Cell Biol 116 (3), 777-783 (1992)
   PUBMED   1530950
REFERENCE   10 (bases 1 to 1149)
  AUTHORS   Kimura,H., Fischer,W.H. and Schubert,D.
  TITLE     Structure, expression and function of a schwannoma-derived growth
            factor
  JOURNAL   Nature 348 (6298), 257-260 (1990)
   PUBMED   2234093
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            On Nov 26, 2020 this sequence version replaced NM_017123.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X55183.1, SRR26643291.35102.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676784 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-239               JAXUCZ010000014.1  17265403-17265641   c
            240-458             JAXUCZ010000014.1  17264234-17264452   c
            459-663             JAXUCZ010000014.1  17261633-17261837   c
            664-819             JAXUCZ010000014.1  17260845-17261000   c
            820-925             JAXUCZ010000014.1  17258441-17258546   c
            926-1149            JAXUCZ010000014.1  17256384-17256607   c
FEATURES             Location/Qualifiers
     source          1..1149
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14p22"
     gene            1..1149
                     /gene="Areg"
                     /note="amphiregulin"
                     /db_xref="GeneID:29183"
                     /db_xref="RGD:2149"
     exon            1..239
                     /gene="Areg"
                     /inference="alignment:Splign:2.1.0"
     CDS             179..910
                     /gene="Areg"
                     /note="AR; SDGF; schwannoma-derived growth factor"
                     /codon_start=1
                     /product="amphiregulin preproprotein"
                     /protein_id="NP_058819.1"
                     /db_xref="GeneID:29183"
                     /db_xref="RGD:2149"
                     /translation="MRTPSLSLALSVLSLLVLGSGHYAAGLELNGTSSGKGEPSSGDH
                     SAGGLVVSEVSTISEMPSGSELSTGDYDYSEEYDNEPQISGYIVDDSVRVEQVIKPKE
                     NKTEGEKSSEKPKRKKKGGKGGKGRRNRKKKKNPCAAKFQNFCIHGECRYIENLEVVT
                     CHCHQDYFGERCGEKTMKTQKKDDSDLSKIALAAIIVFVSAVSVAAIGIITAVLLRKR
                     FFREYEEAEERRRLRQENGTAHAIA"
     exon            240..458
                     /gene="Areg"
                     /inference="alignment:Splign:2.1.0"
     exon            459..663
                     /gene="Areg"
                     /inference="alignment:Splign:2.1.0"
     exon            664..819
                     /gene="Areg"
                     /inference="alignment:Splign:2.1.0"
     exon            820..925
                     /gene="Areg"
                     /inference="alignment:Splign:2.1.0"
     exon            926..1149
                     /gene="Areg"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgccctgtca ttttgagccg agccctaggc gctggcagct ccagcctcct ggagcccggc
       61 ggggctgggc ttccccgcgc cggtgctcgc ccgttgcttc gcggttccgc tgttccggcc
      121 gccgggagcc gctgtcgtgt tgccgcagag accccgacgc cgccgggccg cggaaccaat
      181 gagaactccg tcgctttcgc tggcgctctc agtgctgtcg ctgctggtct taggctcagg
      241 ccattatgca gctgggttgg aactcaatgg caccagctct gggaaaggag aaccgtcctc
      301 tggggaccac agtgctggtg gacttgtggt ttctgaggtc tctaccataa gcgaaatgcc
      361 ttctggcagt gaactctcca caggggacta tgactactcg gaggagtatg ataacgaacc
      421 acaaatatcc ggctatattg tggacgactc agtcagagtt gaacaggtga ttaagcctaa
      481 ggaaaacaag acagaaggag aaaagtcttc agaaaaaccc aaaagaaaga aaaagggagg
      541 caaaggcgga aaaggcagaa gaaacaggaa gaagaaaaag aatccgtgtg ccgccaagtt
      601 tcagaacttc tgcattcatg gtgaatgcag atacatcgag aacctggagg tggtgacctg
      661 ccattgtcat caggattact ttggcgaacg gtgtggagaa aaaaccatga agactcagaa
      721 gaaggatgac agcgacctat ccaagatcgc gttagcagcc ataattgtct ttgtctccgc
      781 cgtaagcgtc gcagctattg gcatcattac cgccgtcctg cttcggaaac gattcttcag
      841 ggaatatgaa gaagcagaag aaagaaggag gctgcggcaa gaaaacggga ctgcacatgc
      901 catagcctag ctgatggcaa ttcaggataa cagtcgagtc actgccaagc cacacccaca
      961 ccagaagtga cgaatcggtc cttctttcag cgaaggctcc agaagttcag ttgtcacttt
     1021 ttgtgatagt cttatttctg tacataaaga aatgtgtgaa gataaaatat tttttcacgt
     1081 tgtaaataat ttatttaata tttaagtgtt atttatttta tagctcatta aatgtttttt
     1141 aaacaaaga
//
