LOCUS       NM_019361               3026 bp    mRNA    linear   ROD 24-OCT-2024
DEFINITION  Rattus norvegicus activity-regulated cytoskeleton-associated
            protein (Arc), mRNA.
ACCESSION   NM_019361
VERSION     NM_019361.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3026)
  AUTHORS   Chen,T.J., Wang,D.C., Liu,P.C., Hung,H.S. and Cheng,T.L.
  TITLE     Enhanced expression of activity-regulated cytoskeleton-associated
            protein in the medial prefrontal cortex is involved in working
            memory performance
  JOURNAL   Kaohsiung J Med Sci 40 (6), 553-560 (2024)
   PUBMED   38623867
  REMARK    GeneRIF: Enhanced expression of activity-regulated
            cytoskeleton-associated protein in the medial prefrontal cortex is
            involved in working memory performance.
REFERENCE   2  (bases 1 to 3026)
  AUTHORS   Chen,T., Xu,Y.P., Chen,Y., Sun,S., Yan,Z.Z. and Wang,Y.H.
  TITLE     Arc regulates brain damage and neuroinflammation via Sirt1
            signaling following subarachnoid hemorrhage
  JOURNAL   Brain Res Bull 203, 110780 (2023)
   PUBMED   37820952
  REMARK    GeneRIF: Arc regulates brain damage and neuroinflammation via Sirt1
            signaling following subarachnoid hemorrhage.
REFERENCE   3  (bases 1 to 3026)
  AUTHORS   McReynolds,J.R., Carreira,M.B. and McIntyre,C.K.
  TITLE     Post-training intra-basolateral complex of the amygdala infusions
            of clenbuterol enhance memory for conditioned place preference and
            increase ARC protein expression in dorsal hippocampal synaptic
            fractions
  JOURNAL   Neurobiol Learn Mem 185, 107539 (2021)
   PUBMED   34648950
  REMARK    GeneRIF: Post-training intra-basolateral complex of the amygdala
            infusions of clenbuterol enhance memory for conditioned place
            preference and increase ARC protein expression in dorsal
            hippocampal synaptic fractions.
REFERENCE   4  (bases 1 to 3026)
  AUTHORS   Bieler,M., Hussain,S., Daaland,E.S.B., Mirrione,M.M., Henn,F.A. and
            Davanger,S.
  TITLE     Changes in concentrations of NMDA receptor subunit GluN2B, Arc and
            syntaxin-1 in dorsal hippocampus Schaffer collateral synapses in a
            rat learned helplessness model of depression
  JOURNAL   J Comp Neurol 529 (12), 3194-3205 (2021)
   PUBMED   33843051
  REMARK    GeneRIF: Changes in concentrations of NMDA receptor subunit GluN2B,
            Arc and syntaxin-1 in dorsal hippocampus Schaffer collateral
            synapses in a rat learned helplessness model of depression.
REFERENCE   5  (bases 1 to 3026)
  AUTHORS   Gheidi,A., Damphousse,C.C. and Marrone,D.F.
  TITLE     Experience-dependent persistent Arc expression is reduced in the
            aged hippocampus
  JOURNAL   Neurobiol Aging 95, 225-230 (2020)
   PUBMED   32861833
  REMARK    GeneRIF: Experience-dependent persistent Arc expression is reduced
            in the aged hippocampus.
REFERENCE   6  (bases 1 to 3026)
  AUTHORS   Liu,D., Bei,D., Parmar,H. and Matus,A.
  TITLE     Activity-regulated, cytoskeleton-associated protein (Arc) is
            essential for visceral endoderm organization during early
            embryogenesis
  JOURNAL   Mech Dev 92 (2), 207-215 (2000)
   PUBMED   10727859
REFERENCE   7  (bases 1 to 3026)
  AUTHORS   Irie,Y., Yamagata,K., Gan,Y., Miyamoto,K., Do,E., Kuo,C.H.,
            Taira,E. and Miki,N.
  TITLE     Molecular cloning and characterization of Amida, a novel protein
            which interacts with a neuron-specific immediate early gene product
            arc, contains novel nuclear localization signals, and causes cell
            death in cultured cells
  JOURNAL   J Biol Chem 275 (4), 2647-2653 (2000)
   PUBMED   10644725
REFERENCE   8  (bases 1 to 3026)
  AUTHORS   Stoss,O., Schwaiger,F.W., Cooper,T.A. and Stamm,S.
  TITLE     Alternative splicing determines the intracellular localization of
            the novel nuclear protein Nop30 and its interaction with the
            splicing factor SRp30c
  JOURNAL   J Biol Chem 274 (16), 10951-10962 (1999)
   PUBMED   10196175
REFERENCE   9  (bases 1 to 3026)
  AUTHORS   Link,W., Konietzko,U., Kauselmann,G., Krug,M., Schwanke,B., Frey,U.
            and Kuhl,D.
  TITLE     Somatodendritic expression of an immediate early gene is regulated
            by synaptic activity
  JOURNAL   Proc Natl Acad Sci U S A 92 (12), 5734-5738 (1995)
   PUBMED   7777577
REFERENCE   10 (bases 1 to 3026)
  AUTHORS   Lyford,G.L., Yamagata,K., Kaufmann,W.E., Barnes,C.A., Sanders,L.K.,
            Copeland,N.G., Gilbert,D.J., Jenkins,N.A., Lanahan,A.A. and
            Worley,P.F.
  TITLE     Arc, a growth factor and activity-regulated gene, encodes a novel
            cytoskeleton-associated protein that is enriched in neuronal
            dendrites
  JOURNAL   Neuron 14 (2), 433-445 (1995)
   PUBMED   7857651
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Nov 26, 2020 this sequence version replaced NM_019361.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U19866.1, SRR26360190.1546469.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            NMD candidate          :: PMID: 7857651
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2001              JAXUCZ010000007.1  108446403-108448403 c
            2002-2141           JAXUCZ010000007.1  108446023-108446162 c
            2142-3026           JAXUCZ010000007.1  108444959-108445843 c
FEATURES             Location/Qualifiers
     source          1..3026
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q34"
     gene            1..3026
                     /gene="Arc"
                     /gene_synonym="rg3.1"
                     /note="activity-regulated cytoskeleton-associated protein"
                     /db_xref="GeneID:54323"
                     /db_xref="RGD:62037"
     exon            1..2001
                     /gene="Arc"
                     /gene_synonym="rg3.1"
                     /inference="alignment:Splign:2.1.0"
     CDS             217..1407
                     /gene="Arc"
                     /gene_synonym="rg3.1"
                     /note="activity regulated cytoskeletal-associated protein;
                     arg3.1; ARC/ARG3.1; activity-regulated gene 3.1 protein"
                     /codon_start=1
                     /product="activity-regulated cytoskeleton-associated
                     protein"
                     /protein_id="NP_062234.2"
                     /db_xref="GeneID:54323"
                     /db_xref="RGD:62037"
                     /translation="MELDHMTTGGLHAYPAPRGGPAAKPNVILQIGKCRAEMLEHVRR
                     THRHLLTEVSKQVERELKGLHRSVGKLENNLDGYVPTGDSQRWKKSIKACLCRCQETI
                     ANLERWVKREMHVWREVFYRLERWADRLESMGGKYPVGSEPARHTVSVGVGGPEPYCQ
                     EADGYDYTVSPYAITPPPAAGELPEQESVGAQQYQSWVPGEDGQPSPGVDTQIFEDPR
                     EFLSHLEEYLRQVGGSEEYWLSQIQNHMNGPAKKWWEFKQGSVKNWVEFKKEFLQYSE
                     GTLSREAIQRELDLPQKQGEPLDQFLWRKRDLYQTLYVDAEEEEIIQYVVGTLQPKFK
                     RFLRHPLPKTLEQLIQRGMEVQDGLEQAAEPSVTPLPTEDETEALTPALTSESVASDR
                     TQPE"
     exon            2002..2141
                     /gene="Arc"
                     /gene_synonym="rg3.1"
                     /inference="alignment:Splign:2.1.0"
     exon            2142..3026
                     /gene="Arc"
                     /gene_synonym="rg3.1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtgctctgg cgagtagtcc tccctcagcc gcagtctctg ggcctcttca gcttgagcgg
       61 cggcgagcct gctacactcg ctaagctcct ccggcaccgc gcacttgcca ctgccactgc
      121 cgcttcgcgc ccgctgcagc cgccggctct gaatccttct ggcttccgcc tcagaggagt
      181 tcttagcctg tcccgaaccg taaccccggc gagcagatgg agctggacca tatgacgacc
      241 ggcggcctcc acgcctaccc tgccccgcgg ggtgggccgg ccgccaaacc caatgtgatc
      301 ctgcagattg gtaagtgccg agctgagatg ctggagcacg tacggaggac ccaccggcat
      361 ctgttgaccg aagtgtccaa gcaggtggag cgagagctga aagggttgca caggtcggtg
      421 ggcaagctgg agaacaactt ggacggctat gtgcccacgg gcgactcaca gcgctggaag
      481 aagtccatca aggcctgtct ctgccgctgc caggagacca tcgccaacct ggagcgctgg
      541 gtcaagcgtg agatgcacgt gtggagggag gtcttctacc gtctggagag gtgggccgac
      601 cgcctggagt ccatgggcgg caagtaccca gtgggcagcg agccggcccg ccacactgtc
      661 tctgtaggtg tggggggtcc agagccctac tgccaggaag ctgatggcta cgactacact
      721 gttagcccct atgccatcac cccgccacct gccgcaggag agctgcctga gcaggagtca
      781 gttggggctc agcaatacca gtcttgggtg ccaggtgagg atgggcaacc aagcccaggt
      841 gtggataccc agatctttga ggacccacgg gagttcctga gccacctgga agagtacctg
      901 cggcaggtgg gtggctctga agaatattgg ctgtcccaga tccagaacca catgaatggg
      961 ccagccaaga agtggtggga gttcaaacag ggctcggtga agaactgggt ggagttcaag
     1021 aaggagtttc tgcagtacag tgagggtacg ctctcccgcg aagccattca gcgggagctg
     1081 gacctgccac agaagcaggg tgagccactt gaccagttcc tctggcgtaa gcgggacctg
     1141 taccagacac tgtatgtgga cgctgaggag gaggagatca ttcagtatgt ggtgggcacc
     1201 ctgcagccca agttcaagcg ctttctgcgc cacccactcc ccaagaccct ggagcagctc
     1261 atccagaggg gcatggaagt tcaggacggc ctggagcagg cagctgagcc ttctgtcacc
     1321 cctctgccca cagaggatga gactgaggca ctcacgcctg ctcttaccag cgagtcagta
     1381 gccagtgaca ggacccagcc tgaatagagg ggccagccca gggtccccag cctgcctgcc
     1441 acacccagtc tgtggctttt gtcaactagg acttgattga gctggggctg acacccaagg
     1501 ggatgccctg tccagccaga caccttctca cccactggcc tgactcacaa ctgccacaca
     1561 accatgattc atggacatca agaagcccct ctcccatagg gctcccacct gccacctacc
     1621 cctcacctgt ctgccctagt cctggccctg tctccagtgg cctcaccctc tacactctca
     1681 gaccatcaga acacctttgg cttcctcatt ctgcatcagt gtccagggcc ctttgggtag
     1741 tcaagaaatc aagtgtctga aaggcaacga aaagtaggca ccaaacccaa ggggcatccc
     1801 agggcagatg ctaaagcaga atcagagatg gccgaaggaa cctctacttc cggggatgca
     1861 gcccgctcct acagacacag cagatccagc tggtgcccta cctgcctccc agagcaactg
     1921 gccagtcttg ggcagcatag ctcccctctc agggtgagct gaagcagcag acctgacgcg
     1981 ctggcgcctc ctggccccca gcagtgattc ataccagtga agaaaagcag acttcggctc
     2041 catgactcag ccatgccagg tggagggtcc cagaggggct gagtcctcac ccccagctga
     2101 ggcagcagct ggagtcttca gagccaggag aacgacacca ggtctcaagc tgctgagaag
     2161 tctttccggc catgtctgga aggggtacca ccccagcacc agcaccgtcc cctcctctct
     2221 tgaagctgcc tgcacagagg ttccaagaca ctttcaaggc agagaaaata ggattacaaa
     2281 gaggaggtgc ctggcagagg gcagcaccca gctcagcctc agagctgaag gtgaagacaa
     2341 gccagcgtga aaccccgggt ctgccacgaa tgcccgctcc gctggccact caccagctgc
     2401 ctgccacaag ccactgcagc ttgagcaggg tctgtgccct ctcagcacag agcccagttc
     2461 gctgcgtggc ctttggcccc cgccagaacc ttgcaggagc cttaaggttc gggccctagc
     2521 ccagcctgac cttacctgct gtgccctgcc tgccggtcaa gtccagtccc aggagacccc
     2581 atgccttggc tcctaggctg ttccaggcac ttccctgacc tgccgggtga ttgcccagct
     2641 ggaacctcat ccacacccca gcaccaacca cctcgtgttg gtaactgctc gtgtctgcag
     2701 tctgagtagg ccatgttgag gttcctccat ctgcctggtc cattggtgtt ctgagaccag
     2761 ttccactgct gttctgacag atcccccacc ctgtgcccct gccagccccc acaggtttat
     2821 ttttgcacat aaaccatgac ccatactaat ttggctagct ctggggacta gggagaccct
     2881 ggagatctca agagtgtggc tatcccctat tttcaccaag ccttcaatat ccagccaggc
     2941 catctgccca caccatctta cctcaaagac agacatatat atatatatac atatatatga
     3001 ttttgttaat aaaactatga aattta
//
