LOCUS       NM_012502               4136 bp    mRNA    linear   ROD 13-FEB-2025
DEFINITION  Rattus norvegicus androgen receptor (Ar), mRNA.
ACCESSION   NM_012502
VERSION     NM_012502.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4136)
  AUTHORS   Karliner,J., Liu,Y. and Merry,D.E.
  TITLE     Mutant androgen receptor induces neurite loss and senescence
            independently of ARE binding in a neuronal model of SBMA
  JOURNAL   Proc Natl Acad Sci U S A 121 (29), e2321408121 (2024)
   PUBMED   38976730
  REMARK    GeneRIF: Mutant androgen receptor induces neurite loss and
            senescence independently of ARE binding in a neuronal model of
            SBMA.
REFERENCE   2  (bases 1 to 4136)
  AUTHORS   Wang,D., Zhu,Z., Fu,Y., Zhang,Q., Zhang,Y., Wang,T., Weng,Y.,
            Wen,Y., Cao,W., Tao,G. and Wang,Y.
  TITLE     Bromodomain-containing protein 4 activates androgen receptor
            transcription and promotes ovarian fibrosis in PCOS
  JOURNAL   Cell Rep 42 (9), 113090 (2023)
   PUBMED   37669164
  REMARK    GeneRIF: Bromodomain-containing protein 4 activates androgen
            receptor transcription and promotes ovarian fibrosis in PCOS.
REFERENCE   3  (bases 1 to 4136)
  AUTHORS   Zarei,F., Moazedi,A.A., Salimi,Z., Pourmotabbed,A., Yousofvand,N.,
            Farshad,M. and Akrami,M.R.
  TITLE     Activation of androgen receptors alters hippocampal synaptic
            plasticity and memory retention through modulation of L-type
            calcium channels
  JOURNAL   Life Sci 314, 121155 (2023)
   PUBMED   36379312
  REMARK    GeneRIF: Activation of androgen receptors alters hippocampal
            synaptic plasticity and memory retention through modulation of
            L-type calcium channels.
            Erratum:[Life Sci. 2023 Jul 1;324:121756. doi:
            10.1016/j.lfs.2023.121756.. PMID: 37164836]
REFERENCE   4  (bases 1 to 4136)
  AUTHORS   Wang,S., Li,X., Xu,W., Gao,J., Wang,Y., Jia,X., Li,G., Pan,Q. and
            Chen,K.
  TITLE     Amelioration of Hepatic Steatosis by the Androgen Receptor
            Inhibitor EPI-001 in Mice and Human Hepatic Cells Is Associated
            with the Inhibition of CYP2E1
  JOURNAL   Int J Mol Sci 23 (24), 16063 (2022)
   PUBMED   36555703
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4136)
  AUTHORS   Xia,T., Ma,J., Sun,Y. and Sun,Y.
  TITLE     Androgen receptor suppresses inflammatory response of airway
            epithelial cells in allergic asthma through MAPK1 and MAPK14
  JOURNAL   Hum Exp Toxicol 41, 9603271221121320 (2022)
   PUBMED   35982617
  REMARK    GeneRIF: Androgen receptor suppresses inflammatory response of
            airway epithelial cells in allergic asthma through MAPK1 and
            MAPK14.
REFERENCE   6  (bases 1 to 4136)
  AUTHORS   Jakubiczka,S., Werder,E.A. and Wieacker,P.
  TITLE     Point mutation in the steroid-binding domain of the androgen
            receptor gene in a family with complete androgen insensitivity
            syndrome (CAIS)
  JOURNAL   Hum Genet 90 (3), 311-312 (1992)
   PUBMED   1487249
REFERENCE   7  (bases 1 to 4136)
  AUTHORS   Ubaidullaev,R.U., Kamildzhanov,A.Kh., Mirzaev,Sh.M.,
            Azhriatova,N.Kh. and Madzhidov,U.A.
  TITLE     [Hygienic rationale maximum allowable concentrations of
            1,2,4-triazole in atmospheric air]
  JOURNAL   Gig Sanit (11-12), 20-22 (1992)
   PUBMED   1298681
REFERENCE   8  (bases 1 to 4136)
  AUTHORS   Saunders,P.T., Padayachi,T., Tincello,D.G., Shalet,S.M. and Wu,F.C.
  TITLE     Point mutations detected in the androgen receptor gene of three men
            with partial androgen insensitivity syndrome
  JOURNAL   Clin Endocrinol (Oxf) 37 (3), 214-220 (1992)
   PUBMED   1424203
REFERENCE   9  (bases 1 to 4136)
  AUTHORS   La Spada,A.R., Wilson,E.M., Lubahn,D.B., Harding,A.E. and
            Fischbeck,K.H.
  TITLE     Androgen receptor gene mutations in X-linked spinal and bulbar
            muscular atrophy
  JOURNAL   Nature 352 (6330), 77-79 (1991)
   PUBMED   2062380
REFERENCE   10 (bases 1 to 4136)
  AUTHORS   Bruchovsky,N. and Van Doorn,E.
  TITLE     Steroid receptor proteins and regulation of growth in mammary
            tumors
  JOURNAL   Recent Results Cancer Res (57), 121-142 (1976)
   PUBMED   1013503
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000021.1.
            
            On Nov 26, 2020 this sequence version replaced NM_012502.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M20133.1, M23264.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2557              JAXUCZ010000021.1  67135317-67137873
            2558-2709           JAXUCZ010000021.1  67234170-67234321
            2710-2826           JAXUCZ010000021.1  67270255-67270371
            2827-3114           JAXUCZ010000021.1  67290478-67290765
            3115-3259           JAXUCZ010000021.1  67298198-67298342
            3260-3390           JAXUCZ010000021.1  67302043-67302173
            3391-3548           JAXUCZ010000021.1  67303004-67303161
            3549-4136           JAXUCZ010000021.1  67303889-67304476
FEATURES             Location/Qualifiers
     source          1..4136
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq22"
     gene            1..4136
                     /gene="Ar"
                     /gene_synonym="Andr; Tfm"
                     /note="androgen receptor"
                     /db_xref="GeneID:24208"
                     /db_xref="RGD:2147"
     exon            1..2557
                     /gene="Ar"
                     /gene_synonym="Andr; Tfm"
                     /inference="alignment:Splign:2.1.0"
     CDS             996..3704
                     /gene="Ar"
                     /gene_synonym="Andr; Tfm"
                     /note="androgen receptor (Testicular feminization), same
                     as Tfm; dihydrotestosterone receptor; nuclear receptor
                     subfamily 3 group C member 4"
                     /codon_start=1
                     /product="androgen receptor"
                     /protein_id="NP_036634.2"
                     /db_xref="GeneID:24208"
                     /db_xref="RGD:2147"
                     /translation="MEVQLGLGRVYPRPPSKTYRGAFQNLFQSVREAIQNPGPRHPEA
                     ASIAPPGACLQQRQETSPRRRRRQQHPEDGSPQAHIRGTTGYLALEEEQQPSQQQSAS
                     EGHPESGCLPEPGAATAPGKGLPQQPPAPPDQDDSAAPSTLSLLGPTFPGLSSCSADI
                     KDILSEAGTMQLLQQQQQQQQQQQQQQQQQQQQQQEVISEGSSSVRAREATGAPSSSK
                     DSYLGGNSTISDSAKELCKAVSVSMGLGVEALEHLSPGEQLRGDCMYASLLGGPPAVR
                     PTPCAPLAECKGLSLDEGPGKGTEETAEYSSFKGGYAKGLEGESLGCSGSSEAGSSGT
                     LEIPSSLSLYKSGAVDEAAAYQNRDYYNFPLALSGPPHPPPPTHPHARIKLENPLDYG
                     SAWAAAAAQCRYGDLASLHGGSVAGPSTGSPPATASSSWHTLFTAEEGQLYGPGGGGG
                     SSSPSDAGPVAPYGYTRPPQGLASQEGDFSASEVWYPGGVVNRVPYPSPSCVKSEMGP
                     WMENYSGPYGDMRLDSTRDHVLPIDYYFPPQKTCLICGDEASGCHYGALTCGSCKVFF
                     KRAAEGKQKYLCASRNDCTIDKFRRKNCPSCRLRKCYEAGMTLGARKLKKLGNLKLQE
                     EGENSSAGSPTEDPSQKMTVSHIEGYECQPIFLNVLEAIEPGVVCAGHDNNQPDSFAA
                     LLSSLNELGERQLVHVVKWAKALPGFRNLHVDDQMAVIQYSWMGLMVFAMGWRSFTNV
                     NSRMLYFAPDLVFNEYRMHKSRMYSQCVRMRHLSQEFGWLQITPQEFLCMKALLLFSI
                     IPVDGLKNQKFFDELRMNYIKELDRIIACKRKNPTSCSRRFYQLTKLLDSVQPIAREL
                     HQFTFDLLIKSHMVSVDFPEMMAEIISVQVPKILSGKVKPIYFHTQ"
     exon            2558..2709
                     /gene="Ar"
                     /gene_synonym="Andr; Tfm"
                     /inference="alignment:Splign:2.1.0"
     exon            2710..2826
                     /gene="Ar"
                     /gene_synonym="Andr; Tfm"
                     /inference="alignment:Splign:2.1.0"
     exon            2827..3114
                     /gene="Ar"
                     /gene_synonym="Andr; Tfm"
                     /inference="alignment:Splign:2.1.0"
     exon            3115..3259
                     /gene="Ar"
                     /gene_synonym="Andr; Tfm"
                     /inference="alignment:Splign:2.1.0"
     exon            3260..3390
                     /gene="Ar"
                     /gene_synonym="Andr; Tfm"
                     /inference="alignment:Splign:2.1.0"
     exon            3391..3548
                     /gene="Ar"
                     /gene_synonym="Andr; Tfm"
                     /inference="alignment:Splign:2.1.0"
     exon            3549..4136
                     /gene="Ar"
                     /gene_synonym="Andr; Tfm"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atccctagga gccagcctgc tgggagaacc agagggtccg gagcaaacct ggaggctgag
       61 agggcatcag aggggaaaag actgagctag ccactccagt gccatacaga agcttaaggg
      121 acataccacg ccagccccag cccagcgaca gccaacgcct gttgcagagc ggcggcttcg
      181 aagccgccgc ccagaagctg ccctttcctc ttcggtgaag tttctaaaag ctgcgggaga
      241 ctcggaggaa gcgaagaaag tgtccggtag gactacgact gcctttgtcc tcctccctcc
      301 tacccctacc cctcctgggt cccctctccc tgagcggact aggcaggctt cctggccagc
      361 cctctcccct acaccaccag ctctgccagc cagtttgcac agaggtaact ccctttggct
      421 gaaagcagac gagcttgttg cccattggaa gggaggcttt tgggagccca gagactgagg
      481 agcaacagca cgctggagag tccctgattc caggttctcc cccctgcacc tcctactgcc
      541 cgcccctcac cctgtgtgtg cagctagaat tgaaaagatg aaaagacagt tggggcttca
      601 gtagtcgaaa gcaaaacaaa agcaaaaaga aaacaaaaag aaaatagccc agttcttatt
      661 tgcacctgct tcagtggaca ttgactttgg aaggcagaga attttccttc cccccagtca
      721 agctttgagc atcttttaat ctgttcttca agtatttagg gacaaactgt gaaactagca
      781 gggcagatcc tgtctagcgc gtgccttcct ttacaggaga ctttgaggct atctgggcgc
      841 tccccccccc ctccctgcaa gttttcttcc ctggagcttc ccgcaggtgg gcagctagct
      901 gcagatacta catcatcagt cagtagaact cttcagagca agagacgagg aggcaggata
      961 agggaattcg gtggaagcta gagacaagct aaaggatgga ggtgcagtta gggctgggaa
     1021 gggtctaccc acggcccccg tccaagacct atcgaggagc gttccagaat ctgttccaga
     1081 gcgtgcgcga agcgatccag aacccgggcc ccaggcaccc tgaggccgct agcatagcac
     1141 ctcccggtgc ctgtttacag cagcggcagg agactagccc ccggcggcgg cggcggcagc
     1201 agcaccctga ggatggctct cctcaagccc acatcagagg caccacaggc tacctggccc
     1261 tggaggagga acagcagcct tcacagcagc agtcagcctc cgagggccac cctgagagcg
     1321 gctgcctccc ggagcctgga gctgccacgg ctcctggcaa ggggctgccg cagcagccac
     1381 cagctcctcc agatcaggat gactcagctg ccccatccac gttgtcccta ctgggcccca
     1441 ctttcccagg cttaagcagc tgctccgcag acattaaaga catcctgagc gaggccggca
     1501 ccatgcaact tcttcagcag cagcagcaac agcaacagca gcagcagcag cagcagcagc
     1561 agcagcagca acagcagcag gaggtaatat ccgaaggcag cagcagcgtg agagcaaggg
     1621 aggccactgg ggctccctct tcctccaagg atagttacct agggggcaat tcgaccatat
     1681 ctgacagtgc caaggagttg tgtaaagcag tgtctgtgtc catggggttg ggtgtggaag
     1741 cactggaaca tctgagtcca ggggagcagc ttcggggcga ctgcatgtac gcgtcgctcc
     1801 tgggaggtcc acccgccgtg cgtcccactc cttgtgcgcc tctggccgaa tgcaaaggtc
     1861 tttccctgga cgaaggcccg ggcaaaggca ctgaagagac tgctgagtat tcctctttca
     1921 agggaggtta cgccaaaggg ttggaaggtg agagtctggg ctgctctggc agcagtgaag
     1981 caggtagctc tgggacactt gagatcccgt cctcactgtc tctgtataag tctggagcag
     2041 tagacgaggc agcagcatac cagaatcgcg actactacaa ctttccgctc gctctgtccg
     2101 ggccgccgca ccccccgccc cctacccatc cacacgcccg catcaagctg gagaacccgt
     2161 tggactacgg cagcgcctgg gctgcggcgg cagcgcaatg ccgctatggg gacttggcta
     2221 gcctacatgg agggagtgta gccggaccca gcactggatc gcccccagcc accgcctctt
     2281 cttcctggca tactctcttc acagctgaag aaggccaatt atatgggcca ggaggcgggg
     2341 gcggcagcag tagcccaagc gatgctgggc ctgtagcccc ctatggctac actcggcccc
     2401 ctcaggggct ggcaagccag gagggtgact tctctgcctc tgaagtgtgg tatcctggtg
     2461 gagttgtgaa cagagtcccc tatcccagtc ccagttgtgt taaaagtgaa atgggacctt
     2521 ggatggagaa ctactccgga ccttatgggg acatgcgttt ggacagtacc agggaccacg
     2581 ttttacccat cgactattac ttcccacccc agaagacctg cctgatctgt ggagatgaag
     2641 cttctggttg tcactacgga gctctcactt gtggcagctg caaggtcttc ttcaaaagag
     2701 ctgcggaagg gaaacagaag tatctatgtg ccagcagaaa tgattgcacc attgataaat
     2761 ttcggaggaa aaattgtcca tcgtgtcgtc tccggaaatg ttatgaagca gggatgactc
     2821 tgggagctcg taagctgaag aaacttggaa atctcaaact acaggaagaa ggagaaaact
     2881 ccagtgctgg tagccccact gaggacccat cccagaagat gactgtatca cacattgaag
     2941 gctatgaatg tcaacctatc tttcttaatg tcctggaagc cattgagcca ggagtggtgt
     3001 gtgccggaca tgacaacaac cagcctgatt cctttgctgc cttgttatct agtctcaacg
     3061 agcttggcga gagacagctt gtacatgtgg tcaagtgggc caaggccttg cctggcttcc
     3121 gcaacttgca tgtggatgac cagatggcag tcattcagta ttcctggatg ggactgatgg
     3181 tatttgccat gggttggcgg tccttcacta atgtcaactc taggatgctc tactttgcac
     3241 ctgacctggt tttcaatgag tatcgcatgc acaagtctcg aatgtacagc cagtgcgtga
     3301 ggatgaggca cctttctcaa gagtttggat ggctccagat aaccccccag gaattcctgt
     3361 gcatgaaagc actgctactc ttcagcatta ttccagtgga tgggctgaaa aatcaaaaat
     3421 tctttgatga acttcgaatg aactacatca aggaacttga tcgcatcatt gcatgcaaaa
     3481 gaaaaaatcc cacatcctgc tcaaggcgct tctaccagct caccaagctc ctggattctg
     3541 tgcagcctat tgcaagagag ctgcatcaat tcacttttga cctgctaatc aagtcccata
     3601 tggtgagcgt ggactttcct gaaatgatgg cagagatcat ctctgtgcaa gtgcccaaga
     3661 tcctttctgg gaaagtcaag cccatctatt tccacacaca gtgaagattt ggaaacccta
     3721 atacccaaac ccaccttgtt cccttttcag atgtcttctg cctgttatat aactctgcac
     3781 tacttctctg cagtgccttg ggggaaattc ctctactgat gtacagtctg tcatgaacat
     3841 gttccccagt tctatttcct gggcttttcc ttctttcttt ttcttcttct ctgcctctct
     3901 taccctccca tggcacattt tgaatccgct gcgtgttgtg gctcctgcct gtgttttgag
     3961 ttttgttgta tttcttcaag tctgtgatga tcttcttgtg gcccagtgtc aactgtgctt
     4021 gtttatagca ctgtgctgtg tgccaaccaa gcaaatgttt actcacctta tgccatggca
     4081 agtttagaga gctataagta tcttgggaag aaacaaacag agagagtaaa aaaacc
//
