LOCUS       NM_001100987            4888 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus aquarius intron-binding spliceosomal factor
            (Aqr), mRNA.
ACCESSION   NM_001100987 XM_001074830 XM_345418
VERSION     NM_001100987.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4888)
  AUTHORS   Bertram,K., Agafonov,D.E., Liu,W.T., Dybkov,O., Will,C.L.,
            Hartmuth,K., Urlaub,H., Kastner,B., Stark,H. and Luhrmann,R.
  TITLE     Cryo-EM structure of a human spliceosome activated for step 2 of
            splicing
  JOURNAL   Nature 542 (7641), 318-323 (2017)
   PUBMED   28076346
REFERENCE   2  (bases 1 to 4888)
  AUTHORS   Chanarat,S. and Strasser,K.
  TITLE     Splicing and beyond: the many faces of the Prp19 complex
  JOURNAL   Biochim Biophys Acta 1833 (10), 2126-2134 (2013)
   PUBMED   23742842
  REMARK    Review article
REFERENCE   3  (bases 1 to 4888)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   4  (bases 1 to 4888)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   5  (bases 1 to 4888)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   6  (bases 1 to 4888)
  AUTHORS   Jurica,M.S., Licklider,L.J., Gygi,S.R., Grigorieff,N. and
            Moore,M.J.
  TITLE     Purification and characterization of native spliceosomes suitable
            for three-dimensional structural analysis
  JOURNAL   RNA 8 (4), 426-439 (2002)
   PUBMED   11991638
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC133727.1.
            
            On or before Aug 13, 2007 this sequence version replaced
            XM_345418.3, XM_001074830.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC133727.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..4888
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q35"
     gene            1..4888
                     /gene="Aqr"
                     /note="aquarius intron-binding spliceosomal factor"
                     /db_xref="GeneID:366163"
                     /db_xref="RGD:1306223"
     exon            1..199
                     /gene="Aqr"
                     /inference="alignment:Splign:2.1.0"
     CDS             125..4579
                     /gene="Aqr"
                     /EC_number="3.6.4.13"
                     /note="intron-binding protein aquarius; aquarius homolog"
                     /codon_start=1
                     /product="RNA helicase aquarius"
                     /protein_id="NP_001094457.1"
                     /db_xref="GeneID:366163"
                     /db_xref="RGD:1306223"
                     /translation="MAAPAQPKKIVAPTVSQINAEFVTQLACKYWAPHIKKKSPFDIK
                     VIEEIYEKEIVKSRFAIRKIMLLEFSQYLENYLWMNYSPEVSSKAYLMSICCMVNEKF
                     RENVPAWETFKKKPDHFPFFFKRILKAALAETDGEFSLHEQTVLLLFLDHCFNSLEVD
                     LIRSQVQQLISLPMWMGLQPARLELELKKTPKLRKFWNLIKKNDEKMDPEAREQAYQE
                     RRFLSQLIQKFISVLKSIPLSEPVTMDKVHYCERFIELMIDLEALLPTRRWFNTILDD
                     SHLLVHCYLSSLVHREEDGHLFSQLLDMLKFYTGFEINDQTGNALTENEMTTIHYDRI
                     TSLQRAAFAHFPELYDFALSNVAEVDARDSLVKFFGPLSSNTLHQVASYLCLLPTLPK
                     NEDTTFDKEFLLELLVSRHERRISQIQQLNQMPLYPTEKIIWDENIVPTEYYSGEGCL
                     ALPKLNLQFLTLHDYLLRNFNLFRLESTYEIRQDIEDSVSRMKPWQSEYGGVVFGGWA
                     RMAQPIVAFTVVEVAKPNIGENWPTRVRADVTINLNVRDHIKDEWEGLRKHDVCFLIT
                     VRPTKPYGTKFDRRRPFIEQVGLVYVRGCEIQGMLDDKGRVIEDGPEPRPNLRGESRT
                     FRVFLDPNQYQQDMTNTIQNGAEDVYDTFNVIMRRKPKENNFKAVLETIRNLMNTDCV
                     VPDWLHDIILGYGDPSSAHYSKMPNQIATLDFNDTFLSIEHLKASFPGHNVKVTVNDP
                     ALQIPPFRITFPVRSGKGKKRKDADGEEDDTEEAKTLIVEPHVIPNRGPYPYNQPKRN
                     TIQFTHTQIEAIRAGMQPGLTMVVGPPGTGKTDVAVQIISNIYHNFPEQRTLIVTHSN
                     QALNQLFEKIMALDIDERHLLRLGHGEEELETEKDFSRYGRVNYVLARRIELLEEVKR
                     LQKSLGVPGDASYTCETAGYFFLYQVMSRWEEYMSRVKNTGSASPDAAEVATFFPFHE
                     YFANAPQPIFKGRSYEEDMEIAEGCFRHIKKIFTQLEEFRASELLRSGLDRSKYLLVK
                     EAKIIAMTCTHAALKRHDLVKLGFKYDNILMEEAAQILEIETFIPLLLQNPQDGFSRL
                     KRWIMIGDHHQLPPVIKNMAFQKYSNMEQSLFTRFVRVGVPTVDLDAQGRARASLCNL
                     YNWRYKNLGNLPHVQLLPEFSTANAGLLYDFQLINVEDFQGVGESEPNPYFYQNLGEA
                     EYVVALFMYMCLLGYPADKISILTTYNGQKHLIRDIINRRCGNNPLIGRPNKVTTVDR
                     FQGQQNDYILLSLVRTRAVGHLRDVRRLVVAMSRARLGLYIFARVSLFQNCFELTPAF
                     SQLTARPLHLHIIPTEPFPTSRKNGERPPHEVQVIKNMPQMANFVYNMYMHLIQTTHH
                     YHQTFLQLPPAMVEEGEEVQSQETEMEAEEETGSVQANLTPSPTDASLSQETPTSQPD
                     CSNQTEAASSHTEDTSALCDITTAAEPVSAAAEAATPQDGPSVPAETK"
     exon            200..256
                     /gene="Aqr"
                     /inference="alignment:Splign:2.1.0"
     exon            257..297
                     /gene="Aqr"
                     /inference="alignment:Splign:2.1.0"
     exon            298..333
                     /gene="Aqr"
                     /inference="alignment:Splign:2.1.0"
     exon            334..454
                     /gene="Aqr"
                     /inference="alignment:Splign:2.1.0"
     exon            455..595
                     /gene="Aqr"
                     /inference="alignment:Splign:2.1.0"
     exon            596..664
                     /gene="Aqr"
                     /inference="alignment:Splign:2.1.0"
     exon            665..765
                     /gene="Aqr"
                     /inference="alignment:Splign:2.1.0"
     exon            766..842
                     /gene="Aqr"
                     /inference="alignment:Splign:2.1.0"
     exon            843..907
                     /gene="Aqr"
                     /inference="alignment:Splign:2.1.0"
     exon            908..1024
                     /gene="Aqr"
                     /inference="alignment:Splign:2.1.0"
     exon            1025..1138
                     /gene="Aqr"
                     /inference="alignment:Splign:2.1.0"
     exon            1139..1242
                     /gene="Aqr"
                     /inference="alignment:Splign:2.1.0"
     exon            1243..1345
                     /gene="Aqr"
                     /inference="alignment:Splign:2.1.0"
     exon            1346..1466
                     /gene="Aqr"
                     /inference="alignment:Splign:2.1.0"
     exon            1467..1608
                     /gene="Aqr"
                     /inference="alignment:Splign:2.1.0"
     exon            1609..1787
                     /gene="Aqr"
                     /inference="alignment:Splign:2.1.0"
     exon            1788..1955
                     /gene="Aqr"
                     /inference="alignment:Splign:2.1.0"
     exon            1956..2125
                     /gene="Aqr"
                     /inference="alignment:Splign:2.1.0"
     exon            2126..2367
                     /gene="Aqr"
                     /inference="alignment:Splign:2.1.0"
     exon            2368..2514
                     /gene="Aqr"
                     /inference="alignment:Splign:2.1.0"
     exon            2515..2584
                     /gene="Aqr"
                     /inference="alignment:Splign:2.1.0"
     exon            2585..2695
                     /gene="Aqr"
                     /inference="alignment:Splign:2.1.0"
     exon            2696..2805
                     /gene="Aqr"
                     /inference="alignment:Splign:2.1.0"
     exon            2806..2941
                     /gene="Aqr"
                     /inference="alignment:Splign:2.1.0"
     exon            2942..3151
                     /gene="Aqr"
                     /inference="alignment:Splign:2.1.0"
     exon            3152..3289
                     /gene="Aqr"
                     /inference="alignment:Splign:2.1.0"
     exon            3290..3361
                     /gene="Aqr"
                     /inference="alignment:Splign:2.1.0"
     exon            3362..3549
                     /gene="Aqr"
                     /inference="alignment:Splign:2.1.0"
     exon            3550..3721
                     /gene="Aqr"
                     /inference="alignment:Splign:2.1.0"
     exon            3722..3892
                     /gene="Aqr"
                     /inference="alignment:Splign:2.1.0"
     exon            3893..3978
                     /gene="Aqr"
                     /inference="alignment:Splign:2.1.0"
     exon            3979..4153
                     /gene="Aqr"
                     /inference="alignment:Splign:2.1.0"
     exon            4154..4267
                     /gene="Aqr"
                     /inference="alignment:Splign:2.1.0"
     exon            4268..4841
                     /gene="Aqr"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgagaactta ggctcccttg tgcccggcgc tgtggcaccc tggcggtagc ttgcagccgc
       61 tgcctgaaag ctttggagaa tcgccgctac gagcctctgg tctgcttcgg aggtgaccgc
      121 tgcgatggcg gctcctgcgc agcccaagaa aatcgtggcc cccaccgtgt cccagatcaa
      181 cgcagagttc gtcacccagc tggcatgtaa atactgggct cctcatatca agaagaaatc
      241 accttttgat ataaaagtga tagaagaaat atatgaaaaa gagatcgtca aatcacggtt
      301 tgccatcaga aaaataatgc tgctggaatt tagccaatat cttgaaaatt atctttggat
      361 gaattattcg ccagaagttt ccagcaaagc ctatttaatg tccatctgct gtatggtgaa
      421 tgagaagttc agagaaaatg tcccagcctg ggagaccttt aagaagaagc cagaccactt
      481 ccccttcttc tttaaacgca tcttgaaagc agcactagct gagactgatg gcgagttctc
      541 cctccacgag cagaccgtgc tcctgctttt cctggatcat tgcttcaata gcttggaagt
      601 agacttgata aggagtcaag tacagcagct tatctccctt cctatgtgga tgggcttgca
      661 gccggcacga ttggaattag aattaaaaaa gacaccaaag ctaaggaaat tctggaactt
      721 gattaaaaag aatgatgaaa agatggaccc agaagcaaga gagcaggcct accaagaaag
      781 gaggtttctt tcccagctca tccagaagtt catctccgtg ttgaagtcca tcccactttc
      841 tgagcctgtc actatggaca aagttcatta ctgtgaaaga ttcatcgaac ttatgattga
      901 tctagaggct ctgctcccca caaggcgctg gttcaacacc atcctggatg actcccacct
      961 cttggtgcac tgttaccttt ccagtcttgt ccacagggaa gaggatggcc atctgttttc
     1021 ccagctatta gacatgctga agttctatac gggctttgaa attaacgacc agactggaaa
     1081 tgccctgaca gagaacgaga tgaccacgat tcactatgac agaatcacat ctctgcagag
     1141 agctgcgttc gcgcatttcc ctgagctcta tgactttgcc ctctccaatg tggcagaagt
     1201 agatgcccgg gattccttgg tcaagttttt tgggcctctc agttcaaaca cactccacca
     1261 ggtggcatca tacctctgcc tcttgccaac gctccctaaa aatgaagata caacttttga
     1321 taaagagttt cttctagaat tgctggtgtc tcgccatgaa cgccgcatct ctcagattca
     1381 gcagttgaat cagatgcctt tgtatcctac tgagaaaatt atctgggatg aaaacatcgt
     1441 ccctaccgag tactattctg gggaaggctg tcttgctctc cccaagttga atttgcagtt
     1501 tttaactcta catgactatc tcctgaggaa ctttaatctc ttccgcttag aatcaactta
     1561 tgaaattaga caagacattg aggacagcgt cagcagaatg aagccatggc aatctgagta
     1621 tggcggtgtc gtgtttggtg gttgggcacg aatggctcag cccattgtgg ctttcactgt
     1681 agtcgaggtt gccaaaccca acattggtga aaactggcca acccgagttc gtgcagatgt
     1741 caccatcaat ctgaatgtca gagaccacat caaggatgag tgggaaggtc ttcgcaaaca
     1801 cgatgtatgc tttttaatta ctgtgcgtcc cacaaaacct tacggcacta agtttgacag
     1861 gaggaggcct tttattgagc aagttggtct ggtgtacgtc agaggctgtg agatccaggg
     1921 catgctggac gacaaagggc gagtcatcga agacggacct gaacccagac ccaatcttag
     1981 aggagagtca aggacatttc gagtattttt ggatccaaac cagtatcaac aggatatgac
     2041 caatactata caaaatggag ccgaagatgt gtacgacact ttcaatgtca taatgaggag
     2101 gaaaccaaag gagaataact tcaaggccgt gttggagact attcgaaatc tgatgaatac
     2161 cgactgcgtg gtcccagact ggctgcatga catcatttta ggttatgggg acccaagtag
     2221 tgcccattat tccaaaatgc ccaatcagat tgctacgttg gatttcaatg acacttttct
     2281 ctccattgaa catttgaaag ccagttttcc tggtcataat gtcaaagtga ccgtgaatga
     2341 cccagctcta caaatacccc ctttcagaat aactttccca gtaagaagtg gaaaggggaa
     2401 gaaaagaaaa gatgcagatg gggaagaaga cgacacggaa gaagcaaaga ccttaattgt
     2461 ggaacctcac gttattccta atagaggtcc ttatccttac aaccagccca aacgtaatac
     2521 aatccagttc actcatacac agatagaggc catccgggcc ggaatgcagc ctggactgac
     2581 tatggttgtg ggaccacctg gtacaggaaa aacagatgtt gcagtccaga tcatttccaa
     2641 catctaccac aattttccag aacagaggac tttaattgtt actcattcca atcaggctct
     2701 gaaccagttg tttgagaaaa tcatggcttt agacattgat gagcgccatc tcctgcgtct
     2761 gggtcatgga gaggaagagc tagagacgga gaaagacttt agcaggtatg gaagagttaa
     2821 ttatgtcctg gctcgaagaa tagaactttt agaagaagtc aaacgattac aaaagagtct
     2881 gggggttccg ggagatgctt cgtatacctg tgaaactgca ggctatttct tcttatatca
     2941 ggtaatgtcg cgttgggaag aatacatgag cagagtgaag aacacaggga gcgccagccc
     3001 agatgctgcg gaggtcgcca cgttcttccc cttccatgag tattttgcca atgctcctca
     3061 gcccatcttt aaaggcagat cttatgaaga agacatggaa atcgcagaag ggtgcttcag
     3121 gcatattaag aaaatcttca ctcagcttga ggaattcaga gcttcagaac tgcttcgcag
     3181 tggactggac aggtctaaat acctcttggt gaaagaagcc aaaatcattg ctatgacgtg
     3241 tactcatgct gccttgaaac gacatgactt ggtcaagttg ggtttcaagt atgacaacat
     3301 tttaatggaa gaggctgctc agattctgga gatagaaacc tttatcccac tacttctgca
     3361 gaatcctcaa gacggattca gccgattgaa acgatggatt atgattggtg atcaccacca
     3421 attgcctcca gtcattaaga acatggcctt tcagaagtat tccaatatgg agcagtctct
     3481 ttttactcgc tttgtccggg ttggagttcc tactgtggac cttgatgctc aagggagagc
     3541 ccgggccagc ttgtgtaacc tctacaactg gcgttacaaa aacctaggga acttgccaca
     3601 cgtgcagctc ctgccagagt tcagcacagc caacgcaggc ctgctgtacg acttccagct
     3661 catcaatgtg gaagacttcc agggagtggg agagtcggag cctaaccctt acttctacca
     3721 gaacctcgga gaggcagagt acgtagtagc gctcttcatg tacatgtgct tgcttggcta
     3781 ccctgcggac aagatcagca ttctgacgac ctacaatgga cagaagcacc tgatccggga
     3841 catcatcaat aggcgctgtg ggaataatcc actcattggg aggccgaaca aggtgacaac
     3901 tgttgatagg ttccaaggtc aacagaatga ctacatcctc ctttctctag tgcggaccag
     3961 ggccgtgggc catttgaggg atgtgcgccg cttggtggta gccatgtcga gagccaggct
     4021 tggcctgtat atcttcgcta gagtatccct cttccaaaat tgctttgaac tgactcctgc
     4081 tttcagccag ctcactgccc gcccactgca tttgcatatt attccaacag aacctttccc
     4141 aacctccaga aagaatggag agagacctcc tcatgaagta caggtaataa agaacatgcc
     4201 ccagatggcg aattttgtgt acaatatgta catgcatttg atacagacga cccaccatta
     4261 tcatcagact ttcttacaac taccgcctgc catggtggaa gaaggtgagg aggttcagag
     4321 ccaagaaaca gaaatggaag cagaagagga aactgggtct gttcaagcta acctcacacc
     4381 cagtccaacg gatgccagcc tgagtcaaga gaccccaact tctcagcctg actgctccaa
     4441 tcagacggag gctgcctcca gtcacacaga agatacctct gctctgtgtg acattactac
     4501 tgcagccgag cctgtctctg cagcggcaga agctgccacc ccacaagatg ggccttctgt
     4561 tcccgcagag accaagtagc ctatctggag cacagcctgg gacattccat ttataaagtc
     4621 taagtgaggt taccttttgg atttcatact cactgtacgg ctttaatgac accagctaat
     4681 gttcagtcct tatgtttatt agctggtttc cttgttttgt atatttttta tttataaata
     4741 taaaaacaac tctagtttca tttgtttatt ccgaagagaa actaatttga ctgctgactg
     4801 catctgaggt aatacctgca ttaaaattgt tttctatgga aaaaaaaaaa aaaaaaaaaa
     4861 aaaaaaaaaa aaaaaaaaaa aaaaaaaa
//
