LOCUS       NM_022960               1740 bp    mRNA    linear   ROD 05-DEC-2024
DEFINITION  Rattus norvegicus aquaporin 9 (Aqp9), mRNA.
ACCESSION   NM_022960
VERSION     NM_022960.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1740)
  AUTHORS   Wu,J., Wang,C. and Ding,H.
  TITLE     LncRNA MALAT1 promotes neuropathic pain progression through the
            miR-154-5p/AQP9 axis in CCI rat models
  JOURNAL   Mol Med Rep 21 (1), 291-303 (2020)
   PUBMED   31746418
  REMARK    GeneRIF: LncRNA MALAT1 promotes neuropathic pain progression
            through the miR1545p/AQP9 axis in CCI rat models.
REFERENCE   2  (bases 1 to 1740)
  AUTHORS   Huang,X., Yu,X., Li,H., Han,L. and Yang,X.
  TITLE     Regulation mechanism of aquaporin 9 gene on inflammatory response
            and cardiac function in rats with myocardial infarction through
            extracellular signal-regulated kinase1/2 pathway
  JOURNAL   Heart Vessels 34 (12), 2041-2051 (2019)
   PUBMED   31218464
  REMARK    GeneRIF: the combination of AQP9 gene knock-down and U0126 showed
            no further effect. Silencing AQP9 gene can inhibit the activation
            of ERK1/2 signaling pathway, attenuate the inflammatory response in
            rats with MI, inhibit apoptosis of myocardial cells, and improve
            cardiac function
REFERENCE   3  (bases 1 to 1740)
  AUTHORS   de Mello Santos,T., Cavariani,M.M., Pereira,D.N., Schimming,B.C.,
            Chuffa,L.G.A. and Domeniconi,R.F.
  TITLE     Maternal Protein Restriction Modulates Angiogenesis and AQP9
            Expression Leading to a Delay in Postnatal Epididymal Development
            in Rat
  JOURNAL   Cells 8 (9), 1094 (2019)
   PUBMED   31533210
  REMARK    GeneRIF: The maternal low-protein diet decreased AQP9 and VEGFr-2
            expression, decreased epididymal microvascularity and altered the
            morphometric features of the epididymal epithelium.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1740)
  AUTHORS   Liu,J.Y., Chen,X.X., Chen,H.Y., Shi,J., Leung,G.P., Tang,S.C.,
            Lao,L.X., Yip,H.K., Lee,K.F., Sze,S.C., Zhang,Z.J. and Zhang,K.Y.
  TITLE     Downregulation of Aquaporin 9 Exacerbates Beta-amyloid-induced
            Neurotoxicity in Alzheimer's Disease Models In vitro and In vivo
  JOURNAL   Neuroscience 394, 72-82 (2018)
   PUBMED   30266683
  REMARK    GeneRIF: Downregulation of aquaporin 9 exacerbates
            beta-amyloid-induced neurotoxicity in Alzheimer's disease models in
            vitro and in vivo.
REFERENCE   5  (bases 1 to 1740)
  AUTHORS   Gotfryd,K., Mosca,A.F., Missel,J.W., Truelsen,S.F., Wang,K.,
            Spulber,M., Krabbe,S., Helix-Nielsen,C., Laforenza,U., Soveral,G.,
            Pedersen,P.A. and Gourdon,P.
  TITLE     Human adipose glycerol flux is regulated by a pH gate in AQP10
  JOURNAL   Nat Commun 9 (1), 4749 (2018)
   PUBMED   30420639
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1740)
  AUTHORS   Kuriyama,H., Kawamoto,S., Ishida,N., Ohno,I., Mita,S.,
            Matsuzawa,Y., Matsubara,K. and Okubo,K.
  TITLE     Molecular cloning and expression of a novel human aquaporin from
            adipose tissue with glycerol permeability
  JOURNAL   Biochem Biophys Res Commun 241 (1), 53-58 (1997)
   PUBMED   9405233
REFERENCE   7  (bases 1 to 1740)
  AUTHORS   Kuwahara,M., Gu,Y., Ishibashi,K., Marumo,F. and Sasaki,S.
  TITLE     Mercury-sensitive residues and pore site in AQP3 water channel
  JOURNAL   Biochemistry 36 (46), 13973-13978 (1997)
   PUBMED   9369468
REFERENCE   8  (bases 1 to 1740)
  AUTHORS   Raina,S., Preston,G.M., Guggino,W.B. and Agre,P.
  TITLE     Molecular cloning and characterization of an aquaporin cDNA from
            salivary, lacrimal, and respiratory tissues
  JOURNAL   J Biol Chem 270 (4), 1908-1912 (1995)
   PUBMED   7530250
REFERENCE   9  (bases 1 to 1740)
  AUTHORS   Zeidel,M.L., Ambudkar,S.V., Smith,B.L. and Agre,P.
  TITLE     Reconstitution of functional water channels in liposomes containing
            purified red cell CHIP28 protein
  JOURNAL   Biochemistry 31 (33), 7436-7440 (1992)
   PUBMED   1510932
REFERENCE   10 (bases 1 to 1740)
  AUTHORS   Preston,G.M., Carroll,T.P., Guggino,W.B. and Agre,P.
  TITLE     Appearance of water channels in Xenopus oocytes expressing red cell
            CHIP28 protein
  JOURNAL   Science 256 (5055), 385-387 (1992)
   PUBMED   1373524
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC085731.1.
            
            On Nov 15, 2004 this sequence version replaced NM_022960.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC085731.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5756307,
                                           SAMEA5760383 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1740
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q24"
     gene            1..1740
                     /gene="Aqp9"
                     /note="aquaporin 9"
                     /db_xref="GeneID:65054"
                     /db_xref="RGD:68433"
     exon            1..25
                     /gene="Aqp9"
                     /inference="alignment:Splign:2.1.0"
     exon            26..182
                     /gene="Aqp9"
                     /inference="alignment:Splign:2.1.0"
     exon            183..224
                     /gene="Aqp9"
                     /inference="alignment:Splign:2.1.0"
     exon            225..400
                     /gene="Aqp9"
                     /inference="alignment:Splign:2.1.0"
     exon            401..574
                     /gene="Aqp9"
                     /inference="alignment:Splign:2.1.0"
     CDS             464..1351
                     /gene="Aqp9"
                     /note="AQP-9; aquaglyceroporin-9; neutral solute channel
                     aquaporin 9"
                     /codon_start=1
                     /product="aquaporin-9"
                     /protein_id="NP_075249.1"
                     /db_xref="GeneID:65054"
                     /db_xref="RGD:68433"
                     /translation="MPSEKDGAKKSLMQRLALKSRIAKETLSEFLGTFIMIVLGCSSI
                     AQAVLSRERFGGIITINIGFASAVVMALYVTFGISGGHINPAVSFAMCAFGRMEWFKF
                     PFYVGAQFLGAFVGAATVFGIYYDGLMAFAGGKLLVVGENATAFIFATYPAPFISTPG
                     AFVDQVVSTMFLLLIVFAMFDSRNLGVPRGLEPVVIGLLIIVLSCSLGLNSGCAMNPA
                     RDLSPRLFTALAGWGFEVFTVGNNFWWIPVVGPMIGAFLGGLIYILFIQMHHSKLDPD
                     MKAEPSENNLEKHELSVIM"
     exon            575..701
                     /gene="Aqp9"
                     /inference="alignment:Splign:2.1.0"
     exon            702..839
                     /gene="Aqp9"
                     /inference="alignment:Splign:2.1.0"
     exon            840..958
                     /gene="Aqp9"
                     /inference="alignment:Splign:2.1.0"
     exon            959..1176
                     /gene="Aqp9"
                     /inference="alignment:Splign:2.1.0"
     exon            1177..1718
                     /gene="Aqp9"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cttaggaagt ccccacagtt gcctggggaa gtcaatacaa ttatatgagt ttccctcata
       61 tcatccagct gtctgaggag agaagacttg aggaaaaacc catggccaag cgtacccaga
      121 gttgggcttg ggtatcaagg gtatagacaa gagccagcag gtcagtggaa ctcaagatgc
      181 agcctgcctc ctcagctgga aatgattgag gacctcctgc aaaggagaaa acaaatcatc
      241 agaaggctgg aattgtgtaa cacgaaaatc tcttctggac cgaggcccat ctctggtttg
      301 gcaacacaac caaagcagca tctcttttct catctcctgg gaaaaaaaaa aaaaaaagaa
      361 aggcaacaga gaaaaagtag ccagagacca gagaataaag tgaaggcagg gaaccgagca
      421 agcagacctt ggtggaaagt gtacctctgg cagaaacccc aagatgcctt ctgagaagga
      481 cggtgccaag aagagcctca tgcagaggct ggccctgaag agccggatag cgaaggagac
      541 actctccgag ttcctgggca cctttataat gattgtcctt ggatgtagct ctattgccca
      601 agcggtcctc agtcgagaac gttttggcgg gatcatcact atcaatattg gatttgcatc
      661 ggcagtcgtg atggctctct atgtgacatt tggtatctct gggggccaca tcaacccagc
      721 tgtgtctttt gcaatgtgcg cctttggaag gatggagtgg ttcaagttcc cattttatgt
      781 gggagcccag tttttgggag cctttgttgg ggctgcaacg gtctttggca tttattatga
      841 tggactcatg gcctttgctg gcggaaaact gctcgtcgta ggagaaaatg caacagcatt
      901 catttttgca acatatccag ctccattcat atccacgcca ggtgcctttg tagaccaagt
      961 ggtgtctacc atgttcctcc ttctgatcgt ctttgccatg tttgactcca gaaacctggg
     1021 tgtccccaga ggcctggagc ctgttgtcat tggcctcctg atcattgtcc tttcctgttc
     1081 tctcggactc aactctggct gtgccatgaa cccagctcga gacctcagtc ccaggctctt
     1141 cactgcactg gcaggatggg ggtttgaggt cttcacagtt ggaaataact tctggtggat
     1201 acctgtcgtg ggtcctatga ttggtgcttt cctgggaggt cttatctaca ttctttttat
     1261 ccaaatgcat cactcgaagc tcgacccaga catgaaggca gagccatctg agaacaacct
     1321 agagaaacac gagctcagtg tcatcatgta gtgggatggc cagatctgca gttaccgttc
     1381 atccagttct ttcttcagag aagatgtcac ctgtgtgcct atgcagactt ggggcggggg
     1441 aatctacctg tctgctagtt ttctctagcc aactgggaca aaaaaattac aaaggcatcc
     1501 gtggaaaact ccaccagtca cccctcccca gaatagcact gactgtttat gatgggtatt
     1561 tgatggaagt ccttactcct aggtgattgc taagaatttt gaaacttgac catgtgcttg
     1621 gctggatagc ctcagagacc tttttttacc ctgtatgaaa ttgtgtcatc aaaggctctg
     1681 tcttcacaat ctataaatac aacattctaa aactgaaaaa aaaaaaaaaa aaaaaaaaaa
//
