LOCUS       NM_019158               1568 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus aquaporin 8 (Aqp8), mRNA.
ACCESSION   NM_019158 XM_346559 XM_347356
VERSION     NM_019158.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1568)
  AUTHORS   Kruger,C., Waldeck-Weiermair,M., Kaynert,J., Pokrant,T.,
            Komaragiri,Y., Otto,O., Michel,T. and Elsner,M.
  TITLE     AQP8 is a crucial H2O2 transporter in insulin-producing RINm5F
            cells
  JOURNAL   Redox Biol 43, 101962 (2021)
   PUBMED   33892285
  REMARK    GeneRIF: AQP8 is a crucial H2O2 transporter in insulin-producing
            RINm5F cells.
REFERENCE   2  (bases 1 to 1568)
  AUTHORS   Vilchis-Landeros,M., Guinzberg,R., Riveros-Rosas,H.,
            Villalobos-Molina,R. and Pina,E.
  TITLE     Aquaporin 8 is involved in H2 O2 -mediated differential regulation
            of metabolic signaling by alpha1 - and beta-adrenoceptors in
            hepatocytes
  JOURNAL   FEBS Lett 594 (10), 1564-1576 (2020)
   PUBMED   32115689
  REMARK    GeneRIF: Aquaporin 8 is involved in H2 O2 -mediated differential
            regulation of metabolic signaling by alpha1 - and
            beta-adrenoceptors in hepatocytes.
REFERENCE   3  (bases 1 to 1568)
  AUTHORS   Danielli,M., Marrone,J., Capiglioni,A.M. and Marinelli,R.A.
  TITLE     Data of H2O2 release from AQP8-knockdown rat hepatocyte
            mitochondria
  JOURNAL   Data Brief 23, 103722 (2019)
   PUBMED   31372390
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1568)
  AUTHORS   Danielli,M., Marrone,J., Capiglioni,A.M. and Marinelli,R.A.
  TITLE     Mitochondrial aquaporin-8 is involved in SREBP-controlled
            hepatocyte cholesterol biosynthesis
  JOURNAL   Free Radic Biol Med 131, 370-375 (2019)
   PUBMED   30579780
  REMARK    GeneRIF: Mitochondrial AQP8 is involved in SREBP2-controlled
            hepatocyte cholesterol biosynthesis.
REFERENCE   5  (bases 1 to 1568)
  AUTHORS   Chao,G. and Zhang,S.
  TITLE     Aquaporins 1, 3 and 8 expression in irritable bowel syndrome rats'
            colon via NF-kappaB pathway
  JOURNAL   Oncotarget 8 (29), 47175-47183 (2017)
   PUBMED   28525373
  REMARK    GeneRIF: liquid water metabolic abnormalities and intestine
            permeability might be the mechanism of IBS by regulating AQP1, AQP3
            and AQP8 via NF-kappaB pathway.
REFERENCE   6  (bases 1 to 1568)
  AUTHORS   Kuwahara,M., Gu,Y., Ishibashi,K., Marumo,F. and Sasaki,S.
  TITLE     Mercury-sensitive residues and pore site in AQP3 water channel
  JOURNAL   Biochemistry 36 (46), 13973-13978 (1997)
   PUBMED   9369468
REFERENCE   7  (bases 1 to 1568)
  AUTHORS   Ishibashi,K., Kuwahara,M., Kageyama,Y., Tohsaka,A., Marumo,F. and
            Sasaki,S.
  TITLE     Cloning and functional expression of a second new aquaporin
            abundantly expressed in testis
  JOURNAL   Biochem Biophys Res Commun 237 (3), 714-718 (1997)
   PUBMED   9299432
REFERENCE   8  (bases 1 to 1568)
  AUTHORS   Raina,S., Preston,G.M., Guggino,W.B. and Agre,P.
  TITLE     Molecular cloning and characterization of an aquaporin cDNA from
            salivary, lacrimal, and respiratory tissues
  JOURNAL   J Biol Chem 270 (4), 1908-1912 (1995)
   PUBMED   7530250
REFERENCE   9  (bases 1 to 1568)
  AUTHORS   Zeidel,M.L., Ambudkar,S.V., Smith,B.L. and Agre,P.
  TITLE     Reconstitution of functional water channels in liposomes containing
            purified red cell CHIP28 protein
  JOURNAL   Biochemistry 31 (33), 7436-7440 (1992)
   PUBMED   1510932
REFERENCE   10 (bases 1 to 1568)
  AUTHORS   Preston,G.M., Carroll,T.P., Guggino,W.B. and Agre,P.
  TITLE     Appearance of water channels in Xenopus oocytes expressing red cell
            CHIP28 protein
  JOURNAL   Science 256 (5055), 385-387 (1992)
   PUBMED   1373524
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC081812.1.
            
            On Sep 16, 2004 this sequence version replaced NM_019158.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC081812.1, AF007775.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760383
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1568
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q36"
     gene            1..1568
                     /gene="Aqp8"
                     /gene_synonym="AQP-8"
                     /note="aquaporin 8"
                     /db_xref="GeneID:29172"
                     /db_xref="RGD:2146"
     exon            1..134
                     /gene="Aqp8"
                     /gene_synonym="AQP-8"
                     /inference="alignment:Splign:2.1.0"
     CDS             123..914
                     /gene="Aqp8"
                     /gene_synonym="AQP-8"
                     /codon_start=1
                     /product="aquaporin-8"
                     /protein_id="NP_062031.1"
                     /db_xref="GeneID:29172"
                     /db_xref="RGD:2146"
                     /translation="MSGEQTPMCSMDLREIKGKETNMADSYHGMSWYEQYIQPCVVEL
                     LGSALFIFIGCLSVIENSPNTGLLQPALAHGLALGLIIATLGNISGGHFNPAVSLAVT
                     LVGGLKTMLLIPYWVSQLFGGMIGAALAKVVSPEERFWNASGAAFAIVQEQEQVAEAL
                     GVEIVMTMLLVLAVCMGAVNEKTMGPLAPFSIGFSVIVDILAGGGISGACMNPARAFG
                     PAVMAGYWDFHWIYWLGPLLAGLFVGLLIRLFIGDEKTRLILKSR"
     exon            135..388
                     /gene="Aqp8"
                     /gene_synonym="AQP-8"
                     /inference="alignment:Splign:2.1.0"
     exon            389..515
                     /gene="Aqp8"
                     /gene_synonym="AQP-8"
                     /inference="alignment:Splign:2.1.0"
     exon            516..730
                     /gene="Aqp8"
                     /gene_synonym="AQP-8"
                     /inference="alignment:Splign:2.1.0"
     exon            731..865
                     /gene="Aqp8"
                     /gene_synonym="AQP-8"
                     /inference="alignment:Splign:2.1.0"
     exon            866..1463
                     /gene="Aqp8"
                     /gene_synonym="AQP-8"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgtccccagt cctttaaaag cgcagagtct agcggaccag tctgagttct ggagttaagt
       61 gagcacatct ccttcagctg gtgcagctcc tggagctctg actcccacct tccggagcag
      121 atatgtctgg ggagcagacg ccgatgtgta gtatggacct acgtgagatc aaggggaagg
      181 agaccaacat ggctgacagt taccatggca tgtcctggta tgagcagtac atacaaccgt
      241 gtgtggtgga acttttgggc tccgctctct tcatcttcat tgggtgtcta tcggtcatcg
      301 agaacagtcc aaatactggg ctcctgcagc ctgccctggc tcatgggctg gccttggggc
      361 tcatcattgc taccttgggg aacatcagcg gtggacactt caaccctgct gtgtcgctgg
      421 cagtcacact ggttggaggc ctcaagacca tgctgctaat tccctactgg gtctcccagc
      481 tgtttggggg aatgatcgga gctgccctgg ctaaggtggt gagtccagag gaaaggttct
      541 ggaatgcgtc tggggcagcc tttgccatag tccaggagca ggagcaggtg gcagaagccc
      601 tgggggtaga gatcgttatg acgatgctgt tggtattggc tgtgtgtatg ggtgccgtca
      661 atgagaagac aatgggtccc ctagccccat tctccattgg tttctctgtc attgtggata
      721 tcctggcagg tggtgggatc tctggagcct gcatgaaccc tgctcgtgcc tttggacctg
      781 ctgtgatggc tggctactgg gacttccatt ggatctactg gctgggccca ctcctggctg
      841 gcctctttgt gggactgctc attaggctct tcattggaga tgagaaaacc cgcctgattc
      901 taaagtcgag gtgaagaact gctggcagca tccccactgc ctggagtcct cagctgtttg
      961 tcctgagttg aggacaggac aattccatta ttttctgcag gacctgagct cagaggagcc
     1021 actctgacag cagcagacct tggcctggct tcccaggcag gcaggcagct gctgctgtcc
     1081 tgagcatgct cctggaacct ggaactcctt tgtgcccatg gactgggctt ggggcccagc
     1141 ctaaagacat gtagagacca catagaaaag gaggacaggt ctctgttctt gagaaagggc
     1201 agggcatggg agagccgagc aggtggagca tgcagttgct aatgcacact gttcattttt
     1261 ccagccctct ttctttttta ctgtgttggg tttggaaccc agtccatgcg tactaggtga
     1321 gcactttgct acggagcctc ctgttctccc caccctcttt cctcttggtt acactgttac
     1381 agaagggctt tcaggagccc aaagatctcc ttgcctcccc agctgccaat ctgactttgt
     1441 aataaatggc ttagtgtttc ctgaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     1501 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     1561 aaaaaaaa
//
