LOCUS       NM_019157               1267 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus aquaporin 7 (Aqp7), mRNA.
ACCESSION   NM_019157
VERSION     NM_019157.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1267)
  AUTHORS   Fruhbeck,G., Mendez-Gimenez,L., Becerril,S., Ramirez,B.,
            Hernandez-Pardos,A.W., Cienfuegos,J.A., Valenti,V., Moncada,R.,
            Catalan,V., Gomez-Ambrosi,J., da Silva,I.V., Soveral,G. and
            Rodriguez,A.
  TITLE     Increased Aquaporin-7 Expression Is Associated with Changes in Rat
            Brown Adipose Tissue Whitening in Obesity: Impact of Cold Exposure
            and Bariatric Surgery
  JOURNAL   Int J Mol Sci 24 (4), 3412 (2023)
   PUBMED   36834823
  REMARK    GeneRIF: Increased Aquaporin-7 Expression Is Associated with
            Changes in Rat Brown Adipose Tissue Whitening in Obesity: Impact of
            Cold Exposure and Bariatric Surgery.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1267)
  AUTHORS   Aggeli,I.K., Kapogiannatou,A., Paraskevopoulou,F. and Gaitanaki,C.
  TITLE     Differential response of cardiac aquaporins to hyperosmotic stress;
            salutary role of AQP1 against the induced apoptosis
  JOURNAL   Eur Rev Med Pharmacol Sci 25 (1), 313-325 (2021)
   PUBMED   33506920
  REMARK    GeneRIF: Differential response of cardiac aquaporins to
            hyperosmotic stress; salutary role of AQP1 against the induced
            apoptosis.
REFERENCE   3  (bases 1 to 1267)
  AUTHORS   da Silva,I.V., Cardoso,C., Mendez-Gimenez,L., Camoes,S.P.,
            Fruhbeck,G., Rodriguez,A., Miranda,J.P. and Soveral,G.
  TITLE     Aquaporin-7 and aquaporin-12 modulate the inflammatory phenotype of
            endocrine pancreatic beta-cells
  JOURNAL   Arch Biochem Biophys 691, 108481 (2020)
   PUBMED   32735865
  REMARK    GeneRIF: Aquaporin-7 and aquaporin-12 modulate the inflammatory
            phenotype of endocrine pancreatic beta-cells.
REFERENCE   4  (bases 1 to 1267)
  AUTHORS   Gotfryd,K., Mosca,A.F., Missel,J.W., Truelsen,S.F., Wang,K.,
            Spulber,M., Krabbe,S., Helix-Nielsen,C., Laforenza,U., Soveral,G.,
            Pedersen,P.A. and Gourdon,P.
  TITLE     Human adipose glycerol flux is regulated by a pH gate in AQP10
  JOURNAL   Nat Commun 9 (1), 4749 (2018)
   PUBMED   30420639
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1267)
  AUTHORS   Lebeck,J., Sondergaard,E. and Nielsen,S.
  TITLE     Increased AQP7 abundance in skeletal muscle from obese men with
            type 2 diabetes
  JOURNAL   Am J Physiol Endocrinol Metab 315 (3), E367-E373 (2018)
   PUBMED   29783856
REFERENCE   6  (bases 1 to 1267)
  AUTHORS   Kuwahara,M., Gu,Y., Ishibashi,K., Marumo,F. and Sasaki,S.
  TITLE     Mercury-sensitive residues and pore site in AQP3 water channel
  JOURNAL   Biochemistry 36 (46), 13973-13978 (1997)
   PUBMED   9369468
REFERENCE   7  (bases 1 to 1267)
  AUTHORS   Ishibashi,K., Kuwahara,M., Gu,Y., Kageyama,Y., Tohsaka,A.,
            Suzuki,F., Marumo,F. and Sasaki,S.
  TITLE     Cloning and functional expression of a new water channel abundantly
            expressed in the testis permeable to water, glycerol, and urea
  JOURNAL   J Biol Chem 272 (33), 20782-20786 (1997)
   PUBMED   9252401
REFERENCE   8  (bases 1 to 1267)
  AUTHORS   Raina,S., Preston,G.M., Guggino,W.B. and Agre,P.
  TITLE     Molecular cloning and characterization of an aquaporin cDNA from
            salivary, lacrimal, and respiratory tissues
  JOURNAL   J Biol Chem 270 (4), 1908-1912 (1995)
   PUBMED   7530250
REFERENCE   9  (bases 1 to 1267)
  AUTHORS   Zeidel,M.L., Ambudkar,S.V., Smith,B.L. and Agre,P.
  TITLE     Reconstitution of functional water channels in liposomes containing
            purified red cell CHIP28 protein
  JOURNAL   Biochemistry 31 (33), 7436-7440 (1992)
   PUBMED   1510932
REFERENCE   10 (bases 1 to 1267)
  AUTHORS   Preston,G.M., Carroll,T.P., Guggino,W.B. and Agre,P.
  TITLE     Appearance of water channels in Xenopus oocytes expressing red cell
            CHIP28 protein
  JOURNAL   Science 256 (5055), 385-387 (1992)
   PUBMED   1373524
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AB000507.2.
            
            [WARNING] On Apr 23, 2024 this sequence was replaced by
            NM_019157.3.
            
            On Jan 14, 2003 this sequence version replaced NM_019157.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB000507.2, BC072695.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1267
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q22"
     gene            1..1267
                     /gene="Aqp7"
                     /note="aquaporin 7"
                     /db_xref="GeneID:29171"
                     /db_xref="RGD:2145"
     exon            1..242
                     /gene="Aqp7"
                     /inference="alignment:Splign:2.1.0"
     exon            243..357
                     /gene="Aqp7"
                     /inference="alignment:Splign:2.1.0"
     CDS             262..1071
                     /gene="Aqp7"
                     /function="mercury-insensitive water, urea and glycerol
                     channel"
                     /note="AQP-7; aquaglyceroporin-7"
                     /codon_start=1
                     /product="aquaporin-7"
                     /protein_id="NP_062030.2"
                     /db_xref="GeneID:29171"
                     /db_xref="RGD:2145"
                     /translation="MAGSVLENIQSVLQKTWVREFLAEFLSTYVLMVFGLGSVAHMVL
                     GERLGSYLGVNLGFGFGVTMGIHVAGGISGAHMNAAVTFTNCALGRMAWKKFPIYVLG
                     QFLGSFLAAATTYLIFYGAINHYAGGELLVTGPKSTANIFATYLPEHMTLWRGFVDEV
                     FVTGMLQLCIFAITDKLNSPALQGTEPLMIGILVCVLGVSLGMNTGYAINPSRDLPPR
                     FFTFIAGWGKKVFSAGNNWWWVPVVAPLLGAYLGGIVYLGLIHAGIPPQGS"
     exon            358..481
                     /gene="Aqp7"
                     /inference="alignment:Splign:2.1.0"
     exon            482..619
                     /gene="Aqp7"
                     /inference="alignment:Splign:2.1.0"
     exon            620..738
                     /gene="Aqp7"
                     /inference="alignment:Splign:2.1.0"
     exon            739..956
                     /gene="Aqp7"
                     /inference="alignment:Splign:2.1.0"
     exon            957..1267
                     /gene="Aqp7"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1267
                     /gene="Aqp7"
                     /note="21 A nucleotides"
ORIGIN      
        1 gccaaacccc tgccctactg acctctcccc tagaggagca caaggggact cacagccgcc
       61 ctgggcaaga ggcaggctct gagtgaggac ttagagactg cagagcctca gttcagttac
      121 agcttgagcc tgccgcagta atggaggacc agaaacaaga ttatctgtga tactgacaga
      181 ggggctgtga gacaaggcta aaaaacagag cagtcacttc agcagagtga gcagggctgc
      241 aggtccaccc acaattccac aatggccggt tctgtgctgg agaacataca atcagtgcta
      301 cagaagactt gggtgcgtga gttcctggcg gagttcctga gtacctatgt cttgatggtg
      361 tttggccttg gttccgtggc tcatatggtt ctaggagaaa ggcttggcag ctatcttggt
      421 gtcaacttgg gttttggttt cggagtgacc atgggaatac atgtggcagg cggcatctct
      481 ggagcccaca tgaacgccgc ggtgactttc actaactgtg cactaggccg aatggcctgg
      541 aagaagttcc ctatatatgt gctgggtcag ttcctgggtt ccttcttagc tgcagctacc
      601 acctacttaa ttttctatgg tgccattaac cactatgcag gtggagaact gttggtgaca
      661 ggtcccaaat ccactgcaaa catttttgcc acctatcttc ctgaacacat gacgctgtgg
      721 cggggcttcg tggatgaggt atttgtgact gggatgctcc agctgtgtat cttcgccatc
      781 acggacaagt tgaacagtcc agcacttcaa gggaccgagc ccctcatgat aggcatcctt
      841 gtttgcgttc ttggggtgtc cctaggcatg aacacaggat atgcaatcaa cccatcccgt
      901 gacctgcctc cccggttctt cactttcatt gctggctggg gcaagaaagt gttcagtgcc
      961 gggaacaact ggtggtgggt gccggtggtg gcaccccttc tgggtgccta cttaggtggc
     1021 attgtatacc tgggcttaat tcacgccggc ataccaccac agggttctta gagattggag
     1081 aattgtacaa caggagacca gaagacgaca gcatcgtcca acgatcccct caccccatct
     1141 cttctcctcc aacttctgcg aaacctaccc tacccataag tggttctgtg cctctagctt
     1201 ctagagtact tcttagtaga gcttgtctgt gaccacaacc cttctgcaat aaagcacacc
     1261 tcatacc
//
