LOCUS       NM_022181               1309 bp    mRNA    linear   ROD 13-FEB-2025
DEFINITION  Rattus norvegicus aquaporin 6 (Aqp6), mRNA.
ACCESSION   NM_022181
VERSION     NM_022181.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1309)
  AUTHORS   Soler,D.C., Kowatz,T., Sloan,A.E., McCormick,T.S., Cooper,K.D.,
            Stepanyan,R., Engel,A. and Vahedi-Faridi,A.
  TITLE     A region within the third extracellular loop of rat Aquaporin 6
            precludes trafficking to plasma membrane in a heterologous cell
            line
  JOURNAL   Sci Rep 11 (1), 13673 (2021)
   PUBMED   34211055
  REMARK    GeneRIF: A region within the third extracellular loop of rat
            Aquaporin 6 precludes trafficking to plasma membrane in a
            heterologous cell line.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1309)
  AUTHORS   Jang,S.Y., Lee,E.S., Ohn,Y.H. and Park,T.K.
  TITLE     Expression of Aquaporin-6 in Rat Retinal Ganglion Cells
  JOURNAL   Cell Mol Neurobiol 36 (6), 965-970 (2016)
   PUBMED   26526333
  REMARK    GeneRIF: confirmed AQP6 expression in retinal ganglion cells and
            Muller cells in vitro
REFERENCE   3  (bases 1 to 1309)
  AUTHORS   Geyer,R.R., Musa-Aziz,R., Qin,X. and Boron,W.F.
  TITLE     Relative CO(2)/NH(3) selectivities of mammalian aquaporins 0-9
  JOURNAL   Am J Physiol Cell Physiol 304 (10), C985-C994 (2013)
   PUBMED   23485707
REFERENCE   4  (bases 1 to 1309)
  AUTHORS   Matsuki-Fukushima,M., Fujita-Yoshigaki,J., Murakami,M.,
            Katsumata-Kato,O., Yokoyama,M. and Sugiya,H.
  TITLE     Involvement of AQP6 in the Mercury-sensitive osmotic lysis of rat
            parotid secretory granules
  JOURNAL   J Membr Biol 246 (3), 209-214 (2013)
   PUBMED   23183829
  REMARK    GeneRIF: AQP6 is involved in osmoregulation to maintain both the
            acid-base and osmotic balance of parotid secretory granules.
REFERENCE   5  (bases 1 to 1309)
  AUTHORS   Hollborn,M., Dukic-Stefanovic,S., Pannicke,T., Ulbricht,E.,
            Reichenbach,A., Wiedemann,P., Bringmann,A. and Kohen,L.
  TITLE     Expression of aquaporins in the retina of diabetic rats
  JOURNAL   Curr Eye Res 36 (9), 850-856 (2011)
   PUBMED   21851171
  REMARK    GeneRIF: AQP6 labeling of the outer plexiform layer was decreased
            in retinal slices from diabetic rats in comparison to slices from
            control rats.
REFERENCE   6  (bases 1 to 1309)
  AUTHORS   Ikeda,M., Beitz,E., Kozono,D., Guggino,W.B., Agre,P. and Yasui,M.
  TITLE     Characterization of aquaporin-6 as a nitrate channel in mammalian
            cells. Requirement of pore-lining residue threonine 63
  JOURNAL   J Biol Chem 277 (42), 39873-39879 (2002)
   PUBMED   12177001
  REMARK    GeneRIF: the primary role of AQP6 may be in cellular regulation
REFERENCE   7  (bases 1 to 1309)
  AUTHORS   Yasui,M., Hazama,A., Kwon,T.H., Nielsen,S., Guggino,W.B. and
            Agre,P.
  TITLE     Rapid gating and anion permeability of an intracellular aquaporin
  JOURNAL   Nature 402 (6758), 184-187 (1999)
   PUBMED   10647010
REFERENCE   8  (bases 1 to 1309)
  AUTHORS   Yasui,M., Kwon,T.H., Knepper,M.A., Nielsen,S. and Agre,P.
  TITLE     Aquaporin-6: An intracellular vesicle water channel protein in
            renal epithelia
  JOURNAL   Proc Natl Acad Sci U S A 96 (10), 5808-5813 (1999)
   PUBMED   10318966
REFERENCE   9  (bases 1 to 1309)
  AUTHORS   Ma,T., Yang,B., Kuo,W.L. and Verkman,A.S.
  TITLE     cDNA cloning and gene structure of a novel water channel expressed
            exclusively in human kidney: evidence for a gene cluster of
            aquaporins at chromosome locus 12q13
  JOURNAL   Genomics 35 (3), 543-550 (1996)
   PUBMED   8812490
REFERENCE   10 (bases 1 to 1309)
  AUTHORS   Ma,T., Frigeri,A., Skach,W. and Verkman,A.S.
  TITLE     Cloning of a novel rat kidney cDNA homologous to CHIP28 and WCH-CD
            water channels
  JOURNAL   Biochem Biophys Res Commun 197 (2), 654-659 (1993)
   PUBMED   7505572
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Nov 26, 2020 this sequence version replaced NM_022181.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF083879.1, SRR26643287.19267.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN11044071 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-528               JAXUCZ010000007.1  132611069-132611596
            529-687             JAXUCZ010000007.1  132612267-132612425
            688-768             JAXUCZ010000007.1  132612681-132612761
            769-1309            JAXUCZ010000007.1  132613464-132614004
FEATURES             Location/Qualifiers
     source          1..1309
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q36"
     gene            1..1309
                     /gene="Aqp6"
                     /note="aquaporin 6"
                     /db_xref="GeneID:29170"
                     /db_xref="RGD:71100"
     exon            1..528
                     /gene="Aqp6"
                     /inference="alignment:Splign:2.1.0"
     CDS             136..966
                     /gene="Aqp6"
                     /note="AQP-6; aquaporin 6, kidney specific"
                     /codon_start=1
                     /product="aquaporin-6"
                     /protein_id="NP_071517.1"
                     /db_xref="GeneID:29170"
                     /db_xref="RGD:71100"
                     /translation="MEPGLCNRAYLLVGGLWTAISKALFAEFLATGLYVFFGVGSVLP
                     WPVALPSVLQVAITFNLATATAVQISWKTSGAHANPAVTLAYLVGSHISLPRAVAYIA
                     AQLAGATVGAALLYGVTPGGVRETLGVNVVHNSTSTGQAVAVELVLTLQLVLCVFASM
                     DSRQTLGSPAAMIGTSVALGHLIGIYFTGCSMNPARSFGPAVIVGKFAVHWIFWVGPL
                     TGAVLASLIYNFILFPDTKTVAQRLAILVGTTKVEKVVDLEPQKKESQTNSEDTEVSV
                     "
     exon            529..687
                     /gene="Aqp6"
                     /inference="alignment:Splign:2.1.0"
     exon            688..768
                     /gene="Aqp6"
                     /inference="alignment:Splign:2.1.0"
     exon            769..1309
                     /gene="Aqp6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgctggggg cacctcagct gggctggtga ggctgccaga gaaagggagg ccagtagagt
       61 tggggagggg tcaagagacc aggaggatcg gagagaatca gggagaagag gcagcagacc
      121 cgaaggcgac cagccatgga gcctgggctg tgtaacaggg cttacctgct ggttggcggg
      181 ctttggaccg ccatcagcaa ggcgcttttt gctgagttcc tggccacagg gctgtacgtt
      241 ttctttggtg tgggctccgt cctgccctgg cccgtggcgc ttccctctgt gctgcaggtt
      301 gccatcacgt tcaacctggc cacagccaca gctgtgcaga tctcctggaa gaccagcggg
      361 gcccacgcca accccgctgt gaccctggcc tacctcgtgg gatcccacat ctctctgccc
      421 cgggctgtgg cctacatagc tgctcagctg gctggggcta cagttggggc tgctcttctt
      481 tatggggtaa ctccaggagg tgtccgagag acccttggag tcaacgtggt ccacaacagc
      541 acctcgactg gccaggcggt ggccgtggag ctggttctga cgctgcagtt ggttctctgt
      601 gtctttgctt ccatggacag tcggcagacc ttgggctccc cagctgccat gattgggacc
      661 tctgtggcac tgggccatct cattgggatc tacttcactg gctgttccat gaacccagct
      721 cgctccttcg gccctgcggt cattgttggg aagtttgcag tccattggat cttctgggta
      781 ggaccgctca caggggctgt cctggcttcg ctgatctaca actttatctt gtttcctgac
      841 accaagaccg tagcccagcg attggccatc cttgtgggta ccacaaaggt ggagaaagtg
      901 gtagacctgg agccccagaa gaaagaatca cagacgaact cagaggacac agaagtgagc
      961 gtgtaacagc ctctggcccc ttgggcttcc agggcaggct gccttgtatg gtgtccctgg
     1021 tgtgtgtggg atctgtccta acagtaggta ccaatcttta tctatccctg accaaacagt
     1081 tgttcccttt ccatttttcc tctcttgaga tacactatgc aacctgacct tctgttcaca
     1141 atgctcccca aaccctgctg gcctcagtct cttgccctgt gaaatggctg ggactagctt
     1201 ctacattgac agacagaaag aatctggagg ttaaatccat ccagttagtt ttccaaggcc
     1261 ttccttgcct tccctctttt cttctttcag tgtttaattt ttacctgtg
//
