LOCUS       NM_012779               1422 bp    mRNA    linear   ROD 06-NOV-2024
DEFINITION  Rattus norvegicus aquaporin 5 (Aqp5), mRNA.
ACCESSION   NM_012779
VERSION     NM_012779.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1422)
  AUTHORS   Bozkurt,A., Karakoy,Z., Aydin,P., Ozdemir,B., Toktay,E., Halici,Z.
            and Cadirci,E.
  TITLE     Targeting Aquaporin-5 by Phosphodiesterase 4 Inhibition Offers New
            Therapeutic Opportunities for Ovarian Ischemia Reperfusion Injury
            in Rats
  JOURNAL   Reprod Sci 31 (7), 2021-2031 (2024)
   PUBMED   38453769
  REMARK    GeneRIF: Targeting Aquaporin-5 by Phosphodiesterase 4 Inhibition
            Offers New Therapeutic Opportunities for Ovarian Ischemia
            Reperfusion Injury in Rats.
REFERENCE   2  (bases 1 to 1422)
  AUTHORS   Akter,M.T., Nezu,A., Akamatsu,T. and Tanimura,A.
  TITLE     Role of aquaporin 5 and glandular blood flow in the
            acetylcholine-induced secretion of saliva in rats
  JOURNAL   Biomed Res 44 (2), 51-63 (2023)
   PUBMED   37005283
  REMARK    GeneRIF: Role of aquaporin 5 and glandular blood flow in the
            acetylcholine-induced secretion of saliva in rats.
REFERENCE   3  (bases 1 to 1422)
  AUTHORS   Tolkach,P.G., Basharin,V.A., Chepur,S.V., Sizova,D.T.,
            Vengerovich,N.G., Yudin,M.A., Nikiforov,A.S. and Chaykina,M.A.
  TITLE     Evaluation of the Content of Aquaporin-5 and Epithelial Sodium
            Channel in the Lungs of Rats during the Development of Toxic
            Pulmonary Edema Caused by Intoxication with Acylating
            Pulmonotoxicants
  JOURNAL   Bull Exp Biol Med 173 (5), 623-627 (2022)
   PUBMED   36210422
  REMARK    GeneRIF: Evaluation of the Content of Aquaporin-5 and Epithelial
            Sodium Channel in the Lungs of Rats during the Development of Toxic
            Pulmonary Edema Caused by Intoxication with Acylating
            Pulmonotoxicants.
REFERENCE   4  (bases 1 to 1422)
  AUTHORS   Yu,Y., Wang,M., Yu,X., Yan,Y., Yu,B. and Zhang,D.
  TITLE     Targeting Forkhead box O1-aquaporin 5 axis mitigates neuropathic
            pain in a CCI rat model through inhibiting astrocytic and
            microglial activation
  JOURNAL   Bioengineered 13 (4), 8567-8580 (2022)
   PUBMED   35324416
  REMARK    GeneRIF: Targeting Forkhead box O1-aquaporin 5 axis mitigates
            neuropathic pain in a CCI rat model through inhibiting astrocytic
            and microglial activation.
REFERENCE   5  (bases 1 to 1422)
  AUTHORS   Lee,S.M., Lee,S.W., Kang,M., Choi,J.K., Park,K., Byun,J.S. and
            Kim,D.Y.
  TITLE     FoxO1 as a Regulator of Aquaporin 5 Expression in the Salivary
            Gland
  JOURNAL   J Dent Res 100 (11), 1281-1288 (2021)
   PUBMED   33840298
  REMARK    GeneRIF: FoxO1 as a Regulator of Aquaporin 5 Expression in the
            Salivary Gland.
REFERENCE   6  (bases 1 to 1422)
  AUTHORS   Kuwahara,M., Gu,Y., Ishibashi,K., Marumo,F. and Sasaki,S.
  TITLE     Mercury-sensitive residues and pore site in AQP3 water channel
  JOURNAL   Biochemistry 36 (46), 13973-13978 (1997)
   PUBMED   9369468
REFERENCE   7  (bases 1 to 1422)
  AUTHORS   Lee,M.D., Bhakta,K.Y., Raina,S., Yonescu,R., Griffin,C.A.,
            Copeland,N.G., Gilbert,D.J., Jenkins,N.A., Preston,G.M. and Agre,P.
  TITLE     The human Aquaporin-5 gene. Molecular characterization and
            chromosomal localization
  JOURNAL   J Biol Chem 271 (15), 8599-8604 (1996)
   PUBMED   8621489
REFERENCE   8  (bases 1 to 1422)
  AUTHORS   Raina,S., Preston,G.M., Guggino,W.B. and Agre,P.
  TITLE     Molecular cloning and characterization of an aquaporin cDNA from
            salivary, lacrimal, and respiratory tissues
  JOURNAL   J Biol Chem 270 (4), 1908-1912 (1995)
   PUBMED   7530250
REFERENCE   9  (bases 1 to 1422)
  AUTHORS   Zeidel,M.L., Ambudkar,S.V., Smith,B.L. and Agre,P.
  TITLE     Reconstitution of functional water channels in liposomes containing
            purified red cell CHIP28 protein
  JOURNAL   Biochemistry 31 (33), 7436-7440 (1992)
   PUBMED   1510932
REFERENCE   10 (bases 1 to 1422)
  AUTHORS   Preston,G.M., Carroll,T.P., Guggino,W.B. and Agre,P.
  TITLE     Appearance of water channels in Xenopus oocytes expressing red cell
            CHIP28 protein
  JOURNAL   Science 256 (5055), 385-387 (1992)
   PUBMED   1373524
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Nov 27, 2020 this sequence version replaced NM_012779.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U16245.1, BC110045.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760400, SAMEA5760476
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-471               JAXUCZ010000007.1  132601528-132601998
            472-636             JAXUCZ010000007.1  132603032-132603196
            637-720             JAXUCZ010000007.1  132603617-132603700
            721-1422            JAXUCZ010000007.1  132604359-132605060
FEATURES             Location/Qualifiers
     source          1..1422
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q36"
     gene            1..1422
                     /gene="Aqp5"
                     /note="aquaporin 5"
                     /db_xref="GeneID:25241"
                     /db_xref="RGD:2144"
     exon            1..471
                     /gene="Aqp5"
                     /inference="alignment:Splign:2.1.0"
     CDS             109..906
                     /gene="Aqp5"
                     /note="AQP-5"
                     /codon_start=1
                     /product="aquaporin-5"
                     /protein_id="NP_036911.1"
                     /db_xref="GeneID:25241"
                     /db_xref="RGD:2144"
                     /translation="MKKEVCSLAFFKAVFAEFLATLIFVFFGLGSALKWPSALPTILQ
                     ISIAFGLAIGTLAQALGPVSGGHINPAITLALLIGNQISLLRAVFYVAAQLVGAIAGA
                     GILYWLAPLNARGNLAVNALNNNTTPGKAMVVELILTFQLALCIFSSTDSRRTSPVGS
                     PALSIGLSVTLGHLVGIYFTGCSMNPARSFGPAVVMNRFSPSHWVFWVGPIVGAMLAA
                     ILYFYLLFPSSLSLHDRVAVVKGTYEPEEDWEDHREERKKTIELTAH"
     exon            472..636
                     /gene="Aqp5"
                     /inference="alignment:Splign:2.1.0"
     exon            637..720
                     /gene="Aqp5"
                     /inference="alignment:Splign:2.1.0"
     exon            721..1422
                     /gene="Aqp5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcaccgcac cgcgcgcaga gccccgcaga cagacgcccg ccgctaccag cgccgccccg
       61 acggccgccc cgcaaccctc ccgctgccac cgggccccca aggccaccat gaaaaaggag
      121 gtgtgctccc ttgccttctt caaggcggtg ttcgcagagt tcctggccac cctcatcttc
      181 gtcttctttg gcctgggctc agcactcaag tggccctcgg ctctgcccac cattctgcaa
      241 atctcaattg cctttggcct ggccataggt accttagccc aagctctggg acctgtgagt
      301 ggtggccaca tcaatccagc cattactctg gccctcttaa taggaaacca gatctcgctg
      361 ctccgagctg tcttctacgt ggcagcccag ctggtgggcg ccattgctgg ggcaggcatc
      421 ctgtactggc tggcgccact caatgcccgg ggtaacctgg ccgtcaatgc gctgaacaac
      481 aacacaacgc ctggcaaggc catggtggtg gagttaatct tgactttcca gctagccctc
      541 tgcatcttct cctccaccga ctctcgccga accagccctg tgggctcccc agccttatcc
      601 attggcttgt ctgtcacact gggccatctt gtggggatct acttcaccgg ctgttccatg
      661 aacccagccc gatctttcgg ccctgcggtg gtcatgaacc ggttcagccc ctctcactgg
      721 gtcttctggg tagggcctat tgtgggggcc atgctggcgg ccatcctcta tttctacctg
      781 ctcttcccct cctctctgag cctccatgat cgcgtggctg tcgtcaaagg cacatatgag
      841 ccggaggagg actgggaaga tcatcgagag gagaggaaga agaccatcga gctgacggca
      901 cactgactgg tgccggacag gggccagtcc ctcagcccct ggaccactgg agaaaaggaa
      961 gacgaagagt ttgaagcacc cctccccaac atcctctcag ctggggaaga ggcattggat
     1021 ccccatgctg cgcacaggga caggagcaga agcccataat gggacacttg ggtgtgggcc
     1081 aagggctgga gtctgacagg gtcagggaca tagccgcttt ggaatcaggc agaatgtctg
     1141 ccacagctca gacctcagag atcgtgaatg cggtgccaag ctcacaggcg gtccaggacc
     1201 acaccagaaa gggacgacag cttgcttatc tctcccaacc cagtatctca agtgccaaag
     1261 ccggccccca ggtggacaga ggggacattt cccccagagc tcttcaggag agggatagat
     1321 ggctcacgga gtgctatttt atttatttct ggtcaaggat gggggtgggg tggggctgct
     1381 ggtgtttgag ctgggcgctt cccaataaac cacctatctt ca
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