LOCUS       NM_031703               1800 bp    mRNA    linear   ROD 07-DEC-2024
DEFINITION  Rattus norvegicus aquaporin 3 (Gill blood group) (Aqp3), mRNA.
ACCESSION   NM_031703
VERSION     NM_031703.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1800)
  AUTHORS   Koral,L., Ovali,M.A., Tufekcioglu,N.K., Karakilic,E., Adali,Y. and
            Uzun,M.
  TITLE     The role of AQP3 and AQP4 channels in cisplatin-induced
            cardiovascular edema and the protective effect of melatonin
  JOURNAL   Mol Biol Rep 48 (11), 7457-7465 (2021)
   PUBMED   34657253
  REMARK    GeneRIF: The role of AQP3 and AQP4 channels in cisplatin-induced
            cardiovascular edema and the protective effect of melatonin.
REFERENCE   2  (bases 1 to 1800)
  AUTHORS   Rose,R., Kemper,B., Schwab,A., Schlatter,E. and Edemir,B.
  TITLE     Unexpected localization of AQP3 and AQP4 induced by migration of
            primary cultured IMCD cells
  JOURNAL   Sci Rep 11 (1), 11930 (2021)
   PUBMED   34099798
  REMARK    GeneRIF: Unexpected localization of AQP3 and AQP4 induced by
            migration of primary cultured IMCD cells.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1800)
  AUTHORS   Gotfryd,K., Mosca,A.F., Missel,J.W., Truelsen,S.F., Wang,K.,
            Spulber,M., Krabbe,S., Helix-Nielsen,C., Laforenza,U., Soveral,G.,
            Pedersen,P.A. and Gourdon,P.
  TITLE     Human adipose glycerol flux is regulated by a pH gate in AQP10
  JOURNAL   Nat Commun 9 (1), 4749 (2018)
   PUBMED   30420639
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1800)
  AUTHORS   Xu,Y., Yao,H., Wang,Q., Xu,W., Liu,K., Zhang,J., Zhao,H. and Hou,G.
  TITLE     Aquaporin-3 Attenuates Oxidative Stress-Induced Nucleus Pulposus
            Cell Apoptosis Through Regulating the P38 MAPK Pathway
  JOURNAL   Cell Physiol Biochem 50 (5), 1687-1697 (2018)
   PUBMED   30384362
  REMARK    GeneRIF: Negative relationship between AQP-3 expression and
            activity of the p38 MAPK pathway in nucleus pulposus cells under
            oxidative damage showed that AQP-3 overexpression partly decreases
            the pathway's activity in nucleus pulposus cells of the same
            condition.
REFERENCE   5  (bases 1 to 1800)
  AUTHORS   Chao,G. and Zhang,S.
  TITLE     Aquaporins 1, 3 and 8 expression in irritable bowel syndrome rats'
            colon via NF-kappaB pathway
  JOURNAL   Oncotarget 8 (29), 47175-47183 (2017)
   PUBMED   28525373
  REMARK    GeneRIF: liquid water metabolic abnormalities and intestine
            permeability might be the mechanism of IBS by regulating AQP1, AQP3
            and AQP8 via NF-kappaB pathway.
REFERENCE   6  (bases 1 to 1800)
  AUTHORS   Raina,S., Preston,G.M., Guggino,W.B. and Agre,P.
  TITLE     Molecular cloning and characterization of an aquaporin cDNA from
            salivary, lacrimal, and respiratory tissues
  JOURNAL   J Biol Chem 270 (4), 1908-1912 (1995)
   PUBMED   7530250
REFERENCE   7  (bases 1 to 1800)
  AUTHORS   Echevarria,M., Windhager,E.E., Tate,S.S. and Frindt,G.
  TITLE     Cloning and expression of AQP3, a water channel from the medullary
            collecting duct of rat kidney
  JOURNAL   Proc Natl Acad Sci U S A 91 (23), 10997-11001 (1994)
   PUBMED   7526388
REFERENCE   8  (bases 1 to 1800)
  AUTHORS   Ishibashi,K., Sasaki,S., Fushimi,K., Uchida,S., Kuwahara,M.,
            Saito,H., Furukawa,T., Nakajima,K., Yamaguchi,Y., Gojobori,T. et
            al.
  TITLE     Molecular cloning and expression of a member of the aquaporin
            family with permeability to glycerol and urea in addition to water
            expressed at the basolateral membrane of kidney collecting duct
            cells
  JOURNAL   Proc Natl Acad Sci U S A 91 (14), 6269-6273 (1994)
   PUBMED   7517548
REFERENCE   9  (bases 1 to 1800)
  AUTHORS   Zeidel,M.L., Ambudkar,S.V., Smith,B.L. and Agre,P.
  TITLE     Reconstitution of functional water channels in liposomes containing
            purified red cell CHIP28 protein
  JOURNAL   Biochemistry 31 (33), 7436-7440 (1992)
   PUBMED   1510932
REFERENCE   10 (bases 1 to 1800)
  AUTHORS   Preston,G.M., Carroll,T.P., Guggino,W.B. and Agre,P.
  TITLE     Appearance of water channels in Xenopus oocytes expressing red cell
            CHIP28 protein
  JOURNAL   Science 256 (5055), 385-387 (1992)
   PUBMED   1373524
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Nov 30, 2020 this sequence version replaced NM_031703.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC127490.1, L35108.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-173               JAXUCZ010000005.1  61040511-61040683   c
            174-300             JAXUCZ010000005.1  61037741-61037867   c
            301-438             JAXUCZ010000005.1  61037318-61037455   c
            439-557             JAXUCZ010000005.1  61036880-61036998   c
            558-775             JAXUCZ010000005.1  61036276-61036493   c
            776-1800            JAXUCZ010000005.1  61035165-61036189   c
FEATURES             Location/Qualifiers
     source          1..1800
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q22"
     gene            1..1800
                     /gene="Aqp3"
                     /note="aquaporin 3 (Gill blood group)"
                     /db_xref="GeneID:65133"
                     /db_xref="RGD:68428"
     exon            1..173
                     /gene="Aqp3"
                     /inference="alignment:Splign:2.1.0"
     CDS             66..944
                     /gene="Aqp3"
                     /note="AQP-3; 31.4 kDa water channel protein;
                     aquaglyceroporin-3"
                     /codon_start=1
                     /product="aquaporin-3"
                     /protein_id="NP_113891.2"
                     /db_xref="GeneID:65133"
                     /db_xref="RGD:68428"
                     /translation="MGRQKELMNRCGEMLHIRYRLLRQALAECLGTLILVMFGCGSVA
                     QVVLSRGTHGGFLTINLAFGFAVTLAILVAGQVSGAHLNPAVTFAMCFLAREPWIKLP
                     IYTLAQTLGAFLGAGIVFGLYYDAIWAFAGNELVVSGPNGTAGIFATYPSGHLDMVNG
                     FFDQFIGTAALIVCVLAIVDPYNNPVPRGLEAFTVGLVVLVIGTSMGFNSGYAVNPAR
                     DFGPRLFTALAGWGSEVFTTGQNWWWVPIVSPLLGSIGGVFVYQLMIGCHLEQPLPST
                     EAENVKLAHMKHKEQI"
     exon            174..300
                     /gene="Aqp3"
                     /inference="alignment:Splign:2.1.0"
     exon            301..438
                     /gene="Aqp3"
                     /inference="alignment:Splign:2.1.0"
     exon            439..557
                     /gene="Aqp3"
                     /inference="alignment:Splign:2.1.0"
     exon            558..775
                     /gene="Aqp3"
                     /inference="alignment:Splign:2.1.0"
     exon            776..1800
                     /gene="Aqp3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctgtgccctg cgctcgccac ttcgcacccg cacgcccgac cgaccgcgcc gccgcctgcc
       61 tcgccatggg tcgacagaag gagttgatga accgttgcgg ggagatgctc cacatccgct
      121 accggctgct tcgccaggct ctggcggagt gcctggggac cctcatcctt gtgatgttcg
      181 gctgtggttc cgtggctcaa gtggtgctca gccgagggac ccatggtggc ttcctcacca
      241 tcaacttggc ttttggcttc gctgtcaccc ttgccatctt ggtggctggc caagtgtctg
      301 gagcccactt gaaccctgct gtgacctttg caatgtgctt cctggcacga gagccctgga
      361 tcaagctgcc catctacaca ctggcacaga ccctcggggc cttcttgggt gctgggattg
      421 tttttgggct ctactatgat gcaatctggg cctttgctgg caatgagctt gttgtctccg
      481 gccccaatgg cacagctggt atctttgcca cctatccctc tggacacttg gatatggtca
      541 atggcttctt tgatcagttc ataggcacag cagcccttat tgtgtgtgtg ctggccattg
      601 ttgaccctta taacaaccct gtgccccggg gcctggaggc cttcactgtg ggccttgtgg
      661 tcctggtcat tgggacctcc atgggcttca attctggcta tgccgtcaac ccagctcgtg
      721 actttggacc tcgccttttc actgccctgg ctggctgggg ttcagaagtc tttacgactg
      781 gccagaactg gtggtgggta cccatcgtct ctccactcct gggttccatt ggtggtgtct
      841 tcgtgtacca gctcatgatt ggctgccacc tggagcagcc cctgccttcc actgaggcag
      901 agaatgtgaa gctggcccac atgaagcaca aggagcagat ctgagtgggc agtgccacac
      961 acacacaccc ccccactgct cactctcttg agtgtccact gactgtgtgg gggacacccc
     1021 ataaaagccc ccttgtgatg cctctcgggc taaaaacgct ccctgtatcc acccccactg
     1081 gatggcccct ccagaattcc tactgaactc tgccagctag gggattaggt tcccctctta
     1141 agcccaagta ggatagcaag taagaccaaa catcctcttg tttctgaaaa ggaagaggat
     1201 gtggagagag agagagagag agagagagag agagagagaa agagagagag agagagagag
     1261 agagagagca agtgtatgtg tgctgttctc caggctgaaa gcaagggcaa gggaccaagt
     1321 tttcaaaaca aactagcagc tcaagggaac ccaggggaag ggagagagtg agtcaggaaa
     1381 gtgccacagt atacttgctt cagggactcc agtgtggagg tggacccagg agtgcgtttc
     1441 taagtatgta tgtgtctact gagttttcga aatggacttc taggcttagg gagcggggga
     1501 ggcataagag gggcgtagct cacatctgga gctgtgatcc tcaactaggg gctgtgtatg
     1561 taatatgttt ctgttataag atagacattg ggaggggcta aagtcctggt cataagtttc
     1621 ataatttgtt ttttttaaat atataaatat atacatacat atatatgtta cagttttagg
     1681 aataggggtg ggaaactcca ctttttaaaa gggtcttcct tcctttaatc ccccaatcaa
     1741 caatgtactg ttgcctttta tatataaaga aaagaataaa atgtatgcat ttgacaggaa
//
