LOCUS       NM_012909               1397 bp    mRNA    linear   ROD 15-JUL-2024
DEFINITION  Rattus norvegicus aquaporin 2 (Aqp2), mRNA.
ACCESSION   NM_012909
VERSION     NM_012909.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1397)
  AUTHORS   Mak,A., Sung,C.C., Pisitkun,T., Khositseth,S. and Knepper,M.A.
  TITLE     'Aquaporin-omics': mechanisms of aquaporin-2 loss in polyuric
            disorders
  JOURNAL   J Physiol 602 (13), 3191-3206 (2024)
   PUBMED   37114282
  REMARK    GeneRIF: 'Aquaporin-omics': mechanisms of aquaporin-2 loss in
            polyuric disorders.
REFERENCE   2  (bases 1 to 1397)
  AUTHORS   Sung,C.C., Poll,B.G., Lin,S.H., Murillo-de-Ozores,A.R., Chou,C.L.,
            Chen,L., Yang,C.R., Chen,M.H., Hsu,Y.J. and Knepper,M.A.
  TITLE     Early Molecular Events Mediating Loss of Aquaporin-2 during
            Ureteral Obstruction in Rats
  JOURNAL   J Am Soc Nephrol 33 (11), 2040-2058 (2022)
   PUBMED   35918145
  REMARK    GeneRIF: Early Molecular Events Mediating Loss of Aquaporin-2
            during Ureteral Obstruction in Rats.
REFERENCE   3  (bases 1 to 1397)
  AUTHORS   Deng,S., Chen,X., Lei,Q. and Lu,W.
  TITLE     AQP2 Promotes Astrocyte Activation by Modulating the
            TLR4/NFkappaB-p65 Pathway Following Intracerebral Hemorrhage
  JOURNAL   Front Immunol 13, 847360 (2022)
   PUBMED   35386692
  REMARK    GeneRIF: AQP2 Promotes Astrocyte Activation by Modulating the
            TLR4/NFkappaB-p65 Pathway Following Intracerebral Hemorrhage.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1397)
  AUTHORS   Ma,W., Liang,X. and Su,Z.
  TITLE     Effects of a Chinese herbal extract on the intestinal tract and
            aquaporin in Adriamycin-induced nephropathy
  JOURNAL   Bioengineered 13 (2), 2732-2745 (2022)
   PUBMED   35068345
  REMARK    GeneRIF: Effects of a Chinese herbal extract on the intestinal
            tract and aquaporin in Adriamycin-induced nephropathy.
REFERENCE   5  (bases 1 to 1397)
  AUTHORS   Baltzer,S., Bulatov,T., Schmied,C., Kramer,A., Berger,B.T.,
            Oder,A., Walker-Gray,R., Kuschke,C., Zuhlke,K., Eichhorst,J.,
            Lehmann,M., Knapp,S., Weston,J., von Kries,J.P., Sussmuth,R.D. and
            Klussmann,E.
  TITLE     Aurora Kinase A Is Involved in Controlling the Localization of
            Aquaporin-2 in Renal Principal Cells
  JOURNAL   Int J Mol Sci 23 (2), 763 (2022)
   PUBMED   35054947
  REMARK    GeneRIF: Aurora Kinase A Is Involved in Controlling the
            Localization of Aquaporin-2 in Renal Principal Cells.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1397)
  AUTHORS   Ma,T., Hasegawa,H., Skach,W.R., Frigeri,A. and Verkman,A.S.
  TITLE     Expression, functional analysis, and in situ hybridization of a
            cloned rat kidney collecting duct water channel
  JOURNAL   Am J Physiol 266 (1 Pt 1), C189-C197 (1994)
   PUBMED   7508187
REFERENCE   7  (bases 1 to 1397)
  AUTHORS   Ma,T., Frigeri,A., Skach,W. and Verkman,A.S.
  TITLE     Cloning of a novel rat kidney cDNA homologous to CHIP28 and WCH-CD
            water channels
  JOURNAL   Biochem Biophys Res Commun 197 (2), 654-659 (1993)
   PUBMED   7505572
REFERENCE   8  (bases 1 to 1397)
  AUTHORS   Zeidel,M.L., Ambudkar,S.V., Smith,B.L. and Agre,P.
  TITLE     Reconstitution of functional water channels in liposomes containing
            purified red cell CHIP28 protein
  JOURNAL   Biochemistry 31 (33), 7436-7440 (1992)
   PUBMED   1510932
REFERENCE   9  (bases 1 to 1397)
  AUTHORS   Preston,G.M., Carroll,T.P., Guggino,W.B. and Agre,P.
  TITLE     Appearance of water channels in Xenopus oocytes expressing red cell
            CHIP28 protein
  JOURNAL   Science 256 (5055), 385-387 (1992)
   PUBMED   1373524
REFERENCE   10 (bases 1 to 1397)
  AUTHORS   Horton,C.E. Jr., Davisson,M.T., Jacobs,J.B., Bernstein,G.T.,
            Retik,A.B. and Mandell,J.
  TITLE     Congenital progressive hydronephrosis in mice: a new recessive
            mutation
  JOURNAL   J Urol 140 (5 Pt 2), 1310-1315 (1988)
   PUBMED   3184310
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Nov 27, 2020 this sequence version replaced NM_012909.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D13906.1, BC128705.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-444               JAXUCZ010000007.1  132590286-132590729
            445-609             JAXUCZ010000007.1  132593305-132593469
            610-690             JAXUCZ010000007.1  132593826-132593906
            691-1397            JAXUCZ010000007.1  132594615-132595321
FEATURES             Location/Qualifiers
     source          1..1397
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q36"
     gene            1..1397
                     /gene="Aqp2"
                     /gene_synonym="AQP-2; aquaporin-2"
                     /note="aquaporin 2"
                     /db_xref="GeneID:25386"
                     /db_xref="RGD:2142"
     exon            1..444
                     /gene="Aqp2"
                     /gene_synonym="AQP-2; aquaporin-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             85..900
                     /gene="Aqp2"
                     /gene_synonym="AQP-2; aquaporin-2"
                     /note="AQP-CD; WCH-CD; aquaporin-CD; ADH water channel;
                     collecting duct water channel protein; water channel
                     protein for renal collecting duct; aquaporin 2 (collecting
                     duct)"
                     /codon_start=1
                     /product="aquaporin-2"
                     /protein_id="NP_037041.3"
                     /db_xref="GeneID:25386"
                     /db_xref="RGD:2142"
                     /translation="MWELRSIAFSRAVLAEFLATLLFVFFGLGSALQWASSPPSVLQI
                     AVAFGLGIGTLVQALGHVSGAHINPAVTVACLVGCHVSFLRAAFYVAAQLLGAVAGAA
                     ILHEITPVEIRGDLAVNALHNNATAGQAVTVELFLTMQLVLCIFASTDERRGDNLGSP
                     ALSIGFSVTLGHLLGIYFTGCSMNPARSLAPAVVTGKFDDHWVFWIGPLVGAIIGSLL
                     YNYLLFPSAKSLQERLAVLKGLEPDTDWEEREVRRRQSVELHSPQSLPRGSKA"
     exon            445..609
                     /gene="Aqp2"
                     /gene_synonym="AQP-2; aquaporin-2"
                     /inference="alignment:Splign:2.1.0"
     exon            610..690
                     /gene="Aqp2"
                     /gene_synonym="AQP-2; aquaporin-2"
                     /inference="alignment:Splign:2.1.0"
     exon            691..1397
                     /gene="Aqp2"
                     /gene_synonym="AQP-2; aquaporin-2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagagaaga gaaagagaga gggagggagg aagagccacc cccgtggccc agacccctgg
       61 ccagcgcgca gaagtcggag cagcatgtgg gaactcagat ccatagcctt ctcccgagca
      121 gtgctggctg agttcttggc cacgctcctt tttgtcttct ttggccttgg ctcagccctc
      181 cagtgggcca gctccccacc ctctgtgctc cagatcgccg tggcctttgg tctgggcatc
      241 ggcaccctgg ttcaggctct gggccatgtc agcggggcac acatcaaccc cgccgtgact
      301 gtggcatgcc tggtgggttg ccatgtctcc ttccttcgag ctgccttcta tgtggctgcc
      361 cagctgctgg gcgccgtggc tggggctgcc atcctccatg agattactcc agtagaaatc
      421 cgtggggacc tggctgtcaa tgctctccac aacaacgcca cagctggcca ggctgtgact
      481 gtagagctct tcctgaccat gcagctggtg ctgtgcatct ttgcctccac cgacgagcgc
      541 cgcggtgaca acctgggtag ccctgccctc tccattggtt tctctgttac cctgggccac
      601 ctccttggga tctatttcac cggttgctcc atgaatccag cccgctccct ggctccagca
      661 gttgtcactg gcaagtttga tgatcactgg gtcttctgga tcggacccct ggtgggcgcc
      721 atcatcggct ccctcctcta caactacctg ctgttcccct cggcaaagag cctgcaggag
      781 cgcttggcag tgctcaaggg cctggagccc gacaccgact gggaggaacg tgaagtgcgg
      841 cggcggcagt cggtggagct ccactctcct cagagcctgc ctcgcggcag caaggcctga
      901 gctcccctgc agcgcaccgc agctcagccg accgacggct cgccccctcc ttccccctga
      961 cccgtcgtcg gttcccagtg cagagtagct gctccagcga gtgcagtgag cctcaagaag
     1021 gggctcgccc gggagcctga cagtacctcc gcccggaagc cttgagctac cctcgagctc
     1081 gccccttgca gggaaccaga cacttgggga ccgaggcgtg gggagggaag gcaggccggc
     1141 gagagacgga gagctctgga gagcccgctc tggtgcctgg ggagaagtgc atagactccc
     1201 ttctggggga ctgtgcttag tgcatctcat tttattaggt tgtaaaagtg ctcgtctccg
     1261 cgtatttctt ttcctcacga acagagtttg catgatcctg agcgtgatcc cgagtgcctg
     1321 tggtgataca gagccgggga ctgtcattcc cgctttggcc ttcttctcct gtacctgcaa
     1381 taaatccact atctctg
//
