LOCUS       NM_173105               1299 bp    mRNA    linear   ROD 13-MAY-2024
DEFINITION  Rattus norvegicus aquaporin 11 (Aqp11), mRNA.
ACCESSION   NM_173105
VERSION     NM_173105.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1299)
  AUTHORS   Ichikawa,R., Takeda,T., Kakigi,A., Ito,H., Kobayashi,T. and
            Hyodo,M.
  TITLE     Expression of AQP-10, -11 and -12 in the rat stria vascularis
  JOURNAL   Acta Otolaryngol 144 (2), 96-99 (2024)
   PUBMED   38511591
  REMARK    GeneRIF: Expression of AQP-10, -11 and -12 in the rat stria
            vascularis.
REFERENCE   2  (bases 1 to 1299)
  AUTHORS   Bestetti,S., Galli,M., Sorrentino,I., Pinton,P., Rimessi,A.,
            Sitia,R. and Medrano-Fernandez,I.
  TITLE     Human aquaporin-11 guarantees efficient transport of H2O2 across
            the endoplasmic reticulum membrane
  JOURNAL   Redox Biol 28, 101326 (2020)
   PUBMED   31546170
REFERENCE   3  (bases 1 to 1299)
  AUTHORS   Hoshino,Y., Sonoda,H., Nishimura,R., Mori,K., Ishibashi,K. and
            Ikeda,M.
  TITLE     Involvement of the NADPH oxidase 2 pathway in renal oxidative
            stress in Aqp11-/- mice
  JOURNAL   Biochem Biophys Rep 17, 169-176 (2019)
   PUBMED   30656220
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1299)
  AUTHORS   Xi,T., Jin,F., Zhu,Y., Wang,J., Tang,L., Wang,Y., Liebeskind,D.S.,
            Scalzo,F. and He,Z.
  TITLE     miR-27a-3p protects against blood-brain barrier disruption and
            brain injury after intracerebral hemorrhage by targeting
            endothelial aquaporin-11
  JOURNAL   J Biol Chem 293 (52), 20041-20050 (2018)
   PUBMED   30337368
  REMARK    GeneRIF: application of exogenous miR-27a-3p may protect against
            post-ICH complications by targeting AQP11 in the capillary
            endothelial cells of the brain.
REFERENCE   5  (bases 1 to 1299)
  AUTHORS   Lee,P.J., Park,H.J., Cho,N. and Kim,H.P.
  TITLE     Aquaporin 11-Dependent Inhibition of Proliferation by Deuterium
            Oxide in Activated Hepatic Stellate Cells
  JOURNAL   Molecules 23 (12), 3209 (2018)
   PUBMED   30563120
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1299)
  AUTHORS   Tchekneva,E.E., Khuchua,Z., Davis,L.S., Kadkina,V., Dunn,S.R.,
            Bachman,S., Ishibashi,K., Rinchik,E.M., Harris,R.C., Dikov,M.M. and
            Breyer,M.D.
  TITLE     Single amino acid substitution in aquaporin 11 causes renal failure
  JOURNAL   J Am Soc Nephrol 19 (10), 1955-1964 (2008)
   PUBMED   18701606
REFERENCE   7  (bases 1 to 1299)
  AUTHORS   Okada,S., Misaka,T., Tanaka,Y., Matsumoto,I., Ishibashi,K.,
            Sasaki,S. and Abe,K.
  TITLE     Aquaporin-11 knockout mice and polycystic kidney disease animals
            share a common mechanism of cyst formation
  JOURNAL   FASEB J 22 (10), 3672-3684 (2008)
   PUBMED   18606867
REFERENCE   8  (bases 1 to 1299)
  AUTHORS   Yakata,K., Hiroaki,Y., Ishibashi,K., Sohara,E., Sasaki,S.,
            Mitsuoka,K. and Fujiyoshi,Y.
  TITLE     Aquaporin-11 containing a divergent NPA motif has normal water
            channel activity
  JOURNAL   Biochim Biophys Acta 1768 (3), 688-693 (2007)
   PUBMED   17178102
  REMARK    Erratum:[Biochim Biophys Acta. 2008 Jun;1778(6):1525]
REFERENCE   9  (bases 1 to 1299)
  AUTHORS   Gorelick,D.A., Praetorius,J., Tsunenari,T., Nielsen,S. and Agre,P.
  TITLE     Aquaporin-11: a channel protein lacking apparent transport function
            expressed in brain
  JOURNAL   BMC Biochem 7, 14 (2006)
   PUBMED   16650285
  REMARK    GeneRIF: AQP11 has a unique distribution in brain:  Purkinje cell
            dendrites, CA1 & CA2 neurons, & cerebral cortical neurons. It is
            functionally distinct from other proteins of the aquaporin
            superfamily and could represent a new aquaporin subfamily.
            Publication Status: Online-Only
REFERENCE   10 (bases 1 to 1299)
  AUTHORS   Morishita,Y., Matsuzaki,T., Hara-chikuma,M., Andoo,A., Shimono,M.,
            Matsuki,A., Kobayashi,K., Ikeda,M., Yamamoto,T., Verkman,A.,
            Kusano,E., Ookawara,S., Takata,K., Sasaki,S. and Ishibashi,K.
  TITLE     Disruption of aquaporin-11 produces polycystic kidneys following
            vacuolization of the proximal tubule
  JOURNAL   Mol Cell Biol 25 (17), 7770-7779 (2005)
   PUBMED   16107722
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AB023644.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB023644.1, BC078694.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132266, SAMD00132294
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1299
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q32"
     gene            1..1299
                     /gene="Aqp11"
                     /note="aquaporin 11"
                     /db_xref="GeneID:286758"
                     /db_xref="RGD:628763"
     exon            1..847
                     /gene="Aqp11"
                     /inference="alignment:Splign:2.1.0"
     CDS             229..1044
                     /gene="Aqp11"
                     /note="AQP-11"
                     /codon_start=1
                     /product="aquaporin-11"
                     /protein_id="NP_775128.1"
                     /db_xref="GeneID:286758"
                     /db_xref="RGD:628763"
                     /translation="MSALLGLPPEVQDTCISLGLMLLVVLFMGLARVIARQQLHRPMV
                     HAFVLEFLATFQLCYCTHELQLLSEQDSGHPTWTLTLIYFFSLVHGLTLVGTASNPCG
                     VMMQMILGGMSPEMGAVRLMAQLVSALCSRYCISALWSLSLTKYHFDKRILACRNPIN
                     TDISKAIIIEAICSFIFHSALLHFQEVRTKLRIHVLAALITFLAYAGGSLTGALFNPA
                     LALSLHFPCFDESFYKFFVVYWVAPSLGVLLMILMFSFFLPWLHNNQLSNKKE"
     exon            848..964
                     /gene="Aqp11"
                     /inference="alignment:Splign:2.1.0"
     exon            965..1289
                     /gene="Aqp11"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccagggacag ctccctcgtc gcctcgcctc ctcccccccc cctccccggc tcaggtcaca
       61 tctgcacagc gcagccgggg aggggaggag ccctccagcg cggaaccggg ctttccactc
      121 ggcccgccct gaggggcgtg ggagggcggg gccgcggact tcggactcca gccacccgac
      181 gctcctcttt ccctgacgct ctcagccatc cctagcggtg agggaaccat gtccgcgcta
      241 ctggggctcc cgcccgaggt gcaggacacc tgcatctcgc tgggactaat gctgttggtc
      301 gtgctgttca tggggctggc ccgcgtgatc gcccggcaac agctgcacag gcccatggtc
      361 cacgccttcg tcctggagtt tctagctacc ttccagctct gctactgcac ccatgagctc
      421 caactgctga gcgagcagga ctcggggcac cccacctgga cgctgacact gatctacttc
      481 ttttccttgg tgcatggcct gaccctggtg ggcacagcta gcaacccgtg cggcgtgatg
      541 atgcagatga ttctgggggg catgtccccc gagatgggtg cggtgaggtt gatggctcag
      601 ctggttagtg ccctatgcag caggtactgc ataagtgccc tgtggagcct gagcctgacc
      661 aagtaccatt tcgacaagag gattttagct tgcaggaatc ccatcaacac cgacatatcc
      721 aaagcgatca tcatagaagc catctgctcc tttattttcc acagcgctct actgcacttc
      781 caggaggtcc gaaccaagct tcgcatccac gtgctggctg cactcatcac ctttttggcc
      841 tatgcaggag ggagcctcac aggagcgctg tttaacccag cactggcact ttcgctgcac
      901 ttcccgtgct ttgacgaatc gttctataag tttttcgtag tatattgggt tgctccttct
      961 ctaggcgtac tgctgatgat cctcatgttc agcttcttcc ttccgtggct gcacaacaac
     1021 caactgagta acaagaagga atgaccactc ccaaagactc aaacgaagtc agtggacgat
     1081 caggctggat gtgacggttt gggcaccttt caaactctgg actcatcctg cttctccttc
     1141 ctttgtggaa ggtgtcttac tgttttcact acctggactt cactgtgaaa atgaggcagc
     1201 ctgtatttct cagttaagac ttgttctttt gagtgatgtg ttaaatgctg ctggaaaagg
     1261 ctcattcatt aaacctctgt aaatcccaaa aaaaaaaaa
//
