LOCUS       NM_012778               2624 bp    mRNA    linear   ROD 07-DEC-2024
DEFINITION  Rattus norvegicus aquaporin 1 (Aqp1), mRNA.
ACCESSION   NM_012778
VERSION     NM_012778.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2624)
  AUTHORS   Lv,W., Liao,J., Li,C., Liu,D., Luo,X., Diao,R., Wang,Y. and Jin,Y.
  TITLE     Aquaporin 1 is renoprotective in septic acute kidney injury by
            attenuating inflammation, apoptosis and fibrosis through inhibition
            of P53 expression
  JOURNAL   Front Immunol 15, 1443108 (2024)
   PUBMED   39238634
  REMARK    GeneRIF: Aquaporin 1 is renoprotective in septic acute kidney
            injury by attenuating inflammation, apoptosis and fibrosis through
            inhibition of P53 expression.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2624)
  AUTHORS   Niedermeyer,S., Yun,X., Trujillo,M., Jiang,H., Andrade,M.R.,
            Kolb,T.M., Suresh,K., Damarla,M. and Shimoda,L.A.
  TITLE     A novel interaction between aquaporin 1 and caspase-3 in pulmonary
            arterial smooth muscle cells
  JOURNAL   Am J Physiol Lung Cell Mol Physiol 326 (5), L638-L645 (2024)
   PUBMED   38375595
  REMARK    GeneRIF: A novel interaction between aquaporin 1 and caspase-3 in
            pulmonary arterial smooth muscle cells.
REFERENCE   3  (bases 1 to 2624)
  AUTHORS   Gonzalez-Marrero,I., Hernandez-Abad,L.G., Gonzalez-Gomez,M.,
            Soto-Viera,M., Carmona-Calero,E.M., Castaneyra-Ruiz,L. and
            Castaneyra-Perdomo,A.
  TITLE     Altered Expression of AQP1 and AQP4 in Brain Barriers and
            Cerebrospinal Fluid May Affect Cerebral Water Balance during
            Chronic Hypertension
  JOURNAL   Int J Mol Sci 23 (20), 12277 (2022)
   PUBMED   36293145
  REMARK    GeneRIF: Altered Expression of AQP1 and AQP4 in Brain Barriers and
            Cerebrospinal Fluid May Affect Cerebral Water Balance during
            Chronic Hypertension.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2624)
  AUTHORS   Ablimit,A., Abdureyim,Z., Yang,P., Azmat,R., Shan,W. and Yao,Q.
  TITLE     Testicular AQP1 expression in a rat model of testicular
            Ischemia-Reperfusion injury
  JOURNAL   J Pediatr Urol 17 (2), 169 (2021)
   PUBMED   33358303
  REMARK    GeneRIF: Testicular AQP1 expression in a rat model of testicular
            Ischemia-Reperfusion injury.
REFERENCE   5  (bases 1 to 2624)
  AUTHORS   Aggeli,I.K., Kapogiannatou,A., Paraskevopoulou,F. and Gaitanaki,C.
  TITLE     Differential response of cardiac aquaporins to hyperosmotic stress;
            salutary role of AQP1 against the induced apoptosis
  JOURNAL   Eur Rev Med Pharmacol Sci 25 (1), 313-325 (2021)
   PUBMED   33506920
  REMARK    GeneRIF: Differential response of cardiac aquaporins to
            hyperosmotic stress; salutary role of AQP1 against the induced
            apoptosis.
REFERENCE   6  (bases 1 to 2624)
  AUTHORS   Abrami,L., Tacnet,F. and Ripoche,P.
  TITLE     Evidence for a glycerol pathway through aquaporin 1 (CHIP28)
            channels
  JOURNAL   Pflugers Arch 430 (3), 447-458 (1995)
   PUBMED   7491270
REFERENCE   7  (bases 1 to 2624)
  AUTHORS   Preston,G.M., Smith,B.L., Zeidel,M.L., Moulds,J.J. and Agre,P.
  TITLE     Mutations in aquaporin-1 in phenotypically normal humans without
            functional CHIP water channels
  JOURNAL   Science 265 (5178), 1585-1587 (1994)
   PUBMED   7521540
REFERENCE   8  (bases 1 to 2624)
  AUTHORS   Deen,P.M., Dempster,J.A., Wieringa,B. and Van Os,C.H.
  TITLE     Isolation of a cDNA for rat CHIP28 water channel: high mRNA
            expression in kidney cortex and inner medulla
  JOURNAL   Biochem Biophys Res Commun 188 (3), 1267-1273 (1992)
   PUBMED   1280133
REFERENCE   9  (bases 1 to 2624)
  AUTHORS   Zeidel,M.L., Ambudkar,S.V., Smith,B.L. and Agre,P.
  TITLE     Reconstitution of functional water channels in liposomes containing
            purified red cell CHIP28 protein
  JOURNAL   Biochemistry 31 (33), 7436-7440 (1992)
   PUBMED   1510932
REFERENCE   10 (bases 1 to 2624)
  AUTHORS   Preston,G.M., Carroll,T.P., Guggino,W.B. and Agre,P.
  TITLE     Appearance of water channels in Xenopus oocytes expressing red cell
            CHIP28 protein
  JOURNAL   Science 256 (5055), 385-387 (1992)
   PUBMED   1373524
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On Nov 26, 2020 this sequence version replaced NM_012778.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X67948.1, BC090068.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-443               JAXUCZ010000004.1  85812784-85813226
            444-608             JAXUCZ010000004.1  85821861-85822025
            609-689             JAXUCZ010000004.1  85822282-85822362
            690-2624            JAXUCZ010000004.1  85823030-85824964
FEATURES             Location/Qualifiers
     source          1..2624
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q24"
     gene            1..2624
                     /gene="Aqp1"
                     /gene_synonym="CHIP28"
                     /note="aquaporin 1"
                     /db_xref="GeneID:25240"
                     /db_xref="RGD:2141"
     exon            1..443
                     /gene="Aqp1"
                     /gene_synonym="CHIP28"
                     /inference="alignment:Splign:2.1.0"
     CDS             60..869
                     /gene="Aqp1"
                     /gene_synonym="CHIP28"
                     /EC_number="2.7.1.21"
                     /note="AQP-1; aquaporin-CHIP; water channel protein for
                     red blood cells and kidney proximal tubule; Aquaporin 1
                     (aquaporin channel forming integral protein 28 (CHIP));
                     aquaporin 1 (Colton blood group)"
                     /codon_start=1
                     /product="aquaporin-1"
                     /protein_id="NP_036910.1"
                     /db_xref="GeneID:25240"
                     /db_xref="RGD:2141"
                     /translation="MASEIKKKLFWRAVVAEFLAMTLFVFISIGSALGFNYPLERNQT
                     LVQDNVKVSLAFGLSIATLAQSVGHISGAHLNPAVTLGLLLSCQISILRAVMYIIAQC
                     VGAIVASAILSGITSSLLENSLGRNDLARGVNSGQGLGIEIIGTLQLVLCVLATTDRR
                     RRDLGGSAPLAIGLSVALGHLLAIDYTGCGINPARSFGSAVLTRNFSNHWIFWVGPFI
                     GSALAVLIYDFILAPRSSDFTDRMKVWTSGQVEEYDLDADDINSRVEMKPK"
     exon            444..608
                     /gene="Aqp1"
                     /gene_synonym="CHIP28"
                     /inference="alignment:Splign:2.1.0"
     exon            609..689
                     /gene="Aqp1"
                     /gene_synonym="CHIP28"
                     /inference="alignment:Splign:2.1.0"
     exon            690..2624
                     /gene="Aqp1"
                     /gene_synonym="CHIP28"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agctcttgga gggagttgag caccaggcat ccagcggtta agtcaaggcc cctgccaaca
       61 tggccagcga aatcaagaag aagctcttct ggagggctgt ggtggctgag ttcctggcca
      121 tgaccctctt cgtcttcatc agcatcggtt ctgccctagg cttcaattac ccactggaga
      181 gaaaccagac gctggtccag gacaatgtga aggtgtcact ggcctttggt ctgagcatcg
      241 ctactctggc ccaaagtgtg ggtcacatca gtggtgctca cctcaaccca gcggtcacac
      301 tggggcttct gctcagctgt cagatcagca tcctccgggc tgtcatgtat atcatcgccc
      361 agtgtgtggg agccatcgtt gcctccgcca tcctctccgg catcacctcc tccctgctcg
      421 agaactcact tggccgaaat gacctggctc gaggtgtgaa ctccggccag ggcctgggca
      481 ttgagatcat tggcaccctg cagctggtgc tgtgcgttct ggctaccact gaccggaggc
      541 gccgagactt aggtggctca gccccacttg ccattggctt gtctgtggct cttggacacc
      601 tgctggccat tgactacact ggctgtggga tcaaccctgc ccggtcattt ggctctgctg
      661 tgctcacccg caacttctca aaccactgga ttttctgggt gggaccattc attgggagtg
      721 ccctggcagt gctgatctat gacttcatcc tggccccacg cagcagcgac tttacagacc
      781 gcatgaaggt gtggaccagt ggccaggtgg aggagtatga cctggatgct gatgatatca
      841 actccagggt ggagatgaag cccaaataga ggaggcttgg cctgggcatc cgtatggggg
      901 tggggcaggg atgggcggag ggaggggagg gctgaactca tattatagac actctgacaa
      961 gctgaccaaa gtcactcccc aagacctggc tgtcccacat ggtctagcct tgtctggggc
     1021 agtaatatca ctgtctttct ttctgtttcc tggtctcaga gcttcctggg gcccaagact
     1081 tatcaactca gcacctcact cctttgacat catggaggag tgaaagggag ggacccacct
     1141 gctagttgtc ccctcagagt gtgctagaaa gtccccctca ctccaaagtt gcccagcaag
     1201 acacccacct taggtgcctg ggattctgcc attgttactt tgtgcctttg atcatggcct
     1261 tccttaggta ggcaccttag ccccaaaggc actttgaggg agaggaagtc ccttagcttt
     1321 cccctttggt ctgacttacc tccaggaccc ttccccttaa actcactcta agaccttgga
     1381 attttcccta tgctgaggcc tcagtgatca cgtctgtaaa gtggcaagga agggacagct
     1441 ttggggactc tgtaagtgtg gacaagccac aggttctaga agggagagtc tagacagcac
     1501 tgcatagtgc acctggctga gctctttccc aacatccaca gcccatgagc acgtgtggat
     1561 gagctacaga gcggagaagc agtccaggat gctgggagtg cctgttcaca cagagagcct
     1621 tcctttaggc aggtctgttg cagcagagta aaggtcattt catggtggag gaagagctca
     1681 tgaaatctct cctagctcta gtgggtctgc tcatgtacca tggcaccaac tggctgtttc
     1741 cctctagtct cccttgcagt gtagatgtga cgtgtgtgtt tattaaagag cactgggcta
     1801 ttgcagcgtc atgtctgagg aaagaagcag ctagacatgc aacagacccc agacagatgc
     1861 ccatgccggg cacacagggg tttggatgcc cctagttcat catgatcaag gaggccactc
     1921 ttgtcctggc ttatgagctg ctggctggat gaatttgacc agagcctgga caatctgaag
     1981 gggctcacta tgtgactcca ggcacagtct ccttattgca aggacctgat gctgtggctt
     2041 ctgctatagc ccaagaacat ctcagagtgc attcagctca gggcttgcat ttagctctct
     2101 gggttattct attcaatccc accaagccag agcagctcta ccactgtgcc gttaaccatg
     2161 tcgtgaaccg agagccacat tcttcaggtg cttagaagca gcagaatagt caggaggcca
     2221 ttgaccactg gcatagtaca gctgcatact cttctccatt ccctagcagg cactatactc
     2281 acttcacagg tcaggacact gaggacccat atgctcaact atatcatatt gggtcaagct
     2341 cagcagtcaa agccatgttt ggccactcca tggtcaatga agtggactcc tctcatttcc
     2401 agcttctccg tttctgcctg gacaatggct aagggccagg gatgggggta ggggtgggag
     2461 tggaggtggt gagagctgtg ctggaggggg gcagggcagg cccatcccac ctggttctgg
     2521 ccactgtgaa ccaggaccct gcatctgtct gctctgtgta tgtttctttg caattggaat
     2581 tccatcttat ggtaagaaaa taaaggacaa tgacttgtaa ggtc
//
