LOCUS       NM_001013061             865 bp    mRNA    linear   ROD 13-JUN-2024
DEFINITION  Rattus norvegicus adenine phosphoribosyl transferase (Aprt), mRNA.
ACCESSION   NM_001013061 XM_214704
VERSION     NM_001013061.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 865)
  AUTHORS   Buschow,S.I., van Balkom,B.W., Aalberts,M., Heck,A.J., Wauben,M.
            and Stoorvogel,W.
  TITLE     MHC class II-associated proteins in B-cell exosomes and potential
            functional implications for exosome biogenesis
  JOURNAL   Immunol Cell Biol 88 (8), 851-856 (2010)
   PUBMED   20458337
REFERENCE   2  (bases 1 to 865)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   3  (bases 1 to 865)
  AUTHORS   Taniguchi,A., Tsuchida,S., Kuno,S., Mita,M., Machida,T.,
            Ioritani,N., Terai,C., Yamanaka,H. and Kamatani,N.
  TITLE     Identification of two novel mutations in adenine
            phosphoribosyltransferase gene in patients with
            2,8-dihydroxyadenine urolithiasis
  JOURNAL   Nucleosides Nucleotides Nucleic Acids 23 (8-9), 1141-1145 (2004)
   PUBMED   15571218
REFERENCE   4  (bases 1 to 865)
  AUTHORS   Silva,M., Silva,C.H., Iulek,J. and Thiemann,O.H.
  TITLE     Three-dimensional structure of human adenine
            phosphoribosyltransferase and its relation to DHA-urolithiasis
  JOURNAL   Biochemistry 43 (24), 7663-7671 (2004)
   PUBMED   15196008
REFERENCE   5  (bases 1 to 865)
  AUTHORS   Khattar,N.H. and Turker,M.S.
  TITLE     A role for certain mouse Aprt sequences in resistance to toxic
            adenine analogs
  JOURNAL   Somat Cell Mol Genet 23 (1), 51-61 (1997)
   PUBMED   9218001
REFERENCE   6  (bases 1 to 865)
  AUTHORS   Tsuchiya,M., Yoshikawa,H., Itakura,M. and Yamashita,K.
  TITLE     Increased de novo purine synthesis by insulin through selective
            enzyme induction in primary cultured rat hepatocytes
  JOURNAL   Am J Physiol 258 (5 Pt 1), C841-C848 (1990)
   PUBMED   2185659
REFERENCE   7  (bases 1 to 865)
  AUTHORS   Beardsley,S., Kunjara,S. and Greenbaum,A.L.
  TITLE     Enzymes of the pathway of purine synthesis in the rat mammary
            gland. Changes in the lactation cycle and the effects of diabetes
  JOURNAL   Biochem J 250 (2), 395-399 (1988)
   PUBMED   2451510
REFERENCE   8  (bases 1 to 865)
  AUTHORS   Hershey,H.V. and Taylor,M.W.
  TITLE     Purification of adenine phosphoribosyltransferase by affinity
            chromatography
  JOURNAL   Prep Biochem 8 (6), 453-462 (1978)
   PUBMED   748918
REFERENCE   9  (bases 1 to 865)
  AUTHORS   Francke,U., Lalley,P.A., Moss,W., Ivy,J. and Minna,J.D.
  TITLE     Gene mapping in Mus musculus by interspecific cell hybridization:
            assignment of the genes for tripeptidase-1 to chromosome 10,
            dipeptidase-2 to chromosome 18, acid phosphatase-1 to chromosome
            12, and adenylate kinase-1 to chromosome 2
  JOURNAL   Cytogenet Cell Genet 19 (2-3), 57-84 (1977)
   PUBMED   198184
REFERENCE   10 (bases 1 to 865)
  AUTHORS   Kozak,C., Nichols,E. and Ruddle,F.H.
  TITLE     Gene linkage analysis in the mouse by somatic cell hybridization:
            assignment of adenine phosphoribosyltransferase to chromosome 8 and
            alpha-galactosidase to the X chromosome
  JOURNAL   Somatic Cell Genet 1 (4), 371-382 (1975)
   PUBMED   1235912
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000019.1.
            
            On Sep 13, 2022 this sequence version replaced NM_001013061.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ228571.1, CN543586.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840109, SAMN16676784
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            RefSeq Select criteria           :: based on single protein-coding
                                                transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-167               JAXUCZ010000019.1  67536861-67537027   c
            168-274             JAXUCZ010000019.1  67536623-67536729   c
            275-408             JAXUCZ010000019.1  67535497-67535630   c
            409-487             JAXUCZ010000019.1  67535225-67535303   c
            488-865             JAXUCZ010000019.1  67534737-67535114   c
FEATURES             Location/Qualifiers
     source          1..865
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19q12"
     gene            1..865
                     /gene="Aprt"
                     /note="adenine phosphoribosyl transferase"
                     /db_xref="GeneID:292072"
                     /db_xref="RGD:1307758"
     exon            1..167
                     /gene="Aprt"
                     /inference="alignment:Splign:2.1.0"
     CDS             88..630
                     /gene="Aprt"
                     /EC_number="2.4.2.7"
                     /codon_start=1
                     /product="adenine phosphoribosyltransferase"
                     /protein_id="NP_001013079.1"
                     /db_xref="GeneID:292072"
                     /db_xref="RGD:1307758"
                     /translation="MSESELQLVARRIRSFPDFPIPGVLFRDISPLLKDPDSFRASIR
                     LLAGHLKSTHGGKIDYIAGLDSRGFLFGPSLAQELGVGCVLIRKRGKLPGPTVSASYS
                     LEYGKAELEIQKDALEPGQKVVIVDDLLATGGTMCAACELLSQLRAEVVECVSLVELT
                     SLKGREKLGPVPFFSLLQYE"
     exon            168..274
                     /gene="Aprt"
                     /inference="alignment:Splign:2.1.0"
     exon            275..408
                     /gene="Aprt"
                     /inference="alignment:Splign:2.1.0"
     exon            409..487
                     /gene="Aprt"
                     /inference="alignment:Splign:2.1.0"
     exon            488..865
                     /gene="Aprt"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggggacgccc cgcccttgtt tcccggattg acttgcccct ggcctgcaga cacccacctc
       61 ctcccttcct cttacatgca tgcggccatg tccgaatctg agttgcagct ggtggcgcgg
      121 cgcatccgca gcttcccgga cttccccatc ccgggcgtgc tgttcaggga tatctcgccc
      181 ctcttgaaag atccggactc cttccgagct tccatccgcc tcctggccgg tcacctgaag
      241 tccacgcacg gcggcaagat cgactacatc gcaggtctgg actccagggg cttcctgttt
      301 ggcccttccc ttgctcagga gctgggggtg ggctgtgtgc tcatccgtaa gcgcgggaag
      361 ctaccaggcc ccactgtatc agcctcctat tctctagagt atgggaaggc tgagctggaa
      421 atccagaaag atgccttaga accggggcag aaagtggtca ttgtggatga tctcctggcc
      481 actggaggaa ccatgtgtgc agcctgtgag ctgctgagcc agctgcgggc tgaggtggtg
      541 gagtgtgtga gcctggtgga gctgacctcc ctgaagggca gggagaagct gggacctgtg
      601 ccattcttct ctctcctgca gtatgagtga ggagctggca aggtggacac accccttgat
      661 aattaagtac acagtggctg ggcccagggc acctaagtga cctttgtaag ctaccggctg
      721 ccctttcgtg aatgagggca ttccattggt cagcagatag ccatgcctat ggatcacctg
      781 gaaccttgca ttttgtacgc ttgccacacc ctcgagtaaa gcagagctgt gctactggag
      841 gtcaataaac tgctttgata tacac
//
