LOCUS       NM_001108741            2964 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus adaptor protein, phosphotyrosine interacting with
            PH domain and leucine zipper 2 (Appl2), mRNA.
ACCESSION   NM_001108741 XM_001079632 XM_343190
VERSION     NM_001108741.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2964)
  AUTHORS   Gao,C., Du,Q., Li,W., Deng,R., Wang,Q., Xu,A. and Shen,J.
  TITLE     Baicalin Modulates APPL2/Glucocorticoid Receptor Signaling Cascade,
            Promotes Neurogenesis, and Attenuates Emotional and Olfactory
            Dysfunctions in Chronic Corticosterone-Induced Depression
  JOURNAL   Mol Neurobiol 55 (12), 9334-9348 (2018)
   PUBMED   29675572
REFERENCE   2  (bases 1 to 2964)
  AUTHORS   Gao,C., Chen,X., Xu,A., Cheng,K. and Shen,J.
  TITLE     Adaptor Protein APPL2 Affects Adult Antidepressant Behaviors and
            Hippocampal Neurogenesis via Regulating the Sensitivity of
            Glucocorticoid Receptor
  JOURNAL   Mol Neurobiol 55 (7), 5537-5547 (2018)
   PUBMED   28965332
REFERENCE   3  (bases 1 to 2964)
  AUTHORS   Wang,B., Li,A., Li,X., Ho,P.W., Wu,D., Wang,X., Liu,Z., Wu,K.K.,
            Yau,S.S., Xu,A. and Cheng,K.K.
  TITLE     Activation of hypothalamic RIP-Cre neurons promotes beiging of WAT
            via sympathetic nervous system
  JOURNAL   EMBO Rep 19 (4) (2018)
   PUBMED   29467283
REFERENCE   4  (bases 1 to 2964)
  AUTHORS   Yeo,J.C., Wall,A.A., Luo,L., Condon,N.D. and Stow,J.L.
  TITLE     Distinct Roles for APPL1 and APPL2 in Regulating Toll-like Receptor
            4 Signaling in Macrophages
  JOURNAL   Traffic 17 (9), 1014-1026 (2016)
   PUBMED   27219021
REFERENCE   5  (bases 1 to 2964)
  AUTHORS   Song,J., Mu,Y., Li,C., Bergh,A., Miaczynska,M., Heldin,C.H. and
            Landstrom,M.
  TITLE     APPL proteins promote TGFbeta-induced nuclear transport of the
            TGFbeta type I receptor intracellular domain
  JOURNAL   Oncotarget 7 (1), 279-292 (2016)
   PUBMED   26583432
REFERENCE   6  (bases 1 to 2964)
  AUTHORS   Urbanska,A., Sadowski,L., Kalaidzidis,Y. and Miaczynska,M.
  TITLE     Biochemical characterization of APPL endosomes: the role of annexin
            A2 in APPL membrane recruitment
  JOURNAL   Traffic 12 (9), 1227-1241 (2011)
   PUBMED   21645192
REFERENCE   7  (bases 1 to 2964)
  AUTHORS   Wang,C., Xin,X., Xiang,R., Ramos,F.J., Liu,M., Lee,H.J., Chen,H.,
            Mao,X., Kikani,C.K., Liu,F. and Dong,L.Q.
  TITLE     Yin-Yang regulation of adiponectin signaling by APPL isoforms in
            muscle cells
  JOURNAL   J Biol Chem 284 (46), 31608-31615 (2009)
   PUBMED   19661063
REFERENCE   8  (bases 1 to 2964)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   9  (bases 1 to 2964)
  AUTHORS   Chial,H.J., Wu,R., Ustach,C.V., McPhail,L.C., Mobley,W.C. and
            Chen,Y.Q.
  TITLE     Membrane targeting by APPL1 and APPL2: dynamic scaffolds that
            oligomerize and bind phosphoinositides
  JOURNAL   Traffic 9 (2), 215-229 (2008)
   PUBMED   18034774
  REMARK    Erratum:[Traffic. 2008 Apr;9(4):623-4]
REFERENCE   10 (bases 1 to 2964)
  AUTHORS   Miaczynska,M., Christoforidis,S., Giner,A., Shevchenko,A.,
            Uttenweiler-Joseph,S., Habermann,B., Wilm,M., Parton,R.G. and
            Zerial,M.
  TITLE     APPL proteins link Rab5 to nuclear signal transduction via an
            endosomal compartment
  JOURNAL   Cell 116 (3), 445-456 (2004)
   PUBMED   15016378
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473960.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001079632.1, XM_343190.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC168167.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132279, SAMD00132280
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2964
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q13"
     gene            1..2964
                     /gene="Appl2"
                     /gene_synonym="RGD1563028"
                     /note="adaptor protein, phosphotyrosine interacting with
                     PH domain and leucine zipper 2"
                     /db_xref="GeneID:362860"
                     /db_xref="RGD:1563028"
     exon            1..140
                     /gene="Appl2"
                     /gene_synonym="RGD1563028"
                     /inference="alignment:Splign:2.1.0"
     CDS             87..2075
                     /gene="Appl2"
                     /gene_synonym="RGD1563028"
                     /note="adaptor protein, phosphotyrosine interaction, PH
                     domain and leucine zipper containing 2; adapter protein
                     containing PH domain, PTB domain and leucine zipper motif
                     2"
                     /codon_start=1
                     /product="DCC-interacting protein 13-beta"
                     /protein_id="NP_001102211.1"
                     /db_xref="GeneID:362860"
                     /db_xref="RGD:1563028"
                     /translation="MPAVDKLLLEEALQDSPQTRSLLSVFEEDAGTLTDYTNQLLQAM
                     QRVYGAQNEMCLATQQLSRQLLAYEKQNFALGKGDEEVISTLHYFSKVMDELNGLHSE
                     LAKQLADTMVLPVIQFREKDLTEVSTLKDLFGLASNEHDLSMAKYSRLPKRKENERVK
                     TDVAKEVAAARRKQHLSSLQYYCALNALQYRKRAAMMEPLIGFAHGQINFFKKGAEMF
                     SKSMDGFLSSVTDMVQSIQVELEAEADKMRVSQQELLSVSESVYTPDIDVATPQINRN
                     LIQKTGYLNLRNKTGLVTTTWERLYFFTQGGNLMCQPRGAVAGGLIQDLDNCSVMAVD
                     CEDRRYCFQISTPSGKPGIILQAESRKEYEEWICAINNISRQIYLTDNPEAVAIKLNQ
                     TALQAVTPITSFGKKQESFYFSQNIKNSDTGYVKIVPKAAASIPETEELIAPGTPIQF
                     DIVLPATEFLDQNRGSRRINPFGETEDDSFPDAEDSLLQQMFIVRFLGSMAVKTDSTT
                     EVIYEAMRQVLAARAIHNIFRTTESHLMVTSQTLRLIDPQTQVSRACFELTSVTQFAA
                     HQENKRLVGFVIRVPESTGEESLSTYIFESNSEGEKICYAINLGKEIIEVQKDPEALA
                     RLMLSVPLTNDGKYVLLNDQADDTGGSPSDHRGAESEA"
     exon            141..239
                     /gene="Appl2"
                     /gene_synonym="RGD1563028"
                     /inference="alignment:Splign:2.1.0"
     exon            240..299
                     /gene="Appl2"
                     /gene_synonym="RGD1563028"
                     /inference="alignment:Splign:2.1.0"
     exon            300..371
                     /gene="Appl2"
                     /gene_synonym="RGD1563028"
                     /inference="alignment:Splign:2.1.0"
     exon            372..459
                     /gene="Appl2"
                     /gene_synonym="RGD1563028"
                     /inference="alignment:Splign:2.1.0"
     exon            460..501
                     /gene="Appl2"
                     /gene_synonym="RGD1563028"
                     /inference="alignment:Splign:2.1.0"
     exon            502..560
                     /gene="Appl2"
                     /gene_synonym="RGD1563028"
                     /inference="alignment:Splign:2.1.0"
     exon            561..707
                     /gene="Appl2"
                     /gene_synonym="RGD1563028"
                     /inference="alignment:Splign:2.1.0"
     exon            708..790
                     /gene="Appl2"
                     /gene_synonym="RGD1563028"
                     /inference="alignment:Splign:2.1.0"
     exon            791..949
                     /gene="Appl2"
                     /gene_synonym="RGD1563028"
                     /inference="alignment:Splign:2.1.0"
     exon            950..1138
                     /gene="Appl2"
                     /gene_synonym="RGD1563028"
                     /inference="alignment:Splign:2.1.0"
     exon            1139..1181
                     /gene="Appl2"
                     /gene_synonym="RGD1563028"
                     /inference="alignment:Splign:2.1.0"
     exon            1182..1238
                     /gene="Appl2"
                     /gene_synonym="RGD1563028"
                     /inference="alignment:Splign:2.1.0"
     exon            1239..1327
                     /gene="Appl2"
                     /gene_synonym="RGD1563028"
                     /inference="alignment:Splign:2.1.0"
     exon            1328..1486
                     /gene="Appl2"
                     /gene_synonym="RGD1563028"
                     /inference="alignment:Splign:2.1.0"
     exon            1487..1539
                     /gene="Appl2"
                     /gene_synonym="RGD1563028"
                     /inference="alignment:Splign:2.1.0"
     exon            1540..1714
                     /gene="Appl2"
                     /gene_synonym="RGD1563028"
                     /inference="alignment:Splign:2.1.0"
     exon            1715..1751
                     /gene="Appl2"
                     /gene_synonym="RGD1563028"
                     /inference="alignment:Splign:2.1.0"
     exon            1752..1892
                     /gene="Appl2"
                     /gene_synonym="RGD1563028"
                     /inference="alignment:Splign:2.1.0"
     exon            1893..1940
                     /gene="Appl2"
                     /gene_synonym="RGD1563028"
                     /inference="alignment:Splign:2.1.0"
     exon            1941..2964
                     /gene="Appl2"
                     /gene_synonym="RGD1563028"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcaggcgcg ggctcggagc taagcctcaa gtccccgagt gctgagtgtc cccttctcgc
       61 gtcccgcgct ccctcactgc cgcgccatgc ccgccgtgga caagctcctg ctggaggagg
      121 cgctgcagga cagcccccag acgaggtccc tgctgagtgt ctttgaagag gatgctggca
      181 ccctcacaga ctacaccaac cagctgctgc aggcgatgca gcgtgtctat ggtgcacaga
      241 atgaaatgtg tctggccacg caacagcttt ccaggcagct gctggcatat gaaaaacaga
      301 attttgcact gggcaaaggc gacgaagaag taatttctac actacattat ttttccaaag
      361 tgatggatga gctcaatggt ctccactcag agctggccaa gcaactggca gacactatgg
      421 ttctccctgt tatacagttc cgagagaagg atctcacaga ggtcagcact ttgaaggatc
      481 tctttggact tgccagcaat gagcatgacc tgtcaatggc aaaatacagc aggctcccta
      541 agagaaagga gaacgagagg gtgaagacgg acgttgcaaa ggaggtggca gctgcccggc
      601 ggaaacagca tctgtcatcc cttcagtact actgtgcact gaacgcactg cagtaccgca
      661 agagggcagc catgatggag ccgctcatag gctttgccca tggacagatt aactttttca
      721 agaaaggagc agagatgttc tccaaaagta tggacggttt cttatcatcc gttacagaca
      781 tggttcagag cattcaggtg gaactggaag ccgaggccga caagatgcgg gtgtcccagc
      841 aggagctgct ttcagtcagt gagtctgttt acactccgga catcgatgtg gccacaccgc
      901 agatcaacag gaacctcatc cagaagactg gctacctcaa tctcagaaac aagacgggac
      961 tggtcaccac cacatgggaa aggctgtact tcttcaccca aggcgggaac ctcatgtgcc
     1021 agcctagggg agctgtggct ggaggcttga ttcaggacct ggacaactgc tctgtgatgg
     1081 cggtggattg cgaagaccga cgatactgct tccagatctc cacgcccagt ggcaaaccgg
     1141 ggataattct ccaggcagag agcagaaagg aatatgaaga gtggatatgt gcaataaaca
     1201 atatctccag gcagatctac ctgacagaca acccagaggc agtagccatc aagttgaatc
     1261 agacggctct tcaggcggtg actccgatta caagctttgg gaaaaaacaa gaaagcttct
     1321 acttcagtca aaacataaaa aattcagaca caggatatgt caagattgtt cccaaagcag
     1381 cagccagcat tcctgagaca gaggaactga ttgcacctgg gacacccatt cagtttgaca
     1441 ttgtacttcc tgcaacggaa ttccttgacc agaacagagg cagcaggcgc atcaaccctt
     1501 ttggtgagac ggaggatgac tcatttccgg acgcagaaga ctctctcttg cagcagatgt
     1561 tcatcgttcg gtttttggga tcgatggcag ttaagacaga cagcactacg gaagtgattt
     1621 atgaagcgat gcgacaagta ctggctgctc gggctattca caacatcttc cgcaccacgg
     1681 agtcccacct gatggttacc agtcagactc tgaggttgat agatcctcag actcaagtgt
     1741 cacgggcctg ttttgagctc accagtgtca cacagtttgc tgctcatcaa gaaaacaaaa
     1801 ggctggttgg cttcgtcatc cgagtgccgg agtctacagg agaagagtct ctgagcacat
     1861 acatttttga aagcaactca gaaggcgaga agatatgtta tgctattaat ttggggaaag
     1921 aaattattga ggttcaaaag gatccagaag cactggctcg attaatgctg tctgtaccac
     1981 taaccaatga cggaaaatat gtactgttaa acgatcaagc agatgacact ggcggaagtc
     2041 caagtgacca cagaggcgca gagtctgaag cataactcac ttgggcatcg ggggtcagag
     2101 cgcgtgggaa ggagagccac tccttaaggg gttttcaact tctctgacgt acaggcacac
     2161 tgacctgatt agaacaccga caatcacgtg tggagtgtac ccttggatgc cctggcacag
     2221 agacttggga gggagacagt cagaaatggg tgagagcgtg cctacccatc tacaaatgct
     2281 attttaggtg ctctgtggta agtctttgct tcagactgtt gggggcccag aatgagagct
     2341 ataaaaatgc attgttcact ttatttggat agcatcactt cagttcctag gatccttttg
     2401 taaatggaaa aaccctggat ttacaacttg ttaaatacta aatagttcct attaatatga
     2461 tctatttttg tattttactt agtttttaag tgcctgtcat tctgaatatt atatatttat
     2521 aacccgctgg tctcatgcct agacctcatg gcattgctat gcaatttggt cttaaacact
     2581 agcagatagc aaatcttcac aacagaacct ttcaaaacaa gctttcattc aaaagcttca
     2641 ggtcctctta aatgtggctg ctttctgggg ctattcactg tgagcaaggg acagctctac
     2701 tagttcctgt ttcttctgag ccagaccttc ctcaaaggga ccaattaatt ttaacactca
     2761 cttgaagctc agcgggctgt ggaactatgt ttgaagttct ggtttctacc ctgatgattc
     2821 tggttcctgg agacccagac caatctccaa ctcctagtta tgaagtagag ataaagatct
     2881 tgaaatcatg cagcataaat taattgtaac caccttcaac aacctgcctt tgtaataatt
     2941 tagcaataaa aactgtttca tctc
//
