LOCUS       NM_001399084            5807 bp    mRNA    linear   ROD 28-MAR-2024
DEFINITION  Rattus norvegicus adaptor protein, phosphotyrosine interacting with
            PH domain and leucine zipper 1 (Appl1), mRNA.
ACCESSION   NM_001399084 XM_039095137
VERSION     NM_001399084.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5807)
  AUTHORS   Du,Y., Duan,Y., Zhao,J., Liu,C., Zhang,Z., Zhang,J., Meng,Z.,
            Wang,X., Lau,W.B., Xie,D., Lopez,B.L., Christopher,T.A., Gao,E.,
            Koch,W.W., Liu,H., Liu,D., Ma,X.L., Gu,G. and Wang,Y.
  TITLE     Dysfunctional APPL1-Mediated Epigenetic Regulation in Diabetic
            Vascular Injury
  JOURNAL   Arterioscler Thromb Vasc Biol 43 (12), e491-e508 (2023)
   PUBMED   37795615
  REMARK    GeneRIF: Dysfunctional APPL1-Mediated Epigenetic Regulation in
            Diabetic Vascular Injury.
REFERENCE   2  (bases 1 to 5807)
  AUTHORS   Tu,X., Zhang,H., Chen,S., Ding,Y.H., Wu,X., Liang,R. and Shi,S.S.
  TITLE     LncRNA CEBPA-AS1 alleviates cerebral ischemia-reperfusion injury by
            sponging miR-340-5p regulating APPL1/LKB1/AMPK pathway
  JOURNAL   FASEB J 36 (1), e22075 (2022)
   PUBMED   34919285
  REMARK    GeneRIF: LncRNA CEBPA-AS1 alleviates cerebral ischemia-reperfusion
            injury by sponging miR-340-5p regulating APPL1/LKB1/AMPK pathway.
REFERENCE   3  (bases 1 to 5807)
  AUTHORS   Bai,L., Yang,J., Zhang,H., Liao,W. and Cen,Y.
  TITLE     PTB domain and leucine zipper motif 1 (APPL1) inhibits myocardial
            ischemia/hypoxia-reperfusion injury via inactivation of apoptotic
            protease activating factor-1 (APAF-1)/Caspase9 signaling pathway
  JOURNAL   Bioengineered 12 (1), 4385-4396 (2021)
   PUBMED   34304702
  REMARK    GeneRIF: PTB domain and leucine zipper motif 1 (APPL1) inhibits
            myocardial ischemia/hypoxia-reperfusion injury via inactivation of
            apoptotic protease activating factor-1 (APAF-1)/Caspase9 signaling
            pathway.
REFERENCE   4  (bases 1 to 5807)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5807)
  AUTHORS   Kido,K., Ato,S., Yokokawa,T., Sato,K. and Fujita,S.
  TITLE     Resistance training recovers attenuated APPL1 expression and
            improves insulin-induced Akt signal activation in skeletal muscle
            of type 2 diabetic rats
  JOURNAL   Am J Physiol Endocrinol Metab 314 (6), E564-E571 (2018)
   PUBMED   29406784
  REMARK    GeneRIF: APPL1 may be a key regulator of insulin resistance in
            skeletal muscle, and Resistance training may be an important
            physiological treatment increasing APPL1 expression, which is
            attenuated in T2 Diabetes.
REFERENCE   6  (bases 1 to 5807)
  AUTHORS   Chial,H.J., Wu,R., Ustach,C.V., McPhail,L.C., Mobley,W.C. and
            Chen,Y.Q.
  TITLE     Membrane targeting by APPL1 and APPL2: dynamic scaffolds that
            oligomerize and bind phosphoinositides
  JOURNAL   Traffic 9 (2), 215-229 (2008)
   PUBMED   18034774
  REMARK    Erratum:[Traffic. 2008 Apr;9(4):623-4]
REFERENCE   7  (bases 1 to 5807)
  AUTHORS   Saito,T., Jones,C.C., Huang,S., Czech,M.P. and Pilch,P.F.
  TITLE     The interaction of Akt with APPL1 is required for
            insulin-stimulated Glut4 translocation
  JOURNAL   J Biol Chem 282 (44), 32280-32287 (2007)
   PUBMED   17848569
REFERENCE   8  (bases 1 to 5807)
  AUTHORS   Zhu,G., Chen,J., Liu,J., Brunzelle,J.S., Huang,B., Wakeham,N.,
            Terzyan,S., Li,X., Rao,Z., Li,G. and Zhang,X.C.
  TITLE     Structure of the APPL1 BAR-PH domain and characterization of its
            interaction with Rab5
  JOURNAL   EMBO J 26 (14), 3484-3493 (2007)
   PUBMED   17581628
REFERENCE   9  (bases 1 to 5807)
  AUTHORS   Li,J., Mao,X., Dong,L.Q., Liu,F. and Tong,L.
  TITLE     Crystal structures of the BAR-PH and PTB domains of human APPL1
  JOURNAL   Structure 15 (5), 525-533 (2007)
   PUBMED   17502098
REFERENCE   10 (bases 1 to 5807)
  AUTHORS   Miaczynska,M., Christoforidis,S., Giner,A., Shevchenko,A.,
            Uttenweiler-Joseph,S., Habermann,B., Wilm,M., Parton,R.G. and
            Zerial,M.
  TITLE     APPL proteins link Rab5 to nuclear signal transduction via an
            endosomal compartment
  JOURNAL   Cell 116 (3), 445-456 (2004)
   PUBMED   15016378
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Jan 4, 2022 this sequence version replaced XM_039095137.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643290.47178.1,
                                           SRR26643289.37637.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760386,
                                           SAMEA5760393 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-121               JAXUCZ010000016.1  2173276-2173396     c
            122-220             JAXUCZ010000016.1  2167935-2168033     c
            221-280             JAXUCZ010000016.1  2162755-2162814     c
            281-352             JAXUCZ010000016.1  2161605-2161676     c
            353-440             JAXUCZ010000016.1  2159529-2159616     c
            441-482             JAXUCZ010000016.1  2158003-2158044     c
            483-541             JAXUCZ010000016.1  2157035-2157093     c
            542-688             JAXUCZ010000016.1  2153562-2153708     c
            689-771             JAXUCZ010000016.1  2152100-2152182     c
            772-930             JAXUCZ010000016.1  2151228-2151386     c
            931-1119            JAXUCZ010000016.1  2149842-2150030     c
            1120-1162           JAXUCZ010000016.1  2148300-2148342     c
            1163-1219           JAXUCZ010000016.1  2146837-2146893     c
            1220-1311           JAXUCZ010000016.1  2145081-2145172     c
            1312-1494           JAXUCZ010000016.1  2144033-2144215     c
            1495-1547           JAXUCZ010000016.1  2141661-2141713     c
            1548-1722           JAXUCZ010000016.1  2133686-2133860     c
            1723-1759           JAXUCZ010000016.1  2133561-2133597     c
            1760-1906           JAXUCZ010000016.1  2132851-2132997     c
            1907-1957           JAXUCZ010000016.1  2131122-2131172     c
            1958-2047           JAXUCZ010000016.1  2130453-2130542     c
            2048-5807           JAXUCZ010000016.1  2125234-2128993     c
FEATURES             Location/Qualifiers
     source          1..5807
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p16"
     gene            1..5807
                     /gene="Appl1"
                     /gene_synonym="RGD1309388"
                     /note="adaptor protein, phosphotyrosine interacting with
                     PH domain and leucine zipper 1"
                     /db_xref="GeneID:290537"
                     /db_xref="RGD:1309388"
     exon            1..121
                     /gene="Appl1"
                     /gene_synonym="RGD1309388"
                     /inference="alignment:Splign:2.1.0"
     CDS             68..2191
                     /gene="Appl1"
                     /gene_synonym="RGD1309388"
                     /note="adaptor protein, phosphotyrosine interaction, PH
                     domain and leucine zipper containing 1"
                     /codon_start=1
                     /product="DCC-interacting protein 13-alpha"
                     /protein_id="NP_001386013.1"
                     /db_xref="GeneID:290537"
                     /db_xref="RGD:1309388"
                     /translation="MPGIDKLPIEETLEDSPQTRSLLGVFEEDATAISNYMNQLYQAM
                     HRIYDAQNELSAATHLTSKLLKEYEKQRFPLGGDDEVMSSTLQQFSKVIDELSSCHAV
                     LSTQLADAMMFPISQFKERDLKEILTLKEVFQIASNDHDAAINRYSRLSKKRENDKVK
                     YEVTEDVYTSRKKQHQTMMHYFCALNTLQYKKKIALLEPLLGYMQAQISFFKMGSENL
                     NGQLEEFLANIGTSVQNVRREMDGDVETMQQTIEDLEVASDPLYLPDPDPTKFPVNRN
                     LTRKAGYLNARNKTGLVSSTWDRQFYFTQGGNLMSQARGDVAGGLAMDIDNCSVMAVD
                     CEDRRYCFQITSFDGKKSSILQAESKKDHEEWICTINNISKQIYLSENPEETAARVNQ
                     SALEAVTPSPSFQQRHESLRPGGQSRPPTARTSSSGSLGSESTNLAALSLDSLVAPDT
                     PIQFDIISPVCEDQPGQAKAFGQGGRRTNPFGESGGSTKSETEDSILHQLFIVRFLGS
                     MEVKSDDHPDVVYETMRQILAARAIHNIFRMTESHLLVTCDCLKLIDPQTQVTRLTFP
                     LPYVVLYATHQENKRLFGFVLRTSGGRSESNLSSVCYIFESNNEGEKICDSVGLAKQI
                     ALHAELDRRASEKQKEIERVKEKQQKELSKQKEIEKDLEEQSRLIAASSRPSQSGSEG
                     QLVLSSSQSEESDLGEEGKKRESEA"
     exon            122..220
                     /gene="Appl1"
                     /gene_synonym="RGD1309388"
                     /inference="alignment:Splign:2.1.0"
     exon            221..280
                     /gene="Appl1"
                     /gene_synonym="RGD1309388"
                     /inference="alignment:Splign:2.1.0"
     exon            281..352
                     /gene="Appl1"
                     /gene_synonym="RGD1309388"
                     /inference="alignment:Splign:2.1.0"
     exon            353..440
                     /gene="Appl1"
                     /gene_synonym="RGD1309388"
                     /inference="alignment:Splign:2.1.0"
     exon            441..482
                     /gene="Appl1"
                     /gene_synonym="RGD1309388"
                     /inference="alignment:Splign:2.1.0"
     exon            483..541
                     /gene="Appl1"
                     /gene_synonym="RGD1309388"
                     /inference="alignment:Splign:2.1.0"
     exon            542..688
                     /gene="Appl1"
                     /gene_synonym="RGD1309388"
                     /inference="alignment:Splign:2.1.0"
     exon            689..771
                     /gene="Appl1"
                     /gene_synonym="RGD1309388"
                     /inference="alignment:Splign:2.1.0"
     exon            772..930
                     /gene="Appl1"
                     /gene_synonym="RGD1309388"
                     /inference="alignment:Splign:2.1.0"
     exon            931..1119
                     /gene="Appl1"
                     /gene_synonym="RGD1309388"
                     /inference="alignment:Splign:2.1.0"
     exon            1120..1162
                     /gene="Appl1"
                     /gene_synonym="RGD1309388"
                     /inference="alignment:Splign:2.1.0"
     exon            1163..1219
                     /gene="Appl1"
                     /gene_synonym="RGD1309388"
                     /inference="alignment:Splign:2.1.0"
     exon            1220..1311
                     /gene="Appl1"
                     /gene_synonym="RGD1309388"
                     /inference="alignment:Splign:2.1.0"
     exon            1312..1494
                     /gene="Appl1"
                     /gene_synonym="RGD1309388"
                     /inference="alignment:Splign:2.1.0"
     exon            1495..1547
                     /gene="Appl1"
                     /gene_synonym="RGD1309388"
                     /inference="alignment:Splign:2.1.0"
     exon            1548..1722
                     /gene="Appl1"
                     /gene_synonym="RGD1309388"
                     /inference="alignment:Splign:2.1.0"
     exon            1723..1759
                     /gene="Appl1"
                     /gene_synonym="RGD1309388"
                     /inference="alignment:Splign:2.1.0"
     exon            1760..1906
                     /gene="Appl1"
                     /gene_synonym="RGD1309388"
                     /inference="alignment:Splign:2.1.0"
     exon            1907..1957
                     /gene="Appl1"
                     /gene_synonym="RGD1309388"
                     /inference="alignment:Splign:2.1.0"
     exon            1958..2047
                     /gene="Appl1"
                     /gene_synonym="RGD1309388"
                     /inference="alignment:Splign:2.1.0"
     exon            2048..5807
                     /gene="Appl1"
                     /gene_synonym="RGD1309388"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aggcggggcc gtgcgcggag ctgtgggcgg ctgccgagtg tcctgccgcc gcccagcctt
       61 cgccacgatg ccggggatcg acaagctgcc cattgaagag accctggagg acagtccgca
      121 gacaaggtct ttactgggcg tatttgaaga agatgctact gctatttcta attatatgaa
      181 ccaattgtat caagctatgc atcggattta tgatgcacag aatgaattaa gtgcagcaac
      241 tcacctgact tcgaaacttt tgaaagaata tgagaagcag cgttttcctc tggggggtga
      301 tgatgaagtt atgagctcta ctttgcagca gttttccaag gtcatagatg agcttagttc
      361 ttgtcatgca gttctttcaa ctcaactcgc tgatgccatg atgttcccca tttcccagtt
      421 taaagaaaga gatctgaaag aaatattgac actaaaagag gtatttcaga ttgctagtaa
      481 tgatcatgat gccgcaatta ataggtacag ccggttgtca aaaaagagag aaaatgacaa
      541 ggtaaagtat gaagtaacag aggatgtgta tacttccagg aaaaagcaac accagaccat
      601 gatgcattat ttttgtgcac taaatactct tcagtacaag aagaaaatag ctttgttaga
      661 acctctgctt ggatacatgc aggctcagat aagtttcttt aagatgggtt ctgaaaatct
      721 caatggacaa ttggaagaat ttttagctaa cattggaaca agtgtacaga atgtgcgaag
      781 ggaaatggat ggggatgtgg agaccatgca acagacaata gaagacttgg aagtagccag
      841 tgacccttta tatctgcctg acccagatcc caccaagttt cccgtcaatc gaaatttaac
      901 ccgaaaggct ggatacctaa atgctaggaa taaaacaggc ttggtgtcat ctacctggga
      961 tagacagttt tacttcacgc agggtggaaa cttaatgagt caagcccgtg gagatgtggc
     1021 aggaggccta gccatggaca tagacaactg ttcagtgatg gctgtggact gcgaagacag
     1081 acgatactgt tttcagatca cttcttttga tggaaaaaaa tcttcaattt tgcaagcaga
     1141 gagtaaaaaa gaccatgaag agtggatctg tacaataaac aacatatcta aacaaatata
     1201 tttgagtgaa aatccagagg aaaccgctgc acgagtgaat cagtctgctc tagaagctgt
     1261 cactccttcc ccatctttcc agcagagaca cgagagcctg cgtccaggag gacaatctcg
     1321 accaccaaca gcacgaacca gcagttcagg atccttggga tcagagtcta caaatttggc
     1381 tgccctctct ctagattctc ttgttgctcc agatacacca atacagtttg atataatttc
     1441 tcctgtgtgt gaagatcagc ctggccaggc aaaagccttt ggtcaaggag gcaggcgtac
     1501 aaatccattt ggagaatctg gaggaagcac aaaatcagaa actgaagact ctattcttca
     1561 tcagttgttt attgtccgat tccttggttc tatggaggta aagtcagatg accatccaga
     1621 tgttgtctat gaaacaatgc gtcagatctt agctgctcgg gccatccaca acatcttccg
     1681 tatgacagaa tcacatttat tagtcacttg tgactgtctg aagttaattg atccacagac
     1741 ccaagttaca aggctcacat ttccattacc atatgtagtt ctgtatgcta cgcaccagga
     1801 aaataaacgg ctttttggat ttgttctccg gacctcaggc ggaagaagtg agagtaatct
     1861 gtcatcagtc tgctatatat ttgagtccaa caatgagggg gaaaagattt gtgattctgt
     1921 tggattggca aaacagatag ctttgcatgc tgaactggat cgtagggcat cagaaaaaca
     1981 aaaggaaata gagagagtaa aagagaaaca acagaaagaa ctcagcaaac agaaagagat
     2041 cgagaaggac ttggaagaac agagtcggct gatagctgcc tccagtagac caagccagtc
     2101 tggtagcgag ggccagcttg ttcttagcag tagccaatca gaggagagtg atttgggaga
     2161 agaaggaaaa aaaagagagt cggaagcgtg aacttgttgt ttttgatttc ccctttccct
     2221 ggaatgtgtc gcatccatgc taaagatcaa ggaagagatt acactttata tttgcgtgtt
     2281 ccggcttcat ttaaaaagac tgaacttgat aacaggttat attgagcatt tccccttaaa
     2341 aataaaatgc tatgcatcat cctccaactc tgcttcctaa acaagacccg cttaatttcc
     2401 tgtagtagat tactgaggaa ttacacttgc tcaagatatt tttcctttaa attgtgaaca
     2461 ttttatttta cactgtaatt ggttgtctcc ataagaaatc atttttcttc agattctgac
     2521 gtttatgtgt gtactttctc cctttcatta ggaatgtttt attggtagtg agggagtgtt
     2581 caactgaatg agcttcaaat cctttttgtg gagaactctg caagtttgca aatgttctaa
     2641 caatatcgag tgcaatagca tttgtataaa atcattagga cggcagatgg tgctgttgac
     2701 aggatggttt gtggcttgct ctgtttctct aatgtactag atcatggcag gaggagagcc
     2761 ctcacatgtc tgttggtgtt ggtgccgtcc ttggtgtttg ttaccgtcat ctccgctctc
     2821 aggttggggc ttgactcact gctgcagagc agtaagggtt aggctgagac taagaattta
     2881 ttgagattgt tgtcgttgtt caaacatttt atactacaat tgacatgtaa agggagtgtt
     2941 gtagactgat acattgtatt ttctgtattg tgaaataatt tttaataagt gacatttcaa
     3001 aagatgttct ataacaatta tgtttactgc ttaaataaaa tgtgcagttt agtttagaaa
     3061 acataatctt ttaaatttta gactgataat cccagtattt tcataatccc acattttgat
     3121 aatgtattga attgccactt tataccacaa aggcaaataa ctaatttatg agtggagaat
     3181 aatttgcact aattattgta aatactttta cttttcaaat gagtaaaaga tctaattcca
     3241 tgaaagactg aaaaggaatg gaacacctca tataatatag gaccaaggaa ggagttagct
     3301 tgctaccgag gttgacatgt ccctccagtc tgtcttctgt caagatttct tagattttaa
     3361 actgtgttta tagattttat tttcatgcgt tctacatgaa aaggtgtata tatacatatg
     3421 tatacaagtt aaatatattg attaatattt tacagtcata catttataga ttttcaagag
     3481 gttaaccact aatttcacaa gtagttttct ttgttctgaa ttagaaatgg tttctgttgt
     3541 agttttcagc atatagctca gtttcacact ctgtacgtcc actgttttct gtaggaacac
     3601 gataacagta tatctaggat cacgacattc tttttatcca tgtgccaaat gggactggtt
     3661 atttaatact ctttaaagtc ttatgttacc caaacatgca gttaataagt atcaatttat
     3721 agagtgcatt tgactaaaag tctgttttgg gcttactaaa gggaatgctt tcatagtagt
     3781 atttccttct tgttaaacta taaacggctg tggttagaat ttgattagtg gtggcaagtc
     3841 ttgattttaa gacttttttt gagattggtt ttgttttgtt tttgatgatt ttgtcagtga
     3901 tagggatcaa acctagggtc tcactaaact accacagagc cacaccccca gccctagttt
     3961 gcagtttcag gaagtctttt cttgatagat gtcctgctga cttcagagtg ttggttggtg
     4021 ctttgcgtgg caataaaaga ctgctatttg gataggaatt taggccagag gtaaaatttt
     4081 ctaattcttt ttaagtcgtg tttcatagga attcccccag tcacgtttat gcccaggagt
     4141 cagatggata tgggttccaa tgcccaggac acatcctgca aggaccagac agtttcagat
     4201 gatctgactt ctgtccatca ccattcaact gtggaattct gcttctcagc tttagtcagc
     4261 tctcctgctt gaagaaggcg tcctgtgaac ttcttcctaa atgttagtgc agatcttctg
     4321 ttacactctc ctccacagtc tctcccagct tttagaaatt aacaaaattg ctttaaaaaa
     4381 aaaaaagaaa tttagcctac taattatatt ctgcattctg ttacctatat tgacagtatt
     4441 tgcttaactg tggtcctaaa ctcaatagaa atcacttcta tgtccttgcg agagacttgt
     4501 tataaacttg ctagagatgg aaaccatcca tttgatcaga gtcgttggat ccctgaggaa
     4561 atcttgtttt ggccattatt taataattac ttggtcttct gacataggaa tgagatgaaa
     4621 tgaaaaaaaa tatttgcttt taataaaagt ctgagcattt agatcacact ttaaaatatt
     4681 taaacacacc agtgtatata caaagcaaac ttttaatttt gtttttagca aatttgttta
     4741 atttctgaga tttttattct acattaataa cataaagatt tgaaactaga atcatactga
     4801 aaattttttt ttatcccagc tctcctttct ctgactttct gggccactgc tctaagtttc
     4861 tgtccatgtt tctttctttt cattttgagc catctttctt tctacttggg cttgcatttt
     4921 cctgcatctc tagccttccg atcagcagtg tctagcactt cagtcaggct cggctgactt
     4981 gggccatgtc ttcacttctg tggaccgtct gaagccctct tgcagcagcc acccgtctcc
     5041 tggactggca catgcaccct tagattcttg cacttggaaa tacaaggagg ggtttccact
     5101 gctgctggtt ggttacagcc gtcttcccag gaggagagtg cattacaggc gcaggaggag
     5161 aaggtggtcc ctggggaatt ttcttaattt tggattttgg agtcccgttg gatctttctg
     5221 cacttctact atctgaataa ccctctgatt tgctctagaa ttgaatgcta ctccttgctg
     5281 agatggtgtg tcgctggtga gcaccatctt atctgaagga ggattgagac acctacgaaa
     5341 gaggattctt tctgagatag gttttctctg ggtagccctg ggtaccctgg aactttatat
     5401 agaccaggtt ggtctagatc agatatccgc ttgcctctgc caagtcaaag gcagcaagga
     5461 gagaccactg tctacactga actgtagtct ctggctatac ttgtaagtaa acaacttcag
     5521 ttacatgaac actggggatt aaatgataat ttatgtgtaa gactgctttg tatgttttgt
     5581 gatttttgta atgtaagtaa attgatatca ctgatattaa ccaactgtgc agtgtacaat
     5641 taaaaatcat tcagcatctc taaaattgga tttgtgatca tggtgtagct tgtggagcag
     5701 aggacttatt ttttcatttg tcaaaatagg tatttactga caaggcttca agaaatatgt
     5761 tgttggattt tttaaatgta taataaaagt ccatgatttt tacagta
//
