LOCUS       NM_019373                787 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Rattus norvegicus apolipoprotein M (Apom), mRNA.
ACCESSION   NM_019373
VERSION     NM_019373.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 787)
  AUTHORS   Jiang,B., Zhang,X., Di,D., Luo,G., Shi,Y., Zhang,J.,
            Berggren-Soderlund,M., Nilsson-Ehle,P. and Xu,N.
  TITLE     Hyperglycemia-induced downregulation of apolipoprotein M expression
            is not via the hexosamine pathway
  JOURNAL   Lipids Health Dis 14, 110 (2015)
   PUBMED   26377577
  REMARK    GeneRIF: Hyperglycemia-induced downregulation of apolipoprotein M
            expression is not via the hexosamine pathway.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 787)
  AUTHORS   Xu,X.L., Mao,Q.Y., Luo,G.H., Nilsson-Ehle,P., He,X.Z. and Xu,N.
  TITLE     Urinary apolipoprotein M could be used as a biomarker of acute
            renal injury: an ischemia-reperfusion injury model of kidney in rat
  JOURNAL   Transplant Proc 45 (6), 2476-2479 (2013)
   PUBMED   23953565
  REMARK    GeneRIF: ApoM occurrence in urine may be considered to be a
            biomarker of acute renal injury.
REFERENCE   3  (bases 1 to 787)
  AUTHORS   Elsoe,S., Ahnstrom,J., Christoffersen,C., Hoofnagle,A.N.,
            Plomgaard,P., Heinecke,J.W., Binder,C.J., Bjorkbacka,H.,
            Dahlback,B. and Nielsen,L.B.
  TITLE     Apolipoprotein M binds oxidized phospholipids and increases the
            antioxidant effect of HDL
  JOURNAL   Atherosclerosis 221 (1), 91-97 (2012)
   PUBMED   22204862
REFERENCE   4  (bases 1 to 787)
  AUTHORS   Dullaart,R.P., Plomgaard,P., de Vries,R., Dahlback,B. and
            Nielsen,L.B.
  TITLE     Plasma apolipoprotein M is reduced in metabolic syndrome but does
            not predict intima media thickness
  JOURNAL   Clin Chim Acta 406 (1-2), 129-133 (2009)
   PUBMED   19539616
REFERENCE   5  (bases 1 to 787)
  AUTHORS   Wu,X., Niu,N., Brismar,K., Zhu,X., Wang,X., Efendic,S., Du,T.,
            Liu,Y., Gu,H.F. and Liu,Y.
  TITLE     Apolipoprotein M promoter polymorphisms alter promoter activity and
            confer the susceptibility to the development of type 1 diabetes
  JOURNAL   Clin Biochem 42 (1-2), 17-21 (2009)
   PUBMED   19007767
REFERENCE   6  (bases 1 to 787)
  AUTHORS   Xu,N., Nilsson-Ehle,P. and Ahren,B.
  TITLE     Suppression of apolipoprotein M expression and secretion in
            alloxan-diabetic mouse: Partial reversal by insulin
  JOURNAL   Biochem Biophys Res Commun 342 (4), 1174-1177 (2006)
   PUBMED   16516154
REFERENCE   7  (bases 1 to 787)
  AUTHORS   Wolfrum,C., Poy,M.N. and Stoffel,M.
  TITLE     Apolipoprotein M is required for prebeta-HDL formation and
            cholesterol efflux to HDL and protects against atherosclerosis
  JOURNAL   Nat Med 11 (4), 418-422 (2005)
   PUBMED   15793583
REFERENCE   8  (bases 1 to 787)
  AUTHORS   Hurt,P., Walter,L., Sudbrak,R., Klages,S., Muller,I., Shiina,T.,
            Inoko,H., Lehrach,H., Gunther,E., Reinhardt,R. and Himmelbauer,H.
  TITLE     The genomic sequence and comparative analysis of the rat major
            histocompatibility complex
  JOURNAL   Genome Res 14 (4), 631-639 (2004)
   PUBMED   15060004
REFERENCE   9  (bases 1 to 787)
  AUTHORS   Zhang,X.Y., Jiao,G.Q., Hurtig,M., Dong,X., Zheng,L., Luo,G.H.,
            Nilsson-Ehle,P., Ye,Q. and Xu,N.
  TITLE     Expression pattern of apolipoprotein M during mouse and human
            embryogenesis
  JOURNAL   Acta Histochem 106 (2), 123-128 (2004)
   PUBMED   15147633
REFERENCE   10 (bases 1 to 787)
  AUTHORS   Blatter,M.C., James,R.W., Borghini,I., Martin,B.M.,
            Hochstrasser,A.C. and Pometta,D.
  TITLE     A novel high-density lipoprotein particle and associated protein in
            rat plasma
  JOURNAL   Biochim Biophys Acta 1042 (1), 19-27 (1990)
   PUBMED   2297521
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX883045.1 and BC089807.1.
            
            On Oct 1, 2009 this sequence version replaced NM_019373.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ219449.1, FQ210093.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-54                BX883045.1         329653-329706       c
            55-787              BC089807.1         4-736
FEATURES             Location/Qualifiers
     source          1..787
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20p12"
     gene            1..787
                     /gene="Apom"
                     /note="apolipoprotein M"
                     /db_xref="GeneID:55939"
                     /db_xref="RGD:620773"
     exon            1..192
                     /gene="Apom"
                     /inference="alignment:Splign:2.1.0"
     CDS             79..651
                     /gene="Apom"
                     /note="apo-M; protein Px"
                     /codon_start=1
                     /product="apolipoprotein M precursor"
                     /protein_id="NP_062246.1"
                     /db_xref="GeneID:55939"
                     /db_xref="RGD:620773"
                     /translation="MFHQVWAALLYLYGLLFNSMNQCPEHSQLMTLGMDDKETPEPHL
                     GLWYFIAGAAPTMEELATFDQVDNIVFNMAAGSAPRQLQLRATIRTKNGVCVPRKWTY
                     HLTEGKGNTELRTEGRPDMKTDLFSISCPGGIMLKETGQGYQRFLLYNRSPHPPEECV
                     EEFQSLTSCLDFKAFLVTPRNQEACPLSSK"
     exon            193..347
                     /gene="Apom"
                     /inference="alignment:Splign:2.1.0"
     exon            348..427
                     /gene="Apom"
                     /inference="alignment:Splign:2.1.0"
     exon            428..526
                     /gene="Apom"
                     /inference="alignment:Splign:2.1.0"
     exon            527..625
                     /gene="Apom"
                     /inference="alignment:Splign:2.1.0"
     exon            626..761
                     /gene="Apom"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagcagact gagcagccag cagagaacag ttaaggtaga ggtccccaga accgcacagc
       61 gccaggtctc ctcccaagat gttccaccaa gtctgggcag cgctgctcta tctctacggc
      121 cttctcttta actccatgaa tcagtgccct gagcacagtc aactaatgac gctgggaatg
      181 gacgacaaag agaccccaga gccccacctg ggcctgtggt actttatcgc tggagcggct
      241 cccaccatgg aagagttggc aacttttgac caggtggaca atattgtctt caacatggcc
      301 gccggctctg ccccaaggca gctccagctt cgcgctacca ttcgcacgaa aaacggggtc
      361 tgcgtgcccc ggaaatggac gtaccacttg actgaaggga aaggaaacac ggaactcaga
      421 actgaagggc gcccagacat gaaaacagac ctcttctcca tctcatgccc aggaggaatc
      481 atgctgaaag agacggggca ggggtaccag cgtttcctcc tctacaaccg atcgccacac
      541 cctccagagg agtgtgtgga ggaattccag tctctgacgt cctgcttgga cttcaaagcc
      601 tttttagtga ctcccaggaa tcaagaggcc tgcccactgt ccagcaagtg acccgtgact
      661 ccacttgtgt cctggacagg cacgatagga gctgagctct gaggggagaa gccggcggct
      721 cccgctcctt ctcatggata ataaagatga attgtcaatc caaaaaaaaa aaaaaaaaaa
      781 aaaaaaa
//
