LOCUS       NM_001009626            1175 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus apolipoprotein H (Apoh), mRNA.
ACCESSION   NM_001009626 XM_213509
VERSION     NM_001009626.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1175)
  AUTHORS   Durigutto,P., Grossi,C., Borghi,M.O., Macor,P., Pregnolato,F.,
            Raschi,E., Myers,M.P., de Groot,P.G., Meroni,P.L. and Tedesco,F.
  TITLE     New insight into antiphospholipid syndrome: antibodies to
            beta2glycoprotein I-domain 5 fail to induce thrombi in rats
  JOURNAL   Haematologica 104 (4), 819-826 (2019)
   PUBMED   30442725
  REMARK    GeneRIF: New insight into antiphospholipid syndrome: antibodies to
            beta2glycoprotein I-domain 5 fail to induce thrombi in rats.
REFERENCE   2  (bases 1 to 1175)
  AUTHORS   Barallobre-Barreiro,J., Gupta,S.K., Zoccarato,A.,
            Kitazume-Taneike,R., Fava,M., Yin,X., Werner,T., Hirt,M.N.,
            Zampetaki,A., Viviano,A., Chong,M., Bern,M., Kourliouros,A.,
            Domenech,N., Willeit,P., Shah,A.M., Jahangiri,M., Schaefer,L.,
            Fischer,J.W., Iozzo,R.V., Viner,R., Thum,T., Heineke,J.,
            Kichler,A., Otsu,K. and Mayr,M.
  TITLE     Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin
            Activity in Human Atrial Fibrillation
  JOURNAL   Circulation 134 (11), 817-832 (2016)
   PUBMED   27559042
REFERENCE   3  (bases 1 to 1175)
  AUTHORS   Barallobre-Barreiro,J., Oklu,R., Lynch,M., Fava,M., Baig,F.,
            Yin,X., Barwari,T., Potier,D.N., Albadawi,H., Jahangiri,M.,
            Porter,K.E., Watkins,M.T., Misra,S., Stoughton,J. and Mayr,M.
  TITLE     Extracellular matrix remodelling in response to venous
            hypertension: proteomics of human varicose veins
  JOURNAL   Cardiovasc Res 110 (3), 419-430 (2016)
   PUBMED   27068509
REFERENCE   4  (bases 1 to 1175)
  AUTHORS   Agostinis,C., Durigutto,P., Sblattero,D., Borghi,M.O., Grossi,C.,
            Guida,F., Bulla,R., Macor,P., Pregnolato,F., Meroni,P.L. and
            Tedesco,F.
  TITLE     A non-complement-fixing antibody to beta2 glycoprotein I as a novel
            therapy for antiphospholipid syndrome
  JOURNAL   Blood 123 (22), 3478-3487 (2014)
   PUBMED   24642748
REFERENCE   5  (bases 1 to 1175)
  AUTHORS   Okubo,S., Miyamoto,M., Takami,K., Kanki,M., Ono,A., Nakatsu,N.,
            Yamada,H., Ohno,Y. and Urushidani,T.
  TITLE     Identification of novel liver-specific mRNAs in plasma for
            biomarkers of drug-induced liver injury and quantitative evaluation
            in rats treated with various hepatotoxic compounds
  JOURNAL   Toxicol Sci 132 (1), 21-31 (2013)
   PUBMED   23288050
REFERENCE   6  (bases 1 to 1175)
  AUTHORS   Aoyama,Y., Chan,Y.L. and Wool,I.G.
  TITLE     The primary structure of rat beta 2-glycoprotein I
  JOURNAL   Nucleic Acids Res 17 (15), 6401 (1989)
   PUBMED   2771654
REFERENCE   7  (bases 1 to 1175)
  AUTHORS   Schousboe,I.
  TITLE     beta 2-Glycoprotein I: a plasma inhibitor of the contact activation
            of the intrinsic blood coagulation pathway
  JOURNAL   Blood 66 (5), 1086-1091 (1985)
   PUBMED   4052628
REFERENCE   8  (bases 1 to 1175)
  AUTHORS   Muller,G., Biering,A., Lux,E. and Richter,V.
  TITLE     [Beta 2 glycoprotein I analysis in patients with
            hyperlipoproteinemia, arteriosclerotic occlusive disease and
            diabetes mellitus]
  JOURNAL   Z Gesamte Inn Med 38 (10), 282-284 (1983)
   PUBMED   6613192
REFERENCE   9  (bases 1 to 1175)
  AUTHORS   Wurm,H., Beubler,E., Polz,E., Holasek,A. and Kostner,G.
  TITLE     Studies on the possible function of beta 2-glycoprotein-I:
            influence in the triglyceride metabolism in the rat
  JOURNAL   Metabolism 31 (5), 484-486 (1982)
   PUBMED   7078428
REFERENCE   10 (bases 1 to 1175)
  AUTHORS   Polz,E. and Kostner,G.M.
  TITLE     The binding of beta 2-glycoprotein-I to human serum lipoproteins:
            distribution among density fractions
  JOURNAL   FEBS Lett 102 (1), 183-186 (1979)
   PUBMED   222615
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC088180.1.
            
            On Jan 13, 2005 this sequence version replaced XM_213509.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC088180.1, FQ209433.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1175
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q32.1"
     gene            1..1175
                     /gene="Apoh"
                     /note="apolipoprotein H"
                     /db_xref="GeneID:287774"
                     /db_xref="RGD:1310625"
     exon            1..72
                     /gene="Apoh"
                     /inference="alignment:Splign:2.1.0"
     CDS             9..1046
                     /gene="Apoh"
                     /note="beta-2-glycoprotein 1; B2GPI; apo-H; beta(2)GPI;
                     beta-2-glycoprotein I"
                     /codon_start=1
                     /product="beta-2-glycoprotein 1 precursor"
                     /protein_id="NP_001009626.1"
                     /db_xref="GeneID:287774"
                     /db_xref="RGD:1310625"
                     /translation="MISPALIFFSAFLCHVAIAGRTCPKPDELPFAVVVPLKTFYDPG
                     EQIVYSCKPGYVSRGGMRRFTCPLTGMWPINTLKCIPRVCPFAGILENGVVRYTTFEY
                     PNTIGFACNPGYYLNGTSSSKCTEEGKWSPELPVCARITCPPPPIPKFAALKEYKTSV
                     GNSSFYQDTVVFKCLPHFAMFGNDTVTCTAHGNWTQLPECREVKCPFPSRPDNGFVNY
                     PAKPVLSYKDKAVFGCHETYKLDGPEEVECTKTGNWSALPSCKASCKLSVKKATVLYQ
                     GQRVKIQDQFKNGMMHGDKVHFYCKNKEKKCSYTEEAQCIDGTIEIPKCFKEHSSLAF
                     WKTDASDVTPC"
     exon            73..249
                     /gene="Apoh"
                     /inference="alignment:Splign:2.1.0"
     exon            250..346
                     /gene="Apoh"
                     /inference="alignment:Splign:2.1.0"
     exon            347..423
                     /gene="Apoh"
                     /inference="alignment:Splign:2.1.0"
     exon            424..612
                     /gene="Apoh"
                     /inference="alignment:Splign:2.1.0"
     exon            613..792
                     /gene="Apoh"
                     /inference="alignment:Splign:2.1.0"
     exon            793..990
                     /gene="Apoh"
                     /inference="alignment:Splign:2.1.0"
     exon            991..1145
                     /gene="Apoh"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 catctacaat gatttctccg gcgctcatct tcttttctgc cttcctctgc catgttgcta
       61 ttgcgggacg gacctgtccg aagccggatg aactaccgtt tgctgtggtt gttcccttaa
      121 aaacattcta tgacccaggg gagcagattg tctattcctg caagccaggc tatgtgtcca
      181 ggggagggat gagacggttt acctgtcctc tcacagggat gtggcccatc aacaccctga
      241 aatgtatacc cagagtgtgt ccttttgccg gaatcttaga aaatggagtt gtacgctaca
      301 cgacttttga atatcccaac accattggct ttgcttgtaa ccctgggtat tatctgaacg
      361 ggactagctc ttctaagtgc acggaggaag gaaaatggag tccagaactt cctgtttgtg
      421 ctcggatcac ctgcccgcca ccaccaattc ctaagtttgc agcccttaag gaatacaaga
      481 cttcagttgg gaacagctct ttttatcagg acacagtggt ctttaaatgc ttgccacact
      541 ttgccatgtt tggaaatgac acagttacgt gcacagccca tggaaactgg acccaattgc
      601 cagaatgccg ggaagtaaaa tgtcccttcc cttcaaggcc agacaatggg tttgtgaatt
      661 accctgcaaa gccggtgctt tcttataaag ataaagccgt atttggttgc catgaaacat
      721 acaaactgga tggcccggaa gaagtggagt gtaccaagac aggaaattgg tcggccctgc
      781 cgagctgtaa agcatcttgc aaactctctg ttaagaaggc caccgtgttg taccaagggc
      841 agagggtgaa gatccaggac cagtttaaga atgggatgat gcatggtgac aaggttcact
      901 tctattgtaa aaataaggag aagaagtgca gctacaccga ggaggctcag tgcatagacg
      961 gcaccatcga gatccccaaa tgcttcaagg agcacagttc tctggctttc tggaaaacgg
     1021 atgcatcaga tgtgacaccg tgctgaagac attttcagaa tcaaaattga atgtctcatt
     1081 tgtatctctg cttgtctgag gaatcaactg aaatagcaga ataaactacc gagttgcctc
     1141 agtcaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaa
//
