LOCUS       NM_138828               1172 bp    mRNA    linear   ROD 03-SEP-2024
DEFINITION  Rattus norvegicus apolipoprotein E (Apoe), transcript variant 2,
            mRNA.
ACCESSION   NM_138828
VERSION     NM_138828.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1172)
  AUTHORS   Lee,B.H., Cevizci,M., Lieblich,S.E., Ibrahim,M., Wen,Y., Eid,R.S.,
            Lamers,Y., Duarte-Guterman,P. and Galea,L.A.M.
  TITLE     Exploring the parity paradox: Differential effects on
            neuroplasticity and inflammation by APOEe4 genotype at middle age
  JOURNAL   Brain Behav Immun 120, 54-70 (2024)
   PUBMED   38772427
  REMARK    GeneRIF: Exploring the parity paradox: Differential effects on
            neuroplasticity and inflammation by APOEe4 genotype at middle age.
REFERENCE   2  (bases 1 to 1172)
  AUTHORS   Chen,H., Zhao,S., Jian,Q., Yan,Y., Wang,S., Zhang,X. and Ji,Y.
  TITLE     The role of ApoE in fatty acid transport from neurons to astrocytes
            under ischemia/hypoxia conditions
  JOURNAL   Mol Biol Rep 51 (1), 320 (2024)
   PUBMED   38393618
  REMARK    GeneRIF: The role of ApoE in fatty acid transport from neurons to
            astrocytes under ischemia/hypoxia conditions.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1172)
  AUTHORS   Matsuo,H., Kawakami,K., Ohara,H., Kaneko,T., Mashimo,T., Yamada,T.
            and Nabika,T.
  TITLE     Apolipoprotein E-depletion accelerates arterial fat deposition in
            the spontaneously hypertensive rat
  JOURNAL   Exp Anim 72 (4), 439-445 (2023)
   PUBMED   37081644
  REMARK    GeneRIF: Apolipoprotein E-depletion accelerates arterial fat
            deposition in the spontaneously hypertensive rat.
REFERENCE   4  (bases 1 to 1172)
  AUTHORS   Jiang,C., Chen,Z., Wang,X., Zhang,Y., Guo,X., Fan,H., Huang,D.,
            He,Y., Tang,X., Ai,Y., Liu,Y., Yang,H. and Hao,D.
  TITLE     Curcumin-activated Olfactory Ensheathing Cells Improve Functional
            Recovery After Spinal Cord Injury by Modulating Microglia
            Polarization Through APOE/TREM2/NF-kappaB Signaling Pathway
  JOURNAL   J Neuroimmune Pharmacol 18 (3), 476-494 (2023)
   PUBMED   37658943
  REMARK    GeneRIF: Curcumin-activated Olfactory Ensheathing Cells Improve
            Functional Recovery After Spinal Cord Injury by Modulating
            Microglia Polarization Through APOE/TREM2/NF-kappaB Signaling
            Pathway.
REFERENCE   5  (bases 1 to 1172)
  AUTHORS   Nguyen,T.D., Watanabe,A., Burleigh,S., Ghaffarzadegan,T.,
            Kanklai,J., Prykhodko,O., Hallenius,F.F. and Nyman,M.
  TITLE     Monobutyrin and monovalerin improve gut-blood-brain biomarkers and
            alter gut microbiota composition in high-fat fed
            apolipoprotein-E-knockout rats
  JOURNAL   Sci Rep 12 (1), 15454 (2022)
   PUBMED   36104381
  REMARK    GeneRIF: Monobutyrin and monovalerin improve gut-blood-brain
            biomarkers and alter gut microbiota composition in high-fat fed
            apolipoprotein-E-knockout rats.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1172)
  AUTHORS   Takahashi,S., Kawarabayasi,Y., Nakai,T., Sakai,J. and Yamamoto,T.
  TITLE     Rabbit very low density lipoprotein receptor: a low density
            lipoprotein receptor-like protein with distinct ligand specificity
  JOURNAL   Proc Natl Acad Sci U S A 89 (19), 9252-9256 (1992)
   PUBMED   1384047
REFERENCE   7  (bases 1 to 1172)
  AUTHORS   Feussner,G., Funke,H., Weng,W., Assmann,G., Lackner,K.J. and
            Ziegler,R.
  TITLE     Severe type III hyperlipoproteinemia associated with unusual
            apolipoprotein E1 phenotype and epsilon 1/'null' genotype
  JOURNAL   Eur J Clin Invest 22 (9), 599-608 (1992)
   PUBMED   1360898
REFERENCE   8  (bases 1 to 1172)
  AUTHORS   Innerarity,T.L., Mahley,R.W., Weisgraber,K.H. and Bersot,T.P.
  TITLE     Apoprotein (E--A-II) complex of human plasma lipoproteins. II.
            Receptor binding activity of a high density lipoprotein subfraction
            modulated by the apo(E--A-II) complex
  JOURNAL   J Biol Chem 253 (17), 6289-6295 (1978)
   PUBMED   210175
REFERENCE   9  (bases 1 to 1172)
  AUTHORS   Weisgraber,K.H. and Mahley,R.W.
  TITLE     Apoprotein (E--A-II) complex of human plasma lipoproteins. I.
            Characterization of this mixed disulfide and its identification in
            a high density lipoprotein subfraction
  JOURNAL   J Biol Chem 253 (17), 6281-6288 (1978)
   PUBMED   210174
REFERENCE   10 (bases 1 to 1172)
  AUTHORS   Utermann,G., Hees,M. and Steinmetz,A.
  TITLE     Polymorphism of apolipoprotein E and occurrence of
            dysbetalipoproteinaemia in man
  JOURNAL   Nature 269 (5629), 604-607 (1977)
   PUBMED   199847
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1 and BC086581.1.
            
            On Jul 25, 2012 this sequence version replaced NM_138828.2.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. All five variants encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ220752.1, FQ218972.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760400, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-57                JAXUCZ010000001.1  88484643-88484699   c
            58-1172             BC086581.1         1-1115
FEATURES             Location/Qualifiers
     source          1..1172
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..1172
                     /gene="Apoe"
                     /gene_synonym="APOEA"
                     /note="apolipoprotein E"
                     /db_xref="GeneID:25728"
                     /db_xref="RGD:2138"
     exon            1..73
                     /gene="Apoe"
                     /gene_synonym="APOEA"
                     /inference="alignment:Splign:2.1.0"
     exon            74..139
                     /gene="Apoe"
                     /gene_synonym="APOEA"
                     /inference="alignment:Splign:2.1.0"
     CDS             97..1035
                     /gene="Apoe"
                     /gene_synonym="APOEA"
                     /note="apo-E"
                     /codon_start=1
                     /product="apolipoprotein E precursor"
                     /protein_id="NP_620183.2"
                     /db_xref="GeneID:25728"
                     /db_xref="RGD:2138"
                     /translation="MKALWALLLVPLLTGCLAEGELEVTDQLPGQSDQPWEQALNRFW
                     DYLRWVQTLSDQVQEELQSSQVTQELTVLMEDTMTEVKAYKKELEEQLGPVAEETRAR
                     LAKEVQAAQARLGADMEDLRNRLGQYRNEVNTMLGQSTEELRSRLSTHLRKMRKRLMR
                     DADDLQKRLAVYKAGAQEGAERGVSAIRERLGPLVEQGRQRTANLGAGAAQPLRDRAQ
                     ALSDRIRGRLEEVGNQARDRLEEVREQMEEVRSKMEEQTQQIRLQAEIFQARIKGWFE
                     PLVEDMQRQWANLMEKIQASVATNSIASTTVPLENQ"
     exon            140..308
                     /gene="Apoe"
                     /gene_synonym="APOEA"
                     /inference="alignment:Splign:2.1.0"
     exon            309..1145
                     /gene="Apoe"
                     /gene_synonym="APOEA"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ataattggac aggtctggga tccggtcccc tgctcagacc ccggaggcta aggagttgtt
       61 tcggaaggag ctgactggcc aatcacaact gggaagatga aggctctgtg ggccctgctg
      121 ttggtcccat tgctgacagg atgcctggcc gagggagagc tggaggtgac agatcagctc
      181 ccagggcaaa gcgaccaacc ctgggagcag gccctgaacc gcttctggga ttacctgcgc
      241 tgggtgcaga cgctttctga ccaggtccag gaagagctgc agagctccca agtcacacag
      301 gaactgacgg tactgatgga ggacactatg acggaagtaa aggcatacaa aaaggagctg
      361 gaggaacagc tgggcccagt ggcggaggag acacgggcca ggctggctaa agaggtgcag
      421 gcggcacagg cccgtctggg agctgacatg gaggatctac gcaaccgact cgggcagtac
      481 cgcaacgagg taaacaccat gctgggccag agcacagagg agctgcggtc gcgcctctcc
      541 acacacctgc gcaagatgcg caagcgcctg atgcgggatg cggatgatct gcagaagcgc
      601 ctggcggtgt acaaggccgg ggcacaggag ggcgccgagc gcggtgtgag tgctatccgt
      661 gagcgcctgg ggccactggt ggagcagggt cgtcagcgca cagccaacct aggcgctggc
      721 gccgcccagc ccctgcgcga tcgcgcccag gctttgagtg accgcatccg agggcggctg
      781 gaggaagtgg gcaaccaggc ccgagaccgc ctagaggagg tgcgtgagca gatggaggag
      841 gtgcgctcca agatggagga gcagacccag cagatacgcc tgcaggccga gatcttccag
      901 gcccgcatca agggctggtt cgagccgcta gtggaagaca tgcagcgcca gtgggcaaac
      961 ctaatggaga agatacaggc ctctgtggct accaactcca ttgcctccac cacagtgccc
     1021 ctggagaatc aatgatcatc cctcacctac gccctgccgc aacatccatg accagccagg
     1081 tggccctgtc ccaagcacca ctctggccct ctggtggccc ttgcttaata aagattctcc
     1141 aagcaaaaaa aaaaaaaaaa aaaaaaaaaa aa
//
