LOCUS       NM_001270683            1178 bp    mRNA    linear   ROD 03-SEP-2024
DEFINITION  Rattus norvegicus apolipoprotein E (Apoe), transcript variant 4,
            mRNA.
ACCESSION   NM_001270683
VERSION     NM_001270683.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1178)
  AUTHORS   Lee,B.H., Cevizci,M., Lieblich,S.E., Ibrahim,M., Wen,Y., Eid,R.S.,
            Lamers,Y., Duarte-Guterman,P. and Galea,L.A.M.
  TITLE     Exploring the parity paradox: Differential effects on
            neuroplasticity and inflammation by APOEe4 genotype at middle age
  JOURNAL   Brain Behav Immun 120, 54-70 (2024)
   PUBMED   38772427
  REMARK    GeneRIF: Exploring the parity paradox: Differential effects on
            neuroplasticity and inflammation by APOEe4 genotype at middle age.
REFERENCE   2  (bases 1 to 1178)
  AUTHORS   Chen,H., Zhao,S., Jian,Q., Yan,Y., Wang,S., Zhang,X. and Ji,Y.
  TITLE     The role of ApoE in fatty acid transport from neurons to astrocytes
            under ischemia/hypoxia conditions
  JOURNAL   Mol Biol Rep 51 (1), 320 (2024)
   PUBMED   38393618
  REMARK    GeneRIF: The role of ApoE in fatty acid transport from neurons to
            astrocytes under ischemia/hypoxia conditions.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1178)
  AUTHORS   Matsuo,H., Kawakami,K., Ohara,H., Kaneko,T., Mashimo,T., Yamada,T.
            and Nabika,T.
  TITLE     Apolipoprotein E-depletion accelerates arterial fat deposition in
            the spontaneously hypertensive rat
  JOURNAL   Exp Anim 72 (4), 439-445 (2023)
   PUBMED   37081644
  REMARK    GeneRIF: Apolipoprotein E-depletion accelerates arterial fat
            deposition in the spontaneously hypertensive rat.
REFERENCE   4  (bases 1 to 1178)
  AUTHORS   Jiang,C., Chen,Z., Wang,X., Zhang,Y., Guo,X., Fan,H., Huang,D.,
            He,Y., Tang,X., Ai,Y., Liu,Y., Yang,H. and Hao,D.
  TITLE     Curcumin-activated Olfactory Ensheathing Cells Improve Functional
            Recovery After Spinal Cord Injury by Modulating Microglia
            Polarization Through APOE/TREM2/NF-kappaB Signaling Pathway
  JOURNAL   J Neuroimmune Pharmacol 18 (3), 476-494 (2023)
   PUBMED   37658943
  REMARK    GeneRIF: Curcumin-activated Olfactory Ensheathing Cells Improve
            Functional Recovery After Spinal Cord Injury by Modulating
            Microglia Polarization Through APOE/TREM2/NF-kappaB Signaling
            Pathway.
REFERENCE   5  (bases 1 to 1178)
  AUTHORS   Nguyen,T.D., Watanabe,A., Burleigh,S., Ghaffarzadegan,T.,
            Kanklai,J., Prykhodko,O., Hallenius,F.F. and Nyman,M.
  TITLE     Monobutyrin and monovalerin improve gut-blood-brain biomarkers and
            alter gut microbiota composition in high-fat fed
            apolipoprotein-E-knockout rats
  JOURNAL   Sci Rep 12 (1), 15454 (2022)
   PUBMED   36104381
  REMARK    GeneRIF: Monobutyrin and monovalerin improve gut-blood-brain
            biomarkers and alter gut microbiota composition in high-fat fed
            apolipoprotein-E-knockout rats.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1178)
  AUTHORS   Takahashi,S., Kawarabayasi,Y., Nakai,T., Sakai,J. and Yamamoto,T.
  TITLE     Rabbit very low density lipoprotein receptor: a low density
            lipoprotein receptor-like protein with distinct ligand specificity
  JOURNAL   Proc Natl Acad Sci U S A 89 (19), 9252-9256 (1992)
   PUBMED   1384047
REFERENCE   7  (bases 1 to 1178)
  AUTHORS   Feussner,G., Funke,H., Weng,W., Assmann,G., Lackner,K.J. and
            Ziegler,R.
  TITLE     Severe type III hyperlipoproteinemia associated with unusual
            apolipoprotein E1 phenotype and epsilon 1/'null' genotype
  JOURNAL   Eur J Clin Invest 22 (9), 599-608 (1992)
   PUBMED   1360898
REFERENCE   8  (bases 1 to 1178)
  AUTHORS   Innerarity,T.L., Mahley,R.W., Weisgraber,K.H. and Bersot,T.P.
  TITLE     Apoprotein (E--A-II) complex of human plasma lipoproteins. II.
            Receptor binding activity of a high density lipoprotein subfraction
            modulated by the apo(E--A-II) complex
  JOURNAL   J Biol Chem 253 (17), 6289-6295 (1978)
   PUBMED   210175
REFERENCE   9  (bases 1 to 1178)
  AUTHORS   Weisgraber,K.H. and Mahley,R.W.
  TITLE     Apoprotein (E--A-II) complex of human plasma lipoproteins. I.
            Characterization of this mixed disulfide and its identification in
            a high density lipoprotein subfraction
  JOURNAL   J Biol Chem 253 (17), 6281-6288 (1978)
   PUBMED   210174
REFERENCE   10 (bases 1 to 1178)
  AUTHORS   Utermann,G., Hees,M. and Steinmetz,A.
  TITLE     Polymorphism of apolipoprotein E and occurrence of
            dysbetalipoproteinaemia in man
  JOURNAL   Nature 269 (5629), 604-607 (1977)
   PUBMED   199847
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1 and BC086581.1.
            
            Transcript Variant: This variant (4) differs in the 5' UTR compared
            to variant 1. All five variants encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ219318.1, SRR26643286.841.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760400, SAMEA5760476
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-79                JAXUCZ010000001.1  88485738-88485816   c
            80-1178             BC086581.1         17-1115
FEATURES             Location/Qualifiers
     source          1..1178
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..1178
                     /gene="Apoe"
                     /gene_synonym="APOEA"
                     /note="apolipoprotein E"
                     /db_xref="GeneID:25728"
                     /db_xref="RGD:2138"
     exon            1..79
                     /gene="Apoe"
                     /gene_synonym="APOEA"
                     /inference="alignment:Splign:2.1.0"
     exon            80..145
                     /gene="Apoe"
                     /gene_synonym="APOEA"
                     /inference="alignment:Splign:2.1.0"
     CDS             103..1041
                     /gene="Apoe"
                     /gene_synonym="APOEA"
                     /note="apo-E"
                     /codon_start=1
                     /product="apolipoprotein E precursor"
                     /protein_id="NP_001257612.1"
                     /db_xref="GeneID:25728"
                     /db_xref="RGD:2138"
                     /translation="MKALWALLLVPLLTGCLAEGELEVTDQLPGQSDQPWEQALNRFW
                     DYLRWVQTLSDQVQEELQSSQVTQELTVLMEDTMTEVKAYKKELEEQLGPVAEETRAR
                     LAKEVQAAQARLGADMEDLRNRLGQYRNEVNTMLGQSTEELRSRLSTHLRKMRKRLMR
                     DADDLQKRLAVYKAGAQEGAERGVSAIRERLGPLVEQGRQRTANLGAGAAQPLRDRAQ
                     ALSDRIRGRLEEVGNQARDRLEEVREQMEEVRSKMEEQTQQIRLQAEIFQARIKGWFE
                     PLVEDMQRQWANLMEKIQASVATNSIASTTVPLENQ"
     exon            146..314
                     /gene="Apoe"
                     /gene_synonym="APOEA"
                     /inference="alignment:Splign:2.1.0"
     exon            315..1151
                     /gene="Apoe"
                     /gene_synonym="APOEA"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ttctcctact gccaccctct gagcaacagc tgggaatggg aacccctgtg caggcggcac
       61 ttcagcaagc atccgagtga ctggccaatc acaactggga agatgaaggc tctgtgggcc
      121 ctgctgttgg tcccattgct gacaggatgc ctggccgagg gagagctgga ggtgacagat
      181 cagctcccag ggcaaagcga ccaaccctgg gagcaggccc tgaaccgctt ctgggattac
      241 ctgcgctggg tgcagacgct ttctgaccag gtccaggaag agctgcagag ctcccaagtc
      301 acacaggaac tgacggtact gatggaggac actatgacgg aagtaaaggc atacaaaaag
      361 gagctggagg aacagctggg cccagtggcg gaggagacac gggccaggct ggctaaagag
      421 gtgcaggcgg cacaggcccg tctgggagct gacatggagg atctacgcaa ccgactcggg
      481 cagtaccgca acgaggtaaa caccatgctg ggccagagca cagaggagct gcggtcgcgc
      541 ctctccacac acctgcgcaa gatgcgcaag cgcctgatgc gggatgcgga tgatctgcag
      601 aagcgcctgg cggtgtacaa ggccggggca caggagggcg ccgagcgcgg tgtgagtgct
      661 atccgtgagc gcctggggcc actggtggag cagggtcgtc agcgcacagc caacctaggc
      721 gctggcgccg cccagcccct gcgcgatcgc gcccaggctt tgagtgaccg catccgaggg
      781 cggctggagg aagtgggcaa ccaggcccga gaccgcctag aggaggtgcg tgagcagatg
      841 gaggaggtgc gctccaagat ggaggagcag acccagcaga tacgcctgca ggccgagatc
      901 ttccaggccc gcatcaaggg ctggttcgag ccgctagtgg aagacatgca gcgccagtgg
      961 gcaaacctaa tggagaagat acaggcctct gtggctacca actccattgc ctccaccaca
     1021 gtgcccctgg agaatcaatg atcatccctc acctacgccc tgccgcaaca tccatgacca
     1081 gccaggtggc cctgtcccaa gcaccactct ggccctctgg tggcccttgc ttaataaaga
     1141 ttctccaagc aaaaaaaaaa aaaaaaaaaa aaaaaaaa
//
