LOCUS       NM_012501                536 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Rattus norvegicus apolipoprotein C3 (Apoc3), transcript variant 1,
            mRNA.
ACCESSION   NM_012501
VERSION     NM_012501.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 536)
  AUTHORS   Kim,D.H., Lee,S., Noh,S.G., Lee,J. and Chung,H.Y.
  TITLE     FoxO6-mediated ApoC3 upregulation promotes hepatic steatosis and
            hyperlipidemia in aged rats fed a high-fat diet
  JOURNAL   Aging (Albany NY) 16 (5), 4095-4115 (2024)
   PUBMED   38441531
  REMARK    GeneRIF: FoxO6-mediated ApoC3 upregulation promotes hepatic
            steatosis and hyperlipidemia in aged rats fed a high-fat diet.
REFERENCE   2  (bases 1 to 536)
  AUTHORS   Syed-Abdul,M.M., Tian,L. and Lewis,G.F.
  TITLE     Unanticipated Enhancement of Intestinal TG Output by Apoc3 ASO
            Inhibition
  JOURNAL   Arterioscler Thromb Vasc Biol 43 (11), 2133-2142 (2023)
   PUBMED   37675633
  REMARK    GeneRIF: Unanticipated Enhancement of Intestinal TG Output by Apoc3
            ASO Inhibition.
REFERENCE   3  (bases 1 to 536)
  AUTHORS   Marin-Vicente,C., Mendes,M., de Los Rios,V., Fernandez-Acenero,M.J.
            and Casal,J.I.
  TITLE     Identification and Validation of Stage-Associated Serum Biomarkers
            in Colorectal Cancer Using MS-Based Procedures
  JOURNAL   Proteomics Clin Appl 14 (1), e1900052 (2020)
   PUBMED   31502404
REFERENCE   4  (bases 1 to 536)
  AUTHORS   Wang,X., Gong,Y., Deng,T., Zhang,L., Liao,X., Han,C., Yang,C.,
            Huang,J., Wang,Q., Song,X., Zhang,T., Yu,T., Zhu,G., Ye,X. and
            Peng,T.
  TITLE     Diagnostic and prognostic significance of mRNA expressions of
            apolipoprotein A and C family genes in hepatitis B virus-related
            hepatocellular carcinoma
  JOURNAL   J Cell Biochem 120 (10), 18246-18265 (2019)
   PUBMED   31211449
REFERENCE   5  (bases 1 to 536)
  AUTHORS   Song,D., Yue,L., Zhan,Y., Zhang,J., Yan,Z., Fan,Y., Yang,H.,
            Zhang,D., Liu,Q., Xia,Z., Qin,P., Jia,J., Yue,M., Yu,J., Zheng,S.,
            Yang,F. and Wang,J.
  TITLE     Detection and identification of serum protein peak at 6648 m/z as a
            novel indicator in breast cancer based on mass spectrometry
  JOURNAL   Discov Med 23 (128), 283-294 (2017)
   PUBMED   28715644
REFERENCE   6  (bases 1 to 536)
  AUTHORS   al Muhtaseb,N., al Yousuf,A. and Bajaj,J.S.
  TITLE     Apolipoprotein A-I, A-II, B, C-II, and C-III in children with
            insulin-dependent diabetes mellitus
  JOURNAL   Pediatrics 89 (5 Pt 1), 936-941 (1992)
   PUBMED   1579407
REFERENCE   7  (bases 1 to 536)
  AUTHORS   Sehayek,E. and Eisenberg,S.
  TITLE     Mechanisms of inhibition by apolipoprotein C of apolipoprotein
            E-dependent cellular metabolism of human triglyceride-rich
            lipoproteins through the low density lipoprotein receptor pathway
  JOURNAL   J Biol Chem 266 (27), 18259-18267 (1991)
   PUBMED   1917954
REFERENCE   8  (bases 1 to 536)
  AUTHORS   Konemori,G., Kawanishi,M., Nakamoto,A., Hiraoka,M. and Kajiyama,G.
  TITLE     [Application of the box plot to evaluate serum lipid levels and
            apolipoprotein levels in patients with cerebral infarction and
            diabetes mellitus]
  JOURNAL   Nihon Ronen Igakkai Zasshi 27 (1), 22-27 (1990)
   PUBMED   2352345
REFERENCE   9  (bases 1 to 536)
  AUTHORS   Kinnunen,P.K. and Ehnolm,C.
  TITLE     Effect of serum and C-apoproteins from very low density
            lipoproteins on human postheparin plasma hepatic lipase
  JOURNAL   FEBS Lett 65 (3), 354-357 (1976)
   PUBMED   182536
REFERENCE   10 (bases 1 to 536)
  AUTHORS   Tanaka,S., Tamura,K. and Mizuno,Y.
  TITLE     [Clinical consideration with special reference to autopsy cases of
            malignant tumor in the oral cavity, treated with Bleomycin
            (author's transl)]
  JOURNAL   Hiroshima Daigaku Shigaku Zasshi 8 (2), 168-175 (1975)
   PUBMED   69641
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1 and AW917416.1.
            
            On Aug 29, 2012 this sequence version replaced NM_012501.1.
            
            Transcript Variant: This variant (1) represents the predominant
            transcript. Variants 1 and 2 both encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ210075.1, FQ210397.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760476 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-49                JAXUCZ010000008.1  55430304-55430352   c
            50-526              AW917416.1         2-478
            527-536             JAXUCZ010000008.1  55428172-55428181   c
FEATURES             Location/Qualifiers
     source          1..536
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q22"
     gene            1..536
                     /gene="Apoc3"
                     /gene_synonym="apo-CIII; ApoC-III"
                     /note="apolipoprotein C3"
                     /db_xref="GeneID:24207"
                     /db_xref="RGD:2136"
     exon            1..72
                     /gene="Apoc3"
                     /gene_synonym="apo-CIII; ApoC-III"
                     /inference="alignment:Splign:2.1.0"
     exon            73..140
                     /gene="Apoc3"
                     /gene_synonym="apo-CIII; ApoC-III"
                     /inference="alignment:Splign:2.1.0"
     CDS             86..388
                     /gene="Apoc3"
                     /gene_synonym="apo-CIII; ApoC-III"
                     /note="apolipoprotein C-3; apolipoprotein C-III"
                     /codon_start=1
                     /product="apolipoprotein C-III precursor"
                     /protein_id="NP_036633.2"
                     /db_xref="GeneID:24207"
                     /db_xref="RGD:2136"
                     /translation="MQPRMLLIVALVALLASARADEGEGSLLLGSMQGYMEQASKTVQ
                     DALSSMQESDIAVVARGWMDNRFKSLKGYWSKFTDKFTGLWESGPEDQLTTPTLEP"
     exon            141..264
                     /gene="Apoc3"
                     /gene_synonym="apo-CIII; ApoC-III"
                     /inference="alignment:Splign:2.1.0"
     exon            265..536
                     /gene="Apoc3"
                     /gene_synonym="apo-CIII; ApoC-III"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aatataaaac agatcagagg cctcccggct tgcctgccca gttttatccc tagaagcagc
       61 tagctactcc aggtgcacag gtgccatgca gccccgaatg ctcctcatcg tggccctcgt
      121 ggctctcctg gcctctgccc gagctgatga gggagaggga tccttgctgc tgggctctat
      181 gcagggctac atggaacaag cctccaagac ggtccaggat gcactaagca gcatgcagga
      241 gtctgatata gctgtggtgg ccaggggctg gatggacaat cgcttcaaat ccctgaaagg
      301 ctactggagc aagttcactg ataagttcac tggcctctgg gagtctggcc ctgaggacca
      361 actaacaaca ccaactcttg agccgtgaga cctccatgtt ccagatgtgt ctggccatct
      421 atcctgctgc ctccgaaggt tgctctaagg ggaaagtata ttctcatgcc tttatccctc
      481 cccagacctc acctaaacat gctgtcccta ataaagctgg acacgaagct gccatg
//
