LOCUS       NM_001085352             518 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus apolipoprotein C2 (Apoc2), mRNA.
ACCESSION   NM_001085352 XM_001076000 XM_214872
VERSION     NM_001085352.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 518)
  AUTHORS   Wang,X., Gong,Y., Deng,T., Zhang,L., Liao,X., Han,C., Yang,C.,
            Huang,J., Wang,Q., Song,X., Zhang,T., Yu,T., Zhu,G., Ye,X. and
            Peng,T.
  TITLE     Diagnostic and prognostic significance of mRNA expressions of
            apolipoprotein A and C family genes in hepatitis B virus-related
            hepatocellular carcinoma
  JOURNAL   J Cell Biochem 120 (10), 18246-18265 (2019)
   PUBMED   31211449
REFERENCE   2  (bases 1 to 518)
  AUTHORS   Todorova,N., Zlatic,C.O., Mao,Y., Yarovsky,I., Howlett,G.J.,
            Gooley,P.R. and Griffin,M.D.
  TITLE     Intra- and Intersubunit Ion-Pair Interactions Determine the Ability
            of Apolipoprotein C-II Mutants To Form Hybrid Amyloid Fibrils
  JOURNAL   Biochemistry 56 (12), 1757-1767 (2017)
   PUBMED   28229588
REFERENCE   3  (bases 1 to 518)
  AUTHORS   Meyer,B.J., Duvillard,L., Owen,A., Packard,C.J. and Caslake,M.J.
  TITLE     Fractionation of cholesteryl ester rich intermediate density
            lipoprotein subpopulations by chondroitin sulphate
  JOURNAL   Atherosclerosis 195 (2), e28-e34 (2007)
   PUBMED   17336988
REFERENCE   4  (bases 1 to 518)
  AUTHORS   Pulawa,L.K., Jensen,D.R., Coates,A. and Eckel,R.H.
  TITLE     Reduction of plasma triglycerides in apolipoprotein C-II transgenic
            mice overexpressing lipoprotein lipase in muscle
  JOURNAL   J Lipid Res 48 (1), 145-151 (2007)
   PUBMED   17018885
REFERENCE   5  (bases 1 to 518)
  AUTHORS   Christoffersen,C., Nielsen,L.B., Axler,O., Andersson,A.,
            Johnsen,A.H. and Dahlback,B.
  TITLE     Isolation and characterization of human apolipoprotein M-containing
            lipoproteins
  JOURNAL   J Lipid Res 47 (8), 1833-1843 (2006)
   PUBMED   16682745
REFERENCE   6  (bases 1 to 518)
  AUTHORS   Kajinami,K., Mabuchi,H., Koizumi,J. and Takeda,R.
  TITLE     Serum apolipoproteins in heterozygous familial hypercholesterolemia
  JOURNAL   Clin Chim Acta 211 (1-2), 93-99 (1992)
   PUBMED   1468157
REFERENCE   7  (bases 1 to 518)
  AUTHORS   Sehayek,E. and Eisenberg,S.
  TITLE     Mechanisms of inhibition by apolipoprotein C of apolipoprotein
            E-dependent cellular metabolism of human triglyceride-rich
            lipoproteins through the low density lipoprotein receptor pathway
  JOURNAL   J Biol Chem 266 (27), 18259-18267 (1991)
   PUBMED   1917954
REFERENCE   8  (bases 1 to 518)
  AUTHORS   Hegele,R.A., Connelly,P.W., Maguire,G.F., Huff,M.W., Leiter,L.,
            Wolfe,B.M., Evans,A.J. and Little,J.A.
  TITLE     An apolipoprotein CII mutation, CIILys19----Thr' identified in
            patients with hyperlipidemia
  JOURNAL   Dis Markers 9 (2), 73-80 (1991)
   PUBMED   1782747
REFERENCE   9  (bases 1 to 518)
  AUTHORS   Kinnunen,P.K., Jackson,R.L., Smith,L.C., Gotto,A.M. Jr. and
            Sparrow,J.T.
  TITLE     Activation of lipoprotein lipase by native and synthetic fragments
            of human plasma apolipoprotein C-II
  JOURNAL   Proc Natl Acad Sci U S A 74 (11), 4848-4851 (1977)
   PUBMED   270715
REFERENCE   10 (bases 1 to 518)
  AUTHORS   Kinnunen,P.K. and Ehnolm,C.
  TITLE     Effect of serum and C-apoproteins from very low density
            lipoproteins on human postheparin plasma hepatic lipase
  JOURNAL   FEBS Lett 65 (3), 354-357 (1976)
   PUBMED   182536
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CO574111.1, BM385272.1 and AA819259.1.
            
            On or before Apr 21, 2007 this sequence version replaced
            XM_214872.3, XM_001076000.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ210737.1, FQ212251.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-181               CO574111.1         1-181
            182-377             BM385272.1         144-339             c
            378-518             AA819259.1         1-141               c
FEATURES             Location/Qualifiers
     source          1..518
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..518
                     /gene="Apoc2"
                     /gene_synonym="Apo-CII; ApoC-II; RGD1560725"
                     /note="apolipoprotein C2"
                     /db_xref="GeneID:292697"
                     /db_xref="RGD:2135"
     exon            1..21
                     /gene="Apoc2"
                     /gene_synonym="Apo-CII; ApoC-II; RGD1560725"
                     /inference="alignment:Splign:2.1.0"
     exon            22..88
                     /gene="Apoc2"
                     /gene_synonym="Apo-CII; ApoC-II; RGD1560725"
                     /inference="alignment:Splign:2.1.0"
     CDS             34..327
                     /gene="Apoc2"
                     /gene_synonym="Apo-CII; ApoC-II; RGD1560725"
                     /note="apolipoprotein C-II"
                     /codon_start=1
                     /product="apolipoprotein C-II precursor"
                     /protein_id="NP_001078821.1"
                     /db_xref="GeneID:292697"
                     /db_xref="RGD:2135"
                     /translation="MGSRFFLALFLALLVLGNEVQGTEEDDPGSSALLDTVQEHLFSY
                     WNSAKAAAGELYQKTYLTSVDEKLRDMYSKSSAAMTTYAGIFTDQLLTLLKGE"
     exon            89..239
                     /gene="Apoc2"
                     /gene_synonym="Apo-CII; ApoC-II; RGD1560725"
                     /inference="alignment:Splign:2.1.0"
     exon            240..501
                     /gene="Apoc2"
                     /gene_synonym="Apo-CII; ApoC-II; RGD1560725"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 catcctgccc attgcactca ggtcccagac agcatggggt ctcgtttctt cctggctcta
       61 ttcctggctc tcctagtgtt gggaaacgag gtccagggga ccgaggaaga tgatccgggc
      121 agctcagctc tgctggacac ggtacaggag cacttgttca gttactggaa ctctgccaag
      181 gcggccgccg gagaactata ccagaagaca tacctgacca gcgtggacga gaaactgagg
      241 gacatgtaca gcaaaagctc ggcggccatg accacgtacg ctggcatttt tacagaccag
      301 ctccttactc tcctgaaagg agagtagtta ctacataaac tccgagttag gggaaaggaa
      361 aaccggacac ccggcccttt tgctctcatc acctgaccag gatggtccta catctccctg
      421 tcccagcatc tcccatcttc ctgcgtccaa ctctagacca aattctttca atgaaagaat
      481 aaatgagtcc agtttccttg gaaaaaaaaa aaaaaaaa
//
