LOCUS       NM_001109996             431 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus apolipoprotein C1 (Apoc1), transcript variant 2,
            mRNA.
ACCESSION   NM_001109996
VERSION     NM_001109996.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 431)
  AUTHORS   Wang,X., Gong,Y., Deng,T., Zhang,L., Liao,X., Han,C., Yang,C.,
            Huang,J., Wang,Q., Song,X., Zhang,T., Yu,T., Zhu,G., Ye,X. and
            Peng,T.
  TITLE     Diagnostic and prognostic significance of mRNA expressions of
            apolipoprotein A and C family genes in hepatitis B virus-related
            hepatocellular carcinoma
  JOURNAL   J Cell Biochem 120 (10), 18246-18265 (2019)
   PUBMED   31211449
REFERENCE   2  (bases 1 to 431)
  AUTHORS   Cohen,M., Yossef,R., Erez,T., Kugel,A., Welt,M., Karpasas,M.M.,
            Bones,J., Rudd,P.M., Taieb,J., Boissin,H., Harats,D., Noy,K.,
            Tekoah,Y., Lichtenstein,R.G., Rubin,E. and Porgador,A.
  TITLE     Serum apolipoproteins C-I and C-III are reduced in stomach cancer
            patients: results from MALDI-based peptidome and immuno-based
            clinical assays
  JOURNAL   PLoS One 6 (1), e14540 (2011)
   PUBMED   21267442
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 431)
  AUTHORS   Westerterp,M., Berbee,J.F., Delsing,D.J., Jong,M.C., Gijbels,M.J.,
            Dahlmans,V.E., Offerman,E.H., Romijn,J.A., Havekes,L.M. and
            Rensen,P.C.
  TITLE     Apolipoprotein C-I binds free fatty acids and reduces their
            intracellular esterification
  JOURNAL   J Lipid Res 48 (6), 1353-1361 (2007)
   PUBMED   17339654
REFERENCE   4  (bases 1 to 431)
  AUTHORS   Masson,D., Pais de Barros,J.P., Zak,Z., Gautier,T., Le Guern,N.,
            Assem,M., Chisholm,J.W., Paterniti,J.R. Jr. and Lagrost,L.
  TITLE     Human apoA-I expression in CETP transgenic rats leads to lower
            levels of apoC-I in HDL and to magnification of CETP-mediated
            lipoprotein changes
  JOURNAL   J Lipid Res 47 (2), 356-365 (2006)
   PUBMED   16282639
REFERENCE   5  (bases 1 to 431)
  AUTHORS   Ricci,F., Kern,S.E., Hruban,R.H. and Iacobuzio-Donahue,C.A.
  TITLE     Stromal responses to carcinomas of the pancreas: juxtatumoral gene
            expression conforms to the infiltrating pattern and not the
            biologic subtype
  JOURNAL   Cancer Biol Ther 4 (3), 302-307 (2005)
   PUBMED   15876873
REFERENCE   6  (bases 1 to 431)
  AUTHORS   Shen,P. and Howlett,G.J.
  TITLE     Two coding regions closely linked to the rat apolipoprotein E gene:
            nucleotide sequences of rat apolipoprotein C-I and ECL cDNA
  JOURNAL   Arch Biochem Biophys 297 (2), 345-353 (1992)
   PUBMED   1379790
REFERENCE   7  (bases 1 to 431)
  AUTHORS   Sehayek,E. and Eisenberg,S.
  TITLE     Mechanisms of inhibition by apolipoprotein C of apolipoprotein
            E-dependent cellular metabolism of human triglyceride-rich
            lipoproteins through the low density lipoprotein receptor pathway
  JOURNAL   J Biol Chem 266 (27), 18259-18267 (1991)
   PUBMED   1917954
REFERENCE   8  (bases 1 to 431)
  AUTHORS   Poensgen,J.
  TITLE     Apolipoprotein C-1 inhibits the hydrolysis by phospholipase A2 of
            phospholipids in liposomes and cell membranes
  JOURNAL   Biochim Biophys Acta 1042 (2), 188-192 (1990)
   PUBMED   2302419
REFERENCE   9  (bases 1 to 431)
  AUTHORS   Shen,P.Y. and Howlett,G.J.
  TITLE     Nucleotide sequence of cDNA for rat apolipoprotein C-I
  JOURNAL   Nucleic Acids Res 17 (15), 6405 (1989)
   PUBMED   2771655
REFERENCE   10 (bases 1 to 431)
  AUTHORS   Kinnunen,P.K. and Ehnolm,C.
  TITLE     Effect of serum and C-apoproteins from very low density
            lipoproteins on human postheparin plasma hepatic lipase
  JOURNAL   FEBS Lett 65 (3), 354-357 (1976)
   PUBMED   182536
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AY327505.1 and BC098670.1.
            
            Transcript Variant: This variant (2) contains an additional 5'
            non-coding exon, therefore, has a different 5' UTR compared to
            transcript variant 1. Transcript variants 1 and 2 encode the same
            protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ212377.1, FQ210440.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132291, SAMD00132293
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-401               AY327505.1         18-418
            402-431             BC098670.1         376-405
FEATURES             Location/Qualifiers
     source          1..431
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..431
                     /gene="Apoc1"
                     /gene_synonym="ALPCI; Apo-CIB; ApoC-IB; LRRG04"
                     /note="apolipoprotein C1"
                     /db_xref="GeneID:25292"
                     /db_xref="RGD:2134"
     exon            1..30
                     /gene="Apoc1"
                     /gene_synonym="ALPCI; Apo-CIB; ApoC-IB; LRRG04"
                     /inference="alignment:Splign:2.1.0"
     exon            31..106
                     /gene="Apoc1"
                     /gene_synonym="ALPCI; Apo-CIB; ApoC-IB; LRRG04"
                     /inference="alignment:Splign:2.1.0"
     CDS             49..315
                     /gene="Apoc1"
                     /gene_synonym="ALPCI; Apo-CIB; ApoC-IB; LRRG04"
                     /note="apo-CI; apoC-I; liver regeneration-related protein
                     LRRG04; apolipoprotein C-I"
                     /codon_start=1
                     /product="apolipoprotein C-I precursor"
                     /protein_id="NP_001103466.1"
                     /db_xref="GeneID:25292"
                     /db_xref="RGD:2134"
                     /translation="MRLFIALPVLIVVVAMALEGPAPAQAAPDFSSAMESLPDKLKEF
                     GNTLEDKARAAIEHIKQKEIMIKTRNWFSETLNKMKEKLKTTFA"
     exon            107..254
                     /gene="Apoc1"
                     /gene_synonym="ALPCI; Apo-CIB; ApoC-IB; LRRG04"
                     /inference="alignment:Splign:2.1.0"
     exon            255..402
                     /gene="Apoc1"
                     /gene_synonym="ALPCI; Apo-CIB; ApoC-IB; LRRG04"
                     /inference="alignment:Splign:2.1.0"
     regulatory      384..389
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Apoc1"
                     /gene_synonym="ALPCI; Apo-CIB; ApoC-IB; LRRG04"
     polyA_site      402
                     /gene="Apoc1"
                     /gene_synonym="ALPCI; Apo-CIB; ApoC-IB; LRRG04"
ORIGIN      
        1 gcgggcctcc tgagagaacc ttagatccag ggtgcccctc cagccaggat gaggctcttc
       61 atcgcacttc ctgtcctgat cgtggtcgta gccatggctt tggaaggccc agcccctgcc
      121 caggcggccc ctgacttttc cagcgcaatg gagagcttac cggataaact aaaagagttt
      181 gggaacactt tggaagataa ggcccgggca gccattgagc atatcaaaca gaaggaaatt
      241 atgatcaaga ctcggaactg gttttcagag acgctcaaca aaatgaagga gaaattaaaa
      301 accacatttg cctgagtgcc tggcgagcca cctcgcagca gcaaagaggg ccacgtgacg
      361 ggccaggtcc ctcttcaaat accaataaaa acttgtagag aaaaaaaaaa aaaaaaaaaa
      421 aaaaaaaaaa a
//
