LOCUS       NM_001033703            1756 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus apolipoprotein B mRNA editing enzyme catalytic
            subunit 3 (Apobec3), mRNA.
ACCESSION   NM_001033703 XM_235485
VERSION     NM_001033703.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1756)
  AUTHORS   Nagamachi,A., Matsui,H., Asou,H., Ozaki,Y., Aki,D., Kanai,A.,
            Takubo,K., Suda,T., Nakamura,T., Wolff,L., Honda,H. and Inaba,T.
  TITLE     Haploinsufficiency of SAMD9L, an endosome fusion facilitator,
            causes myeloid malignancies in mice mimicking human diseases with
            monosomy 7
  JOURNAL   Cancer Cell 24 (3), 305-317 (2013)
   PUBMED   24029230
REFERENCE   2  (bases 1 to 1756)
  AUTHORS   Li,S.X., Barrett,B.S., Harper,M.S., Heilman,K.J., Halemano,K.,
            Steele,A.K., Guo,K., Silverman,R.H. and Santiago,M.L.
  TITLE     Ribonuclease L is not critical for innate restriction and adaptive
            immunity against Friend retrovirus infection
  JOURNAL   Virology 443 (1), 134-142 (2013)
   PUBMED   23725696
REFERENCE   3  (bases 1 to 1756)
  AUTHORS   Phalora,P.K., Sherer,N.M., Wolinsky,S.M., Swanson,C.M. and
            Malim,M.H.
  TITLE     HIV-1 replication and APOBEC3 antiviral activity are not regulated
            by P bodies
  JOURNAL   J Virol 86 (21), 11712-11724 (2012)
   PUBMED   22915799
REFERENCE   4  (bases 1 to 1756)
  AUTHORS   Ooms,M., Krikoni,A., Kress,A.K., Simon,V. and Munk,C.
  TITLE     APOBEC3A, APOBEC3B, and APOBEC3H haplotype 2 restrict human
            T-lymphotropic virus type 1
  JOURNAL   J Virol 86 (11), 6097-6108 (2012)
   PUBMED   22457529
REFERENCE   5  (bases 1 to 1756)
  AUTHORS   Chen,Z., Eggerman,T.L., Bocharov,A.V., Baranova,I.N.,
            Vishnyakova,T.G., Kurlander,R.J., Csako,G. and Patterson,A.P.
  TITLE     Hypermutation of ApoB mRNA by rat APOBEC-1 overexpression mimics
            APOBEC-3 hypermutation
  JOURNAL   J Mol Biol 418 (1-2), 65-81 (2012)
   PUBMED   22326345
  REMARK    GeneRIF: It was found that rat APOBEC-1 overexpression had a
            hypermutation pattern similar to that of APOBEC-3s on its substrate
            apolipoprotein B mRNA.
REFERENCE   6  (bases 1 to 1756)
  AUTHORS   OhAinle,M., Kerns,J.A., Li,M.M., Malik,H.S. and Emerman,M.
  TITLE     Antiretroelement activity of APOBEC3H was lost twice in recent
            human evolution
  JOURNAL   Cell Host Microbe 4 (3), 249-259 (2008)
   PUBMED   18779051
REFERENCE   7  (bases 1 to 1756)
  AUTHORS   OhAinle,M., Kerns,J.A., Malik,H.S. and Emerman,M.
  TITLE     Adaptive evolution and antiviral activity of the conserved
            mammalian cytidine deaminase APOBEC3H
  JOURNAL   J Virol 80 (8), 3853-3862 (2006)
   PUBMED   16571802
REFERENCE   8  (bases 1 to 1756)
  AUTHORS   Chen,H., Lilley,C.E., Yu,Q., Lee,D.V., Chou,J., Narvaiza,I.,
            Landau,N.R. and Weitzman,M.D.
  TITLE     APOBEC3A is a potent inhibitor of adeno-associated virus and
            retrotransposons
  JOURNAL   Curr Biol 16 (5), 480-485 (2006)
   PUBMED   16527742
REFERENCE   9  (bases 1 to 1756)
  AUTHORS   Delebecque,F., Suspene,R., Calattini,S., Casartelli,N., Saib,A.,
            Froment,A., Wain-Hobson,S., Gessain,A., Vartanian,J.P. and
            Schwartz,O.
  TITLE     Restriction of foamy viruses by APOBEC cytidine deaminases
  JOURNAL   J Virol 80 (2), 605-614 (2006)
   PUBMED   16378963
REFERENCE   10 (bases 1 to 1756)
  AUTHORS   Chesebro,B., Wehrly,K., Doig,D. and Nishio,J.
  TITLE     Antibody-induced modulation of Friend virus cell surface antigens
            decreases virus production by persistent erythroleukemia cells:
            influence of the Rfv-3 gene
  JOURNAL   Proc Natl Acad Sci U S A 76 (11), 5784-5788 (1979)
   PUBMED   293683
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Mar 18, 2021 this sequence version replaced NM_001033703.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC101878.1, SRR26643292.30856.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            RefSeq Select criteria           :: based on conservation,
                                                expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-148               JAXUCZ010000007.1  113314196-113314343
            149-305             JAXUCZ010000007.1  113316842-113316998
            306-585             JAXUCZ010000007.1  113319405-113319684
            586-700             JAXUCZ010000007.1  113319823-113319937
            701-863             JAXUCZ010000007.1  113330710-113330872
            864-1125            JAXUCZ010000007.1  113331692-113331953
            1126-1238           JAXUCZ010000007.1  113332201-113332313
            1239-1756           JAXUCZ010000007.1  113332789-113333306
FEATURES             Location/Qualifiers
     source          1..1756
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q34"
     gene            1..1756
                     /gene="Apobec3"
                     /gene_synonym="Apobec3b; Apobec3f"
                     /note="apolipoprotein B mRNA editing enzyme catalytic
                     subunit 3"
                     /db_xref="GeneID:315137"
                     /db_xref="RGD:1307800"
     exon            1..148
                     /gene="Apobec3"
                     /gene_synonym="Apobec3b; Apobec3f"
                     /inference="alignment:Splign:2.1.0"
     CDS             96..1253
                     /gene="Apobec3"
                     /gene_synonym="Apobec3b; Apobec3f"
                     /EC_number="3.5.4.38"
                     /note="probable DNA dC->dU-editing enzyme APOBEC3;
                     apolipoprotein B editing complex 3; apolipoprotein B mRNA
                     editing enzyme, catalytic polypeptide-like 3F;
                     apolipoprotein B mRNA editing enzyme, catalytic
                     polypeptide-like 3B; apolipoprotein B mRNA editing enzyme
                     catalytic subunit 3B"
                     /codon_start=1
                     /product="DNA dC->dU-editing enzyme APOBEC3"
                     /protein_id="NP_001028875.1"
                     /db_xref="GeneID:315137"
                     /db_xref="RGD:1307800"
                     /translation="MGPVCLGCSHRRPYSPIRNPLKKLYQQTFYFHFKNVRYAWGRKN
                     NFLCYEVNGMDCALPVPLRQGVFRKQGHIHAELCFIYWFHDKVLRVLSPMEEFKVTWY
                     MSWSPCSKCAEQVARFLAAHRNLSLAIFSSRLYYYLRNPNYQQKLCRLIQEGVHVAAM
                     DLPEFKKCWNKFVDNDGQPFRPWMRLRINFSFYDCKLQEIFSRMNLLREDVFYLQFNN
                     SHRVKPVQNRYYRRKSYLCYQLERANGQEPLKGYLLYKKGEQHVEILFLEKMRSMELS
                     QVRITCYLTWSPCPNCARQLAAFKKDHPDLILRIYTSRLYFYWRKKFQKGLCTLWRSG
                     IHVDVMDLPQFADCWTNFVNPQRPFRPWNELEKNSWRIQRRLRRIKESWGL"
     exon            149..305
                     /gene="Apobec3"
                     /gene_synonym="Apobec3b; Apobec3f"
                     /inference="alignment:Splign:2.1.0"
     exon            306..585
                     /gene="Apobec3"
                     /gene_synonym="Apobec3b; Apobec3f"
                     /inference="alignment:Splign:2.1.0"
     exon            586..700
                     /gene="Apobec3"
                     /gene_synonym="Apobec3b; Apobec3f"
                     /inference="alignment:Splign:2.1.0"
     exon            701..863
                     /gene="Apobec3"
                     /gene_synonym="Apobec3b; Apobec3f"
                     /inference="alignment:Splign:2.1.0"
     exon            864..1125
                     /gene="Apobec3"
                     /gene_synonym="Apobec3b; Apobec3f"
                     /inference="alignment:Splign:2.1.0"
     exon            1126..1238
                     /gene="Apobec3"
                     /gene_synonym="Apobec3b; Apobec3f"
                     /inference="alignment:Splign:2.1.0"
     exon            1239..1756
                     /gene="Apobec3"
                     /gene_synonym="Apobec3b; Apobec3f"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggaagtcact cgaacttctg gggtctccca aagccagggc ctgtacattg gcagttgtac
       61 aaatgcaacc ccagggtctg gggcccaacg ctgggatggg accagtgtgc ctgggatgca
      121 gccatcgcag accctattca ccgatcagaa acccgctaaa gaagttatat caacaaacat
      181 tctactttca ttttaagaac gtacgctatg cctggggtcg aaagaataac ttcttgtgct
      241 atgaagtgaa tgggatggac tgcgctttac ctgtccccct tcgccaaggg gtcttcagga
      301 aacagggcca catccacgcc gaactctgct tcatatactg gttccacgac aaagtcctga
      361 gagtgctgtc cccgatggaa gagttcaagg tcacgtggta catgtcctgg agcccctgca
      421 gcaagtgcgc ggagcaggta gccaggttcc tggccgcaca ccgcaaccta agcctggcca
      481 tcttcagctc ccgcttgtac tactacttaa ggaacccgaa ctaccagcag aagctctgca
      541 ggctgattca ggaaggagtc cacgtggctg ccatggacct accagaattt aaaaagtgtt
      601 ggaacaagtt tgtggacaat gacggccaac cattcaggcc ttggatgaga ctgagaataa
      661 attttagttt ctatgattgc aagcttcagg agattttcag ccgaatgaat ctgctaaggg
      721 aagatgtatt ttacttgcaa tttaacaaca gccaccgggt caagccagtc cagaatcgct
      781 actatcgcag gaagtcctat ctgtgctacc aactggagcg ggccaatggc caagagccac
      841 tcaaaggcta cctgctatac aagaaaggtg aacagcatgt agaaatcctc ttccttgaga
      901 agatgcggtc catggagctg agccaagtgc gaattacctg ctacctcacc tggagcccct
      961 gcccaaactg tgcccggcaa ctcgctgcat tcaaaaagga tcacccagac ctaattctgc
     1021 ggatctatac ctcccgcctg tatttctact ggaggaagaa gttccagaag gggctgtgta
     1081 ctctgtggcg atcagggatc cacgtggacg tcatggacct ccctcagttt gctgactgct
     1141 ggacaaactt tgtgaacccg caaaggccct ttaggccatg gaatgaactg gagaaaaaca
     1201 gctggcgcat acaaaggcgg ctccggagga tcaaggagtc ctggggcctg taagatttgg
     1261 tgaataactt tgaaaatctg caccttggac ccccgttgcc ttgaacagca agaagaggtt
     1321 caagaaaatc ttttggtgac ccccccccaa ccccaagtct atttctttgt tttcctttct
     1381 gttttgttgt cgtcttgctt tggtttgaag acagggtctc accgtgtagc ttgccacgct
     1441 ggaacgcaat actagaccaa ctggccttaa actgtgaaat ccacctgcca gtgtcttctt
     1501 tttatctttt ttatttttcc atcaataggt gctttatttt gtacttgaaa attttcagtt
     1561 gggccgggca tggtgacaca gcatgcctct aatcgcaggc aaaggcagga ggatctccct
     1621 gagcttgagg ccagtctggc ctacatagtg ggctctagga cagccagaac tacacagagg
     1681 gaccctgtct aaaaaataat atgaatgaat aaataaataa atgggagaaa taaaagaaag
     1741 aagagattaa gtttta
//
