LOCUS       NM_012907               1320 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus apolipoprotein B mRNA editing enzyme catalytic
            subunit 1 (Apobec1), mRNA.
ACCESSION   NM_012907
VERSION     NM_012907.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1320)
  AUTHORS   Li,X., Wang,Y., Liu,Y., Yang,B., Wang,X., Wei,J., Lu,Z., Zhang,Y.,
            Wu,J., Huang,X., Yang,L. and Chen,J.
  TITLE     Base editing with a Cpf1-cytidine deaminase fusion
  JOURNAL   Nat Biotechnol 36 (4), 324-327 (2018)
   PUBMED   29553573
  REMARK    GeneRIF: To overcome this limitation, we developed a
            CRISPR-Cpf1-based BE by fusing the rat cytosine deaminase APOBEC1
            to a catalytically inactive version of Lachnospiraceae bacterium
            Cpf1.
REFERENCE   2  (bases 1 to 1320)
  AUTHORS   Fossat,N., Tourle,K., Radziewic,T., Barratt,K., Liebhold,D.,
            Studdert,J.B., Power,M., Jones,V., Loebel,D.A. and Tam,P.P.
  TITLE     C to U RNA editing mediated by APOBEC1 requires RNA-binding protein
            RBM47
  JOURNAL   EMBO Rep 15 (8), 903-910 (2014)
   PUBMED   24916387
REFERENCE   3  (bases 1 to 1320)
  AUTHORS   Saraconi,G., Severi,F., Sala,C., Mattiuz,G. and Conticello,S.G.
  TITLE     The RNA editing enzyme APOBEC1 induces somatic mutations and a
            compatible mutational signature is present in esophageal
            adenocarcinomas
  JOURNAL   Genome Biol 15 (7), 417 (2014)
   PUBMED   25085003
  REMARK    GeneRIF: Results show that expression of APOBEC1 induces a mutator
            phenotype in 2 different cellular models.
            Erratum:[Genome Biol. 2014;15(11):497]
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1320)
  AUTHORS   Li,W., Cheng,X., Chen,H.S. and He,Z.Y.
  TITLE     Apobec-1 increases cyclooxygenase-2 and aggravates injury in
            oxygen-deprived neurogenic cells and middle cerebral artery
            occlusion rats
  JOURNAL   Neurochem Res 38 (7), 1434-1445 (2013)
   PUBMED   23609497
  REMARK    GeneRIF: Apobec-1 increased COX-2 expression and COX-2 mRNA
            stabilization in neurogenic cells, and failed to catalyze C-to-U
            editing of COX-2 mRNA
REFERENCE   5  (bases 1 to 1320)
  AUTHORS   Sun,H., Samarghandi,A., Zhang,N., Yao,Z., Xiong,M. and Teng,B.B.
  TITLE     Proprotein convertase subtilisin/kexin type 9 interacts with
            apolipoprotein B and prevents its intracellular degradation,
            irrespective of the low-density lipoprotein receptor
  JOURNAL   Arterioscler Thromb Vasc Biol 32 (7), 1585-1595 (2012)
   PUBMED   22580899
REFERENCE   6  (bases 1 to 1320)
  AUTHORS   Osuga,J., Yagyu,H., Ohashi,K., Harada,K., Yazaki,Y., Yamada,N. and
            Ishibashi,S.
  TITLE     Effects of apo E deficiency on plasma lipid levels in mice lacking
            APOBEC-1
  JOURNAL   Biochem Biophys Res Commun 236 (2), 375-378 (1997)
   PUBMED   9240444
REFERENCE   7  (bases 1 to 1320)
  AUTHORS   Phung,T.L., Sowden,M.P., Sparks,J.D., Sparks,C.E. and Smith,H.C.
  TITLE     Regulation of hepatic apolipoprotein B RNA editing in the
            genetically obese Zucker rat
  JOURNAL   Metabolism 45 (9), 1056-1058 (1996)
   PUBMED   8781289
REFERENCE   8  (bases 1 to 1320)
  AUTHORS   Morrison,J.R., Paszty,C., Stevens,M.E., Hughes,S.D., Forte,T.,
            Scott,J. and Rubin,E.M.
  TITLE     Apolipoprotein B RNA editing enzyme-deficient mice are viable
            despite alterations in lipoprotein metabolism
  JOURNAL   Proc Natl Acad Sci U S A 93 (14), 7154-7159 (1996)
   PUBMED   8692961
REFERENCE   9  (bases 1 to 1320)
  AUTHORS   Hirano,K., Young,S.G., Farese,R.V. Jr., Ng,J., Sande,E.,
            Warburton,C., Powell-Braxton,L.M. and Davidson,N.O.
  TITLE     Targeted disruption of the mouse apobec-1 gene abolishes
            apolipoprotein B mRNA editing and eliminates apolipoprotein B48
  JOURNAL   J Biol Chem 271 (17), 9887-9890 (1996)
   PUBMED   8626621
REFERENCE   10 (bases 1 to 1320)
  AUTHORS   Teng,B., Burant,C.F. and Davidson,N.O.
  TITLE     Molecular cloning of an apolipoprotein B messenger RNA editing
            protein
  JOURNAL   Science 260 (5115), 1816-1819 (1993)
   PUBMED   8511591
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC085335.1.
            
            On Nov 15, 2004 this sequence version replaced NM_012907.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC085335.1, L07114.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN09767679, SAMN09767680
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1320
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q42"
     gene            1..1320
                     /gene="Apobec1"
                     /gene_synonym="apobec-1; REPR"
                     /note="apolipoprotein B mRNA editing enzyme catalytic
                     subunit 1"
                     /db_xref="GeneID:25383"
                     /db_xref="RGD:2133"
     exon            1..510
                     /gene="Apobec1"
                     /gene_synonym="apobec-1; REPR"
                     /inference="alignment:Splign:2.1.0"
     CDS             495..1184
                     /gene="Apobec1"
                     /gene_synonym="apobec-1; REPR"
                     /EC_number="3.5.4.36"
                     /note="apolipoprotein B mRNA-editing enzyme 1;
                     apolipoprotein B mRNA editing enzyme, catalytic
                     polypeptide 1; Apolipoprotein B editing protein;
                     apolipoprotein B editing complex 1; mRNA(cytosine(6666))
                     deaminase 1; apo B messenger RNA-editing protein"
                     /codon_start=1
                     /product="C->U-editing enzyme APOBEC-1"
                     /protein_id="NP_037039.1"
                     /db_xref="GeneID:25383"
                     /db_xref="RGD:2133"
                     /translation="MSSETGPVAVDPTLRRRIEPHEFEVFFDPRELRKETCLLYEINW
                     GGRHSIWRHTSQNTNKHVEVNFIEKFTTERYFCPNTRCSITWFLSWSPCGECSRAITE
                     FLSRYPHVTLFIYIARLYHHADPRNRQGLRDLISSGVTIQIMTEQESGYCWRNFVNYS
                     PSNEAHWPRYPHLWVRLYVLELYCIILGLPPCLNILRRKQPQLTFFTIALQSCHYQRL
                     PPHILWATGLK"
     exon            511..538
                     /gene="Apobec1"
                     /gene_synonym="apobec-1; REPR"
                     /inference="alignment:Splign:2.1.0"
     exon            539..936
                     /gene="Apobec1"
                     /gene_synonym="apobec-1; REPR"
                     /inference="alignment:Splign:2.1.0"
     exon            937..1055
                     /gene="Apobec1"
                     /gene_synonym="apobec-1; REPR"
                     /inference="alignment:Splign:2.1.0"
     exon            1056..1274
                     /gene="Apobec1"
                     /gene_synonym="apobec-1; REPR"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccaaggtcct gcttttgcat cttaagccgc ccctcctttc tccaacagac acgaggagca
       61 aagggtaact gagagggagt agcaggtaaa gcccacagtg ttctcaccgg gtcaccctga
      121 ggacttctta gttataggag ctgcttcatt ctctccgatc cgtgctggct tctctcccac
      181 tctcacttga aggaagggga aagctttcta agtttagccg tcactctgga atttaacatc
      241 atcgatgttc tactgtgcag cgttgatggt tcgatgggct ctctccaggg aggacggaaa
      301 tccagatgcc acttccttct tcatttacat agcattcata tcacgtcgcg actgacgctc
      361 aggaatgagt catcctgtgt ccctgcaggt ggccgtgggc acacctgagg aagcaaagtc
      421 cggcacgcag ctggcagcag ccatcgccgc aacataagct cccgaggaag gagtccagag
      481 acacagagag caagatgagt tccgagacag gccctgtagc tgttgatccc actctgagga
      541 gaagaattga gccccacgag tttgaagtct tctttgaccc ccgggaactt cggaaagaga
      601 cctgtctgct gtatgagatc aactggggag gaaggcacag catctggcga cacacgagcc
      661 aaaacaccaa caaacacgtt gaagtcaatt tcatagaaaa atttactaca gaaagatact
      721 tttgtccaaa caccagatgc tccattacct ggttcctgtc ctggagtccc tgtggggagt
      781 gctccagggc cattacagaa tttttgagcc gataccccca tgtaactctg tttatttata
      841 tagcacggct ttatcaccac gcagatcctc gaaatcggca aggactcagg gaccttatta
      901 gcagcggtgt tactatccag atcatgacgg agcaagagtc tggctactgc tggaggaatt
      961 ttgtcaacta ctccccttcg aatgaagctc attggccaag gtacccccat ctgtgggtga
     1021 ggctgtacgt actggaactc tactgcatca ttttaggact tccaccctgt ttaaatattt
     1081 taagaagaaa acaacctcaa ctcacgtttt tcacgattgc tcttcaaagc tgccattacc
     1141 aaaggctacc accccacatc ctgtgggcca cagggttgaa atgacttctg ggagttgggg
     1201 atggatgaaa tgactccttg tatgtcttga cagcaagcat tgattaccca ctaaagagcg
     1261 actgccacaa ggaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
//
