LOCUS       NM_080576               1870 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus apolipoprotein A5 (Apoa5), transcript variant 1,
            mRNA.
ACCESSION   NM_080576 XM_346820
VERSION     NM_080576.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1870)
  AUTHORS   Chen,J., Luo,J., Yang,X., Ouyang,M., Zhu,T., Li,Y., Luo,P.,
            Chen,Y., Li,Z. and Li,J.
  TITLE     Expression of ApoA5 and its function in the right ventricular
            failing and remodeling secondary to pulmonary hypertension
  JOURNAL   J Cell Physiol 236 (2), 1013-1024 (2021)
   PUBMED   32602585
  REMARK    GeneRIF: Expression of ApoA5 and its function in the right
            ventricular failing and remodeling secondary to pulmonary
            hypertension.
REFERENCE   2  (bases 1 to 1870)
  AUTHORS   Zhang,L.S., Sato,H., Yang,Q., Ryan,R.O., Wang,D.Q., Howles,P.N. and
            Tso,P.
  TITLE     Apolipoprotein A-V is present in bile and its secretion increases
            with lipid absorption in Sprague-Dawley rats
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 309 (11), G918-G925 (2015)
   PUBMED   26505974
  REMARK    GeneRIF: Demonstrate that apoA-V is secreted into bile, introducing
            a potential route of delivery of hepatic apoA-V to the gut lumen.
REFERENCE   3  (bases 1 to 1870)
  AUTHORS   Feng,Q., Baker,S.S., Liu,W., Arbizu,R.A., Aljomah,G., Khatib,M.,
            Nugent,C.A., Baker,R.D., Forte,T.M., Hu,Y. and Zhu,L.
  TITLE     Increased apolipoprotein A5 expression in human and rat
            non-alcoholic fatty livers
  JOURNAL   Pathology 47 (4), 341-348 (2015)
   PUBMED   25938357
  REMARK    GeneRIF: Our data support the hypothesis that apoA5 promotes
            hepatic TG storage and therefore contributes to the pathogenesis of
            non-alcoholic fatty liver disease
REFERENCE   4  (bases 1 to 1870)
  AUTHORS   Wang,M.H., Li,J., Yeung,V.S., Zee,B.C., Yu,R.H., Ho,S. and
            Waye,M.M.
  TITLE     Four pairs of gene-gene interactions associated with increased risk
            for type 2 diabetes (CDKN2BAS-KCNJ11), obesity (SLC2A9-IGF2BP2,
            FTO-APOA5), and hypertension (MC4R-IGF2BP2) in Chinese women
  JOURNAL   Meta Gene 2, 384-391 (2014)
   PUBMED   25606423
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1870)
  AUTHORS   Blade,A.M., Fabritius,M.A., Hou,L., Weinberg,R.B. and Shelness,G.S.
  TITLE     Biogenesis of apolipoprotein A-V and its impact on VLDL
            triglyceride secretion
  JOURNAL   J Lipid Res 52 (2), 237-244 (2011)
   PUBMED   21115968
  REMARK    GeneRIF: apoA-V inefficiently traffics within the secretory
            pathway, that its intracellular itinerary can be regulated by
            changes in cellular TG accumulation, and that apoA-V synthesis can
            modulate VLDL TG mobilization and secretion.
REFERENCE   6  (bases 1 to 1870)
  AUTHORS   Weinberg,R.B., Cook,V.R., Beckstead,J.A., Martin,D.D.,
            Gallagher,J.W., Shelness,G.S. and Ryan,R.O.
  TITLE     Structure and interfacial properties of human apolipoprotein A-V
  JOURNAL   J Biol Chem 278 (36), 34438-34444 (2003)
   PUBMED   12810715
REFERENCE   7  (bases 1 to 1870)
  AUTHORS   Horinek,A., Vrablik,M., Ceska,R., Adamkova,V., Poledne,R. and
            Hubacek,J.A.
  TITLE     T-1131-->C polymorphism within the apolipoprotein AV gene in
            hypertriglyceridemic individuals
  JOURNAL   Atherosclerosis 167 (2), 369-370 (2003)
   PUBMED   12818421
REFERENCE   8  (bases 1 to 1870)
  AUTHORS   Talmud,P.J., Hawe,E., Martin,S., Olivier,M., Miller,G.J.,
            Rubin,E.M., Pennacchio,L.A. and Humphries,S.E.
  TITLE     Relative contribution of variation within the APOC3/A4/A5 gene
            cluster in determining plasma triglycerides
  JOURNAL   Hum Mol Genet 11 (24), 3039-3046 (2002)
   PUBMED   12417525
REFERENCE   9  (bases 1 to 1870)
  AUTHORS   van der Vliet,H.N., Sammels,M.G., Leegwater,A.C., Levels,J.H.,
            Reitsma,P.H., Boers,W. and Chamuleau,R.A.
  TITLE     Apolipoprotein A-V: a novel apolipoprotein associated with an early
            phase of liver regeneration
  JOURNAL   J Biol Chem 276 (48), 44512-44520 (2001)
   PUBMED   11577099
REFERENCE   10 (bases 1 to 1870)
  AUTHORS   Pennacchio,L.A., Olivier,M., Hubacek,J.A., Cohen,J.C., Cox,D.R.,
            Fruchart,J.C., Krauss,R.M. and Rubin,E.M.
  TITLE     An apolipoprotein influencing triglycerides in humans and mice
            revealed by comparative sequencing
  JOURNAL   Science 294 (5540), 169-173 (2001)
   PUBMED   11588264
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC089780.1.
            
            On Mar 27, 2013 this sequence version replaced NM_080576.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Both variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC089780.1, CO574180.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1870              BC089780.1         1-1870
FEATURES             Location/Qualifiers
     source          1..1870
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q22"
     gene            1..1870
                     /gene="Apoa5"
                     /gene_synonym="apo-AV; apoA-V"
                     /note="apolipoprotein A5"
                     /db_xref="GeneID:140638"
                     /db_xref="RGD:70903"
     exon            1..52
                     /gene="Apoa5"
                     /gene_synonym="apo-AV; apoA-V"
                     /inference="alignment:Splign:2.1.0"
     exon            53..109
                     /gene="Apoa5"
                     /gene_synonym="apo-AV; apoA-V"
                     /inference="alignment:Splign:2.1.0"
     CDS             70..1173
                     /gene="Apoa5"
                     /gene_synonym="apo-AV; apoA-V"
                     /note="regeneration-associated protein 3; apolipoprotein
                     A-V"
                     /codon_start=1
                     /product="apolipoprotein A-V precursor"
                     /protein_id="NP_542143.1"
                     /db_xref="GeneID:140638"
                     /db_xref="RGD:70903"
                     /translation="MAAVITWALALLSVFATVQARKSFWEYFGQNSQGKGMMGQQQKL
                     AQESLKGSLEQDLYNMNNFLEKLGPLREPGKEPPRLAQDPEGIRKQLQQELEEVSTRL
                     EPYMAAKHQQVGWNLEGLRQQLKPYTVELMEQVGLSVQDLQEQLRMVGKGTKAQLLGG
                     VDEAMSLLQDMQSRVLHHTDRVKELFHPYAERLVTGIGHHVQELHRSVAPHAVASPAR
                     LSRCVQTLSHKLTRKAKDLHTSIQRNLDQLRDELSTFIRVSTDGADNRDSLDPQALSD
                     EVRQRLQAFRHDTYLQIAAFTQAIDQETEEIQHQLAPPPPSHSAFAPELGHSDSNKAL
                     SRLQSRLDDLWEDIAYGLHDQGHSQNNPEGHSG"
     exon            110..209
                     /gene="Apoa5"
                     /gene_synonym="apo-AV; apoA-V"
                     /inference="alignment:Splign:2.1.0"
     exon            210..1841
                     /gene="Apoa5"
                     /gene_synonym="apo-AV; apoA-V"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggtaatctct gtagggcagc ctgcgttcca ggctcgctac tttgtgacag agagagcatc
       61 gtggaaagca tggctgccgt catcacctgg gcactcgccc tcctctcagt gtttgcaact
      121 gtacaggcga ggaagagctt ctgggagtac ttcggccaga acagccaggg caaaggcatg
      181 atgggccagc agcagaagct ggcacaggag agcctgaaag gtagcttgga gcaagacctc
      241 tacaatatga acaatttcct agaaaagctg ggacccttga gagagcctgg gaaggagcct
      301 cctcggctgg cacaggatcc agaaggcatt cggaagcagt tgcagcaaga gctggaggaa
      361 gtgagcacac gcctggagcc ctacatggct gcaaagcacc agcaggtcgg ctggaacctg
      421 gagggcttga ggcagcagtt gaaaccctac acggtcgagc tgatggagca ggtaggcctg
      481 agcgtgcagg atctgcaaga acagctgcgc atggtgggaa aaggcaccaa ggcccagctc
      541 ctggggggcg tggatgaggc gatgagcctg ctgcaggata tgcaaagtcg agtgctgcac
      601 catacggacc gagtcaaaga actcttccac ccttatgcag aacgcttggt gactggaatt
      661 gggcaccatg tgcaggagct gcaccggagt gttgctcctc acgcagttgc cagccccgcg
      721 agactcagtc gctgcgtgca gaccctgtcc cacaaactca cacgtaaggc gaaggacttg
      781 cacaccagca tccaacgcaa cctagatcag ctgcgagatg agctcagtac cttcatccgt
      841 gtcagcacag acggggcaga caacagagac tccctggacc ctcaagctct ctctgacgag
      901 gtccgccaga gactccaggc ttttcgacat gacacctacc tgcagatcgc tgcattcact
      961 caggccattg accaggagac cgaggaaatc cagcaccagc tggcaccacc cccgcctagc
     1021 cacagcgcct tcgctccaga gttgggacac tcagacagta ataaggccct gagcagactg
     1081 cagagccggc tggacgacct ctgggaagat attgcctatg gccttcatga ccagggccat
     1141 agtcagaata accctgaggg tcactcaggt taactctgca gctcgttgtc tggaccctga
     1201 gccttcagca tggcctaata ggcagagggt ggagggtcct gcatactatt ggcgaggcca
     1261 ccaaaggtgc tgctgcccca acctgtccgg cctcctcaac tcccccactc aggtgcatta
     1321 cactcagtag gtttggcaaa cacagcttct ggtgctcatt tgggatccta aggagcaaga
     1381 gtggggtgaa gggagtgggg agatggtgtg cgggggagac tgactgcaaa ccagtacttg
     1441 accgttgcta gaaacctgtg tcactacaac ctggagcccg gctcctatta cttcatgcct
     1501 gatggtcgct gttatagtcg gtctacagag gggaactcct gtctccccag ggttgtcatg
     1561 acagcctttg ttggaagaga gcaggagaac atgacacgta tgatggagtg tgtacatccc
     1621 tgccagtggt cctgctgggg gatcagtgat gggatggggt agagccccta tttccttaga
     1681 gaactctaac ccaaataagg aactgagccc tctgcagtga gggcttctga aaaccctgta
     1741 catagcaaac tgtgtgccct cttcatcatg cagtccccac ctcctgattc tcgggatgga
     1801 actgactttt ggttggaatg aaatagacgc tcatgatgga aaaaaaaaaa aaaaaaaaaa
     1861 aaaaaaaaaa
//
