LOCUS       NM_012737               1425 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus apolipoprotein A4 (Apoa4), mRNA.
ACCESSION   NM_012737
VERSION     NM_012737.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1425)
  AUTHORS   Liu,M., Shen,L., Xu,M., Wang,D.Q. and Tso,P.
  TITLE     Estradiol Enhances Anorectic Effect of Apolipoprotein A-IV through
            ERalpha-PI3K Pathway in the Nucleus Tractus Solitarius
  JOURNAL   Genes (Basel) 11 (12), 1494 (2020)
   PUBMED   33322656
  REMARK    GeneRIF: Estradiol Enhances Anorectic Effect of Apolipoprotein A-IV
            through ERalpha-PI3K Pathway in the Nucleus Tractus Solitarius.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1425)
  AUTHORS   Wang,X., Gong,Y., Deng,T., Zhang,L., Liao,X., Han,C., Yang,C.,
            Huang,J., Wang,Q., Song,X., Zhang,T., Yu,T., Zhu,G., Ye,X. and
            Peng,T.
  TITLE     Diagnostic and prognostic significance of mRNA expressions of
            apolipoprotein A and C family genes in hepatitis B virus-related
            hepatocellular carcinoma
  JOURNAL   J Cell Biochem 120 (10), 18246-18265 (2019)
   PUBMED   31211449
REFERENCE   3  (bases 1 to 1425)
  AUTHORS   Wang,Z., Wang,L., Zhang,Z., Feng,L., Song,X. and Wu,J.
  TITLE     Apolipoprotein A-IV involves in glucose and lipid metabolism of rat
  JOURNAL   Nutr Metab (Lond) 16, 41 (2019)
   PUBMED   31303888
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1425)
  AUTHORS   Shen,L., Lo,C.C., Woollett,L.A. and Liu,M.
  TITLE     Apolipoprotein A-IV exerts its anorectic action through a PI3K/Akt
            signaling pathway in the hypothalamus
  JOURNAL   Biochem Biophys Res Commun 494 (1-2), 152-157 (2017)
   PUBMED   29037812
  REMARK    GeneRIF: demonstrate a critical role of the PI3K/Akt pathway in
            apoA-IV's anorectic action in lean rats and suggest a defective
            PI3K pathway in the ventromedial hypothalamus is responsible for
            the impaired apoA-IV's anorectic action in the diet-induced obese
            animals
REFERENCE   5  (bases 1 to 1425)
  AUTHORS   Barallobre-Barreiro,J., Gupta,S.K., Zoccarato,A.,
            Kitazume-Taneike,R., Fava,M., Yin,X., Werner,T., Hirt,M.N.,
            Zampetaki,A., Viviano,A., Chong,M., Bern,M., Kourliouros,A.,
            Domenech,N., Willeit,P., Shah,A.M., Jahangiri,M., Schaefer,L.,
            Fischer,J.W., Iozzo,R.V., Viner,R., Thum,T., Heineke,J.,
            Kichler,A., Otsu,K. and Mayr,M.
  TITLE     Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin
            Activity in Human Atrial Fibrillation
  JOURNAL   Circulation 134 (11), 817-832 (2016)
   PUBMED   27559042
REFERENCE   6  (bases 1 to 1425)
  AUTHORS   Duverger,N., Murry-Brelier,A., Latta,M., Reboul,S., Castro,G.,
            Mayaux,J.F., Fruchart,J.C., Taylor,J.M., Steinmetz,A. and
            Denefle,P.
  TITLE     Functional characterization of human recombinant apolipoprotein AIV
            produced in Escherichia coli
  JOURNAL   Eur J Biochem 201 (2), 373-383 (1991)
   PUBMED   1935934
REFERENCE   7  (bases 1 to 1425)
  AUTHORS   Langner,C.A., Birkenmeier,E.H., Roth,K.A., Bronson,R.T. and
            Gordon,J.I.
  TITLE     Characterization of the peripheral neuropathy in neonatal and adult
            mice that are homozygous for the fatty liver dystrophy (fld)
            mutation
  JOURNAL   J Biol Chem 266 (18), 11955-11964 (1991)
   PUBMED   2050689
REFERENCE   8  (bases 1 to 1425)
  AUTHORS   Boyles,J.K., Notterpek,L.M. and Anderson,L.J.
  TITLE     Accumulation of apolipoproteins in the regenerating and
            remyelinating mammalian peripheral nerve. Identification of
            apolipoprotein D, apolipoprotein A-IV, apolipoprotein E, and
            apolipoprotein A-I
  JOURNAL   J Biol Chem 265 (29), 17805-17815 (1990)
   PUBMED   2120218
REFERENCE   9  (bases 1 to 1425)
  AUTHORS   Ito,Y., Azrolan,N., O'Connell,A., Walsh,A. and Breslow,J.L.
  TITLE     Hypertriglyceridemia as a result of human apo CIII gene expression
            in transgenic mice
  JOURNAL   Science 249 (4970), 790-793 (1990)
   PUBMED   2167514
REFERENCE   10 (bases 1 to 1425)
  AUTHORS   Schonfeld,G., George,P.K., Miller,J., Reilly,P. and Witztum,J.
  TITLE     Apolipoprotein C-II and C-III levels in hyperlipoproteinemia
  JOURNAL   Metabolism 28 (10), 1001-1010 (1979)
   PUBMED   226830
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Nov 27, 2020 this sequence version replaced NM_012737.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M00002.1, FQ218620.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760400, SAMEA5760475
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-141               JAXUCZ010000008.1  55435779-55435919
            142-268             JAXUCZ010000008.1  55436195-55436321
            269-1425            JAXUCZ010000008.1  55437004-55438160
FEATURES             Location/Qualifiers
     source          1..1425
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q22"
     gene            1..1425
                     /gene="Apoa4"
                     /gene_synonym="Apo-AIV; ApoA-IV; apoAIV"
                     /note="apolipoprotein A4"
                     /db_xref="GeneID:25080"
                     /db_xref="RGD:2132"
     exon            1..141
                     /gene="Apoa4"
                     /gene_synonym="Apo-AIV; ApoA-IV; apoAIV"
                     /inference="alignment:Splign:2.1.0"
     CDS             93..1268
                     /gene="Apoa4"
                     /gene_synonym="Apo-AIV; ApoA-IV; apoAIV"
                     /note="apolipoprotein A-IV"
                     /codon_start=1
                     /product="apolipoprotein A-IV precursor"
                     /protein_id="NP_036869.2"
                     /db_xref="GeneID:25080"
                     /db_xref="RGD:2132"
                     /translation="MFLKAVVLTVALVAITGTQAEVTSDQVANVMWDYFTQLSNNAKE
                     AVEQLQKTDVTQQLNTLFQDKLGNINTYADDLQNKLVPFAVQLSGHLTKETERVREEI
                     QKELEDLRANMMPHANKVSQMFGDNVQKLQEHLRPYATDLQAQINAQTQDMKRQLTPY
                     IQRMQTTIQDNVENLQSSMVPFANELKEKFNQNMEGLKGQLTPRANELKATIDQNLED
                     LRSRLAPLAEGVQEKLNHQMEGLAFQMKKNAEELQTKVSTNIDQLQKNLAPLVEDVQS
                     KLKGNTEGLQKSLEDLNKQLDQQVEVFRRAVEPLGDKFNMALVQQMEKFRQQLGSDSG
                     DVESHLSFLEKNLREKVSSFMSTLQKKGSPDQPLALPLPEQVQEQVQEQVQPKPLES"
     exon            142..268
                     /gene="Apoa4"
                     /gene_synonym="Apo-AIV; ApoA-IV; apoAIV"
                     /inference="alignment:Splign:2.1.0"
     exon            269..1425
                     /gene="Apoa4"
                     /gene_synonym="Apo-AIV; ApoA-IV; apoAIV"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aatcctcaca gcgacacagg tgaaccgttt cttctgacgc taggaaacat ccagtgtagc
       61 tggggctgtc ccaacccagt gaggagccca ggatgttcct gaaggctgtg gtgctgaccg
      121 tggccctggt ggccatcacc gggacccagg ctgaggtcac ttccgaccag gtggccaatg
      181 tgatgtggga ctacttcacc cagctaagca acaatgccaa ggaggctgtg gaacaactgc
      241 agaagacaga tgtcactcaa cagctcaata ccctcttcca ggacaaactt gggaacatta
      301 acacctatgc cgatgacctg cagaacaagc tggtgccctt cgccgttcaa ctgagtggac
      361 atctaaccaa ggaaacagag agggtgaggg aagagatcca gaaggagctc gaggacctac
      421 gggccaacat gatgccccat gccaacaaag tgagccagat gttcggggac aacgtgcaga
      481 agttgcagga acacctgagg ccctatgcca cggacctgca agctcagatc aacgcacaga
      541 cccaggatat gaaacgccag ctgaccccct acatccagcg catgcagacc acaatacaag
      601 acaatgtgga aaacctgcag tcctccatgg tgccctttgc caacgagcta aaggaaaagt
      661 ttaaccagaa tatggaaggg ctcaaggggc aactaacccc ccgtgccaac gagctgaagg
      721 ccacgatcga ccagaacctg gaagacctgc gcagcagact ggcccctctc gcggagggtg
      781 tgcaggaaaa actcaaccat cagatggaag gcttggcctt ccagatgaag aagaacgctg
      841 aggagctcca gaccaaggtc tccacaaata tcgaccagct gcagaagaat ctggccccgc
      901 tggtggaaga tgtgcaaagc aagctgaaag gcaacacgga aggactgcag aagtctctgg
      961 aagacctgaa caagcagctg gaccagcagg tggaggtgtt ccggcgtgct gtggagcccc
     1021 tgggggataa gttcaacatg gctctggtgc agcagatgga gaagttcagg cagcagctgg
     1081 gctccgattc gggggacgtg gaaagccact tgagcttcct ggagaagaac ctgagggaaa
     1141 aggtcagctc ctttatgagc accctgcaaa aaaaggggag cccagaccag cccctagccc
     1201 tccccctccc ggagcaggtt caggaacagg tccaggagca ggtgcagccc aaacctctgg
     1261 agagctgagc tgtccctggt gtcctcggcc catcacagca gcagacacct gccctgcccc
     1321 accacctgtc tgtcactctg ttcccaagca cttctcgtac cagcttgagg acacatgtcc
     1381 tgtgggtgac gatacctcct ctcgttactc aataaagcat ctgag
//
