LOCUS       NP_037244                102 aa            linear   ROD 26-DEC-2024
DEFINITION  apolipoprotein A-II preproprotein [Rattus norvegicus].
ACCESSION   NP_037244 XP_006250300
VERSION     NP_037244.1
DBSOURCE    REFSEQ: accession NM_013112.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 102)
  AUTHORS   Wang,X., Gong,Y., Deng,T., Zhang,L., Liao,X., Han,C., Yang,C.,
            Huang,J., Wang,Q., Song,X., Zhang,T., Yu,T., Zhu,G., Ye,X. and
            Peng,T.
  TITLE     Diagnostic and prognostic significance of mRNA expressions of
            apolipoprotein A and C family genes in hepatitis B virus-related
            hepatocellular carcinoma
  JOURNAL   J Cell Biochem 120 (10), 18246-18265 (2019)
   PUBMED   31211449
REFERENCE   2  (residues 1 to 102)
  AUTHORS   Yeh,F.L., Wang,Y., Tom,I., Gonzalez,L.C. and Sheng,M.
  TITLE     TREM2 Binds to Apolipoproteins, Including APOE and CLU/APOJ, and
            Thereby Facilitates Uptake of Amyloid-Beta by Microglia
  JOURNAL   Neuron 91 (2), 328-340 (2016)
   PUBMED   27477018
REFERENCE   3  (residues 1 to 102)
  AUTHORS   Bastos-Amador,P., Royo,F., Gonzalez,E., Conde-Vancells,J.,
            Palomo-Diez,L., Borras,F.E. and Falcon-Perez,J.M.
  TITLE     Proteomic analysis of microvesicles from plasma of healthy donors
            reveals high individual variability
  JOURNAL   J Proteomics 75 (12), 3574-3584 (2012)
   PUBMED   22516433
REFERENCE   4  (residues 1 to 102)
  AUTHORS   Tanaka,N., Abe-Dohmae,S., Iwamoto,N., Fitzgerald,M.L. and
            Yokoyama,S.
  TITLE     Helical apolipoproteins of high-density lipoprotein enhance
            phagocytosis by stabilizing ATP-binding cassette transporter A7
  JOURNAL   J Lipid Res 51 (9), 2591-2599 (2010)
   PUBMED   20495215
REFERENCE   5  (residues 1 to 102)
  AUTHORS   Onat,A., Hergenc,G., Ayhan,E., Ugur,M. and Can,G.
  TITLE     Impaired anti-inflammatory function of apolipoprotein A-II
            concentrations predicts metabolic syndrome and diabetes at 4 years
            follow-up in elderly Turks
  JOURNAL   Clin Chem Lab Med 47 (11), 1389-1394 (2009)
   PUBMED   19817643
REFERENCE   6  (residues 1 to 102)
  AUTHORS   Strobl,W., Chan,L. and Patsch,W.
  TITLE     Differential regulation of hepatic apolipoprotein A-I and A-II gene
            expression by thyroid hormone in rat liver
  JOURNAL   Atherosclerosis 97 (2-3), 161-170 (1992)
   PUBMED   1466661
REFERENCE   7  (residues 1 to 102)
  AUTHORS   Mahlberg,F.H. and Rothblat,G.H.
  TITLE     Cellular cholesterol efflux. Role of cell membrane kinetic pools
            and interaction with apolipoproteins AI, AII, and Cs
  JOURNAL   J Biol Chem 267 (7), 4541-4550 (1992)
   PUBMED   1537840
REFERENCE   8  (residues 1 to 102)
  AUTHORS   Staels,B., van Tol,A., Andreu,T. and Auwerx,J.
  TITLE     Fibrates influence the expression of genes involved in lipoprotein
            metabolism in a tissue-selective manner in the rat
  JOURNAL   Arterioscler Thromb 12 (3), 286-294 (1992)
   PUBMED   1547188
REFERENCE   9  (residues 1 to 102)
  AUTHORS   Ritter,M.C. and Scanu,A.M.
  TITLE     Apolipoprotein A-II and structure of human serum high density
            lipoproteins. An approach by reassembly techniques
  JOURNAL   J Biol Chem 254 (7), 2517-2525 (1979)
   PUBMED   218942
REFERENCE   10 (residues 1 to 102)
  AUTHORS   Weisgraber,K.H. and Mahley,R.W.
  TITLE     Apoprotein (E--A-II) complex of human plasma lipoproteins. I.
            Characterization of this mixed disulfide and its identification in
            a high density lipoprotein subfraction
  JOURNAL   J Biol Chem 253 (17), 6281-6288 (1978)
   PUBMED   210174
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000013.1.
            
            On Apr 23, 2024 this sequence version replaced XP_006250300.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ210648.1, FQ210458.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760400, SAMEA5760475
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..102
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q24"
     Protein         1..102
                     /product="apolipoprotein A-II preproprotein"
                     /note="apolipoprotein A-II"
                     /calculated_mol_wt=9552
     Region          1..100
                     /region_name="ApoA-II"
                     /note="Apolipoprotein A-II (ApoA-II); pfam04711"
                     /db_xref="CDD:461404"
     sig_peptide     1..18
                     /note="propagated from UniProtKB/Swiss-Prot (P04638.1)"
                     /calculated_mol_wt=1905
     mat_peptide     24..102
                     /product="apolipoprotein A-II"
                     /calculated_mol_wt=8956
     CDS             1..102
                     /gene="Apoa2"
                     /gene_synonym="Apo-AII; ApoA-II; APOAII"
                     /coded_by="NM_013112.2:63..371"
                     /db_xref="GeneID:25649"
                     /db_xref="RGD:2131"
ORIGIN      
        1 mkllamvall vticslegal vrrqaaetdv qtlfsqylqs ltdygkdlme kaqpseiqnq
       61 akayfqnaqe rltpfvqrtg tnlmdflsrl mspeekpapa ak
//
